메뉴 건너뛰기




Volumn 7, Issue 3, 2011, Pages

Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN FOB1; RIBOSOME DNA; RIBOSOME RNA; SILENT INFORMATION REGULATOR PROTEIN 2; UNCLASSIFIED DRUG; CYSTEINE SYNTHASE; DNA BINDING PROTEIN; FOB1 PROTEIN, S CEREVISIAE; MET17 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SILENT INFORMATION REGULATOR PROTEIN; SIR2 PROTEIN, S CEREVISIAE; SIRTUIN 2;

EID: 79953758066     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002015     Document Type: Article
Times cited : (88)

References (68)
  • 1
    • 0034626769 scopus 로고    scopus 로고
    • The age of cancer
    • DePinho RA, (2000) The age of cancer. Nature 408: 248-254.
    • (2000) Nature , vol.408 , pp. 248-254
    • DePinho, R.A.1
  • 2
    • 0027254069 scopus 로고
    • How many mutations are required for tumorigenesis? Implications from human cancer data
    • Renan MJ, (1993) How many mutations are required for tumorigenesis? Implications from human cancer data. Mol Carcinog 7: 139-146.
    • (1993) Mol Carcinog , vol.7 , pp. 139-146
    • Renan, M.J.1
  • 3
    • 0016176530 scopus 로고
    • Errors in DNA replication as a basis of malignant changes
    • Loeb LA, Springgate CF, Battula N, (1974) Errors in DNA replication as a basis of malignant changes. Cancer Res 34: 2311-2321.
    • (1974) Cancer Res , vol.34 , pp. 2311-2321
    • Loeb, L.A.1    Springgate, C.F.2    Battula, N.3
  • 4
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG Jr, (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68: 820-823.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 820-823
    • Knudson Jr., A.G.1
  • 5
    • 38949110294 scopus 로고    scopus 로고
    • Does age influence loss of heterozygosity?
    • Carr LL, Gottschling DE, (2008) Does age influence loss of heterozygosity? Exp Gerontol 43: 123-129.
    • (2008) Exp Gerontol , vol.43 , pp. 123-129
    • Carr, L.L.1    Gottschling, D.E.2
  • 6
    • 59149099298 scopus 로고    scopus 로고
    • Emerging paradigms in cancer genetics: Some important findings from high-density single nucleotide polymorphism array studies
    • Bacolod MD, Schemmann GS, Giardina SF, Paty P, Notterman DA, et al. (2009) Emerging paradigms in cancer genetics: some important findings from high-density single nucleotide polymorphism array studies. Cancer Res 69: 723-727.
    • (2009) Cancer Res , vol.69 , pp. 723-727
    • Bacolod, M.D.1    Schemmann, G.S.2    Giardina, S.F.3    Paty, P.4    Notterman, D.A.5
  • 9
    • 0348047594 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes
    • Ivessa AS, Lenzmeier BA, Bessler JB, Goudsouzian LK, Schnakenberg SL, et al. (2003) The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. Mol Cell 12: 1525-1536.
    • (2003) Mol Cell , vol.12 , pp. 1525-1536
    • Ivessa, A.S.1    Lenzmeier, B.A.2    Bessler, J.B.3    Goudsouzian, L.K.4    Schnakenberg, S.L.5
  • 10
    • 0030133624 scopus 로고    scopus 로고
    • A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities
    • Kobayashi T, Horiuchi T, (1996) A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities. Genes Cells 1: 465-474.
    • (1996) Genes Cells , vol.1 , pp. 465-474
    • Kobayashi, T.1    Horiuchi, T.2
  • 11
    • 0141819143 scopus 로고    scopus 로고
    • An age-induced switch to a hyper-recombinational state
    • McMurray MA, Gottschling DE, (2003) An age-induced switch to a hyper-recombinational state. Science 301: 1908-1911.
    • (2003) Science , vol.301 , pp. 1908-1911
    • McMurray, M.A.1    Gottschling, D.E.2
  • 12
    • 67549136242 scopus 로고    scopus 로고
    • Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect
    • Veatch JR, McMurray MA, Nelson ZW, Gottschling DE, (2009) Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137: 1247-1258.
