Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats

Neuropharmacology

Volumn 63, Issue 8, 2012, Pages 1346-1359

  Cheung, T H C ^a,b   Nolan, B C ^a,b,e   Hammerslag, L R ^a,b,f   Weber, S M ^a,b   Durbin, J P ^c   Peartree, N A ^a,b   MacH, R H ^c   Luedtke, R R ^d   Neisewander, J L ^a,b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^e Quincy University   (United States)

^f UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cocaine addiction; D3 dopamine receptors; D3 selective compound; Self administration

Indexed keywords

DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; WC 10; WC 26; WC 44;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; DRUG SELF ADMINISTRATION; DRUG TARGETING; LATENT PERIOD; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT;

ANIMALS; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTOR ACTIVITY; PIPERAZINES; PSYCHOTROPIC DRUGS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D3; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; SUCROSE;

EID: 84867522887     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.08.011     Document Type: Article

References (82)

1. C. Achat-Mendes, P. Grundt, J.J. Cao, D.M. Platt, A.H. Newman, and R.D. Spealman Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys J. Pharmacol. Exp. Ther. 334 2010 556 565
2. A.C. Barrett, J.R. Miller, J.M. Dohrmann, and S.B. Caine Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats Neuropharmacology 47 2004 256 273
3. B.L. Blaylock, R.W. Gould, A. Banala, P. Grundt, R.R. Luedtke, A.H. Newman, and M.A. Nader Influence of cocaine history on the behavioral effects of dopamine D-3 receptor-selective compounds in monkeys Neuropsychopharmacology 36 2011 1104 1113
4. B.L. Blaylock, and M.A. Nader Dopamine D3 receptor function and cocaine exposure Neuropsychopharmacology 37 2012 297 298
5. M.L. Bouthenet, E. Souil, M.P. Martres, P. Sokoloff, B. Giros, and J.C. Schwartz Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA Brain Res. 564 1991 203 219
6. J.J. Burmeister, E.M. Lungren, K.F. Kirschner, and J.L. Neisewander Differential roles of 5-HT receptor subtypes in cue and cocaine reinstatement of cocaine-seeking behavior in rats Neuropsychopharmacology 29 2004 660 668
7. S.B. Caine, and G.F. Koob Pretreatment with the dopamine agonist 7-OH-DPAT shifts the cocaine self-administration dose-effect function to the left under different schedules in the rat Behav. Pharmacol. 6 1995 333 347
8. S.B. Caine, G.F. Koob, L.H. Parsons, B.J. Everitt, J.C. Schwartz, and P. Sokoloff D3 receptor test in vitro predicts decreased cocaine self-administration in rats Neuroreport 8 1997 2373 2377
9. S.B. Caine, S.S. Negus, N.K. Mello, and J. Bergman Effects of dopamine D1-like and D2-like agonists in rats that self-administer cocaine J. Pharmacol. Exp. Ther. 291 1999 353 360
10. S.B. Caine, S.S. Negus, N.K. Mello, S. Patel, L. Bristow, J. Kulagowski, D. Vallone, A. Saiardi, and E. Borrelli Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists J. Neurosci. 22 2002 2977 2988
11. L. Cervo, S. Burbassi, M. Colovic, and S. Caccia Selective antagonist at D3 receptors, but not non-selective partial agonists, influences the expression of cocaine-induced conditioned place preference in free-feeding rats Pharmacol. Biochem. Behav. 82 2005 727 734
12. W.H. Chu, Z. Tu, E. McElveen, J.B. Xu, M. Taylor, R.R. Luedtke, and R.H. Mach Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D-3 receptor ligands Bioorg. Med. Chem. 13 2005 77 87
13. G.T. Collins, J.M. Witkin, A.H. Newman, K.A. Svensson, P. Grundt, J.J. Cao, and J.H. Woods Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior J. Pharmacol. Exp. Ther. 314 2005 310 319
14. K.L. Conrad, K. Ford, M. Marinelli, and M.E. Wolf Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration Neuroscience 169 2010 182 194
15. P.W. Czoty, C. McCabe, and M.A. Nader Effects of the 5-HT1A agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on cocaine choice in cynomolgus monkeys Behav. Pharmacol. 16 2005 187 191
