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Volumn 94, Issue 9, 2008, Pages 3447-3460

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters

Author keywords

[No Author keywords available]

Indexed keywords

HISTOCOMPATIBILITY ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MHC BINDING PEPTIDE; OLIGOPEPTIDE;

EID: 43649103144     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1529/biophysj.107.116897     Document Type: Article
Times cited : (22)

References (53)
  • 2
    • 33646150237 scopus 로고    scopus 로고
    • Immune synapses in T-cell activation
    • Cemerski, S., and A. Shaw. 2006. Immune synapses in T-cell activation. Curr. Opin. Immunol. 18:298-304.
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 298-304
    • Cemerski, S.1    Shaw, A.2
  • 3
    • 0025286210 scopus 로고
    • Quantitation of antigen- presenting cell MHC class-II peptide complexes necessary for T-cell stimulation
    • Harding, C. V., and E. R. Unanue. 1990. Quantitation of antigen- presenting cell MHC class-II peptide complexes necessary for T-cell stimulation. Nature. 346:574-576.
    • (1990) Nature , vol.346 , pp. 574-576
    • Harding, C.V.1    Unanue, E.R.2
  • 4
    • 0025182003 scopus 로고
    • The minimal number of class-II MHC antigen complexes needed for T-cell activation
    • Demotz, S., H. M. Grey, and A. Sette. 1990. The minimal number of class-II MHC antigen complexes needed for T-cell activation. Science. 249:1028-1030.
    • (1990) Science , vol.249 , pp. 1028-1030
    • Demotz, S.1    Grey, H.M.2    Sette, A.3
  • 5
    • 0037167816 scopus 로고    scopus 로고
    • Direct observation of ligand recognition by T cells
    • Irvine, D. J., M. A. Purbhoo, M. Krogsgaard, and M. M. Davis. 2002. Direct observation of ligand recognition by T cells. Nature. 419:845-849.
    • (2002) Nature , vol.419 , pp. 845-849
    • Irvine, D.J.1    Purbhoo, M.A.2    Krogsgaard, M.3    Davis, M.M.4
  • 7
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature. 375:148-151.
    • (1995) Nature , vol.375 , pp. 148-151
    • Valitutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 8
    • 0033558278 scopus 로고    scopus 로고
    • Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: Relationship to the quality of individual TCR signaling events
    • Itoh, Y., B. Hemmer, R. Martin, and R. N. Germain. 1999. Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events. J. Immunol. 162:2073-2080.
    • (1999) J. Immunol , vol.162 , pp. 2073-2080
    • Itoh, Y.1    Hemmer, B.2    Martin, R.3    Germain, R.N.4
  • 9
    • 0034288890 scopus 로고    scopus 로고
    • Triggering the TCR complex cause the downregulation of non- engaged receptors by a signal transduction-dependent mechanism
    • José, E. S., A. Borroto, F. Niedergang, A. Alcover, and B. Alarcóin. 2000. Triggering the TCR complex cause the downregulation of non- engaged receptors by a signal transduction-dependent mechanism. Immunity. 12:161-170.
    • (2000) Immunity , vol.12 , pp. 161-170
    • José, E.S.1    Borroto, A.2    Niedergang, F.3    Alcover, A.4    Alarcóin, B.5
  • 10
    • 0033737310 scopus 로고    scopus 로고
    • A mathematical analysis of TCR serial triggering and down-regulation
    • Sousa, J., and J. Carneiro. 2000. A mathematical analysis of TCR serial triggering and down-regulation. Eur. J. Immunol. 30:3219-3227.
    • (2000) Eur. J. Immunol , vol.30 , pp. 3219-3227
    • Sousa, J.1    Carneiro, J.2
  • 12
    • 0037331525 scopus 로고    scopus 로고
    • Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
    • Holler, P. D., and D. M. Kranz. 2003. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity. 18:255-264.
    • (2003) Immunity , vol.18 , pp. 255-264
    • Holler, P.D.1    Kranz, D.M.2
  • 13
    • 0035146577 scopus 로고    scopus 로고
    • Calculations show substantial serial engagement of T cell receptors
    • Wofsy, C., D. Coombs, and B. Goldstein. 2001. Calculations show substantial serial engagement of T cell receptors. Biophys. J. 80:606-612.
