The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: Functional characterization and physiological relevance

Pflugers Archiv European Journal of Physiology

Volumn 451, Issue 1, 2005, Pages 72-80

  Dietrich, Alexander ^a   Kalwa, Hermann ^a   Rost, Benjamin R ^a   Gudermann, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Bayliss effect; DAG sensitive TRPC3, TRPC6, TRPC7; Functional characterization; Non selective cation channels; Physiological function; Pulmonary arterial hypertension; Smooth muscle cells

Indexed keywords

CATION CHANNEL; MEMBRANE PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ANIMAL TISSUE; CELL LINE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE POTENTIAL; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; TRANSIENT RECEPTOR POTENTIAL CANONICAL 3; TRANSIENT RECEPTOR POTENTIAL CANONICAL 6; TRANSIENT RECEPTOR POTENTIAL CANONICAL 7;

ANIMALS; DIGLYCERIDES; HUMANS; PHOSPHOLIPASE C; PROTEIN STRUCTURE, QUATERNARY; TISSUE DISTRIBUTION; TRPC CATION CHANNELS;

EID: 26444514142     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-005-1460-0     Document Type: Review

References (88)

1. Balzer M, Lintschinger B, Groschner K (1999) Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells. Cardiovasc Res 42:543-549
2. 2+ influx. J Biol Chem 280:12908-12916
3. Basora N, Boulay G, Bilodeau L, Rousseau E, and Payet M (2003) 20-Hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells. J Biol Chem 278:31709-31716
4. Beech DJ, Muraki K, Flemming R (2004) Non-selective cat-ionic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 559(3):685-706
5. Berridge MJ (1997) Elementary and global aspects of calcium imaging. J Physiol 499:291-306
6. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709-720
7. q class of G protein. J Biol Chem 272:29672-29680
8. 2+ entry. Proc Natl Acad Sci USA 96:14955-14960
9. 2+ entry of TRPC6 in HEK-293c cells calmodulin. Cell Calcium 32:201-207
10. q protein coupled receptor activation. J Biol Chem 279:7241-7246
11. Chu X, Tong Q, Cheung JY, Wozney J, Conrad K, Mazack V, Zhang W, Stahl R, Barber DL, Miller BA (2004) Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. J Biol Chem 279:10514-10522
12. Clapham D (2003). TRP channels as cellular sensors. Nature 426:517-524
13. Dietrich A, Gollasch M, Chubanov V, Mederos y Schnitzler M, Dubrovska G, Herz U, Renz H, Gudermann T, Birnbaumer L (2003) Studies on TRPC6 deficient mice reveal its non-redundant role in the regulation of smooth muscle tone. Naunyn-Schmiedebergs Arch Pharmacol 367(Suppl):238
14. Dietrich A, Mederos y Schnitzler M, Emmel J, Kalwa H, Hofmann T, Gudermann T (2003) N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. J Biol Chem 278:47842-47852
15. Dietrich A, Mederos y Schnitzler M, Storch U, Lauterbach B, Essin K, Obst M, Gross V, Gollasch M, Birnbaumer L, Gudermann T (2004) TRPC6 deficient mice develop an elevated blood-pressure and an early onset of the myogenic tone in cerebral arteries. Naunyn-Schmiedebergs Arch Pharmacol 369(Suppl):242
16. Goel M, Sinkins WG, Schilling WP (2002) Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem 277:48303-48310
17. Groschner K, Rosker C, Lukas M (2004) Role of TRP channels in oxidative stress. Novartis Found Symp 258:222-235
18. Gudermann T, Mederos y Schnitzler M, Dietrich A (2004) Receptor-operated cation entry - more than esoteric terminology? Science STKE 243:pe35
19. Guillemette J, Caron AZ, Regimbald-Dumas Y, Argiun G, Mignery GA, Boulay G, Guilemette G (2005) Expression of a truncated form of inositol 1,4,5-trisphosphate receptor type III in the cytosol of DT40 triple inositol 1,4,5-trisphosphate receptor-knockout cells. Cell Calcium 37:97-104
20. Halaszovich CR, Zitt C, Jüngling E, Lückhoff A (2000) Inhibition of TRP3 channels by lanthanides. J Biol Chem 275:37423-37428
21. Hassock SR, Zhu MX, Trost C, Flockerzi V, Authi KS (2002) Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood 100:2801-2811
22. Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K (2004) Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 279:18887-18894
23. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263
24. Hofmann T, Schaefer M, Schultz G, and Gudermann T (2000) Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. J Mol Med 78:14-25
25. Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99:7461-7466
26. 2+ influx in stably transfected HEK293 cells. FEBS Lett 422(3):333-338
27. 2+-permeable cation channel. Circ Res 88:325-332
28. 2+ entry: toward a proliferation or a simplification. FASEB J 6:3085-3091
29. Jung S, Strotmann R, Schultz G, Plant TD (2002) TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. Am J Physiol 282:C347-C359
30. Jung S, Mühle A, Schaefer M, Strotmann R, Schultz G, Plant TD (2003) Lanthanides potentiate TRPC5 currents by an action ar extracellular sites close to the pore mouth. J Biol Chem 278:3562-3571
31. 3 receptors and store-operated Htrp3 channels. Nature 396:478-482
32. 2+-permeable nonselective cation channels in vascular smooth muscle: a physiological perspective. J Cardiovasc Electrophysiol 13:493-501
33. Lee YM, Kim BJ, Kim HJ, Yang DK, Zhu MX, Lee KP, So K, Kim W (2003) TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am J Physiol 284:G604-G616
34. 2+. Cell Signal 17:437-445
35. Li H-S, Shawn X-Z, Montell C (1999) Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron 24:261-273
36. Li S, Westwick J, Poll C (2003) Transient receptor potential (TRP) channels as potential drug targets in respiratory disease. Cell Calcium 33:551-558
37. Li Y, Jia Y-C, Cui K, Li N, Zheng Z-Y, Wang Y-Z, Yuan X-B (2005) Essential role of TRPC channels in the guidance of nerve growth cones by brain derived neurotrophic factor. Nature 434:894-898
38. 2+ channels in pulmonary arterial smooth muscle cells. Circ Res 95:496-505
39. Lievremont JP, Bird GS, Putney JW Jr (2004) Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. Am J Physiol 287:C1709-C1716
40. Lockwich TP, Liu X, Singh BB, Jadlowiec J, Weiland S, Ambudkar IS (2000) Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem 275:11934-11942
41. 2+ influx without disruption of Trp3-inositol trisphosphate receptor association. J Biol Chem 276:4201-4208
42. 2+ influx. Biochemistry 37:9776-9783
43. Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40:551-561
44. Lussier MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, Boulay G (2005) MxA, a member of the dynamin superfamily, interacts with the ankyrin like repeat domain of TRPC. J Biol Chem 280:19393-19400
45. Mederos y Schnitzler M, Storch U, Dietrich A, Gudermann T (2004) Increased currents in isolated smooth muscle cells of TRPC6-deficient mice. Naunyn-Schmiedebergs Arch Pharmacol 369(Suppl):247
46. Montell (2005) The TRP superfamily of cation channels. Science STKE. 2005(272):re3
47. Ohki G, Miyoshi M, Murata K, Ishibashi M, Imai M, Suzuki M (2000) A calcium-activated cation current by an alternative spliced form of Trp3 in the heart. J Biol Chem 275:39055-39060
48. 2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359-27370
49. Otsuka Y, Sakagami H, Owada Y, Kondo H (1998) Differential location of mRNAs for mammalian trps, presumptive capacitative calcium entry channels, in the adult mouse brain. Tohoku J Exp Med 185:139-146
50. Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T (2005) Illumination of the melanopsin signalling pathway. Science 307:600-604
51. 2+ entry: evidence for a secretion like coupling model. Cell 98:487-499
52. Putney JW Jr (2004) The enigmatic TRPCs: multifunctional cation channels. Trends Cell Biol 14:282-286
53. Philipp S, Strauss B, Hirnet D, Wissenbach U, Mery L, Flockerzi V, Hoth M (2003) TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes. J Biol Chem 278:26629-26638
54. Qiu X, Kumbalasiri T, Carlson SM, Wong KY, Krishna V, Provencio I, Berson DM (2005) Induction of photosensitivity by heterologous expression of melanopsin. Nature 433:745-749
55. Reading SA, Earley S, Waldron BJ, Welsh DG, Brayden JE (2005) TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries. Am J Physiol 288:H2055-H2061
56. 2+ influx. J Biol Chem 277:12302-12309
