Inhibition of transmitter release and attenuation of anti-retroviral- associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35065-35077

  Wilson, Sarah M ^a   Schmutzler, Brian S ^a   Brittain, Joel M ^a   Dustrude, Erik T ^a   Ripsch, Matthew S ^a   Pellman, Jessica J ^a   Yeum, Tae Sung ^a   Hurley, Joyce H ^a   Hingtgen, Cynthia M ^a   White, Fletcher A ^a   Khanna, Rajesh ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Sophia Therapeutics LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINOCICEPTION; BINDING AFFINITIES; C TERMINUS; CALCITONIN GENE-RELATED PEPTIDES; CALCIUM INFLUX; CHANNEL COMPLEX; CO-IMMUNOPRECIPITATION EXPERIMENTS; DORSAL ROOT GANGLION NEURONS; FIRST INTRACELLULAR LOOPS; HUMAN IMMUNODEFICIENCY VIRUS; IN-VITRO; INTRAPERITONEALLY; MICRO-SCALES; NANOMOLAR; NEUROFIBROMATOSIS TYPE 1; NEUROPATHIC PAIN; NEUROPEPTIDES; NEUROTRANSMITTER RELEASE; NOCICEPTION; PERIPHERAL NEUROPATHY; PHYSIOLOGICAL FUNCTIONS; PRESYNAPTIC; PROTEIN TRANSDUCTION DOMAINS; SIDE EFFECT; TAT PROTEIN; TILING ARRAY;

BINDING ENERGY; CALCIUM; DEPOLARIZATION; EXPERIMENTS; MAMMALS; NEURONS; TRANSMITTERS; VIRUSES;

PEPTIDES;

CALCITONIN GENE RELATED PEPTIDE; CALCIUM CHANNEL CAV1.2; CALCIUM CHANNEL CAV2.2; CALCIUM CHANNEL N TYPE; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; PEPTIDE; TRANSACTIVATOR PROTEIN; TYROSYLGLYCYLARGINYLLYSYLLYSYLARGINYLARGINYLGLUTAMINYLARGINYLARGINYLARGINYLASPARAGINYLSERYLSERYLPHENYLALANYLSERYLISOLEUCYLHISTIDINYLCYSTEINYLSERYLSERYLSERYLTRYPTOPHYLGLUTAMYLGLUTAMIC ACID; TYROSYLGLYCYLARGINYLLYSYLLYSYLARGINYLARGINYLGLUTAMINYLARGINYLARGINYLARGINYLTYROSYLLEUCYLGLUTAMYLTRYPTOPHYLISOLEUCYLOHENYLALANYLLYSYLALANYLGLUTAMYLGLUTAMYLVALYLMETHIONYLLEUCYLALANYLGLUTAMIC ACID; UNCLASSIFIED DRUG; ZALCITABINE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CELL TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG PROTEIN BINDING; FEMALE; GENE; GENE MUTATION; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; NEUROTRANSMITTER RELEASE; NF1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVE INJURY; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SPINAL GANGLION; TIBIAL NERVE;

AIDS-ASSOCIATED NEPHROPATHY; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM; CALCIUM CHANNELS, N-TYPE; GANGLIA, SPINAL; HUMANS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NEUROFIBROMATOSIS 1; NEUROFIBROMIN 1; NEURONS; NEUROTRANSMITTER AGENTS; NOCICEPTION; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TIBIAL NEUROPATHY;

EID: 84867431882     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.378695     Document Type: Article

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