    • (2009) Cell , vol.137 , pp. 1247-1258
    • Veatch, J.R.1    McMurray, M.A.2    Nelson, Z.W.3    Gottschling, D.E.4
  • 13
    • 35548983375 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability
    • Baruffini E, Lodi T, Dallabona C, Foury F, (2007) A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability. Genetics 177: 1227-1231.
    • (2007) Genetics , vol.177 , pp. 1227-1231
    • Baruffini, E.1    Lodi, T.2    Dallabona, C.3    Foury, F.4
  • 14
    • 70350136778 scopus 로고    scopus 로고
    • Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains
    • Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE, (2009) Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics 183: 365-383.
    • (2009) Genetics , vol.183 , pp. 365-383
    • Dimitrov, L.N.1    Brem, R.B.2    Kruglyak, L.3    Gottschling, D.E.4
  • 15
    • 63449085311 scopus 로고    scopus 로고
    • Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis
    • doi:10.1371/journal.pgen.1000407
    • Hess DC, Myers CL, Huttenhower C, Hibbs MA, Hayes AP, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5: e1000407 doi:10.1371/journal.pgen.1000407.
    • (2009) PLoS Genet , vol.5
    • Hess, D.C.1    Myers, C.L.2    Huttenhower, C.3    Hibbs, M.A.4    Hayes, A.P.5
  • 16
    • 70649106968 scopus 로고    scopus 로고
    • The mother enrichment program: A genetic system for facile replicative life span analysis in Saccharomyces cerevisiae
    • Lindstrom DL, Gottschling DE, (2009) The mother enrichment program: a genetic system for facile replicative life span analysis in Saccharomyces cerevisiae. Genetics 183: 413-422, 411SI-413SI.
    • (2009) Genetics , vol.183
    • Lindstrom, D.L.1    Gottschling, D.E.2
  • 17
    • 52049083189 scopus 로고    scopus 로고
    • A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae
    • Andersen MP, Nelson ZW, Hetrick ED, Gottschling DE, (2008) A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae. Genetics 179: 1179-1195.
    • (2008) Genetics , vol.179 , pp. 1179-1195
    • Andersen, M.P.1    Nelson, Z.W.2    Hetrick, E.D.3    Gottschling, D.E.4
  • 18
    • 0029770113 scopus 로고    scopus 로고
    • A useful colony colour phenotype associated with the yeast selectable/counter-selectable marker MET15
    • Cost GJ, Boeke JD, (1996) A useful colony colour phenotype associated with the yeast selectable/counter-selectable marker MET15. Yeast 12: 939-941.
    • (1996) Yeast , vol.12 , pp. 939-941
    • Cost, G.J.1    Boeke, J.D.2
  • 19
    • 0015131590 scopus 로고
    • Genetic analysis of spontaneous half-sectored colonies of Saccharomyces cerevisiae
    • Johnston JR, (1971) Genetic analysis of spontaneous half-sectored colonies of Saccharomyces cerevisiae. Genet Res 18: 179-184.
    • (1971) Genet Res , vol.18 , pp. 179-184
    • Johnston, J.R.1
  • 20
    • 0015796452 scopus 로고
    • A yeast strain for visual screening for the two reciprocal products of mitotic crossing over
    • Zimmermann FK, (1973) A yeast strain for visual screening for the two reciprocal products of mitotic crossing over. Mutat Res 21: 263-269.
    • (1973) Mutat Res , vol.21 , pp. 263-269
    • Zimmermann, F.K.1
  • 21
    • 0018423970 scopus 로고
    • Yeast ribosomal DNA genes are located on chromosome XII
    • Petes TD, (1979) Yeast ribosomal DNA genes are located on chromosome XII. Proc Natl Acad Sci U S A 76: 410-414.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 410-414
    • Petes, T.D.1
  • 22
    • 0024291357 scopus 로고
    • A replication fork barrier at the 3′ end of yeast ribosomal RNA genes
    • Brewer BJ, Fangman WL, (1988) A replication fork barrier at the 3′ end of yeast ribosomal RNA genes. Cell 55: 637-643.
