Hypertrophy of podocytes: A mechanism to cope with increased glomerular capillary pressures?

Kidney International

Volumn 67, Issue 1, 2005, Pages 373-374

  Kriz, Wilhelm ^a,b   Endlich, Karlhans ^a  

^a University of Heidelberg ^*

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PRESSURE; CAPILLARY PRESSURE; EDITORIAL; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; GLOMERULUS CAPILLARY PRESSURE; HYPERTROPHY; MESANGIUM; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; RENOVASCULAR HYPERTENSION;

EID: 10944254699     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2005.00141.x     Document Type: Editorial

References (16)

1. VERSEPUT G, PROVOOST A, BRAAM B, et al: Angiotensin-converting enzyme inhibition in the prevention and treatment of chronic renal damage in the hypertensive fawn-hooded rat. J Am Soc Nephrol 8:249-259, 1997
2. KRETZLER M, KOEPPEN-HAGEMANN I, KRIZ W: Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomized desoxycorticosterone rat. Virchows Arch A Pathol Anat Histopathol 425:181-193, 1994
3. IVERSEN B, AMANN K, KVAM F, et al: Increased glomerular capillary pressure and size mediate glomerulosclerosis in SHR juxtamedullary cortex. Am J Physiol 274:F365-F373, 1998
4. KRIZ W, ELGER M, MUNDEL P, et al: Structure-stabilizing forces in the glomerular tuft. J Am Soc Nephrol 5:1731-1739, 1995
5. KRIZ W, ELGER M, LEMLEY K, et al: Structure of the glomerular mesangium: A biomechanical interpretation. Kidney Int 38(Suppl 30):S2-S9, 1990
6. KRIZ W, HACKENTHAL E, NOBILING R, et al: A role for podocytes to counteract capillary wall distension. Kidney Int 45:369-376, 1994
7. KRIZ W, MUNDEL P, ELGER M: The contractile apparatus of podocytes is arranged to counteract GBM expansion. Contrib Nephrol 107:1-9, 1994
8. SHANKLAND S, PETERMANN A, PIPPIN J, et al: Mechanical stretch induces podocyte hypertrophy in vitro. Kidney Int 67:157-166, 2005
9. ENDLICH N, KRESS K, REISER J, et al. Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 12:413-422, 2001
10. ENDLICH N, SUNOHARA M, NIETFIELD W, et al: Analysis of differential gene expression in stretched podocytes: Osteopontin enhances adaptation of podocytes to mechanical stress. FASEB J 16:1850-1852, 2002
11. WITHERDEN I, MATHIESON P, SALEEM M: The differentiated glomerular podocyte displays key features of a contractile smooth muscle cell. J Am Soc Nephrol 14:F-PO444, 159A, 2003
12. + channel: Potential implications for the control of glomerular filtration. J Am Soc Nephrol, in press
13. PETERMANN A, HIROMURA K, BLONSKI M, et al: Mechanical stress reduces podocyte proliferation in vitro. Kidney Int 61:40-50, 2002
14. RISER B, CORTES P, YEE J: Modelling the effects of vascular stress in mesangial cells. Curr Opin Nephrol Hypertens 9:43-47, 2000
15. CHAPMAN G, DURANTE W, HELLUMS J, et al: Physiological cyclic stretch causes cell cycle arrest in cultured vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 278:H748-H754, 2000
16. MARTINEAU L, MCVEIGH L, JASMIN B, et al: p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: Implications for the actin cytoskeleton. Am J Physiol Renal Physiol 286:F693-701, 2004