Munc18: A presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein

Channels

Volumn 1, Issue 1, 2007, Pages 12-21

  Chan, Allen W ^a   Khanna, Rajesh ^a   Li, Qi ^a   Stanley, Elise F ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Calcium channel; CaV22; Docking complex; DRG; Exocytosis; Munc18; N type; Synprint; Unc18; Vesicle docking

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CALCIUM CHANNEL N TYPE; CAV2.2 PROTEIN, RAT; MUNC18 PROTEIN; NERVE PROTEIN; SNARE PROTEIN; STXBP1 PROTEIN, RAT; SYNAPTOTAGMIN; SYNTAXIN 1;

ALTERNATIVE RNA SPLICING; ANIMAL; ARTICLE; CELL LINE; CHICK EMBRYO; CHICKEN; CYTOLOGY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RAT; SPINAL GANGLION; SPRAGUE DAWLEY RAT; SYNAPSE VESICLE; SYNAPTOSOME;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CALCIUM CHANNELS, N-TYPE; CELL LINE; CHICK EMBRYO; CHICKENS; GANGLIA, SPINAL; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUNC18 PROTEINS; NERVE TISSUE PROTEINS; NEUROTRANSMITTER AGENTS; PRESYNAPTIC TERMINALS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; SNARE PROTEINS; SYNAPTIC VESICLES; SYNAPTOTAGMINS; SYNTAXIN 1;

EID: 34547616916     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.3694     Document Type: Article

References (49)

