Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades

Circulation Research

Volumn 104, Issue 7, 2009, Pages 860-869

  Aboualaiwi, Wissam A ^a   Takahashi, Maki ^a   Mell, Blair R ^a   Jones, Thomas J ^a,c   Ratnam, Shobha ^a   Kolb, Robert J ^b   Nauli, Surya M ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Biophysical force; Endothelia; Mechanotransduction; Primary cilium; Shear stress

Indexed keywords

CALCIUM CHANNEL; CALMODULIN; NITRIC OXIDE; POLYCYSTIN 2; PROTEIN KINASE B; PROTEIN KINASE C; PURINERGIC RECEPTOR; POLYCYSTIC KIDNEY DISEASE 2 PROTEIN; POLYCYSTIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; BIOCHEMISTRY; BIOSYNTHESIS; BLOOD FLOW; BLOOD PRESSURE; CILIARY ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; EUKARYOTIC FLAGELLUM; FLUID FLOW; FORCE; HUMAN; HUMAN CELL; ISOLATED ARTERY; KIDNEY POLYCYSTIC DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SHEAR STRESS; VASCULAR ENDOTHELIUM; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; ENZYMOLOGY; GENETICS; HYPERTENSION; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM; MOUSE MUTANT; MUTATION; PATHOPHYSIOLOGY; RNA INTERFERENCE; TIME;

ANIMALS; BLOOD PRESSURE; CALCIUM SIGNALING; CALMODULIN; CELLS, CULTURED; CILIA; ENDOTHELIAL CELLS; HUMANS; HYPERTENSION; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, KNOCKOUT; MUTATION; NITRIC OXIDE; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRESS, MECHANICAL; TIME FACTORS; TRPP CATION CHANNELS;

EID: 65249117068     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.192765     Document Type: Article

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