    • (1988) Cell , vol.55 , pp. 637-643
    • Brewer, B.J.1    Fangman, W.L.2
  • 23
    • 0032535478 scopus 로고    scopus 로고
    • Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: Requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I
    • Kobayashi T, Heck DJ, Nomura M, Horiuchi T, (1998) Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. Genes Dev 12: 3821-3830.
    • (1998) Genes Dev , vol.12 , pp. 3821-3830
    • Kobayashi, T.1    Heck, D.J.2    Nomura, M.3    Horiuchi, T.4
  • 24
    • 0344629438 scopus 로고    scopus 로고
    • The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork
    • Kobayashi T, (2003) The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork. Mol Cell Biol 23: 9178-9188.
    • (2003) Mol Cell Biol , vol.23 , pp. 9178-9188
    • Kobayashi, T.1
  • 25
    • 52049125947 scopus 로고    scopus 로고
    • Replication fork arrest, recombination and the maintenance of ribosomal DNA stability
    • Tsang E, Carr AM, (2008) Replication fork arrest, recombination and the maintenance of ribosomal DNA stability. DNA Repair (Amst) 7: 1613-1623.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1613-1623
    • Tsang, E.1    Carr, A.M.2
  • 26
    • 0031444239 scopus 로고    scopus 로고
    • Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism
    • Zou H, Rothstein R, (1997) Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell 90: 87-96.
    • (1997) Cell , vol.90 , pp. 87-96
    • Zou, H.1    Rothstein, R.2
  • 27
    • 0032519306 scopus 로고    scopus 로고
    • An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast
    • Belli G, Gari E, Piedrafita L, Aldea M, Herrero E, (1998) An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast. Nucleic Acids Res 26: 942-947.
    • (1998) Nucleic Acids Res , vol.26 , pp. 942-947
    • Belli, G.1    Gari, E.2    Piedrafita, L.3    Aldea, M.4    Herrero, E.5
  • 28
    • 77957363057 scopus 로고    scopus 로고
    • Cohesin is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes
    • doi:10.1371/journal.pgen.1001006
    • Covo S, Westmoreland JW, Gordenin DA, Resnick MA, (2010) Cohesin is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes. PLoS Genet 6: e1001006 doi:10.1371/journal.pgen.1001006.
    • (2010) PLoS Genet , vol.6
    • Covo, S.1    Westmoreland, J.W.2    Gordenin, D.A.3    Resnick, M.A.4
  • 29
    • 0026709385 scopus 로고
    • Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
    • Kadyk LC, Hartwell LH, (1992) Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics 132: 387-402.
    • (1992) Genetics , vol.132 , pp. 387-402
    • Kadyk, L.C.1    Hartwell, L.H.2
  • 30
    • 57349093701 scopus 로고    scopus 로고
    • Role for perinuclear chromosome tethering in maintenance of genome stability
    • Mekhail K, Seebacher J, Gygi SP, Moazed D, (2008) Role for perinuclear chromosome tethering in maintenance of genome stability. Nature 456: 667-670.
    • (2008) Nature , vol.456 , pp. 667-670
    • Mekhail, K.1    Seebacher, J.2    Gygi, S.P.3    Moazed, D.4
  • 31
    • 33751112515 scopus 로고    scopus 로고
    • Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer
    • Huang J, Brito IL, Villen J, Gygi SP, Amon A, et al. (2006) Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev 20: 2887-2901.
    • (2006) Genes Dev , vol.20 , pp. 2887-2901
    • Huang, J.1    Brito, I.L.2    Villen, J.3    Gygi, S.P.4    Amon, A.5
  • 32
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein M, McVey M, Guarente L, (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580.
    • (1999) Genes Dev , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 33
    • 0024536650 scopus 로고
    • A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
    • Gottlieb S, Esposito RE, (1989) A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56: 771-776.
    • (1989) Cell , vol.56 , pp. 771-776
    • Gottlieb, S.1    Esposito, R.E.2
  • 34
    • 0030831573 scopus 로고    scopus 로고
    • Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA
    • Fritze CE, Verschueren K, Strich R, Easton Esposito R, (1997) Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J 16: 6495-6509.
