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Volumn 106, Issue 29, 2009, Pages 11901-11906

Protein-free small nuclear RNAs catalyze a two-step splicing reaction

Author keywords

Catalysis; Ribozymes; snRNAs; Spliceosome; U6

Indexed keywords

MESSENGER RNA PRECURSOR; OLIGONUCLEOTIDE; RIBONUCLEOPROTEIN; RIBOZYME; SMALL NUCLEAR RNA;

EID: 67749098066     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0902020106     Document Type: Article
Times cited : (56)

References (39)
  • 1
    • 0038049910 scopus 로고    scopus 로고
    • Group II introns: Structure and catalytic versatility of large natural ribozymes
    • Lehmann K, Schmidt U (2003) Group II introns: Structure and catalytic versatility of large natural ribozymes. Crit Rev Biochem Mol Biol 38:249-303.
    • (2003) Crit Rev Biochem Mol Biol , vol.38 , pp. 249-303
    • Lehmann, K.1    Schmidt, U.2
  • 2
    • 27844569938 scopus 로고    scopus 로고
    • Group II introns: Ribozymes that splice RNA and invade DNA
    • eds Gesteland RF, Cech TR, Atkins JF Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp
    • Pyle AM, Lambowitz AM (2006) Group II introns: Ribozymes that splice RNA and invade DNA. The RNA World, eds Gesteland RF, Cech TR, Atkins JF (Cold Spring Harbor Laboratory Press, Cold Spring Harbor), pp 469-506.
    • (2006) The RNA World , pp. 469-506
    • Pyle, A.M.1    Lambowitz, A.M.2
  • 3
    • 0022131865 scopus 로고
    • On the origin of RNA splicing and introns
    • Sharp PA (1985) On the origin of RNA splicing and introns. Cell 42:397-400.
    • (1985) Cell , vol.42 , pp. 397-400
    • Sharp, P.A.1
  • 4
    • 0022552726 scopus 로고
    • The generality of self-splicing RNA: Relationship to nuclear mRNA splicing
    • Cech TR (1986) The generality of self-splicing RNA: Relationship to nuclear mRNA splicing. Cell 44:207-210.
    • (1986) Cell , vol.44 , pp. 207-210
    • Cech, T.R.1
  • 5
    • 0033792637 scopus 로고    scopus 로고
    • The question remains: Is the spliceosome a ribozyme?
    • Collins CA, Guthrie C (2000) The question remains: Is the spliceosome a ribozyme? Nat Struct Biol 7:850-854.
    • (2000) Nat Struct Biol , vol.7 , pp. 850-854
    • Collins, C.A.1    Guthrie, C.2
  • 6
    • 0344198459 scopus 로고    scopus 로고
    • The spliceosome: The most complex macromolecular machine in the cell?
    • Nilsen TW (2003) The spliceosome: The most complex macromolecular machine in the cell? Bioessays 25:1147-1149.
    • (2003) Bioessays , vol.25 , pp. 1147-1149
    • Nilsen, T.W.1
  • 7
    • 33645213731 scopus 로고    scopus 로고
    • Spliceosome structure and function
    • eds Gesteland RF, Cech TR, Atkins JF Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp
    • Will CL, Luhrmann R (2006) Spliceosome structure and function. The RNA World, eds Gesteland RF, Cech TR, Atkins JF (Cold Spring Harbor Laboratory Press, Cold Spring Harbor), pp 369-400.
    • (2006) The RNA World , pp. 369-400
    • Will, C.L.1    Luhrmann, R.2
  • 8
    • 0032489021 scopus 로고    scopus 로고
    • Mechanical devices of the spliceosome: Motors, clocks, springs, and things
    • Staley JP, Guthrie C (1998) Mechanical devices of the spliceosome: Motors, clocks, springs, and things. Cell 92:315-326.
    • (1998) Cell , vol.92 , pp. 315-326
    • Staley, J.P.1    Guthrie, C.2
  • 9
    • 34347400372 scopus 로고    scopus 로고
    • The spliceosome: Caught in a web of shifting interactions
    • Valadkhan S (2007) The spliceosome: Caught in a web of shifting interactions. Curr Opin Struct Biol 17:310-315.
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 310-315