    • (2001) Biophys. J , vol.80 , pp. 606-612
    • Wofsy, C.1    Coombs, D.2    Goldstein, B.3
  • 14
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • McKeithan, K. 1995. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA. 92:5042-5046.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5042-5046
    • McKeithan, K.1
  • 15
    • 23344444616 scopus 로고    scopus 로고
    • T cell activation: Kinetic proofreading, serial engagement and cell adhesion
    • Coombs, D., and B. Goldstein. 2005. T cell activation: Kinetic proofreading, serial engagement and cell adhesion. J. Comput. Appl. Math. 184:121-139.
    • (2005) J. Comput. Appl. Math , vol.184 , pp. 121-139
    • Coombs, D.1    Goldstein, B.2
  • 17
    • 0036795530 scopus 로고    scopus 로고
    • Activated TCR remain marked for internalization after dissociation from peptide-MHC
    • Coombs, D., A. M. Kalergis, S. G. Nathenson, C. Wofsy, and B. Goldstein. 2002. Activated TCR remain marked for internalization after dissociation from peptide-MHC. Nat. Immunol. 3:926-931.
    • (2002) Nat. Immunol , vol.3 , pp. 926-931
    • Coombs, D.1    Kalergis, A.M.2    Nathenson, S.G.3    Wofsy, C.4    Goldstein, B.5
  • 20
    • 27544441784 scopus 로고    scopus 로고
    • Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    • Campi, G., R. Varma, and M. L. Dustin. 2005. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202:1031-1036.
    • (2005) J. Exp. Med , vol.202 , pp. 1031-1036
    • Campi, G.1    Varma, R.2    Dustin, M.L.3
  • 21
    • 33746011209 scopus 로고    scopus 로고
    • T cell receptor-proximal signals are sustained in peripheral micro- clusters and terminated in the central supramolecular activation cluster
    • Varma, R., G. Campi, T. Yokosuka, T. Saito, and M. L. Dustin. 2006. T cell receptor-proximal signals are sustained in peripheral micro- clusters and terminated in the central supramolecular activation cluster. Immunity. 25:117-127.
    • (2006) Immunity , vol.25 , pp. 117-127
    • Varma, R.1    Campi, G.2    Yokosuka, T.3    Saito, T.4    Dustin, M.L.5
  • 24
    • 0026681679 scopus 로고
    • The T cell receptor as a multicomponent signaling machine: CD4/CD8 coreceptors and CD45 in T cell activation
    • Janeway, C. A. 1992. The T cell receptor as a multicomponent signaling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10:645-674.
    • (1992) Annu. Rev. Immunol , vol.10 , pp. 645-674
    • Janeway, C.A.1
  • 26
    • 0021524072 scopus 로고
    • Diffusion-limited forward rate constants in two dimensions: Application to the trapping of cell surface receptors by coated pits
    • Goldstein, B., R. Griego, and C. Wofsy. 1984. Diffusion-limited forward rate constants in two dimensions: application to the trapping of cell surface receptors by coated pits. Biophys. J. 46:573-583.
    • (1984) Biophys. J , vol.46 , pp. 573-583
    • Goldstein, B.1    Griego, R.2    Wofsy, C.3
  • 27
    • 0030061494 scopus 로고    scopus 로고
    • Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area
    • Dustin, M. L., L. M. Ferguson, P. Y. Chan, T. A. Springer, and D. E. Golan. 1996. Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area. J. Cell Biol. 132:465-474.
    • (1996) J. Cell Biol , vol.132 , pp. 465-474
    • Dustin, M.L.1    Ferguson, L.M.2    Chan, P.Y.3    Springer, T.A.4    Golan, D.E.5
  • 28
    • 0030927323 scopus 로고    scopus 로고
    • Making the T cell receptor go the distance: A topological view of T cell activation
    • Shaw, A. S., and M. L. Dustin. 1997. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity. 6:361-369.
    • (1997) Immunity , vol.6 , pp. 361-369
    • Shaw, A.S.1    Dustin, M.L.2
  • 29
    • 0037154747 scopus 로고    scopus 로고
    • T cell receptor signaling precedes immunological synapse formation
    • Lee, K. H., A. D. Holdorf, M. L. Dustin, A. C. Chan, P. M. Allen, and A. S. Shaw. 2002. T cell receptor signaling precedes immunological synapse formation. Science. 295:1539-1542.