16. T.J. De Vries, A.N.M. Schoffelmeer, R. Binnekade, H. Raaso, and L. Vanderschuren Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization Neuropsychopharmacology 26 2002 18 26
17. T.J. De Vries, A.N.M. Schoffelmeer, R. Binnekade, and L. Vanderschuren Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration Psychopharmacology 143 1999 254 260
18. J. Diaz, D. Levesque, C.H. Lammers, N. Griffon, M.P. Martres, J.C. Schwartz, and P. Sokoloff Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain Neuroscience 65 1995 731 745
19. C.T. Dourish, P.H. Hutson, and G. Curzon Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat Psychopharmacology 86 1985 197 204
20. C. Duarte, C. Lefebvre, F. Chaperon, M. Hamon, and M.H. Thiebot Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats Neuropsychopharmacology 28 2003 1903 1915
21. I.S. Ebenezer Effects of the 5-HT1A agonist 8-OH-DPAT on food intake in food-deprived rats Neuroreport 3 1992 1019 1022
22. M.W. Feltenstein, C.A. Altar, and R.E. See Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse Biol. Psychiatry 61 2007 582 590
23. M.W. Feltenstein, P.H. Do, and R.E. See Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapse Psychopharmacology 207 2009 401 411
24. R.A. Fuchs, L.T.L. Tran-Nguyen, S.M. Weber, T.V. Khroyan, and J.L. Neisewander Effects of 7-OH-DPAT on cocaine-seeking behavior and on re-establishment of cocaine self-administration Pharmacol. Biochem. Behav. 72 2002 623 632
25. K. Gal, and I. Gyertyan Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats Drug Alcohol Depend. 81 2006 63 70
26. J.G. Gilbert, A.H. Newman, E.L. Gardner, C.R. Ashby Jr., C.A. Heidbreder, A.C. Pak, X.Q. Peng, and Z.X. Xi Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors Synapse 57 2005 17 28
27. P. Grundt, E.E. Carlson, J. Cao, C.J. Bennett, E. McElveen, M. Taylor, R.R. Luedtke, and A.H. Newman Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor J. Med. Chem. 48 2005 839 848
28. C.A. Heidbreder, and A.H. Newman Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders Ann. N. Y Acad. Sci. 1187 2010 4 34
29. A.E. Higley, K. Spiller, P. Grundt, A.H. Newman, S.W. Kiefer, Z.X. Xi, and E.L. Gardner PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats J. Psychopharmacol. 25 2011 263 273
30. M.Y. Ho, S. Body, S. Kheramin, C.M. Bradshaw, and E. Szabadi Effects of 8-OH-DPAT and WAY-100635 on performance on a time-constrained progressive-ratio schedule Psychopharmacology 167 2003 137 144
31. D.C. Howell Statistical Methods for Psychology fourth ed. 2007 Wadsworth Belmont, California
32. J.N. Joyce, and M.J. Millan Dopamine D3 receptor antagonists as therapeutic agents Drug Discov. Today 10 2005 917 925
33. P.W. Kalivas, and N.D. Volkow The neural basis of addiction: a pathology of motivation and choice Am. J. Psychiatry 162 2005 1403 1413
34. G. Keppel, and T.D. Wickens Design and Analysis: a Researcher's Handbook fourth ed. 2004 Prentice-Hall London
35. T.V. Khroyan, D.A. Baker, and J.L. Neisewander Dose-dependent effects of the D-3-preferring agonist 7-OH-DPAT on motor behaviors and place conditioning Psychopharmacology 122 1995 351 357
36. T.V. Khroyan, R.L. Barrett-Larimore, J.K. Rowlett, and R.D. Spealman Dopamine D1-and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists J. Pharmacol. Exp. Ther. 294 2000 680 687
37. J.D. Kilts, H.S. Connery, E.G. Arrington, M.M. Lewis, C.P. Lawler, G.S. Oxford, K.L. O'Malley, R.D. Todd, B.L. Blake, D.E. Nichols, and R.B. Mailman Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D(2L) receptor-transfected MN9D cells and pituitary lactotrophs J. Pharmacol. Exp. Ther. 301 2002 1179 1189
38. P.R. Kufahl, N.S. Pentkowski, K. Heintzelman, and J.L. Neisewander Cocaine-induced Fos expression is detectable in the frontal cortex and striatum of rats under isoflurane but not alpha-chloralose anesthesia: Implications for FMRI J. Neurosci. Meth. 181 2009 241 248