    • (1997) EMBO J , vol.16 , pp. 6495-6509
    • Fritze, C.E.1    Verschueren, K.2    Strich, R.3    Easton Esposito, R.4
  • 35
    • 2342666131 scopus 로고    scopus 로고
    • SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast
    • Kobayashi T, Horiuchi T, Tongaonkar P, Vu L, Nomura M, (2004) SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast. Cell 117: 441-453.
    • (2004) Cell , vol.117 , pp. 441-453
    • Kobayashi, T.1    Horiuchi, T.2    Tongaonkar, P.3    Vu, L.4    Nomura, M.5
  • 36
    • 67149099680 scopus 로고    scopus 로고
    • Histone H4 lysine 16 acetylation regulates cellular lifespan
    • Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, et al. (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459: 802-807.
    • (2009) Nature , vol.459 , pp. 802-807
    • Dang, W.1    Steffen, K.K.2    Perry, R.3    Dorsey, J.A.4    Johnson, F.B.5
  • 37
    • 0031827438 scopus 로고    scopus 로고
    • Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p
    • Smith JS, Brachmann CB, Pillus L, Boeke JD, (1998) Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics 149: 1205-1219.
    • (1998) Genetics , vol.149 , pp. 1205-1219
    • Smith, J.S.1    Brachmann, C.B.2    Pillus, L.3    Boeke, J.D.4
  • 38
    • 0031019155 scopus 로고    scopus 로고
    • Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss
    • Holmes SG, Rose AB, Steuerle K, Saez E, Sayegh S, et al. (1997) Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss. Genetics 145: 605-614.
    • (1997) Genetics , vol.145 , pp. 605-614
    • Holmes, S.G.1    Rose, A.B.2    Steuerle, K.3    Saez, E.4    Sayegh, S.5
  • 39
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles-a cause of aging in yeast
    • Sinclair DA, Guarente L, (1997) Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91: 1033-1042.
    • (1997) Cell , vol.91 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 40
    • 0020606021 scopus 로고
    • Pedigree analysis of plasmid segregation in yeast
    • Murray AW, Szostak JW, (1983) Pedigree analysis of plasmid segregation in yeast. Cell 34: 961-970.
    • (1983) Cell , vol.34 , pp. 961-970
    • Murray, A.W.1    Szostak, J.W.2
  • 41
    • 69749092718 scopus 로고    scopus 로고
    • The effect of replication initiation on gene amplification in the rDNA and its relationship to aging
    • Ganley AR, Ide S, Saka K, Kobayashi T, (2009) The effect of replication initiation on gene amplification in the rDNA and its relationship to aging. Mol Cell 35: 683-693.
    • (2009) Mol Cell , vol.35 , pp. 683-693
    • Ganley, A.R.1    Ide, S.2    Saka, K.3    Kobayashi, T.4
  • 42
    • 0033120871 scopus 로고    scopus 로고
    • Elimination of replication block protein Fob1 extends the life span of yeast mother cells
    • Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, et al. (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3: 447-455.
    • (1999) Mol Cell , vol.3 , pp. 447-455
    • Defossez, P.A.1    Prusty, R.2    Kaeberlein, M.3    Lin, S.J.4    Ferrigno, P.5
  • 43
    • 0022181381 scopus 로고
    • Substrate specificity of the DNA unwinding activity of the RecBC enzyme of Escherichia coli
    • Taylor AF, Smith GR, (1985) Substrate specificity of the DNA unwinding activity of the RecBC enzyme of Escherichia coli. J Mol Biol 185: 431-443.
    • (1985) J Mol Biol , vol.185 , pp. 431-443
    • Taylor, A.F.1    Smith, G.R.2
  • 44
    • 4143102539 scopus 로고    scopus 로고
    • rDNA enhancer affects replication initiation and mitotic recombination: Fob1 mediates nucleolytic processing independently of replication
    • Burkhalter MD, Sogo JM, (2004) rDNA enhancer affects replication initiation and mitotic recombination: Fob1 mediates nucleolytic processing independently of replication. Mol Cell 15: 409-421.