    • Valadkhan, S.1
  • 10
    • 34250660469 scopus 로고    scopus 로고
    • The spliceosome: A ribozyme at heart?
    • Valadkhan S (2007) The spliceosome: A ribozyme at heart? Biol Chem 388:693-697.
    • (2007) Biol Chem , vol.388 , pp. 693-697
    • Valadkhan, S.1
  • 11
    • 0002340095 scopus 로고    scopus 로고
    • RNA-RNA interactions in nuclear pre-mRNA splicing
    • eds Simons RW, Grunberg-Manago M Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp
    • Nilsen TW (1998) RNA-RNA interactions in nuclear pre-mRNA splicing. RNA Structure and Function, eds Simons RW, Grunberg-Manago M (Cold Spring Harbor Laboratory Press, Cold Spring Harbor), pp 279-307.
    • (1998) RNA Structure and Function , pp. 279-307
    • Nilsen, T.W.1
  • 12
    • 0028175201 scopus 로고
    • Randomization-selection analysis of snRNAs in vivo: Evidence for a tertiary interaction in the spliceosome
    • Madhani HD, Guthrie C (1994) Randomization-selection analysis of snRNAs in vivo: Evidence for a tertiary interaction in the spliceosome. Genes Dev 8:1071-1086.
    • (1994) Genes Dev , vol.8 , pp. 1071-1086
    • Madhani, H.D.1    Guthrie, C.2
  • 13
    • 0033962271 scopus 로고    scopus 로고
    • A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast
    • Valadkhan S, Manley JL (2000) A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast. RNA 6:206-219.
    • (2000) RNA , vol.6 , pp. 206-219
    • Valadkhan, S.1    Manley, J.L.2
  • 14
    • 0027923620 scopus 로고
    • Involvement of U6 snRNA in 57prime; splice site selection
    • Kandels-Lewis S, Seraphin B (1993) Involvement of U6 snRNA in 57prime; splice site selection. Science 262:2035-2039.
    • (1993) Science , vol.262 , pp. 2035-2039
    • Kandels-Lewis, S.1    Seraphin, B.2
  • 15
    • 0026453396 scopus 로고
    • Evidence for a base-pairing interaction between U6 small nuclear RNA and 5′ splice site during the splicing reaction in yeast
    • Sawa H, Abelson J (1992) Evidence for a base-pairing interaction between U6 small nuclear RNA and 5′ splice site during the splicing reaction in yeast. Proc Natl Acad Sci USA 89:11269-11273.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11269-11273
    • Sawa, H.1    Abelson, J.2
  • 16
    • 0026524532 scopus 로고
    • Association of U6 snRNA with the 5′-splice site region of pre-mRNA in the spliceosome
    • Sawa H, Shimura Y (1992) Association of U6 snRNA with the 5′-splice site region of pre-mRNA in the spliceosome. Genes Dev 6:244-254.
    • (1992) Genes Dev , vol.6 , pp. 244-254
    • Sawa, H.1    Shimura, Y.2
  • 17
    • 32444443532 scopus 로고    scopus 로고
    • Repositioning of the reaction intermediate within the catalytic center of the spliceosome
    • Konarska MM, Vilardell J, Query CC (2006) Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Mol Cell 21:543-553.
    • (2006) Mol Cell , vol.21 , pp. 543-553
    • Konarska, M.M.1    Vilardell, J.2    Query, C.C.3
  • 18
    • 0027739853 scopus 로고
    • The U5 and U6 small nuclear RNAs as active site components of the spliceosome
    • Sontheimer EJ, Steitz JA (1993) The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science 262:1989-1996.
    • (1993) Science , vol.262 , pp. 1989-1996
    • Sontheimer, E.J.1    Steitz, J.A.2
  • 19
    • 41749109563 scopus 로고    scopus 로고
    • Crystal structure of a self-spliced group II intron
    • Toor N, Keating KS, Taylor SD, Pyle AM (2008) Crystal structure of a self-spliced group II intron. Science 320:77-82.
    • (2008) Science , vol.320 , pp. 77-82
    • Toor, N.1    Keating, K.S.2    Taylor, S.D.3    Pyle, A.M.4