39. R. Kumar, L.R. Riddle, S.A. Griffin, W.H. Chu, S. Vangveravong, J. Neisewander, R.H. Mach, and R.R. Luedtke Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in rats Neuropharmacology 56 2009 956 969
40. B. Le Foll, J. Diaz, and P. Sokoloff Increased dopamine D3 receptor expression accompanying behavioral sensitization to nicotine in rats Synapse 47 2003 176 183
41. B. Le Foll, H. Frances, J. Diaz, J.C. Schwartz, and P. Sokoloff Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice Eur. J. Neurosci. 15 2002 2016 2026
42. B. Le Foll, S.R. Goldberg, and P. Sokoloff The dopamine D3 receptor and drug dependence: effects on reward or beyond? Neuropharmacology 49 2005 525 541
43. B. Levant The D3 dopamine receptor: neurobiology and potential clinical relevance Pharmacol. Rev. 49 1997 231 252
44. 3 receptor in rat brain using 7-[3H]hydroxy-N, N-di-n-propyl-2-aminotetralin Proc. Natl. Acad. Sci. U. S. A. 89 1992 8155 8159
45. R.R. Luedtke, and R.H. Mach Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders Curr. Pharm. Des. 9 2003 643 671
46. R.H. Mach, Y. Huang, R.A. Freeman, L. Wu, S. Blair, and R.R. Luedtke Synthesis of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors Bioorg. Med. Chem. 11 2003 225 233
47. R.B. Mailman GPCR functional selectivity has therapeutic impact Trends Pharmacol. Sci. 28 2007 390 396
48. J.L. Martelle, R. Claytor, J.T. Ross, B.A. Reboussin, A.H. Newman, and M.A. Nader Effects of two novel D-3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl) benzamide], on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys J. Pharmacol. Exp. Ther. 321 2007 573 582
49. J.W. Mauchly Significance test for sphericity of a normal n-variate distribution Ann. Math. Stat. 11 1940 204 209
50. M.J. Millan, L. Maiofiss, D. Cussac, V. Audinot, J.A. Boutin, and A. Newman-Tancredi Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes J. Pharmacol. Exp. Ther. 303 2002 791 804
51. D.M. Mottola, J.D. Kilts, M.M. Lewis, H.S. Connery, Q.D. Walker, S.R. Jones, R.G. Booth, D.K. Hyslop, M. Piercey, R.M. Wightman, C.P. Lawler, D.E. Nichols, and R.B. Mailman Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D-2 receptors linked to adenylate cyclase J. Pharmacol. Exp. Ther. 301 2002 1166 1178
52. J.L. Neisewander, R.A. Fuchs, L.T. Tran-Nguyen, S.M. Weber, G.P. Coffey, and J.N. Joyce Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior Neuropsychopharmacology 29 2004 1479 1487
53. A.H. Newman, P. Grundt, and M.A. Nader Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents J. Med. Chem. 48 2005 3663 3679
54. R. Peltier, and S. Schenk Effects of serotonergic manipulations on cocaine self-administration in rats Psychopharmacology 110 1993 390 394
55. X.Q. Peng, C.R. Ashby, K. Spiller, X. Li, J. Li, N. Thomasson, M.J. Millan, E. Mocaer, C. Munoz, E.L. Gardner, and Z.X. Xi The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats Neuropharmacology 56 2009 752 760
56. D.M. Platt, J.S. Rodefer, J.K. Rowlett, and R.D. Spealman Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys Psychopharmacology 166 2003 298 305
57. L. Pulvirenti, C. Balducci, M. Piercy, and G.F. Koob Characterization of the effects of the partial dopamine agonist terguride on cocaine self-administration in the rat J. Pharmacol. Exp. Ther. 286 1998 1231 1238
58. L. Pulvirenti, and G.F. Koob Being partial to psychostimulant addiction therapy Trends Pharmacol. Sci. 23 2002 151 153
59. S. Schenk Effects of the serotonin 5-HT2 antagonist, ritanserin, and the serotonin 5-HT1A antagonist, WAY 100635, on cocaine-seeking in rats Pharmacol. Biochem. Behav. 67 2000 363 369
60. 3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities Mol. Brain Res. 45 1997 335 339
61. D.W. Self, W.J. Barnhart, D.A. Lehman, and E.J. Nestler Opposite modulation of cocaine-seeking behavior by D-1- and D-2-like dopamine receptor agonists Science 271 1996 1586 1589
62. D.A. Shapiro, S. Renock, E. Arrington, L.A. Chiodo, L.X. Liu, D.R. Sibley, B.L. Roth, and R. Mailman Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology Neuropsychopharmacology 28 2003 1400 1411