    • (2004) Mol Cell , vol.15 , pp. 409-421
    • Burkhalter, M.D.1    Sogo, J.M.2
  • 45
    • 49649106438 scopus 로고    scopus 로고
    • A mechanism for asymmetric segregation of age during yeast budding
    • Shcheprova Z, Baldi S, Frei SB, Gonnet G, Barral Y, (2008) A mechanism for asymmetric segregation of age during yeast budding. Nature 454: 728-734.
    • (2008) Nature , vol.454 , pp. 728-734
    • Shcheprova, Z.1    Baldi, S.2    Frei, S.B.3    Gonnet, G.4    Barral, Y.5
  • 46
    • 79953743685 scopus 로고    scopus 로고
    • A Crisis Caused by the Loss of the Mitochondrial Genome in Saccharomyces cerevisiae
    • Seattle, University of Washington
    • Veatch JR, (2008) A Crisis Caused by the Loss of the Mitochondrial Genome in Saccharomyces cerevisiae. Seattle University of Washington.
    • (2008)
    • Veatch, J.R.1
  • 47
    • 25444510786 scopus 로고    scopus 로고
    • Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event
    • Teh MT, Blaydon D, Chaplin T, Foot NJ, Skoulakis S, et al. (2005) Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res 65: 8597-8603.
    • (2005) Cancer Res , vol.65 , pp. 8597-8603
    • Teh, M.T.1    Blaydon, D.2    Chaplin, T.3    Foot, N.J.4    Skoulakis, S.5
  • 49
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Paques F, Haber JE, (1999) Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 63: 349-404.
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 50
    • 0030053650 scopus 로고    scopus 로고
    • Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae
    • Smeal T, Claus J, Kennedy B, Cole F, Guarente L, (1996) Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84: 633-642.
    • (1996) Cell , vol.84 , pp. 633-642
    • Smeal, T.1    Claus, J.2    Kennedy, B.3    Cole, F.4    Guarente, L.5
  • 51
    • 13944255453 scopus 로고    scopus 로고
    • Genes determining yeast replicative life span in a long-lived genetic background
    • Kaeberlein M, Kirkland KT, Fields S, Kennedy BK, (2005) Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126: 491-504.
    • (2005) Mech Ageing Dev , vol.126 , pp. 491-504
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 52
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • Imai S, Armstrong CM, Kaeberlein M, Guarente L, (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800.
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 53
    • 23044478150 scopus 로고    scopus 로고
    • Summary: Epigenetics-from phenomenon to field
    • Gottschling DE, (2004) Summary: epigenetics-from phenomenon to field. Cold Spring Harb Symp Quant Biol 69: 507-519.
    • (2004) Cold Spring Harb Symp Quant Biol , vol.69 , pp. 507-519
    • Gottschling, D.E.1
  • 54
    • 18844402900 scopus 로고    scopus 로고
    • Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing
    • Michel AH, Kornmann B, Dubrana K, Shore D, (2005) Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing. Genes Dev 19: 1199-1210.
    • (2005) Genes Dev , vol.19 , pp. 1199-1210
    • Michel, A.H.1    Kornmann, B.2    Dubrana, K.3    Shore, D.4
  • 55
    • 0037329820 scopus 로고    scopus 로고
    • Sir2p suppresses recombination of replication forks stalled at the replication fork barrier of ribosomal DNA in Saccharomyces cerevisiae
    • Benguria A, Hernandez P, Krimer DB, Schvartzman JB, (2003) Sir2p suppresses recombination of replication forks stalled at the replication fork barrier of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res 31: 893-898.
    • (2003) Nucleic Acids Res , vol.31 , pp. 893-898
    • Benguria, A.1    Hernandez, P.2    Krimer, D.B.3    Schvartzman, J.B.4
  • 56
    • 0028556445 scopus 로고
    • Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span
    • Kennedy BK, Austriaco NR Jr, Guarente L, (1994) Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 127: 1985-1993.
    • (1994) J Cell Biol , vol.127 , pp. 1985-1993
    • Kennedy, B.K.1    Austriaco Jr., N.R.2    Guarente, L.3
  • 57
    • 0038604455 scopus 로고    scopus 로고
    • Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiae
    • Weitao T, Budd M, Hoopes LL, Campbell JL, (2003) Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiae. J Biol Chem 278: 22513-22522.
