Gamete formation resets the aging clock in yeast

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 76, Issue , 2011, Pages 73-80

  Unal E ^a   Amon, A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 104; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NDT80; UNCLASSIFIED DRUG;

ARTICLE; CELL AGING; CELL FATE; CELL RENEWAL; CIRCADIAN RHYTHM; GAMETOGENESIS; LIFE EXTENSION; LIFESPAN; MITOSIS; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; SACCHAROMYCES CEREVISIAE; SPOROGENESIS; AGING; BUDDING YEAST; CAENORHABDITIS ELEGANS; CELL DAMAGE; DNA REPLICATION; FUNGAL STRAIN; MOLECULAR BIOLOGY; NONHUMAN; PHENOTYPE; REJUVENATION; YEAST CELL;

BIOLOGICAL CLOCKS; GERM CELLS; SACCHAROMYCES CEREVISIAE; TIME FACTORS;

EID: 84867423260     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2011.76.011379     Document Type: Article

References (61)

1. Ahmad Y, Boisvert FM, Gregor P, Cobley A, Lamond AI. 2009. NOPdb: Nucleolar Proteome Database-2008 update. Nucleic Acids Res 37: 181-184.
2. Blackburn EH, Greider CW, Szostak JW. 2006. Telomeres and telomerase: The path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med 12: 1133-1138.
3. Chan JN, Poon BP, Salvi J, Olsen JB, Emili A, Mekhail K. 2011. Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains. Devl Cell 20: 867-879.
4. Chu S, DeRisi J, Eisen M, Mulholland J, Botstein D, Brown PO, Herskowitz I. 1998. The transcriptional program of sporulation in budding yeast. Science 282: 699-705.
5. Curran SP, Wu X, Riedel CG, Ruvkun G. 2009. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459: 1079-1084.
6. Dammann R, Lucchini R, Koller T, Sogo JM. 1993. Chromatin structures and transcription of rDNA in yeast Saccharomyces cerevisiae. Nucleic Acids Res 21: 2331-2338.
7. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL. 2009. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459: 802-807.
8. D'Angelo MA, Raices M, Panowski SH, Hetzer MW. 2009. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell 136: 284-295.
9. Derry WB, Putzke AP, Rothman JH. 2001. Caenorhabditis elegans p53: Role in apoptosis, meiosis, and stress resistance. Science 294: 591-595.
10. De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M, Levy N. 2003. Lamin a truncation in Hutchinson-Gilford progeria. Science 300: 2055.
11. Ephrussi A, Lehmann R. 1992. Induction of germ cell formation by oskar. Nature 358: 387-392.
12. Erjavec N, Larsson L, Grantham J, Nystrom T. 2007. Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Devl 21: 2410-2421.
13. Fabrizio P, Longo VD. 2003. The chronological life span of Saccharomyces cerevisiae. Aging Cell 2: 73-81.
14. Fuchs J, Loidl J. 2004. Behaviour of nucleolus organizing regions (NORs) and nucleoli during mitotic and meiotic divisions in budding yeast. Chromosome Res 12: 427-438.
15. Goudeau J, Aguilaniu H. 2011. Carbonylated proteins are eliminated during reproduction in C. elegans. Aging Cell 9: 991-1003.
16. Govin J, Dorsey J, Gaucher J, Rousseaux S, Khochbin S, Berger SL. 2010a. Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis. Genes Dev 24: 1772-1786.
17. Govin J, Schug J, Krishnamoorthy T, Dorsey J, Khochbin S, Berger SL. 2010b. Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae. Nucleic Acids Res 38: 4599-4606.
18. Guarente L. 1997. Link between aging and the nucleolus. Genes Devl 11: 2449-2455.
19. Guarente L. 2008. Mitochondria - A nexus for aging, calorie restriction, and sirtuins? Cell 132: 171-176
20. Ide S, Miyazaki T, Maki H, Kobayashi T. 2010. Abundance of ribosomal RNA gene copies maintains genome integrity. Science 327: 693-696.
21. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadinanos J, et al. 2010. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469: 102-106.
22. Johnson FB, Sinclair DA, Guarente L. 1999. Molecular biology of aging. Cell 96: 291-302.
23. Katz DJ, Edwards TM, Reinke V, Kelly WG. 2009. AC. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell 137: 308-320.
24. Kirkwood TB. 1987. Immortality of the germ-line versus disposability of the soma. Basic Life Sci 42: 209-218.
25. Kobayashi T. 2008. A new role of the rDNA and nucleolus in the nucleus - rDNA instability maintains genome integrity. Bioessays 30: 267-272.
26. Krishnamoorthy T, Chen X, Govin J, Cheung WL, Dorsey J, Schindler K, Winter E, Allis CD, Guacci V, Khochbin S, Fuller MT, et al. 2006. Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Devl 20: 2580-2592.
27. Lane D, Levine A. 2010. p53 Research: The past thirty years and the next thirty years. Cold Spring Harb Perspect Biol 2: a000893.
