Mechanoregulation of cytoskeletal dynamics by TRP channels

European Journal of Cell Biology

Volumn 91, Issue 11-12, 2012, Pages 834-846

  Kuipers, Arthur J ^a   Middelbeek, Jeroen ^a   van Leeuwen, Frank N ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adhesion sites; Axons; Calcium; Cardiovascular; Cytoskeleton; Mechanotransduction; Migration; Podocytes; TRP channels

Indexed keywords

TRANSIENT RECEPTOR POTENTIAL CHANNEL;

CARDIOVASCULAR RESPONSE; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CYTOSKELETON; KIDNEY FUNCTION; MECHANOTRANSDUCTION; NOCICEPTION; PRIORITY JOURNAL; SHEAR STRESS; SHORT SURVEY;

ANIMALS; CELL ADHESION; CELL MOVEMENT; CYTOSKELETON; HUMANS; MECHANOTRANSDUCTION, CELLULAR; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84867400949     PISSN: 01719335     EISSN: 16181298     Source Type: Journal    
DOI: 10.1016/j.ejcb.2012.05.006     Document Type: Short Survey

References (191)

1. AbouAlaiwi W.A., Takahashi M., Mell B.R., Jones T.J., Ratnam S., Kolb R.J., Nauli S.M. Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ. Res. 2009, 104:860-869.
2. Ahmad F., Seidman J.G., Seidman C.E. The genetic basis for cardiac remodeling. Annu. Rev. Genomics Hum. Genet. 2005, 6:185-216.
3. Alessandri-Haber N., Dina O.A., Chen X., Levine J.D. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J. Neurosci. 2009, 29:6217-6228.
4. Alessandri-Haber N., Dina O.A., Joseph E.K., Reichling D.B., Levine J.D. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 2008, 28:1046-1057.
5. Alessandri-Haber N., Dina O.A., Yeh J.J., Parada C.A., Reichling D.B., Levine J.D. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J. Neurosci. 2004, 24:4444-4452.
6. Alessandri-Haber N., Yeh J.J., Boyd A.E., Parada C.A., Chen X., Reichling D.B., Levine J.D. Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 2003, 39:497-511.
7. Aman A., Piotrowski T. Cell migration during morphogenesis. Dev. Biol. 2010, 341:20-33.
8. Andrade Y.N., Fernandes J., Vazquez E., Fernandez-Fernandez J.M., Arniges M., Sanchez T.M., Villalon M., Valverde M.A. TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J. Cell Biol. 2005, 168:869-874.
9. Arnadottir J., Chalfie M. Eukaryotic mechanosensitive channels. Annu. Rev. Biophys. 2010, 39:111-137.
10. Asanuma K., Yanagida-Asanuma E., Faul C., Tomino Y., Kim K., Mundel P. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat. Cell Biol. 2006, 8:485-491.
11. Barbee K.A., Mundel T., Lal R., Davies P.F. Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers. Am. J. Physiol. 1995, 268:H1765-H1772.
12. Bashaw G.J., Klein R. Signaling from axon guidance receptors. Cold Spring Harb. Perspect. Biol. 2010, 2:a001941.
13. Berbari N.F., O'Connor A.K., Haycraft C.J., Yoder B.K. The primary cilium as a complex signaling center. Curr. Biol. 2009, 19:R526-R535.
14. Boca M., D'Amato L., Distefano G., Polishchuk R.S., Germino G.G., Boletta A. Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion. Mol. Biol. Cell 2007, 18:4050-4061.
15. Bomben V.C., Turner K.L., Barclay T.T., Sontheimer H. Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas. J. Cell. Physiol. 2011, 226:1879-1888.
16. 2+ channels formed by TRPC1 TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. Cell Calcium 2008, 44:492-506.
17. Bush E.W., Hood D.B., Papst P.J., Chapo J.A., Minobe W., Bristow M.R., Olson E.N., McKinsey T.A. Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling. J. Biol. Chem. 2006, 281:33487-33496.
18. Caterina M.J., Leffler A., Malmberg A.B., Martin W.J., Trafton J., Petersen-Zeitz K.R., Koltzenburg M., Basbaum A.I., Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000, 288:306-313.
