Synthesis of 2-(5-Bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 2, 2003, Pages 225-233

  Mach, Robert H ^a   Huang, Yunsheng ^a   Freeman, Rebekah A ^b   Wu, Li ^a   Blair, Suwanna ^a   Luedtke, Robert R ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (5 BROMO 2,3 DIMETHOXYPHENYL) 5 [2 (3 PYRIDAL)PIPERIDINYL]METHYL 1H PYRROLE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; DOPAMINE RECEPTOR; IODINE; NEUROLEPTIC AGENT; SIGMA OPIATE RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; ANIMAL; ARMYWORM; BRAIN; CELL LINE; CELL MEMBRANE; CHEMISTRY; GUINEA PIG; HUMAN; IC 50; KINETICS; METABOLISM; RAT; SYNTHESIS;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CELL LINE; CELL MEMBRANE; GUINEA PIGS; HUMANS; INHIBITORY CONCENTRATION 50; IODINE ISOTOPES; KINETICS; PYRROLES; RATS; RECEPTORS, DOPAMINE; RECEPTORS, SIGMA; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037449354     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00341-3     Document Type: Article

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