Merging structural motifs of functionalized amino acids and α-aminoamides results in novel anticonvulsant compounds with significant effects on slow and fast inactivation of voltage-gated sodium channels and in the treatment of neuropathic pain

ACS Chemical Neuroscience

Volumn 2, Issue 6, 2011, Pages 317-332

  Wang, Yuying ^a   Wilson, Sarah M ^a   Brittain, Joel M ^a   Ripsch, Matthew S ^a   Salomé, Christophe ^c   Park, Ki Duk ^c   White, Fletcher A ^a   Khanna, Rajesh ^a   Kohn, Harold ^b,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c University of North Carolina   (United States)

Author keywords

Lacosamide; neuropathic pain; safinamide; slow fast inactivation; sodium channel; state dependent

Indexed keywords

GLUTAMIC ACID; MORPHINE; POTASSIUM CHLORIDE; SODIUM CHANNEL BLOCKING AGENT; VERATRIDINE; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CALCIUM TRANSPORT; CATECHOLAMINE NERVE CELL; CHEMICAL BOND; CHIMERA; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; FEMALE; HYPERPOLARIZATION; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN MOTIF; RAT; TIBIAL NERVE; WHOLE CELL;

EID: 79959205997     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200024z     Document Type: Article

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