Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic β-Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Aoyagi, Kyota ^a   Ohara Imaizumi, Mica ^a   Nishiwaki, Chiyono ^a   Nakamichi, Yoko ^a   Ueki, Kohjiro ^b   Kadowaki, Takashi ^b   Nagamatsu, Shinya ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL GRANULE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; INSULIN RELEASE; MALE; MEMBRANE FUSION; MOUSE; NEWCOMER GRANULE FUSION; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; FURANS; GLUCOSE; HYDRAZONES; INSULIN; INSULIN-SECRETING CELLS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; PYRIMIDINES; SECRETORY VESICLES; SIGNAL TRANSDUCTION; SULFONAMIDES; UP-REGULATION;

EID: 84867536713     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047381     Document Type: Article

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