Comparison of the effects of clozapine and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on progressive ratio schedule performance: Evidence against the involvement of 5-HT1A receptors in the behavioural effects of clozapine

Psychopharmacology

Volumn 181, Issue 2, 2005, Pages 381-391

  Zhang, Z ^a,b   Rickard, J F ^a   Body, S ^a   Asgari, K ^a   Bradshaw, C M ^a   Szabadi, E ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

5,7 Dihydroxytryptamine; 5 HT1A receptors; 8 OH DPAT; Antipsychotics; Clozapine; Motor impairment; Progressive ratio schedule; Reinforcer efficacy; WAY 100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5,7 DIHYDROXYTRYPTAMINE; CLOZAPINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEMALE; MOTIVATION; NONHUMAN; PERFORMANCE; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; REINFORCEMENT; SEROTONINERGIC SYSTEM; TASK PERFORMANCE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BEHAVIOR, ANIMAL; CLOZAPINE; CONDITIONING, OPERANT; FEMALE; PSYCHOPHARMACOLOGY; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN, 5-HT1; REINFORCEMENT SCHEDULE; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 27144537777     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-2258-7     Document Type: Article

References (42)

1. Aberman JE, Ward SJ, Salamone JD (1998) Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance. Pharmacol Biochem Behav 61:341-348
2. 1A receptor in schizophrenia: a promising target for novel atypical neuroleptics? J Psychopharmacol 15:37-46
3. Barnes NM, Sharpe T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152
4. Barr AM, Philips AG (1998) Withdrawal following repeated exposure to D-amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement. Psychopharmacology 141:99-106
5. Bizo LA, Killeen PR (1997) Models of ratio schedule performance. J Exp Psychol Anim Behav Processes 23:351-367
6. 2-adrenoceptor subtypes in post-mortem human brain. J Psychopharmacol 12:151-154
7. Body S, Kheramin S, Mobini S, Ho M-Y, Velazquez-Martinez DN, Bradshaw CM, Szabadi E (2002) Antagonism by WAY-100635 of the effects of 8-OH-DPAT on performance on a free-operant timing schedule in intact and 5-HT-depleted rats. Behav Pharmacol 13:603-614
8. 2A receptors. Psychopharmacology 176:154-165
9. 3 antagonist raclopride on progressive ratio operant responding. Behav Pharmacol 6:127-132
10. 1A receptors by clozapine in the primate brain: a PET study. Psychopharmacology 166:234-240
11. Corrigan PW, Reinke RR, Landsberger SA, Charate A, Toombs GA (2003) The effects of atypical antipsychotic medications on psychosocial outcomes. Schizophr Res 63:97-101
12. 1A agonists and the antipsychotics, clozapine, ziprasidone and S16924, but not haloperidol, to the discriminative stimuli elicited by PD 128,907 and 7-OH-DPAT. Neuropharmacology 40:899-910
13. 1A receptor agonists: recent developments and controversial issues. Psychopharmacology 121:1-26
14. Hamill S, Trevitt JT, Nowend KL, Carlson BB, Salamone JD (1999) Nucleus accumbens dopamine depletion and time-constrained progressive ratio performance: effects of different ratio requirements. Pharmacol Biochem Behav 64:21-27
15. 2 adrenoceptor blockade. Science 286:105-107
16. Ho M-Y, Body S, Kheramin S, Bradshaw CM, Szabadi E (2003) Effects of 8-OH-DPAT and WAY-100635 on performance on a time-constrained progressive-ratio schedule. Psychopharmacology 167:137-144
17. Hodos W (1961) Progressive ratio as a measure of reward strength. Science 134:943-944
18. Hodos W, Kalman G (1963) Effects of increment size and reinforcer volume on progressive ratio performance. J Exp Anal Behav 6:389-392
19. Hoyer D, Hannon JP, Martin GR (2002) Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71:533-554
20. 1A receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. J Neurochem 76:1521-1531
21. Imai H, Steindler DA, Kitai ST (1986) The organization of divergent axonal projections of the midbrain raphe nuclei in the rat. J Comp Neurol 243:363-380
22. Kheramin S, Body S, Miranda Herrera F, Bradshaw CM, Szabadi E, Deakin JFW, Anderson IM (2005) The effect of orbital prefrontal cortex lesions on performance on a progressive ratio schedule: implications for models of inter-temporal choice. Behav Brain Res 156:145-152
23. Killeen PR (1994) Mathematical principles of reinforcement. Behav Brain Sci 17:105-172
24. Killeen PR, Sitomer MT (2003) MPR. Behav Processes 62:49-64
25. Killeen PR, Cate H, Tran T (1993) Scaling pigeons' choice of feeds: bigger is better. J Exp Anal Behav 60:203-217
26. King DJ, Waddington JL (2004) Antipsychotic drugs and the treatment of schizophrenia. In: King DJ (ed) Seminars in psychopharmacology, 2nd edn. Gaskell, London, pp 316-380
27. Leysen JE (2000) Receptor profiles of antipsychotics. In: Ellenbrook BA, Cools AR (eds) Atypical antipsychotics. Birkhauser, Basel, pp 57-81
28. Meltzer HY (1999) The role of sertonin in antipsychotic drug action. Neuropsychopharmacology 21:106S-115S
29. i values. J Pharmacol Exp Ther 251:238-246
30. Mobini S, Chiang T-J, Ho M-Y, Bradshaw CM, Szabadi E (2000) Comparison of the effects of clozapine, haloperidol, chlorpromazine and D-amphetamine on performance on a time-constrained progressive ratio schedule and on locomotor behaviour in the rat. Psychopharmacology 152:47-54
31. Müller-Spahn F (2002) Current use of atypical antipsychotics. Eur Psychiatr 17(suppl 4):377-384
32. 35S]GTP S binding study. Eur J Pharmacol 355:245-256
33. Paxinos G, Watson C (1998) The brain in stereotaxic coordinates, 2nd edn. Academic, New York
34. 1A ligands in preclinical behavioral models for antipsychotic and extrapyramidal effects. Psychopharmacology 144:20-29
35. Reilly MP (2003) Extending mathematical principles of reinforcement into the domain of behavioral pharmacology. Behav Processes 62:75-88
36. Roberts DCS, Richardson NR (1992) Self-administration of psychostimulants using progressive ratio schedules of reinforcement. In: Boulton A, Baker G, Wu PH (eds) Neuromethods, vol 24: animal models of drug addiction. Humana, New York, pp 233-269
37. 1A receptor activation. Eur J Pharmacol 338:R3-R5
38. Skjoldager P, Pierre PJ, Mittleman G (1993) Reinforcer magnitude and progressive ratio responding in the rat: effects of increased effort, prefeeding, and extinction. Learn Motiv 24:303-343
39. Stewart WJ (1975) Progressive ratio reinforcement schedules: a review and evaluation. Aust J Psychol 27:9-22
40. Wogar MA, Bradshaw CM, Szabadi E (1992) Impaired acquisition of temporal differentiation performance following lesions of the ascending 5-hydroxytryptaminergic pathways. Psychopharmacology 107:373-378
41. Young CD, Meltzer HY, Deutch AY (1998) Effects of desmethylclozapine on fos protein expression in the forebrain: in vivo biological activity of the clozapine metabolite. Neuropsychopharmacology 19:99-103
42. Zhang Z, Rickard JF, Asgari K, Body S, Bradshaw CM, Szabadi E (2005) Quantitative analysis of the effects of some 'atypical' and 'conventional' antipsychotics on progressive ratio schedule performance. Psychopharmacology, in press