CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy

Molecular Pain

Volumn 8, Issue , 2012, Pages

  Piekarz, Andrew D ^a   Due, Michael R ^a   Khanna, May ^a   Wang, Bo ^a,b   Ripsch, Matthew S ^a   Wang, Ruizhong ^a   Meroueh, Samy O ^a,b   Vasko, Michael R ^a,b   White, Fletcher A ^a,b   Khanna, Rajesh ^a,b,c  

^a Department of Pharmacology and Toxicology ^*  (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Sophia Therapeutics LLC   (United States)

Author keywords

AIDS therapy induced chronic pain; Calcium channels; Excitability; Molecular dynamics; Nociception; Peptide

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCIUM CHANNEL R TYPE; CALCIUM CHANNEL T TYPE; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; PEPTIDE DERIVATIVE; STAVUDINE; TRANSACTIVATOR PROTEIN; TRANSACTIVATOR PROTEIN VOLTAGE GATED CALCIUM CHANNEL BINDING DOMAIN 3 PEPTIDE CONJUGATE; TRANSACTIVATOR PROTEIN VOLTAGE GATED CALCIUM CHANNEL BINDING DOMAIN 3A6K PEPTIDE CONJUGATE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG PROTEIN BINDING; FEMALE; HYPERALGESIA; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR MODEL; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPATHIC PAIN; NONHUMAN; PAIN RECEPTOR; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN UNFOLDING; RAT; SENSORY NERVE CELL; SINGLE DRUG DOSE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AMINO ACID SEQUENCE; ANIMALS; CALCIUM CHANNELS, N-TYPE; CELL SEPARATION; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; HYPERALGESIA; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ION CHANNEL GATING; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NEURALGIA; NEUROTRANSMITTER AGENTS; NOCICEPTION; NOCICEPTORS; PEPTIDES; PERIPHERAL NERVOUS SYSTEM DISEASES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84867432306     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-54     Document Type: Article

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