메뉴 건너뛰기




Volumn 98, Issue 1, 2012, Pages 26-32

Thymus and type 1 diabetes: An update

Author keywords

AIRE; Autoimmunity; Coxsackie virus B4; Insulin family; Self tolerance; Thymus; Type I diabetes

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; AUTOIMMUNE REGULATOR PROTEIN;

EID: 84867399286     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2012.05.023     Document Type: Review
Times cited : (20)

References (75)
  • 1
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965, 14:619-633.
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 3
    • 33646165128 scopus 로고    scopus 로고
    • The central role of central tolerance
    • Kyewski B., Klein L. The central role of central tolerance. Annu Rev Immunol 2006, 24:571-605.
    • (2006) Annu Rev Immunol , vol.24 , pp. 571-605
    • Kyewski, B.1    Klein, L.2
  • 4
    • 36448949476 scopus 로고    scopus 로고
    • Generating intrathymic microenvironments to establish T-cell tolerance
    • Anderson G., Lane P.J.L., Jenkinson E.J. Generating intrathymic microenvironments to establish T-cell tolerance. Nat Rev Immunol 2007, 7:954-962.
    • (2007) Nat Rev Immunol , vol.7 , pp. 954-962
    • Anderson, G.1    Lane, P.J.L.2    Jenkinson, E.J.3
  • 5
    • 64249113126 scopus 로고    scopus 로고
    • Learning to be tolerant: how T cells keep out of trouble
    • Holländer G.A., Peterson P. Learning to be tolerant: how T cells keep out of trouble. J Intern Med 2009, 265:541-561.
    • (2009) J Intern Med , vol.265 , pp. 541-561
    • Holländer, G.A.1    Peterson, P.2
  • 6
    • 70349242192 scopus 로고    scopus 로고
    • Central tolerance: essential for preventing autoimmune disease
    • von Boehmer H. Central tolerance: essential for preventing autoimmune disease. Eur J Immunol 2009, 39:2313-2316.
    • (2009) Eur J Immunol , vol.39 , pp. 2313-2316
    • von Boehmer, H.1
  • 7
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakagushi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakagushi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 8
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    • Nakayama M., Abiru N., Moriyama H., Babaya N., Liu E., Miao D., et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005, 435:220-223.
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3    Babaya, N.4    Liu, E.5    Miao, D.6
  • 9
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • Kent S.C., Chen Y., Bregoli L., Clemmings S.M., Kenyon N.S., Ricordi C., et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005, 435:224-228.
    • (2005) Nature , vol.435 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3    Clemmings, S.M.4    Kenyon, N.S.5    Ricordi, C.6
  • 10
    • 80052146396 scopus 로고    scopus 로고
    • Beyond the hormone: insulin as an autoimmune target in type 1 diabetes
    • Brezar V., Carel J.C., Boitard C., Mallone R. Beyond the hormone: insulin as an autoimmune target in type 1 diabetes. Endocr Rev 2011, 32:623-669.
    • (2011) Endocr Rev , vol.32 , pp. 623-669
    • Brezar, V.1    Carel, J.C.2    Boitard, C.3    Mallone, R.4
  • 11
    • 0037478632 scopus 로고    scopus 로고
    • Identification of the β cells antigen targeted by a prevalent population of diabetogenic CD8+ T cells in autoimmune diabetes
    • Lieberman S.M., Evans A.M., Han B., Takati T., Vinnitskaya Y., Caldwell J.A., et al. Identification of the β cells antigen targeted by a prevalent population of diabetogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A 2003, 100:8384-8388.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8384-8388
    • Lieberman, S.M.1    Evans, A.M.2    Han, B.3    Takati, T.4    Vinnitskaya, Y.5    Caldwell, J.A.6
  • 12
    • 36749011882 scopus 로고    scopus 로고
    • The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    • Wenzlau J.M., Juhl K., Yu L., Moua O., Sarkar S.A., Gottlieb P., et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A 2007, 104:17040-17045.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17040-17045
    • Wenzlau, J.M.1    Juhl, K.2    Yu, L.3    Moua, O.4    Sarkar, S.A.5    Gottlieb, P.6
  • 14
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • Bluestone J.A., Herold K., Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010, 464:1293-1300.
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 15
  • 16
    • 0038303191 scopus 로고    scopus 로고
    • The role of T cells in the pathogenesis of type 1 diabetes: from cause to cure
    • Roep B.O. The role of T cells in the pathogenesis of type 1 diabetes: from cause to cure. Diabetologia 2003, 46:305-321.
    • (2003) Diabetologia , vol.46 , pp. 305-321