19. Chachisvilis M., Zhang Y.L., Frangos J.A. G protein-coupled receptors sense fluid shear stress in endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:15463-15468.
20. 2+/calmodulin-dependent kinase II holoenzyme. Cell 2011, 146:732-745.
21. Chen J.P., Luan Y., You C.X., Chen X.H., Luo R.C., Li R. TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca(2+) influx. Cell Calcium 2010, 47:425-432.
22. Christensen A.P., Corey D.P. TRP channels in mechanosensation: direct or indirect activation?. Nat. Rev. Neurosci. 2007, 8:510-521.
23. Chung M.K., Jung S.J., Oh S.B. Role of TRP channels in pain sensation. Adv. Exp. Med. Biol. 2011, 704:615-636.
24. Clapham D.E. TRP channels as cellular sensors. Nature 2003, 426:517-524.
25. Clark K., Langeslag M., van Leeuwen B., Ran L., Ryazanov A.G., Figdor C.G., Moolenaar W.H., Jalink K., van Leeuwen F.N. TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J. 2006, 25:290-301.
26. Clark K., Middelbeek J., van Leeuwen F.N. Interplay between TRP channels and the cytoskeleton in health and disease. Eur. J. Cell Biol. 2008, 87:631-640.
27. Conde C., Caceres A. Microtubule assembly, organization and dynamics in axons and dendrites. Nat. Rev. Neurosci. 2009, 10:319-332.
28. Cortright D.N., Szallasi A. TRP channels and pain. Curr. Pharm. Des. 2009, 15:1736-1749.
29. Cuajungco M.P., Grimm C., Heller S. TRP channels as candidates for hearing and balance abnormalities in vertebrates. Biochim. Biophys. Acta 2007, 1772:1022-1027.
30. da Costa D.S., Meotti F.C., Andrade E.L., Leal P.C., Motta E.M., Calixto J.B. The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. Pain 2010, 148:431-437.
31. Damann N., Owsianik G., Li S., Poll C., Nilius B. The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils. Acta Physiol. (Oxf.) 2009, 195:3-11.
32. Damann N., Voets T., Nilius B. TRPs in our senses. Curr. Biol. 2008, 18:R880-R889.
33. Davies P.F., Robotewskyj A., Griem M.L. Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces. J. Clin. Invest. 1994, 93:2031-2038.
34. Davis J.B., Gray J., Gunthorpe M.J., Hatcher J.P., Davey P.T., Overend P., Harries M.H., Latcham J., Clapham C., Atkinson K., Hughes S.A., Rance K., Grau E., Harper A.J., Pugh P.L., Rogers D.C., Bingham S., Randall A., Sheardown S.A. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 2000, 405:183-187.
35. del Rio A., Perez-Jimenez R., Liu R., Roca-Cusachs P., Fernandez J.M., Sheetz M.P. Stretching single talin rod molecules activates vinculin binding. Science 2009, 323:638-641.
36. Dent E.W., Gupton S.L., Gertler F.B. The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb. Perspect. Biol. 2011, 3:a001800.
37. Di A., Malik A.B. TRP channels and the control of vascular function. Curr. Opin. Pharmacol. 2010, 10:127-132.
38. Dietrich A., Chubanov V., Gudermann T. Renal TRPathies. J. Am. Soc. Nephrol. 2010, 21:736-744.
39. Dietrich A., Kalwa H., Rost B.R., Gudermann T. The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch. 2005, 451:72-80.
40. Dina O.A., McCarter G.C., de Coupade C., Levine J.D. Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain. Neuron 2003, 39:613-624.
41. Discher D.E., Janmey P., Wang Y.L. Tissue cells feel and respond to the stiffness of their substrate. Science 2005, 310:1139-1143.
42. Dixit N., Yamayoshi I., Nazarian A., Simon S.I. Migrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium flux. J. Immunol. 2011, 187:472-481.
43. Dryer S.E., Reiser J. TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am. J. Physiol. Renal Physiol. 2010, 299:F689-F701.
44. Durvasula R.V., Petermann A.T., Hiromura K., Blonski M., Pippin J., Mundel P., Pichler R., Griffin S., Couser W.G., Shankland S.J. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int. 2004, 65:30-39.
45. Dyachenko V., Husse B., Rueckschloss U., Isenberg G. Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels. Cell Calcium 2009, 45:38-54.
46. Earley S., Brayden J.E. Transient receptor potential channels and vascular function. Clin. Sci. (Lond.) 2010, 119:19-36.
47. Eder P., Molkentin J.D. TRPC channels as effectors of cardiac hypertrophy. Circ. Res. 2011, 108:265-272.
48. Edwards G., Feletou M., Weston A.H. Endothelium-derived hyperpolarising factors and associated pathways: a synopsis. Pflugers Arch. 2010, 459:863-879.
49. Eid S.R., Crown E.D., Moore E.L., Liang H.A., Choong K.C., Dima S., Henze D.A., Kane S.A., Urban M.O. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol. Pain 2008, 4:48.
50. Endlich N., Endlich K. Stretch, tension and adhesion - adaptive mechanisms of the actin cytoskeleton in podocytes. Eur. J. Cell Biol. 2006, 85:229-234.
51. Endlich N., Kress K.R., Reiser J., Uttenweiler D., Kriz W., Mundel P., Endlich K. Podocytes respond to mechanical stress in vitro. J. Am. Soc. Nephrol. 2001, 12:413-422.
52. Eyckmans J., Boudou T., Yu X., Chen C.S. A hitchhiker's guide to mechanobiology. Dev. Cell 2011, 21:35-47.
53. Faul C., Asanuma K., Yanagida-Asanuma E., Kim K., Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol. 2007, 17:428-437.
54. Faul C., Donnelly M., Merscher-Gomez S., Chang Y.H., Franz S., Delfgaauw J., Chang J.M., Choi H.Y., Campbell K.N., Kim K., Reiser J., Mundel P. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat. Med. 2008, 14:931-938.
55. Fiorio Pla A., Ong H.L., Cheng K.T., Brossa A., Bussolati B., Lockwich T., Paria B., Munaron L., Ambudkar I.S. TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling. Oncogene 2011, 31:200-212.
56. Firth A.L., Remillard C.V., Yuan J.X. TRP channels in hypertension. Biochim. Biophys. Acta 2007, 1772:895-906.
57. Fischer E., Legue E., Doyen A., Nato F., Nicolas J.F., Torres V., Yaniv M., Pontoglio M. Defective planar cell polarity in polycystic kidney disease. Nat. Genet. 2006, 38:21-23.
58. Forman J.R., Qamar S., Paci E., Sandford R.N., Clarke J. The remarkable mechanical strength of polycystin-1 supports a direct role in mechanotransduction. J. Mol. Biol. 2005, 349:861-871.
59. Gardel M.L., Schneider I.C., Aratyn-Schaus Y., Waterman C.M. Mechanical integration of actin and adhesion dynamics in cell migration. Annu. Rev. Cell Dev. Biol. 2010, 26:315-333.
60. Geiger B., Spatz J.P., Bershadsky A.D. Environmental sensing through focal adhesions. Nat. Rev. Mol. Cell Biol. 2009, 10:21-33.
61. Geppetti P., Nassini R., Materazzi S., Benemei S. The concept of neurogenic inflammation. BJU Int. 2008, 101(Suppl. 3):2-6.
62. Giannone G., Ronde P., Gaire M., Beaudouin J., Haiech J., Ellenberg J., Takeda K. Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions. J. Biol. Chem. 2004, 279:28715-28723.
63. Goel M., Sinkins W., Keightley A., Kinter M., Schilling W.P. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Pflugers Arch. 2005, 451:87-98.
64. Gomez G.A., McLachlan R.W., Yap A.S. Productive tension: force-sensing and homeostasis of cell-cell junctions. Trends Cell Biol. 2011, 21:499-505.
65. Gomez T.M., Robles E., Poo M., Spitzer N.C. Filopodial calcium transients promote substrate-dependent growth cone turning. Science 2001, 291:1983-1987.
66. Gomez T.M., Spitzer N.C. In vivo regulation of axon extension and pathfinding by growth-cone calcium transients. Nature 1999, 397:350-355.
67. Goswami C., Hucho T. Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton. FEBS J. 2008, 275:4684-4699.
68. Goswami C., Kuhn J., Heppenstall P.A., Hucho T. Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLoS One 2010, 5:e11654.
69. Goswami C., Schmidt H., Hucho F. TRPV1 at nerve endings regulates growth cone morphology and movement through cytoskeleton reorganization. FEBS J. 2007, 274:760-772.
70. 2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J. Biol. Chem. 2010, 285:4213-4223.
71. Haga J.H., Li Y.S., Chien S. Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J. Biomech. 2007, 40:947-960.
72. Hanaoka K., Qian F., Boletta A., Bhunia A.K., Piontek K., Tsiokas L., Sukhatme V.P., Guggino W.B., Germino G.G. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 2000, 408:990-994.
73. Hayakawa K., Tatsumi H., Sokabe M. Actin stress fibers transmit and focus force to activate mechanosensitive channels. J. Cell Sci. 2008, 121:496-503.
74. Hill J.A., Olson E.N. Cardiac plasticity. N. Engl. J. Med. 2008, 358:1370-1380.
75. Hoffman B.D., Grashoff C., Schwartz M.A. Dynamic molecular processes mediate cellular mechanotransduction. Nature 2011, 475:316-323.
76. Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 1999, 397:259-263.
77. Holakovska B., Grycova L., Bily J., Teisinger J. Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails. Amino Acids 2011, 40:741-748.
78. Huan Y., van Adelsberg J. Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J. Clin. Invest. 1999, 104:1459-1468.
79. Humphries J.D., Wang P., Streuli C., Geiger B., Humphries M.J., Ballestrem C. Vinculin controls focal adhesion formation by direct interactions with talin and actin. J. Cell Biol. 2007, 179:1043-1057.
80. Huveneers S., Oldenburg J., Spanjaard E., van der Krogt G., Grigoriev I., Akhmanova A., Rehmann H., de Rooij J. Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling. J. Cell Biol. 2012, 196:641-652.
81. Inoue R., Jian Z., Kawarabayashi Y. Mechanosensitive TRP channels in cardiovascular pathophysiology. Pharmacol. Ther. 2009, 123:371-385.
82. Israeli S., Amsler K., Zheleznova N., Wilson P.D. Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells. Am. J. Physiol. Cell Physiol. 2010, 298:C831-C846.
83. Jaalouk D.E., Lammerding J. Mechanotransduction gone awry. Nat. Rev. Mol. Cell Biol. 2009, 10:63-73.
84. 2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. J. Neurosci. 2006, 26:5656-5664.
85. Johnson B.D., Mather K.J., Wallace J.P. Mechanotransduction of shear in the endothelium: basic studies and clinical implications. Vasc. Med. 2011, 16:365-377.
86. Joly D., Ishibe S., Nickel C., Yu Z., Somlo S., Cantley L.G. The polycystin 1-C-terminal fragment stimulates ERK-dependent spreading of renal epithelial cells. J. Biol. Chem. 2006, 281:26329-26339.
87. Jones R.C., Xu L., Gebhart G.F. The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J. Neurosci. 2005, 25:10981-10989.
88. Jones T.J., Nauli S.M. Mechanosensory calcium signaling. Adv. Exp. Med. Biol. 2012, 740:1001-1015.
89. Kang L., Gao J., Schafer W.R., Xie Z., Xu X.Z. C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron 2010, 67:381-391.
90. Katoh K., Kano Y., Ookawara S. Role of stress fibers and focal adhesions as a mediator for mechano-signal transduction in endothelial cells in situ. Vasc. Health Risk Manage. 2008, 4:1273-1282.
91. Kerstein P.C., del Camino D., Moran M.M., Stucky C.L. Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol. Pain 2009, 5:19.
92. Kiyonaka S., Kato K., Nishida M., Mio K., Numaga T., Sawaguchi Y., Yoshida T., Wakamori M., Mori E., Numata T., Ishii M., Takemoto H., Ojida A., Watanabe K., Uemura A., Kurose H., Morii T., Kobayashi T., Sato Y., Sato C., Hamachi I., Mori Y. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:5400-5405.
93. 2+-dependent internalization of integrins in cultured endothelial cells. J. Cell Sci. 2011, 124:3859-3870.
94. Kobori T., Smith G.D., Sandford R., Edwardson J.M. The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement. J. Biol. Chem. 2009, 284:35507-35513.
95. Komarova Y., Malik A.B. Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu. Rev. Physiol. 2010, 72:463-493.
96. Kottgen M., Buchholz B., Garcia-Gonzalez M.A., Kotsis F., Fu X., Doerken M., Boehlke C., Steffl D., Tauber R., Wegierski T., Nitschke R., Suzuki M., Kramer-Zucker A., Germino G.G., Watnick T., Prenen J., Nilius B., Kuehn E.W., Walz G. TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 2008, 182:437-447.
97. Kriz W., Endlich K. Hypertrophy of podocytes: a mechanism to cope with increased glomerular capillary pressures?. Kidney Int. 2005, 67:373-374.
98. Kriz W., Hackenthal E., Nobiling R., Sakai T., Elger M., Hahnel B. A role for podocytes to counteract capillary wall distension. Kidney Int. 1994, 45:369-376.
99. Kuwahara K., Wang Y., McAnally J., Richardson J.A., Bassel-Duby R., Hill J.A., Olson E.N. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J. Clin. Invest. 2006, 116:3114-3126.
100. Kwan H.Y., Huang Y., Yao X. TRP channels in endothelial function and dysfunction. Biochim. Biophys. Acta 2007, 1772:907-914.
101. Lamoureux P., Buxbaum R.E., Heidemann S.R. Direct evidence that growth cones pull. Nature 1989, 340:159-162.
102. Lamoureux P., Heidemann S.R., Martzke N.R., Miller K.E. Growth and elongation within and along the axon. Dev. Neurobiol. 2010, 70:135-149.
103. Langeslag M., Clark K., Moolenaar W.H., van Leeuwen F.N., Jalink K. Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J. Biol. Chem. 2007, 282:232-239.
104. Large W.A., Saleh S.N., Albert A.P. Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle. Cell Calcium 2009, 45:574-582.
105. Lauffenburger D.A., Horwitz A.F. Cell migration: a physically integrated molecular process. Cell 1996, 84:359-369.
106. Leckband D.E., Le Duc Q., Wang N., de Rooij J. Mechanotransduction at cadherin-mediated adhesions. Curr. Opin. Cell Biol. 2011, 23:523-530.
107. Lehen'kyi V., Prevarskaya N. Oncogenic TRP channels. Adv. Exp. Med. Biol. 2011, 704:929-945.
108. Levine J.D., Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochim. Biophys. Acta 2007, 1772:989-1003.
109. Li Y., Jia Y.C., Cui K., Li N., Zheng Z.Y., Wang Y.Z., Yuan X.B. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature 2005, 434:894-898.
110. Li Y.S., Haga J.H., Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells. J. Biomech. 2005, 38:1949-1971.
111. Lohmann C., Finski A., Bonhoeffer T. Local calcium transients regulate the spontaneous motility of dendritic filopodia. Nat. Neurosci. 2005, 8:305-312.
112. Lorenzo I.M., Liedtke W., Sanderson M.J., Valverde M.A. TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:12611-12616.
113. 2+ influx. Arterioscler. Thromb. Vasc. Biol. 2010, 30:851-858.
114. Malhas A.N., Abuknesha R.A., Price R.G. Interaction of the leucine-rich repeats of polycystin-1 with extracellular matrix proteins: possible role in cell proliferation. J. Am. Soc. Nephrol. 2002, 13:19-26.
115. Malik B., Stillman M. Chemotherapy-induced peripheral neuropathy. Curr. Neurol. Neurosci. Rep. 2008, 8:56-65.
116. Matthews B.D., Thodeti C.K., Tytell J.D., Mammoto A., Overby D.R., Ingber D.E. Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr. Biol. (Camb.) 2010, 2:435-442.
117. McCleskey E.W., Gold M.S. Ion channels of nociception. Annu. Rev. Physiol. 1999, 61:835-856.
118. McCleverty C.J., Koesema E., Patapoutian A., Lesley S.A., Kreusch A. Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci. 2006, 15:2201-2206.
119. Mederos y Schnitzler M., Storch U., Meibers S., Nurwakagari P., Breit A., Essin K., Gollasch M., Gudermann T. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 2008, 27:3092-3103.
120. 2+ influx and vasodilation in response to shear stress. Am. J. Physiol. Heart Circ. Physiol. 2010, 298:H466-H476.
121. Minke B., Cook B. TRP channel proteins and signal transduction. Physiol. Rev. 2002, 82:429-472.
122. Miyamoto T., Petrus M.J., Dubin A.E., Patapoutian A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nat. Commun. 2011, 2:369.
123. Moller C.C., Wei C., Altintas M.M., Li J., Greka A., Ohse T., Pippin J.W., Rastaldi M.P., Wawersik S., Schiavi S., Henger A., Kretzler M., Shankland S.J., Reiser J. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J. Am. Soc. Nephrol. 2007, 18:29-36.
124. Monet M., Gkika D., Lehen'kyi V., Pourtier A., Vanden Abeele F., Bidaux G., Juvin V., Rassendren F., Humez S., Prevarsakaya N. Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim. Biophys. Acta 2009, 1793:528-539.
125. Monet M., Lehen'kyi V., Gackiere F., Firlej V., Vandenberghe M., Roudbaraki M., Gkika D., Pourtier A., Bidaux G., Slomianny C., Delcourt P., Rassendren F., Bergerat J.P., Ceraline J., Cabon F., Humez S., Prevarskaya N. Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res. 2010, 70:1225-1235.
126. Montell C. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci. STKE 2001, 2001:re1.
127. Montell C. TRP channels in Drosophila photoreceptor cells. J. Physiol. 2005, 567:45-51.
128. Montell C., Rubin G.M. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 1989, 2:1313-1323.
129. Muraki K., Iwata Y., Katanosaka Y., Ito T., Ohya S., Shigekawa M., Imaizumi Y. TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ. Res. 2003, 93:829-838.
130. Nakayama H., Wilkin B.J., Bodi I., Molkentin J.D. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J. 2006, 20:1660-1670.
131. Nauli S.M., Alenghat F.J., Luo Y., Williams E., Vassilev P., Li X., Elia A.E., Lu W., Brown E.M., Quinn S.J., Ingber D.E., Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 2003, 33:129-137.
132. Nauli S.M., Kawanabe Y., Kaminski J.J., Pearce W.J., Ingber D.E., Zhou J. Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 2008, 117:1161-1171.
133. Nauli S.M., Rossetti S., Kolb R.J., Alenghat F.J., Consugar M.B., Harris P.C., Ingber D.E., Loghman-Adham M., Zhou J. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J. Am. Soc. Nephrol. 2006, 17:1015-1025.
134. Nicol X., Hong K.P., Spitzer N.C. Spatial and temporal second messenger codes for growth cone turning. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:13776-13781.
135. Nijenhuis T., Sloan A.J., Hoenderop J.G., Flesche J., van Goor H., Kistler A.D., Bakker M., Bindels R.J., de Boer R.A., Moller C.C., Hamming I., Navis G., Wetzels J.F., Berden J.H., Reiser J., Faul C., van der Vlag J. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am. J. Pathol. 2011, 179:1719-1732.
136. Oancea E., Wolfe J.T., Clapham D.E. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ. Res. 2006, 98:245-253.
137. Onohara N., Nishida M., Inoue R., Kobayashi H., Sumimoto H., Sato Y., Mori Y., Nagao T., Kurose H. TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J. 2006, 25:5305-5316.
138. Patel A., Honore E. Polycystins and renovascular mechanosensory transduction. Nat. Rev. Nephrol. 2010, 6:530-538.
139. Patel A., Sharif-Naeini R., Folgering J.R., Bichet D., Duprat F., Honore E. Canonical TRP channels and mechanotransduction: from physiology to disease states. Pflugers Arch. 2010, 460:571-581.
140. Pelham R.J., Wang Y. Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:13661-13665.
141. 2+-sensitive intermediate-conductance K+ channels in MDCK cells. J. Membr. Biol. 2003, 191:193-200.
142. Praetorius H.A., Spring K.R. Bending the MDCK cell primary cilium increases intracellular calcium. J. Membr. Biol. 2001, 184:71-79.
143. Prevarskaya N., Skryma R., Shuba Y. Calcium in tumour metastasis: new roles for known actors. Nat. Rev. Cancer 2011, 11:609-618.
144. Qian F., Wei W., Germino G., Oberhauser A. The nanomechanics of polycystin-1 extracellular region. J. Biol. Chem. 2005, 280:40723-40730.
145. Ramsey I.S., Delling M., Clapham D.E. An introduction to TRP channels. Annu. Rev. Physiol. 2006, 68:619-647.
146. Raychowdhury M.K., McLaughlin M., Ramos A.J., Montalbetti N., Bouley R., Ausiello D.A., Cantiello H.F. Characterization of single channel currents from primary cilia of renal epithelial cells. J. Biol. Chem. 2005, 280:34718-34722.
147. Reiser J., Polu K.R., Moller C.C., Kenlan P., Altintas M.M., Wei C., Faul C., Herbert S., Villegas I., Avila-Casado C., McGee M., Sugimoto H., Brown D., Kalluri R., Mundel P., Smith P.L., Clapham D.E., Pollak M.R. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat. Genet. 2005, 37:739-744.
148. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., Parsons J.T., Horwitz A.R. Cell migration: integrating signals from front to back. Science 2003, 302:1704-1709.
149. Ro J.Y., Lee J.S., Zhang Y. Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia. Pain 2009, 144:270-277.
150. Roitbak T., Ward C.J., Harris P.C., Bacallao R., Ness S.A., Wandinger-Ness A. A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells. Mol. Biol. Cell 2004, 15:1334-1346.
151. Rose D.M., Alon R., Ginsberg M.H. Integrin modulation and signaling in leukocyte adhesion and migration. Immunol. Rev. 2007, 218:126-134.
152. Salathe M. Regulation of mammalian ciliary beating. Annu. Rev. Physiol. 2007, 69:401-422.
153. Schaff U.Y., Dixit N., Procyk E., Yamayoshi I., Tse T., Simon S.I. Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow. Blood 2010, 115:657-666.
154. Schlondorff J., Del Camino D., Carrasquillo R., Lacey V., Pollak M.R. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. Am. J. Physiol. Cell Physiol. 2009, 296:C558-C569.
155. Seth M., Zhang Z.S., Mao L., Graham V., Burch J., Stiber J., Tsiokas L., Winn M., Abramowitz J., Rockman H.A., Birnbaumer L., Rosenberg P. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ. Res. 2009, 105:1023-1030.
156. Sharif-Naeini R., Folgering J.H., Bichet D., Duprat F., Lauritzen I., Arhatte M., Jodar M., Dedman A., Chatelain F.C., Schulte U., Retailleau K., Loufrani L., Patel A., Sachs F., Delmas P., Peters D.J., Honore E. Polycystin-1 and -2 dosage regulates pressure sensing. Cell 2009, 139:587-596.
157. Shibasaki K., Murayama N., Ono K., Ishizaki Y., Tominaga M. TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J. Neurosci. 2010, 30:4601-4612.
158. Sokabe T., Fukumi-Tominaga T., Yonemura S., Mizuno A., Tominaga M. The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J. Biol. Chem. 2010, 285:18749-18758.
159. Spassova M.A., Hewavitharana T., Xu W., Soboloff J., Gill D.L. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16586-16591.
160. Su L.T., Agapito M.A., Li M., Simonson W.T., Huttenlocher A., Habas R., Yue L., Runnels L.W. TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J. Biol. Chem. 2006, 281:11260-11270.
161. Suter D.M., Miller K.E. The emerging role of forces in axonal elongation. Prog. Neurobiol. 2011, 94:91-101.
162. Suzuki M., Mizuno A., Kodaira K., Imai M. Impaired pressure sensation in mice lacking TRPV4. J. Biol. Chem. 2003, 278:22664-22668.
163. Tai Y., Feng S., Du W., Wang Y. Functional roles of TRPC channels in the developing brain. Pflugers Arch. 2009, 458:283-289.
164. Takeichi M. Self-organization of animal tissues: cadherin-mediated processes. Dev. Cell 2011, 21:24-26.
165. 2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth. J. Biol. Chem. 2009, 284:28554-28562.
166. Talavera K., Nilius B., Voets T. Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci. 2008, 31:287-295.
167. Theveneau E., Mayor R. Collective cell migration of the cephalic neural crest: the art of integrating information. Genesis 2011, 49:164-176.
168. Thodeti C.K., Matthews B., Ravi A., Mammoto A., Ghosh K., Bracha A.L., Ingber D.E. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ. Res. 2009, 104:1123-1130.
169. Thoumine O. Interplay between adhesion turnover and cytoskeleton dynamics in the control of growth cone migration. Cell Adhes. Migr. 2008, 2:263-267.
170. 2+ signaling, TRP channels, and endothelial permeability. Microcirculation 2006, 13:693-708.
171. Tominaga M., Caterina M.J. Thermosensation and pain. J. Neurobiol. 2004, 61:3-12.
172. Torres V.E., Harris P.C. Autosomal dominant polycystic kidney disease: the last 3 years. Kidney Int. 2009, 76:149-168.
173. Tsai F.C., Meyer T. Ca(2+) pulses control local cycles of lamellipodia retraction and adhesion along the front of migrating cells. Curr. Biol. 2012, 22:837-842.
174. Tsiokas L., Arnould T., Zhu C., Kim E., Walz G., Sukhatme V.P. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:3934-3939.
175. Vallee R.B., Seale G.E., Tsai J.W. Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones. Trends Cell Biol. 2009, 19:347-355.
176. Vanhoutte P.M., Shimokawa H., Tang E.H., Feletou M. Endothelial dysfunction and vascular disease. Acta Physiol. (Oxf.) 2009, 196:193-222.
177. Vennekens R. Emerging concepts for the role of TRP channels in the cardiovascular system. J. Physiol. 2011, 589:1527-1534.
178. Wan X., Juranka P., Morris C.E. Activation of mechanosensitive currents in traumatized membrane. Am. J. Physiol. 1999, 276:C318-C327.
179. Wang Y., Jarad G., Tripathi P., Pan M., Cunningham J., Martin D.R., Liapis H., Miner J.H., Chen F. Activation of NFAT signaling in podocytes causes glomerulosclerosis. J. Am. Soc. Nephrol. 2010, 21:1657-1666.
180. Waning J., Vriens J., Owsianik G., Stuwe L., Mally S., Fabian A., Frippiat C., Nilius B., Schwab A. A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration. Cell Calcium 2007, 42:17-25.
181. Wayman G.A., Kaech S., Grant W.F., Davare M., Impey S., Tokumitsu H., Nozaki N., Banker G., Soderling T.R. Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J. Neurosci. 2004, 24:3786-3794.
182. Wei C., Wang X., Chen M., Ouyang K., Song L.S., Cheng H. Calcium flickers steer cell migration. Nature 2009, 457:901-905.
183. Wen Z., Han L., Bamburg J.R., Shim S., Ming G.L., Zheng J.Q. BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J. Cell Biol. 2007, 178:107-119.
184. Winn M.P., Conlon P.J., Lynn K.L., Farrington M.K., Creazzo T., Hawkins A.F., Daskalakis N., Kwan S.Y., Ebersviller S., Burchette J.L., Pericak-Vance M.A., Howell D.N., Vance J.M., Rosenberg P.B. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 2005, 308:1801-1804.
185. 2+ BK channel activity and cell migration. J. Biomed. Sci. 2009, 16:90.
186. Wondergem R., Ecay T.W., Mahieu F., Owsianik G., Nilius B. HGF/SF and menthol increase human glioblastoma cell calcium and migration. Biochem. Biophys. Res. Commun. 2008, 372:210-215.
187. Wu L.J., Sweet T.B., Clapham D.E. International Union of Basic and Clinical Pharmacology: LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol. Rev. 2010, 62:381-404.
188. Wu X., Eder P., Chang B., Molkentin J.D. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:7000-7005.
189. Yao X., Garland C.J. Recent developments in vascular endothelial cell transient receptor potential channels. Circ. Res. 2005, 97:853-863.
190. Yogi A., Callera G.E., Antunes T.T., Tostes R.C., Touyz R.M. Transient receptor potential melastatin 7 (TRPM7) cation channels, magnesium and the vascular system in hypertension. Circ. J. 2011, 75:237-245.
191. Zou Y., Akazawa H., Qin Y., Sano M., Takano H., Minamino T., Makita N., Iwanaga K., Zhu W., Kudoh S., Toko H., Tamura K., Kihara M., Nagai T., Fukamizu A., Umemura S., Iiri T., Fujita T., Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat. Cell Biol. 2004, 6:499-506.