Human Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Functions as a Dimer in Living Cells

DNA and Cell Biology

Volumn 23, Issue 2, 2004, Pages 111-117

  Xie, Qiuhong ^a   Matsunaga, Shigeru ^a   Niimi, Setsuko ^a   Ogawa, Setsuko ^a   Tokuyasu, Ken ^a   Sakakibara, Yoshikiyo ^a   Machida, Sachiko ^a,b  

^a NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYSTEINE; DIMER; DISULFIDE; LOW DENSITY LIPOPROTEIN RECEPTOR; LOX 1, HUMAN; LOX-1, HUMAN; MONOMER; OLIGOMER; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; TETRAMER; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ARTICLE; CELL LYSATE; CELL STRAIN COS1; CELL STRAIN COS7; CERCOPITHECUS; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; DIMERIZATION; DISULFIDE BOND; ESCHERICHIA COLI; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; IN VIVO STUDY; MEMBRANE PERMEABILITY; METABOLISM; MOLECULAR RECOGNITION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; REDUCTION; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; DNA, COMPLEMENTARY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; PRECIPITIN TESTS; RECEPTORS, LDL;

ANIMALIA; CERCOPITHECUS; ESCHERICHIA COLI; HOMO;

EID: 1242269763     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454904322759920     Document Type: Article

References (25)

1. ANGERS, S., SALAHPOUR, A., JOLY, E., HILAIRET, S., CHELSKY, D., DENNIS, M., and BOUVIER, M. (2000). Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc. Natl. Acad. Sci. USA 97, 3684-3689.
2. BAI, M., TRIVEDI, S., and BROWN, E.M. (1998). Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 Cells. J. Biol. Chem. 273, 23605-23610.
3. CHEN, M., INOUE, K., NARUMIYA, S., MASAKI, T., and SAWAMURA, T. (2001a). Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein. FEBS Lett. 499, 215-219.
4. CHEN, M., KAKUTANI, M., MINAMI, M., KATAOKA, H., KUME, N., NARUMIYA, S., KITA, T., MASAKI, T., and SAWAMURA, T. (2000). Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler. Thromb. Vasc. Biol. 20, 1107-1115.
5. CHEN, M., NARUMIYA, S., MASAKI, T., and SAWAMURA, T. (2001b). Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Biochem. J. 355, 289-296.
6. DE WINTHER, M.P., VAN DIJK, K.W., HAVEKES, L.M., and HOFKER, M.H. (2000). Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20, 290-297.
7. ELOMAA, O., KANGAS, M., SAHLBERG, C., TUUKKANEN, J., SORMUNEN, R., LIAKKA, A., THESLEFF, I., KRAAL, G., and TRYGGVASON, K. (1995). Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell 80, 603-609.
8. HOSHIKAWA, H., SAWAMURA, T., KAKUTANI, M., AOYAMA, T., NAKAMURA, T., and MASAKI, T. (1998). High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1). Biochem. Biophys. Res. Commun. 245, 841-846.
9. JONO, T., MIYAZAKI, A., NAGAI, R., SAWAMURA, T., KITAMURA, T., and HORIUCHI, S. (2002). Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). FEBS Lett. 511, 170-174.
10. JORDAN, B.A., TRAPAIDZE, N., GOMES, I., NIVARTHI, R., and DEVI, L.A. (2001). Oligomerization of opioid receptors with beta 2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation. Proc. Natl. Acad. Sci. USA 98, 343-348.
11. KAKUTANI, M., MASAKI, T., and SAWAMURA, T. (2000). A platelet- endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1. Proc. Natl. Acad. Sci. USA 97, 360-364.
12. KODAMA, T., FREEMAN, M., ROHRER, L., ZABRECKY, J., MATSUDAIRA, P., and KRIEGER, M. (1990). Type 1 macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature 343, 531-535.
13. KODAMA, T., REDDY, P., KISHIMOTO, C., and KRIEGER, M. (1988). Purification and characterization of a bovine acetyl low density lipoprotein receptor. Proc. Natl. Acad. Sci. USA 85, 9238-9242.
14. KOHN, W.D., MANT, C.T., and HODGES, R.S. (1997). alpha-Helical protein assembly motifs. J. Biol. Chem. 272, 2583-2586.
15. MORIWAKI, H., KUME, N., SAWAMURA, T., AOYAMA, T., HOSHIKAWA, H., OCHI, H., NISHI, E., MASAKI, T., and KITA, T. (1998). Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein. Arterioscler. Thromb. Vasc. Biol. 18, 1541-1547.
16. NAGASE, M., ABE, J., TAKAHASHI, K., ANDO, J., HIROSE, S., and FUJITA, T. (1998). Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene. J. Biol. Chem. 273, 33702-33707.
17. OKA, K., SAWAMURA, T., KIKUTA, K., ITOKAWA, S., KUME, N., KITA, T., and MASAKI, T. (1998). Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc. Natl. Acad. Sci. USA 95, 9535-9540.
18. PENMAN, M., LUX, A., FREEDMAN, N.J., ROHRER, L., EKKEL, Y., MCKINSTRY, H., RESNICK, D., and KRIEGER, M. (1991). The type I and type II bovine scavenger receptors expressed in Chinese hamster ovary cells are trimeric proteins with collagenous triple helical domains comprising noncovalently associated monomers and Cys83-disulfide-linked dimers. J. Biol. Chem. 266, 23985-23993.
19. ROHRER, L., FREEMAN, M., KODAMA, T., PENMAN, M., and KRIEGER, M. (1990). Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature 343, 570-572.
20. ROMANO, C., MILLER, J.K., HYRC, K., DIKRANIAN, S., MENNERICK, S., TAKEUCHI, Y., GOLDBERG, M.P., and O'MALLEY, K.L. (2001). Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization. Mol. Pharmacol. 59, 46-53.
21. SAWAMURA, T., KUME, N., AOYAMA, T., MORIWAKI, H., HOSHIKAWA, H., AIBA, Y., TANAKA, T., MIWA, S., KATSURA, Y., KITA, T., et al. (1997). An endothelial receptor for oxidized low-density lipoprotein. Nature 386, 73-77.
22. SHI, X., NIIMI, S., OHTANI, T., and MACHIDA, S. (2001a). Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor. J. Cell Sci. 114, 1273-1282.
23. SHI, X., OGAWA, S., OTANI, T., and MACHIDA, S. (2001b). Involvement of conserved hydrophobic residues in the CTLD of human lectin-like oxidized LDL receptor in ligand binding. Mol. Cell Biol. Res. Commun. 4, 292-298.
24. SHIMAOKA, T., KUME, N., MINAMI, M., HAYASHIDA, K., SAWAMURA, T., KITA, T., and YONEHARA, S. (2001). LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J. Immunol. 166, 5108-5114.
25. ZENG, F.-Y., and WESS, J. (1999). Identification and molecular characterization of m3 muscarinic receptor dimers. J. Biol. Chem. 274, 19487-19497.