    • Roep, B.O.1
  • 17
    • 0029898286 scopus 로고    scopus 로고
    • The thymic repertoire of neuroendocrine self-peptides: physiological implications in T-cell life and death
    • Martens H., Goxe B., Geenen V. The thymic repertoire of neuroendocrine self-peptides: physiological implications in T-cell life and death. Immunol Today 1996, 17:312-317.
    • (1996) Immunol Today , vol.17 , pp. 312-317
    • Martens, H.1    Goxe, B.2    Geenen, V.3
  • 18
    • 0342894680 scopus 로고    scopus 로고
    • Identification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with major histocompatibility complex class I molecules
    • Vanneste Y., Ntodou-Thome A., Vandersmissen E., Charlet C., Franchimont D., Martens H., et al. Identification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with major histocompatibility complex class I molecules. J Neuroimmunol 1997, 76:161-166.
    • (1997) J Neuroimmunol , vol.76 , pp. 161-166
    • Vanneste, Y.1    Ntodou-Thome, A.2    Vandersmissen, E.3    Charlet, C.4    Franchimont, D.5    Martens, H.6
  • 19
    • 0030583725 scopus 로고    scopus 로고
    • Cytokine production by human thymic epithelial cells: control by the immune recognition of the neurohypophysial self-antigen
    • Martens H., Malgrange B., Robert F., Charlet C., De Groote D., Heymann D., et al. Cytokine production by human thymic epithelial cells: control by the immune recognition of the neurohypophysial self-antigen. Regul Pept 1996, 67:39-45.
    • (1996) Regul Pept , vol.67 , pp. 39-45
    • Martens, H.1    Malgrange, B.2    Robert, F.3    Charlet, C.4    De Groote, D.5    Heymann, D.6
  • 20
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self-shadow in the thymus by the Aire protein
    • Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., et al. Projection of an immunological self-shadow in the thymus by the Aire protein. Science 2002, 298:1395-1401.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzins, S.P.5    Turley, S.J.6
  • 21
    • 0004258385 scopus 로고
    • An insulin-like thymic factor: a preliminary report
    • Pansky B., House E.L., Cone L.A. An insulin-like thymic factor: a preliminary report. Diabetes 1965, 14:325-332.
    • (1965) Diabetes , vol.14 , pp. 325-332
    • Pansky, B.1    House, E.L.2    Cone, L.A.3
  • 22
    • 0027168691 scopus 로고
    • Evidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
    • Geenen V., Achour I., Robert F., Vandersmissen E., Sodoyez J.C., Defresne M.P., et al. Evidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily. Thymus 1993, 21:115-127.
    • (1993) Thymus , vol.21 , pp. 115-127
    • Geenen, V.1    Achour, I.2    Robert, F.3    Vandersmissen, E.4    Sodoyez, J.C.5    Defresne, M.P.6
  • 23
    • 0028301977 scopus 로고
    • T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in the thymus
    • Jolicœur C., Hanahan D., Smith K. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in the thymus. Proc Natl Acad Sci U S A 1994, 91:6707-6711.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6707-6711
    • Jolicœur, C.1    Hanahan, D.2    Smith, K.3
  • 24
    • 0347986564 scopus 로고    scopus 로고
    • The thymic insulin-like growth factor axis: Involvement in physiology and disease
    • Geenen V. The thymic insulin-like growth factor axis: Involvement in physiology and disease. Horm Metab Res 2003, 35:656-663.
    • (2003) Horm Metab Res , vol.35 , pp. 656-663
    • Geenen, V.1
  • 26
    • 0034463082 scopus 로고    scopus 로고
    • Involvement of insulin-like growth factors in early T cell development: a study using fetal thymic organ cultures
    • Kecha O., Brilot F., Martens H., Franchimont N., Renard C., Greimers R., et al. Involvement of insulin-like growth factors in early T cell development: a study using fetal thymic organ cultures. Endocrinology 2000, 141:1209-1217.
    • (2000) Endocrinology , vol.141 , pp. 1209-1217
    • Kecha, O.1    Brilot, F.2    Martens, H.3    Franchimont, N.4    Renard, C.5    Greimers, R.6
  • 27
    • 84876095309 scopus 로고    scopus 로고
    • Presentation of neuroendocrine self in the thymus: a necessity for integrated evolution of the immune and neuroendocrine systems
    • in press
    • Geenen V. Presentation of neuroendocrine self in the thymus: a necessity for integrated evolution of the immune and neuroendocrine systems. Ann NY Acad Sci, in press.
    • Ann NY Acad Sci.
    • Geenen, V.1
  • 29
    • 0041335584 scopus 로고    scopus 로고
    • Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in nonobeses diabetic mouse