28. Lindstrom DL, Leverich CK, Henderson KA, Gottschling DE. 2011. Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. PLoS Genet 7: e1002015.
29. Liu B, Larsson L, Caballero A, Hao X, Oling D, Grantham J, Nystrom T. 2010. The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 140: 257-267.
30. Marston AL, Amon A. 2004. Meiosis: cell-cycle controls shuffle and deal. Nat Rev Mol Cell Biol 5: 983-997.
31. Mekhail K, Seebacher J, Gygi SP, Moazed D. 2008. Role for perinuclear chromosome tethering in maintenance of genome stability. Nature 456: 667-670.
32. Morimoto RI. 2008. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 22: 1427-1438.
33. Mortimer RK, Johnston JR. 1959. Life span of individual yeast cells. Nature 183: 1751-1752.
34. Neiman AM. 2005. Ascospore formation in the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev 69: 565-584.
35. Nystrom T. 2005. Role of oxidative carbonylation in protein quality control and senescence. EMBO J 24: 1311-1317.
36. Park HO, Bi E. 2007. Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev 71: 48-96.
37. Pederson T, Tsai RY. 2009. In search of nonribosomal nucleolar protein function and regulation. J Cell Biol 184: 771-776.
38. Planta RJ. 1997. Regulation of ribosome synthesis in yeast. Yeast 13: 1505-1518.
39. Primig M, Williams RM, Winzeler EA, Tevzadze GG, Conway AR, Hwang SY, Davis RW, Esposito RE. 2000. The core meiotic transcriptome in budding yeasts. Nat Genet 26: 415-423.
40. Salk D, Au K, Hoehn H, Martin GM. 1985. Cytogenetic aspects of Werner syndrome. Adv Exp Med Biol 190: 541-546.
41. Schaetzlein S, Rudolph KL. 2005. Telomere length regulation during cloning, embryogenesis and ageing. Reprod Fertil Dev 17: 85-96.
42. Schaetzlein S, Lucas-Hahn A, Lemme E, Kues WA, Dorsch M, Manns MP, Niemann H, Rudolph KL. 2004. Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci 101: 8034-8038.
43. Shcheprova Z, Baldi S, Frei SB, Gonnet G, Barral Y. 2008. A mechanism for asymmetric segregation of age during yeast budding. Nature 454: 728-734.
44. Sinclair DA, Guarente L. 1997. Extrachromosomal rDNA circles - A cause of aging in yeast. Cell 91: 1033-1042.
45. Sinclair DA, Mills K, Guarente L. 1997. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277: 1313-1316.
46. Sinclair D, Mills K, Guarente L. 1998. Aging in Saccharomyces cerevisiae. Annu Rev Microbiol 52: 533-560.
47. Smeal T, Claus J, Kennedy B, Cole F, Guarente L. 1996. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84: 633-642.
48. Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, Zhu Z, Elvin JA, Bronson RT, Crum CP, McKeon F. 2006. p63 protects the female germ line during meiotic arrest. Nature 444: 624-628.
49. Teichert U, Mechler B, Muller H, Wolf DH. 1987. Protein degradation in yeast. Biochem Soc Trans 15: 811-815.
50. Teichert U, Mechler B, Muller H, Wolf DH. 1989. Lysosomal (vacuolar) proteinases of yeast are essential catalysts for protein degradation, differentiation, and cell survival. J Biol Chem 264: 16037-16045.
51. Tessarz P, Schwarz M, Mogk A, Bukau B. 2009. The yeast AAA{thorn} chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins. Mol Cell Biol 29: 3738-3745.
52. Thomsen R, Saguez C, Nasser T, Jensen TH. 2008. General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants. RNA 14: 706-716.
53. Tomas-Loba A, Flores I, Fernandez-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borras C, Matheu A, Klatt P, Flores JM, et al. 2008. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 135: 609-622.
54. Tsang CK, Li H, Zheng XS. 2007. Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J 26: 448-458.
55. Unal E, Kinde B, Amon A. 2011. Gametogenesis eliminates age-induced cellular damage and resets life span in yeast. Science 332: 1554-1557.
56. Veatch JR, McMurray MA, Nelson ZW, Gottschling DE. 2009. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137: 1247-1258.
57. Ventura N, Rea SL, Schiavi A, Torgovnick A, Testi R, Johnson TE. 2009. p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell 8: 380-393.
58. Visintin R, Amon A. 2000. The nucleolus: the magician's hat for cell cycle tricks. Curr Opin Cell Biol 12: 372-377.
59. Vizlin-Hodzic D, Ryme J, Simonsson S, Simonsson T. 2009. Developmental studies of Xenopus shelterin complexes: the message to reset telomere length is already present in the egg. FASEB J 23: 2587-2594.
60. Wang K, Klionsky DJ. 2011. Mitochondria removal by autophagy. Autophagy 3: 297-300.
61. Warner JR, McIntosh KB. 2009. How common are extraribosomal functions of ribosomal proteins? Mol Cell 34: 3-11.