    • (2003) J Biol Chem , vol.278 , pp. 22513-22522
    • Weitao, T.1    Budd, M.2    Hoopes, L.L.3    Campbell, J.L.4
  • 58
    • 0345708269 scopus 로고    scopus 로고
    • Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stability
    • Weitao T, Budd M, Campbell JL, (2003) Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stability. Mutat Res 532: 157-172.
    • (2003) Mutat Res , vol.532 , pp. 157-172
    • Weitao, T.1    Budd, M.2    Campbell, J.L.3
  • 59
    • 46249112206 scopus 로고    scopus 로고
    • Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae
    • doi:10.1371/journal.pgen.1000105
    • Casper AM, Mieczkowski PA, Gawel M, Petes TD, (2008) Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae. PLoS Genet 4: e1000105 doi:10.1371/journal.pgen.1000105.
    • (2008) PLoS Genet , vol.4
    • Casper, A.M.1    Mieczkowski, P.A.2    Gawel, M.3    Petes, T.D.4
  • 60
    • 0027515187 scopus 로고
    • A gene with specific and global effects on recombination of sequences from tandemly repeated genes in Saccharomyces cerevisiae
    • Keil RL, McWilliams AD, (1993) A gene with specific and global effects on recombination of sequences from tandemly repeated genes in Saccharomyces cerevisiae. Genetics 135: 711-718.
    • (1993) Genetics , vol.135 , pp. 711-718
    • Keil, R.L.1    McWilliams, A.D.2
  • 61
    • 0036606186 scopus 로고    scopus 로고
    • Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA
    • Ivessa AS, Zhou JQ, Schulz VP, Monson EK, Zakian VA, (2002) Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev 16: 1383-1396.
    • (2002) Genes Dev , vol.16 , pp. 1383-1396
    • Ivessa, A.S.1    Zhou, J.Q.2    Schulz, V.P.3    Monson, E.K.4    Zakian, V.A.5
  • 62
    • 38049090214 scopus 로고    scopus 로고
    • DNA replication stress, genome instability and aging
    • Burhans WC, Weinberger M, (2007) DNA replication stress, genome instability and aging. Nucleic Acids Res 35: 7545-7556.
    • (2007) Nucleic Acids Res , vol.35 , pp. 7545-7556
    • Burhans, W.C.1    Weinberger, M.2
  • 63
    • 0032579440 scopus 로고    scopus 로고
    • Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
    • Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, et al. (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14: 115-132.
    • (1998) Yeast , vol.14 , pp. 115-132
    • Brachmann, C.B.1    Davies, A.2    Cost, G.J.3    Caputo, E.4    Li, J.5
  • 64
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorski RS, Hieter P, (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorski, R.S.1    Hieter, P.2
  • 66
    • 0020998506 scopus 로고
    • Import of proteins into mitochondria: A 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane
    • Riezman H, Hase T, van Loon AP, Grivell LA, Suda K, et al. (1983) Import of proteins into mitochondria: a 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane. EMBO J 2: 2161-2168.
    • (1983) EMBO J , vol.2 , pp. 2161-2168
    • Riezman, H.1    Hase, T.2    van Loon, A.P.3    Grivell, L.A.4    Suda, K.5
  • 67
    • 0036194936 scopus 로고    scopus 로고
    • Replication fork block protein, Fob1, acts as an rDNA region specific recombinator in S. cerevisiae
    • Johzuka K, Horiuchi T, (2002) Replication fork block protein, Fob1, acts as an rDNA region specific recombinator in S. cerevisiae. Genes Cells 7: 99-113.
    • (2002) Genes Cells , vol.7 , pp. 99-113
    • Johzuka, K.1    Horiuchi, T.2
  • 68
    • 0028840090 scopus 로고
    • The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids
    • Drysdale CM, Duenas E, Jackson BM, Reusser U, Braus GH, et al. (1995) The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids. Mol Cell Biol 15: 1220-1233.
    • (1995) Mol Cell Biol , vol.15 , pp. 1220-1233
    • Drysdale, C.M.1    Duenas, E.2    Jackson, B.M.3    Reusser, U.4    Braus, G.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.