In Silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

Journal of Biological Chemistry

Volumn 285, Issue 33, 2010, Pages 25296-25307

  Wang, Yuying ^a   Brittain, Joel M ^a   Jarecki, Brian W ^a,c   Park, Ki Duk ^b   Wilson, Sarah M ^a   Wang, Bo ^a   Hale, Rachel ^a   Meroueh, Samy O ^a   Cummins, Theodore R ^a   Khanna, Rajesh ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of North Carolina   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL TARGETS; CORTICAL NEURONS; IN-SILICO; INACTIVATED STATE; LYSATES; NEURONAL MODEL; PUTATIVE BINDING SITES; RAT BRAIN; SENSITIVE PROPERTIES; SODIUM CHANNEL; STEADY STATE VOLTAGE; WILD TYPES;

BINDING ENERGY; BIOCHEMISTRY; COMPUTER AIDED DESIGN; DENDRIMERS; DOCKING; DRUG INTERACTIONS; ELECTROPHYSIOLOGY; PROTEINS; SODIUM; TOXIC MATERIALS;

BINDING SITES;

ALANINE; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; HARKOSERIDE; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN; BRAIN CELL; CELL LYSATE; COMPUTER MODEL; CONTROLLED STUDY; DENDRITIC CELL; ELECTROPHYSIOLOGY; GENE CONSTRUCT; GENE INACTIVATION; GENE OVEREXPRESSION; MALE; MOLECULAR DOCKING; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; RAT; STEADY STATE;

ACETAMIDES; ANIMALS; BINDING SITES; CELLS, CULTURED; ELECTROPHYSIOLOGY; EPILEPSY; IMMUNOBLOTTING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS;

RATTUS;

EID: 77955474694     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.128801     Document Type: Article

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