  • 20
    • 33745755054 scopus 로고    scopus 로고
    • Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes
    • Rhode BM, Hartmuth K, Westhof E, Luhrmann R (2006) Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes. EMBO J 25:2475-2486.
    • (2006) EMBO J , vol.25 , pp. 2475-2486
    • Rhode, B.M.1    Hartmuth, K.2    Westhof, E.3    Luhrmann, R.4
  • 21
    • 0035909314 scopus 로고    scopus 로고
    • Splicing-related catalysis by protein-free snRNAs
    • Valadkhan S, Manley JL (2001) Splicing-related catalysis by protein-free snRNAs. Nature 413:701-707.
    • (2001) Nature , vol.413 , pp. 701-707
    • Valadkhan, S.1    Manley, J.L.2
  • 22
    • 0038719932 scopus 로고    scopus 로고
    • Characterization of the catalytic activity of U2 and U6 snRNAs
    • Valadkhan S, Manley JL (2003) Characterization of the catalytic activity of U2 and U6 snRNAs. RNA 9:892-904.
    • (2003) RNA , vol.9 , pp. 892-904
    • Valadkhan, S.1    Manley, J.L.2
  • 23
    • 36248936068 scopus 로고    scopus 로고
    • Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing
    • Valadkhan S, Mohammadi A, Wachtel C, Manley JL (2007) Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing. RNA 13:2300-2311.
    • (2007) RNA , vol.13 , pp. 2300-2311
    • Valadkhan, S.1    Mohammadi, A.2    Wachtel, C.3    Manley, J.L.4
  • 24
    • 57149111020 scopus 로고    scopus 로고
    • Is the spliceosome a ribonucleoprotein enzyme?
    • Abelson J (2008) Is the spliceosome a ribonucleoprotein enzyme? Nat Struct Mol Biol 15:1235-1237.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 1235-1237
    • Abelson, J.1
  • 25
    • 0030833215 scopus 로고    scopus 로고
    • Metal ion catalysis during splicing of premessenger RNA
    • Sontheimer EJ, Sun S, Piccirilli JA (1997) Metal ion catalysis during splicing of premessenger RNA. Nature 388:801-805.
    • (1997) Nature , vol.388 , pp. 801-805
    • Sontheimer, E.J.1    Sun, S.2    Piccirilli, J.A.3
  • 26
    • 0033965261 scopus 로고    scopus 로고
    • Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: Extending the parallels between the spliceosome and group II introns
    • Gordon PM, Sontheimer EJ, Piccirilli JA (2000) Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: Extending the parallels between the spliceosome and group II introns. RNA 6:199-205.
    • (2000) RNA , vol.6 , pp. 199-205
    • Gordon, P.M.1    Sontheimer, E.J.2    Piccirilli, J.A.3
  • 27
    • 0020027615 scopus 로고
    • Heterogeneous nuclear RNA promotes synthesis of (2′,5′)oligoadenylate and is cleaved by the (2′,5′)oligoadenylate-activated endoribonuclease
    • Nilsen TW, Maroney PA, Robertson HD, Baglioni C (1982) Heterogeneous nuclear RNA promotes synthesis of (2′,5′)oligoadenylate and is cleaved by the (2′,5′)oligoadenylate-activated endoribonuclease. Mol Cell Biol 2:154-160.
    • (1982) Mol Cell Biol , vol.2 , pp. 154-160
    • Nilsen, T.W.1    Maroney, P.A.2    Robertson, H.D.3    Baglioni, C.4
  • 28
    • 0016281633 scopus 로고
    • Nuclease from Penicillium citrinum. III. Substrate specificity of nuclease P1
    • Fujimoto M, Kuninaka A, Yoshino H (1974) Nuclease from Penicillium citrinum. III. Substrate specificity of nuclease P1 Agricultur Biol Chem 38:1555-1561.
    • (1974) Agricultur Biol Chem , vol.38 , pp. 1555-1561
    • Fujimoto, M.1    Kuninaka, A.2    Yoshino, H.3
  • 29
    • 0031671299 scopus 로고    scopus 로고
    • More than one way to splice an RNA: Branching without a bulge and splicing without branching in group II introns
    • Chu VT, Liu Q, Podar M, Perlman PS, Pyle AM (1998) More than one way to splice an RNA: Branching without a bulge and splicing without branching in group II introns. RNA 4:1186-1202.
    • (1998) RNA , vol.4 , pp. 1186-1202
    • Chu, V.T.1    Liu, Q.2    Podar, M.3    Perlman, P.S.4    Pyle, A.M.5
  • 30
    • 0032568012 scopus 로고    scopus 로고
    • Group II intron splicing in vivo by first-step hydrolysis
    • Podar M, Chu VT, Pyl AM, Perlman PS (1998) Group II intron splicing in vivo by first-step hydrolysis. Nature 391:915-918.
    • (1998) Nature , vol.391 , pp. 915-918
    • Podar, M.1    Chu, V.T.2    Pyl, A.M.3    Perlman, P.S.4
  • 31
    • 46449086933 scopus 로고    scopus 로고
    • Both catalytic steps of nuclear pre-mRNA splicing are reversible
    • Tseng CK, Cheng SC (2008) Both catalytic steps of nuclear pre-mRNA splicing are reversible. Science 320:1782-1784.
    • (2008) Science , vol.320 , pp. 1782-1784
    • Tseng, C.K.1    Cheng, S.C.2
  • 32
    • 0026670431 scopus 로고
    • Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing
    • Wassarman DA, Steitz JA (1992) Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing. Science 257:1918-1925.
    • (1992) Science , vol.257 , pp. 1918-1925
    • Wassarman, D.A.1    Steitz, J.A.2
  • 34
    • 0034649666 scopus 로고    scopus 로고
    • Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
    • Yean SL, Wuenschell G, Termini J, Lin RJ (2000) Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome. Nature 408:881-884.
    • (2000) Nature , vol.408 , pp. 881-884
    • Yean, S.L.1    Wuenschell, G.2    Termini, J.3    Lin, R.J.4
  • 35
    • 52949123649 scopus 로고    scopus 로고
    • Toward predicting self-splicing and protein-facilitated splicing of group I introns
    • Vicens Q, Paukstelis PJ, Westhof E, Lambowitz AM, Cech TR (2008) Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA 14:2013-2029.
    • (2008) RNA , vol.14 , pp. 2013-2029
    • Vicens, Q.1    Paukstelis, P.J.2    Westhof, E.3    Lambowitz, A.M.4    Cech, T.R.5
  • 36
    • 0023003333 scopus 로고
    • Efficient trans-splicing of a yeast mitochondrial RNA group II intron implicates a strong 5′ exon-intron interaction
    • Jacquier A, Rosbash M (1986) Efficient trans-splicing of a yeast mitochondrial RNA group II intron implicates a strong 5′ exon-intron interaction. Science 234:1099-1104.
    • (1986) Science , vol.234 , pp. 1099-1104
    • Jacquier, A.1    Rosbash, M.2
  • 37
    • 0023850025 scopus 로고
    • Group II intron self-splicing. Alternative reaction conditions yield novel products
    • Jarrell KA, Peebles CL, Dietrich RC, Romiti SL, Perlman PS (1988) Group II intron self-splicing. Alternative reaction conditions yield novel products. J Biol Chem 263:3432-3439.
    • (1988) J Biol Chem , vol.263 , pp. 3432-3439
    • Jarrell, K.A.1    Peebles, C.L.2    Dietrich, R.C.3    Romiti, S.L.4    Perlman, P.S.5
  • 38
    • 17844395704 scopus 로고    scopus 로고
    • Prp8 protein: At the heart of the spliceosome
    • Grainger RJ, Beggs JD (2005) Prp8 protein: At the heart of the spliceosome. RNA 11:533-557.
    • (2005) RNA , vol.11 , pp. 533-557
    • Grainger, R.J.1    Beggs, J.D.2
  • 39
    • 0347763706 scopus 로고    scopus 로고
    • Roles of protein subunits in RNA-protein complexes: Lessons from ribonuclease P
    • Hsieh J, Andrews AJ, Fierke CA (2004) Roles of protein subunits in RNA-protein complexes: Lessons from ribonuclease P. Biopolymers 73:79-89.
    • (2004) Biopolymers , vol.73 , pp. 79-89
    • Hsieh, J.1    Andrews, A.J.2    Fierke, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.