    • (2002) Science , vol.295 , pp. 1539-1542
    • Lee, K.H.1    Holdorf, A.D.2    Dustin, M.L.3    Chan, A.C.4    Allen, P.M.5    Shaw, A.S.6
  • 31
    • 4444298148 scopus 로고    scopus 로고
    • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
    • Li, Q. J., A. R. Dinner, S. Y. Qi, D. J. Irvine, J. B. Huppa, M. M. Davis, and A. K. Chakraborty. 2004. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat. Immunol. 5:791-799.
    • (2004) Nat. Immunol , vol.5 , pp. 791-799
    • Li, Q.J.1    Dinner, A.R.2    Qi, S.Y.3    Irvine, D.J.4    Huppa, J.B.5    Davis, M.M.6    Chakraborty, A.K.7
  • 34
    • 85031365871 scopus 로고    scopus 로고
    • Reference deleted in proof
    • Reference deleted in proof.
  • 35
    • 0036864648 scopus 로고    scopus 로고
    • Interface accumulation of receptor/ ligand couples in lymphocyte activation: Methods, mechanisms, and significance
    • Wulfing, C., I. Tskvitaria-Fuller, N. Burroughs, M. D. Sjaastad, J. Klem, and J. D. Schatzle. 2002. Interface accumulation of receptor/ ligand couples in lymphocyte activation: methods, mechanisms, and significance. Immunol. Rev. 189:64-83.
    • (2002) Immunol. Rev , vol.189 , pp. 64-83
    • Wulfing, C.1    Tskvitaria-Fuller, I.2    Burroughs, N.3    Sjaastad, M.D.4    Klem, J.5    Schatzle, J.D.6
  • 36
    • 0035937132 scopus 로고    scopus 로고
    • T cell receptor binding to a pMHCII ligand is kinetically distinct from and independent of CD4
    • Xiong, Y., P. Kern, H. Chang, and E. Reinherz. 2001. T cell receptor binding to a pMHCII ligand is kinetically distinct from and independent of CD4. J. Biol. Chem. 276:5659-5667.
    • (2001) J. Biol. Chem , vol.276 , pp. 5659-5667
    • Xiong, Y.1    Kern, P.2    Chang, H.3    Reinherz, E.4
  • 37
    • 0042971650 scopus 로고    scopus 로고
    • Molecular interactions mediating T cell antigen recognition
    • van der Merwe, P. A., and S. J. Davis. 2003. Molecular interactions mediating T cell antigen recognition. Annu. Rev. Immunol. 21:659-684.
    • (2003) Annu. Rev. Immunol , vol.21 , pp. 659-684
    • van der Merwe, P.A.1    Davis, S.J.2
  • 38
    • 0029008301 scopus 로고
    • Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/ζ complex
    • Thome, M., P. Duplay, M. Guttinger, and O. Acuto. 1995. Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/ζ complex. J. Exp. Med. 181:1997-2006.
    • (1995) J. Exp. Med , vol.181 , pp. 1997-2006
    • Thome, M.1    Duplay, P.2    Guttinger, M.3    Acuto, O.4
  • 39
    • 0029661957 scopus 로고    scopus 로고
    • The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex
    • Thome, M., V. Germain, J. P. DiSanto, and O. Acuto. 1996. The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex. Eur. J. Immunol. 26:2093-2100.
    • (1996) Eur. J. Immunol , vol.26 , pp. 2093-2100
    • Thome, M.1    Germain, V.2    DiSanto, J.P.3    Acuto, O.4
  • 40
    • 0028534722 scopus 로고
    • Evidence for dimers of MHC class II molecules in B lymphocytes and their role in low affinity T cell responses
    • Schafer, P., and S. Pierce. 1994. Evidence for dimers of MHC class II molecules in B lymphocytes and their role in low affinity T cell responses. Immunity. 1:699-707.
    • (1994) Immunity , vol.1 , pp. 699-707
    • Schafer, P.1    Pierce, S.2
  • 41
    • 0035863899 scopus 로고    scopus 로고
    • Amino acid substitutions in the putative MHC class II ''dimer of dimers interface inhibit CD4(+) T cell activation
    • Lindstedt, R., N. Monk, G. Lombardi, and R. Lechler. 2001. Amino acid substitutions in the putative MHC class II ''dimer of dimers" interface inhibit CD4(+) T cell activation. J. Immunol. 166:800-808.
    • (2001) J. Immunol , vol.166 , pp. 800-808
    • Lindstedt, R.1    Monk, N.2    Lombardi, G.3    Lechler, R.4
  • 42
    • 0033710093 scopus 로고    scopus 로고
    • The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