63. P. Sokoloff, B. Giros, M.P. Martres, M.L. Bouthenet, and J.C. Schwartz Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics Nature 347 1990 146 151
64. R. Song, R.F. Yang, N. Wu, R.B. Su, J. Li, X.Q. Peng, X. Li, J. Gaal, Z.X. Xi, and E.L. Gardner YQA14: a novel dopamine D(3) receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D(3) receptor-knockout mice Addict. Biol. 17 2012 259 273
65. G. Sorensen, T.N. Sager, J.H. Petersen, L.T. Brennum, P. Thogersen, C.H. Bengtsen, M. Thomsen, G. Wörtwein, A. Fink-Jensen, and D.P.D. Woldbye Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice Psychopharmacology 199 2008 37 46
66. R. Spangler, N.L. Goddard, N.M. Avena, B.G. Hoebel, and S.F. Leibowitz Elevated D3 dopamine receptor mRNA in dopaminergic and dopaminoceptive regions of the rat brain in response to morphine Brain Res. Mol. Brain Res. 111 2003 74 83
67. K. Spiller, Z.X. Xi, X.Q. Peng, A.H. Newman, C.R. Ashby Jr., C. Heidbreder, J. Gaal, and E.L. Gardner The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats Psychopharmacology (Berl.) 196 2008 533 542
68. 3 dopamine receptors in the brain reward circuits of human cocaine fatalities J. Neurosci. 16 1996 6100 6106
69. K. Svensson, A. Carlsson, and N. Waters Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release J. Neural Transm-Gen Sect. 95 1994 71 74
70. M. Taylor, P. Grundt, S.A. Griffin, A.H. Newman, and R.R. Luedtke Dopamine D3 receptor selective ligands with varying intrinsic Efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways Synapse 64 2010 251 266
71. M. Thomsen, A. Fink-Jensen, D.P.D. Woldbye, G. Wortwein, T.N. Sager, R. Holm, L.M. Pepe, and S.B. Caine Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats Psychopharmacology 201 2008 43 53
72. J.D. Urban, W.P. Clarke, M. von Zastrow, D.E. Nichols, B. Kobilka, H. Weinstein, J.A. Javitch, B.L. Roth, A. Christopoulos, P.M. Sexton, K.J. Miller, M. Spedding, and R.B. Mailman Functional selectivity and classical concepts of quantitative pharmacology J. Pharmacol. Exp. Ther. 320 2007 1 13
73. V. Vengeliene, F. Leonardi-Essmann, S. Perreau-Lenz, P. Gebicke-Haerter, K. Drescher, G. Gross, and R. Spanagel The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse FASEB J. 20 2006 2223 2233
74. 3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats J. Neurosci. 22 2002 9595 9603
75. Q. Wang, R.H. Mach, R.R. Luedtke, and D.E. Reichert Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methods J. Chem. Inf. Model. 50 2010 1970 1985
76. M. Weber, W.L. Chang, J.P. Durbin, P.E. Park, R.R. Luedtke, R.H. Mach, and N.R. Swerdlow Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44 Pharmacol. Biochem. Behav. 93 2009 141 147
77. R.A. Wise Dopamine, learning and motivation Nat. Rev. Neurosci. 5 2004 483 494
78. Z.X. Xi, and E.L. Gardner Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction CNS Drug Rev. 13 2007 240 259
79. Z.X. Xi, J.G. Gilbert, A.C. Pak, C.R. Ashby Jr., C.A. Heidbreder, and E.L. Gardner Selective dopamine D-3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost- variable-payoff fixed-ratio cocaine self-administration in rats Eur. J. Neurosci. 21 2005 3427 3438
80. Z.X. Xi, A.H. Newman, J.G. Gilbert, A.C. Pak, X.Q. Peng, C.R. Ashby Jr., L. Gitajn, and E.L. Gardner The novel dopamine D-3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats Neuropsychopharmacology 31 2006 1393 1405
81. J. Xu, W. Chu, Z. Tu, L.A. Jones, R.R. Luedtke, J.S. Perlmutter, M.A. Mintun, and R.H. Mach [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl) piperazin-1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization Synapse 63 2009 717 728
82. Z. Zhang, J.F. Rickard, S. Body, K. Asgari, C.M. Bradshaw, and E. Szabadi Comparison of the effects of clozapine and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on progressive ratio schedule performance: evidence against the involvement of 5-HT1A receptors in the behavioural effects of clozapine Psychopharmacology 181 2005 381 391