57. 2+ exchanger. J Biol Chem 279:13696-13704
58. Schilling WP (2001) TRP proteins. Novel therapeutic targets for regional blood pressure control? Circ Res 88:256-259
59. Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, Inoue R (2004) Multiple regulation of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol 561:415-432
60. 2+ influx. Mol Cell 15:635-646
61. Smani T, Zakharov SI, Csutora P, Leno E, Trepakova ES, Bolotina VM (2004) A novel mechanism for the store-operated calcium influx pathway. Nat Cell Biol 6:113-120
62. Strübing C, Kaprivinski G, Kaprivinski L, Clapham DE (2003) Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem 278:39014-39019
63. Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu MX (2001) Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of Trp channels. J Biol Chem 276:21303-21310
64. Trebak M, Bird GS, McKay RR, Putney JW Jr (2002) Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J Biol Chem 277:21617-21623
65. Trebak M, Bird GS, McKay RR, Birnbaumer L, Putney JW Jr (2003a) Signaling mechanism for receptor-activated TRPC3 channels. J Biol Chem 278:16244-16252
66. Trebak M, Vazques G, Bird GS, Putney JW Jr (2003b) The TRPC3/6/7 subfamily of cation channels. Cell Calcium 33:451-461
67. Trebak M, Hempel N, Wedel BJ, Smyth JT, Bird GS, Putney JW Jr (2005) Negative regulation of TRPC3 channels by protein kinase C mediated phosphorylation of serine 712. Mol Pharmacol 67:558-563
68. Tseng P-H, Lin H-P, Hu H, Wang C, Zhu MX, Chen C-S (2004) The Canonical Transient Receptor Potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system. Biochemistry 43:11701-11708
69. Vannier B, Zhu X, Brown D, Birnbaumer L (1998) The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry. J Biol Chem 273:8675-8679
70. 1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature 434:99-104
71. Vazques G, Lièvremont J-P, Bird GStJ, Putney JW Jr (2001) Human Trp3 forms both inositol trisphosphate receptor-dependent and independent store-operated cation channels in DT 40 avian B-lymphocytes. Proc Natl Acad Sci USA 98:11777-11782
72. Vazquez G, Wedel BJ, Trebak M, Bird GS, Putney JW Jr (2003) Expression level of TRPC3 channel determines its mechanism of activation. J Biol Chem 278:21649-21654
73. Vazques G, Wedel BJ, Kawasaki BT, Bird GStJ, Putney JW Jr (2004) Obligatory Role of src kinase in the signaling mechanism for TRPC3 cation channels. J Biol Chem 279:40521-40528
74. 3 receptor-knockout cells. J Biol Chem 2768:33980-33985
75. Venkatachalam K, Zheng F, Gill DL (2003) Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerin and protein kinase C. J Biol Chem 278:29031-29040
76. 3 receptor-independent process. J Biol Chem 278:25758-25765
77. Welsh DG, Morielli AD, Nelson MT, Brayden JE (2002) Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90:248-250
78. 2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger. Cell 98:475-485
79. Yildirim E, Kawasaki BT, Birnbaumer L (2005) Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. Proc Natl Acad Sci USA 102:3307-3311
80. Yip H, Chan W-Y, Leung P-C, Kwan H-Y, Liu C, Huang Y, Michel V, Yew D T-W, Yao X (2004) Expression of TRPC homologues in endothelial cells and smooth muscle layers of human arteries. Histochem Cell Biol 122:553-561
81. Yu Y, Sweeney M, Zhang S, Platoshyn O, Landsberg JW, Rothman A, Yuan JX-J (2003) PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol 284:C316-C330
82. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan, JX.-J (2004) Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 101:13861-13866
83. 3 receptors. Cell 144:777-789
84. 2+ channel isoforms. J Biol Chem 276:13331-13339
85. Zhang Z, Tang J, Tikunova S, Johnson JD, Chen Z, Qin N, Dietrich A, Stefani S, Birnbaumer L, Zhu MX (2001) Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc Natl Acad Sci USA 98:3168-3173
86. 2+ entry. Cell 85:661-671
87. 2+ entry. J Biol Chem 273:133-142
88. Zitt C, Obukhov AG, Strübing C, Zobel A, Kalkbrenner F, Lückhoff A, Schultz G (1997) Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J Cell Biol 138:1333-41