    • Moriyama H., Abiru N., Paronen J., Sikora K., Liu E., Miao D., et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in nonobeses diabetic mouse. Proc Natl Acad Sci U S A 2003, 100:10376-10381.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10376-10381
    • Moriyama, H.1    Abiru, N.2    Paronen, J.3    Sikora, K.4    Liu, E.5    Miao, D.6
  • 30
    • 0036315824 scopus 로고    scopus 로고
    • Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance
    • Chentoufi A.A., Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance. Diabetes 2002, 51:1383-1390.
    • (2002) Diabetes , vol.51 , pp. 1383-1390
    • Chentoufi, A.A.1    Polychronakos, C.2
  • 31
    • 70349194383 scopus 로고    scopus 로고
    • Thymus-specific deletion of insulin induces autoimmune diabetes
    • Fan Y., Rudert W.A., Grupillo M., He J., Sisino G., Trucco M. Thymus-specific deletion of insulin induces autoimmune diabetes. Embo J 2009, 28:2812-2824.
    • (2009) Embo J , vol.28 , pp. 2812-2824
    • Fan, Y.1    Rudert, W.A.2    Grupillo, M.3    He, J.4    Sisino, G.5    Trucco, M.6
  • 32
    • 69949172829 scopus 로고    scopus 로고
    • Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells
    • Levi D., Polychronakos C. Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells. Diabetologia 2009, 52:2151-2158.
    • (2009) Diabetologia , vol.52 , pp. 2151-2158
    • Levi, D.1    Polychronakos, C.2
  • 33
    • 33750581391 scopus 로고    scopus 로고
    • Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones
    • Palumbo M.O., Levi D., Chentoufi A.A., Polychronakos C. Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones. Diabetes 2006, 55:2595-2601.
    • (2006) Diabetes , vol.55 , pp. 2595-2601
    • Palumbo, M.O.1    Levi, D.2    Chentoufi, A.A.3    Polychronakos, C.4
  • 34
    • 56749184864 scopus 로고    scopus 로고
    • Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated
    • Villasenor J., Besse W., Benoist C., Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A 2008, 105:15854-15859.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 15854-15859
    • Villasenor, J.1    Besse, W.2    Benoist, C.3    Mathis, D.4
  • 35
    • 77957584132 scopus 로고    scopus 로고
    • Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes
    • Noso S., Kataoka K., Kawabata Y., Babaya N., Hiromine Y., Yamaji K., et al. Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes. Diabetes 2010, 59:2579-2587.
    • (2010) Diabetes , vol.59 , pp. 2579-2587
    • Noso, S.1    Kataoka, K.2    Kawabata, Y.3    Babaya, N.4    Hiromine, Y.5    Yamaji, K.6
  • 36
    • 0015299534 scopus 로고
    • A reassessment of the forbidden clone hypothesis of autoimmune diseases
    • Burnet F.M. A reassessment of the forbidden clone hypothesis of autoimmune diseases. Aust J Exp Biol Med 1973, 50:1-9.
    • (1973) Aust J Exp Biol Med , vol.50 , pp. 1-9
    • Burnet, F.M.1
  • 37
    • 0020067836 scopus 로고
    • Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB:W rat
    • Like A.A., Kslaukis E., Williams R.M., Rossini A.A. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB:W rat. Science 1982, 644-646.
    • (1982) Science , pp. 644-646
    • Like, A.A.1    Kslaukis, E.2    Williams, R.M.3    Rossini, A.A.4
  • 38
    • 0024318793 scopus 로고
    • Thymus transplantation and disease prevention in the diabetes-prone Bio-Breeding rat
    • Georgiou H.M., Bellgrau D. Thymus transplantation and disease prevention in the diabetes-prone Bio-Breeding rat. J Immunol 1989, 142:3400-3405.
    • (1989) J Immunol , vol.142 , pp. 3400-3405
    • Georgiou, H.M.1    Bellgrau, D.2
  • 39
    • 0028816927 scopus 로고
    • Induction of insulitis in a athymic (nude) mice. The effect of NOD thymus and pancreas transplantation
    • Georgiou H.M., Mandel T.E. Induction of insulitis in a athymic (nude) mice. The effect of NOD thymus and pancreas transplantation. Diabetes 1995, 44:49-59.
    • (1995) Diabetes , vol.44 , pp. 49-59
    • Georgiou, H.M.1    Mandel, T.E.2
  • 40
    • 0029097982 scopus 로고
    • DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity
    • Whalen B.J., Rossini A.A., Mordes J.P., Greiner D.L. DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity. Diabetes 1995, 44:963-967.
    • (1995) Diabetes , vol.44 , pp. 963-967
    • Whalen, B.J.1    Rossini, A.A.2    Mordes, J.P.3    Greiner, D.L.4
  • 41
    • 0030999992 scopus 로고    scopus 로고
    • Abnormal T cell selection on NOD thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice
    • Thomas-Vaslin V., Damotte D., Coltey M., Le Douarin N.M., Coutinho A., Salaün J. Abnormal T cell selection on NOD thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice. