General acid-base catalysis mediated by nucleobases in the hairpin ribozyme

Journal of the American Chemical Society

Volumn 134, Issue 40, 2012, Pages 16717-16724

  Kath Schorr, Stephanie ^a   Wilson, Timothy J ^a   Li, Nan Sheng ^b   Lu, Jun ^b   Piccirilli, Joseph A ^b   Lilley, David M J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-BASE CATALYSIS; CATALYTIC MECHANISMS; CLEAVAGE RATES; EXPERIMENTAL EVIDENCE; GENERAL BASE CATALYSIS; HAIRPIN RIBOZYME; LEAVING GROUPS; MOST PROBABLE EXPLANATION; NUCLEOBASES; OXYGEN ATOM; PH DEPENDENCE; PHOSPHODIESTERS; RIBOZYMES;

CATALYSIS; RNA; SULFUR;

QUANTUM CHEMISTRY;

5' PHOSPHOROTHIOLATE; PHOSPHATE; PHOSPHOROTHIOIC ACID DERIVATIVE; PURINE; RIBOZYME; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; NUCLEIC ACID BASE SUBSTITUTION; PH; PROTON TRANSPORT; REDUCTION; RNA CLEAVAGE;

BASE SEQUENCE; CATALYSIS; HYDROGEN-ION CONCENTRATION; PHOSPHATES; PURINES; RNA, CATALYTIC; SUBSTRATE SPECIFICITY;

EID: 84867356016     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3067429     Document Type: Article

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