A transition-state interaction shifts nucleobase ionization toward neutrality to facilitate small ribozyme catalysis

Journal of the American Chemical Society

Volumn 134, Issue 41, 2012, Pages 16933-16936

  Liberman, Joseph A ^a   Guo, Man ^b   Jenkins, Jermaine L ^a   Krucinska, Jolanta ^a   Chen, Yuanyuan ^b   Carey, Paul R ^b   Wedekind, Joseph E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOLOGICAL REACTION; CHEMICAL ATTRIBUTES; CONFORMATIONAL STATE; HAIRPIN RIBOZYME; IMINO GROUPS; NUCLEOBASES; PHOSPHODIESTER BONDS; RIBOZYMES; RNA STRUCTURES; TRANSITION-STATE; TRANSITION-STATE ANALOGUES;

CHEMICAL BONDS; CONFORMATIONS; CRYSTALLOGRAPHY; RNA;

IONIZATION;

RIBOZYME;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; IONIZATION; PHASE TRANSITION; RIBOZYME CATALYSIS; RNA STRUCTURE; STATIC ELECTRICITY; TRANSITION STATE INTERACTION SHIFTS NUCLEOBASE IONIZATION;

ADENINE; BIOCATALYSIS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC;

EID: 84867521047     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3070528     Document Type: Article

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