1. Hata Y, Slaughter CA, Sudhof TC. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature (Lond) 1993; 366:347-51.
2. Rizo J, Sudhof TC. Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci 2002; 3:641-53.
3. Okamoto M, Matsuyama T, Sugita M. Ultrastructural localization of mint1 at synapses in mouse hippocampus. Eur J Neurosci 2000; 12:3067-72.
4. Weimer RM, Richmond JE, Davis WS, Hadwiger G, Nonet ML, Jorgensen EM. Defects in synaptic vesicle docking in unc-18 mutants. Nat Neurosci 2003; 6:1023-30.
5. Halachmi N, Lev Z. The Sec1 family: A novel family of proteins involved in synaptic transmission and general secretion. J Neurochem 1996; 66:889-97.
6. Jahn R. Sec1/Munc18 proteins: Mediators of membrane fusion moving to center stage. Neuron 2000; 27:201-4.
7. Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Sudhof TC. Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science 2000; 287:864-9.
8. Pevsner J, Hsu SC, Scheller RH. n-Sec1: A neural-specific syntaxin-binding protein. Proc Natl Acad Sci USA 1994; 91:1445-9.
9. Misura KM, Scheller RH, Weis WI. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature (Lond) 2000; 404:355-62.
10. Kee Y, Lin RC, Hsu SC, Scheller RH. Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation. Neuron 1995; 14:991-8.
11. Okamoto M, Südhof TC. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. J Biol Chem 1997; 272:31459-64.
12. Dresbach T, Burns ME, O'Connor V, DeBello WM, Betz H, Augustine GJ. A neuronal Sec1 homolog regulates neurotransmitter release at the squid giant synapse. J Neurosci 1998; 18:2923-32.
13. Korteweg N, Maia AS, Verhage M, Burbach JP. Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion. Eur J Neurosci 2004; 19:2944-52.
14. Toonen RF, Kochubey O, de WH, Gulyas-Kovacs A, Konijnenburg B, Sorensen JB, Klingauf J, Verhage M. Dissecting docking and tethering of secretory vesicles at the target membrane. EMBO J 2006; In press.
15. Ciufo LF, Barclay JW, Burgoyne RD, Morgan A. Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Mol Biol Cell 2005; 16:470-82.
16. Hata Y, Südhof TC. A novel ubiquitous form of Munc-18 interacts with multiple syntaxins: Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. J Biol Chem 1995; 270:13022-8.
17. Verhage M, de Vries KJ, Roshol H, Burbach JP, Gispen WH, Sudhof TC. DOC2 proteins in rat brain: Complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. Neuron 1997; 18:453-61.
18. Khanna R, Li Q, Sun L, Collins TJ, Stanley EF. N type Ca(2+) channels and RIM scaffold protein covary at the presynaptic transmitter release face but are components of independent protein complexes. Neuroscience 2006.
19. Li Q, Lau A, Morris TJ, Guo L, Fordyce CB, Stanley EF. A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: Analysis by quantitative immunocolocalization. J Neurosci 2004; 24:4070-81.
20. Khanna R, Sun L, Li Q, Guo L, Stanley EF. Long splice variant N type calcium channels are clustered at presynaptic transmitter release sites without modular adaptor proteins. Neuroscience 2006; 138:1115-25.
21. Huttner WB, Schiebler W, Greengard P, De Camilli P. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol 1983; 96:1374-88.
22. Juhaszova M, Church PJ, Blaustein MP, Stanley EF. The synaptic cleft and the location of calcium transporters. Eur J Neurosci 2000; 12:839-46.
23. Khanna R, Myers MP, Laine M, Papazian DM. Glycosylation increases potassium channel stability and surface expression in mammalian cells. J Biol Chem 2001; 276:34028-34.
24. Chan AW, Stanley EF. Slow inhibition of N-type calcium channels with GTP gamma S reflects the basal G protein-GDP turnover rate. Pflugers Arch 2003; 446:183-8.
25. Shea TB, Yabe JT, Ortiz D, Pimenta A, Loomis P, Goldman RD, Amin N, Pant HC. Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons. J Cell Sci 2004; 117:933-41.
26. Yabe JT, Chan WK, Chylinski TM, Lee S, Pimenta AF, Shea TB. Neurofilaments consist of distinct populations that can be distinguished by C-terminal phosphorylation, bundling, and axonal transport rate in growing axonal neurites. J Neurosci 2001; 21:2195-205.
27. Yabe JT, Chan WK, Chylinski TM, Lee S, Pimenta AF, Shea TB. The predominant form in which neurofilament subunits undergo axonal transport varies during axonal initiation, elongation, and maturation. Cell Motil Cytoskeleton 2001; 48:61-83.
28. Stanley EF. Single calcium channels on a cholinergic presynaptic nerve terminal. Neuron 1991; 7:585-91.
29. Stanley EF, Goping G. Characterization of a calcium current in a vertebrate cholinergic presynaptic nerve terminal. J Neurosci 1991; 11:985-93.
30. Mirotznik RR, Zheng X, Stanley EF. G-Protein types involved in calcium channel inhibition at a presynaptic nerve terminal. J Neurosci 2000; 20:7614-21.
31. Morris TJ, Stanley EF. A simple method for immunocytochemical staining with multiple rabbit polyclonal antibodies. J Neurosci Methods 2003; 127:149-55.
32. Sheng ZH, Rettig J, Takahashi M, Catterall WA. Identification of a syntaxin-binding site on N-type calcium channels. Neuron 1994; 13:1303-13.
33. Ling S, Sheng JZ, Braun JE, Braun AP. Syntaxin 1A coassociates with native rat brain and cloned large conductance, calcium-activated potassium channels in situ. J Physiol 2003; 553:65-81.
34. Fujita Y, Sasaki T, Fukui K, Kotani H, Kimura T, Hata Y, Südhof TC, Scheller RH, Takai Y. Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C-Its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. J Biol Chem 1996; 271:7265-8.
35. Barclay JW, Craig TJ, Fisher RJ, Ciufo LF, Evans GJ, Morgan A, Burgoyne RD. Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis. J Biol Chem 2003; 278:10538-45.
36. Maximov A, Bezprozvanny I. Synaptic targeting of N-type calcium channels in hippocampal neurons. J Neurosci 2002; 22:6939-52.
37. Jarvis SE, Zamponi GW. Distinct molecular determinants govern syntaxin 1A-mediated inactivation and G-protein inhibition of N-type calcium channels. J Neurosci 2001; 21:2939-48.
38. Zamponi GW. Regulation of presynaptic calcium channels by synaptic proteins. J Pharmacol Sci 2003; 92:79-83.
39. Atlas D. Functional and physical coupling of voltage-sensitive calcium channels with exocytotic proteins: Ramifications for the secretion mechanism. J Neurochem 2001; 77:972-85.
40. Bezprozvanny I, Scheller RH, Tsien RW. Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature (Lond) 1995; 378:623-6.
41. Stanley EF. Syntaxin I modulation of presynaptic calcium channel inactivation revealed by botulinum toxin C1. Eur J Neurosci 2003; 17:1303-5.
42. Wiser O, Bennett MK, Atlas D. Functional interaction of syntaxin and SNAP-25 with voltage sensitive L-and N-type Ca2+ channels. EMBO J 1996; 15:4100-10.
43. Jarvis SE, Barr W, Feng ZP, Hamid J, Zamponi GW. Molecular determinants of syntaxin 1 modulation of N-type calcium channels. J Biol Chem 2002; 277:44399-407.
44. Gladycheva SE, Ho CS, Lee YY, Stuenkel EL. Regulation of syntaxin1A-munc18 complex for SNARE pairing in HEK293 cells. J Physiol 2004; 558:857-71.
45. Bouwman J, Maia AS, Camoletto PG, Posthuma G, Roubos EW, Oorschot VM, Klumperman J, Verhage M. Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience 2004; 126:115-26.
46. Garcia EP, McPherson PS, Chilcote TJ, Takei K, De Camilli P. rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. J Cell Biol 1995; 129:105-20.
47. O'Connor V, Heuss C, De Bello WM, Dresbach T, Charlton MP, Hunt JH, Pellegrini LL, Hodel A, Burger MM, Betz H, Augustine GJ, Schäfer T. Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion. Proc Natl Acad Sci USA 1997; 94:12186-91.
48. Perez-Branguli F, Muhaisen A, Blasi J. Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. Mol Cell Neurosci 2002; 20:169-80.
49. Khanna R, Li Q, Stanley EF. 'Fractional recovery' analysis of a presynaptic synaptotagmin 1-anchored endocytic protein complex. PLoS One 2006; 1:e67.