    • Cochran, J. R., T. O. Cameron, and L. J. Stern. 2000. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity. 12:241-250.
    • (2000) Immunity , vol.12 , pp. 241-250
    • Cochran, J.R.1    Cameron, T.O.2    Stern, L.J.3
  • 43
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • Krogsgaard, M., Q. J. Li, C. Sumen, J. B. Huppa, M. Huse, and M. M. Davis. 2005. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature. 434:238-243.
    • (2005) Nature , vol.434 , pp. 238-243
    • Krogsgaard, M.1    Li, Q.J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 44
    • 0036841122 scopus 로고    scopus 로고
    • Translational diffusion of individual class II MHC membrane proteins in cells
    • Vrljic, M., S. Y. Nishinura, S. Brasselet, W. E. Moerner, and H. M. McConnell. 2002. Translational diffusion of individual class II MHC membrane proteins in cells. Biophys. J. 83:2681-2692.
    • (2002) Biophys. J , vol.83 , pp. 2681-2692
    • Vrljic, M.1    Nishinura, S.Y.2    Brasselet, S.3    Moerner, W.E.4    McConnell, H.M.5
  • 45
    • 0036776238 scopus 로고    scopus 로고
    • Correlation of a dynamic model for immunological synapse formation with effector functions: Two pathways to synapse formation
    • Lee, S.-J. E., Y. Hori, J. T. Groves, M. L. Dustin, and A. K. Chakraborty. 2002. Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. Trends Immunol. 23:492-499.
    • (2002) Trends Immunol , vol.23 , pp. 492-499
    • Lee, S.-J.E.1    Hori, Y.2    Groves, J.T.3    Dustin, M.L.4    Chakraborty, A.K.5
  • 47
    • 2442651482 scopus 로고    scopus 로고
    • T cell killing does not require the formation of a stable mature immu- nological synapse
    • Purbhoo, M. A., D. J. Irvine, J. B. Huppa, and M. M. Davis. 2004. T cell killing does not require the formation of a stable mature immu- nological synapse. Nat. Immunol. 5:524-530.
    • (2004) Nat. Immunol , vol.5 , pp. 524-530
    • Purbhoo, M.A.1    Irvine, D.J.2    Huppa, J.B.3    Davis, M.M.4
  • 48
    • 0346244099 scopus 로고    scopus 로고
    • T-cell-antigen recognition and the immunological synapse
    • Huppa, J. B., and M. M. Davis. 2003. T-cell-antigen recognition and the immunological synapse. Nat. Rev. Immunol. 3:973-983.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 973-983
    • Huppa, J.B.1    Davis, M.M.2
  • 49
    • 0030956033 scopus 로고    scopus 로고
    • Single -particle tracking: Applications to membrane dynamics
    • Saxton, M. J., and K. Jacobson. 1997. Single -particle tracking: applications to membrane dynamics. Annu. Rev. Biophys. Biomol. Struct. 26: 373-399.
    • (1997) Annu. Rev. Biophys. Biomol. Struct , vol.26 , pp. 373-399
    • Saxton, M.J.1    Jacobson, K.2
  • 50
    • 0348047600 scopus 로고    scopus 로고
    • Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
    • Krogsgaard, M., N. Prado, E. J. Adams, X. L. He, D. C. Chow, D. B. Wilson, K. C. Garcia, and M. M. Davis. 2003. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol. Cell. 12:1367-1378.
    • (2003) Mol. Cell , vol.12 , pp. 1367-1378
    • Krogsgaard, M.1    Prado, N.2    Adams, E.J.3    He, X.L.4    Chow, D.C.5    Wilson, D.B.6    Garcia, K.C.7    Davis, M.M.8
  • 51
    • 0035811034 scopus 로고    scopus 로고
    • Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis
    • Garcia, K. C., C. G. Radu, J. Ho, R. J. Ober, and E. S. Ward. 2001. Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA. 98:6818-6823.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6818-6823
    • Garcia, K.C.1    Radu, C.G.2    Ho, J.3    Ober, R.J.4    Ward, E.S.5
  • 53
    • 85031352629 scopus 로고    scopus 로고
    • Analysis of membrane-localized binding kinetics with FRAP
    • In press
    • Dushek, O., R. Das, and D. Coombs. Analysis of membrane-localized binding kinetics with FRAP. Eur. Biophys J. In press.
    • Eur. Biophys J
    • Dushek, O.1    Das, R.2    Coombs, D.3


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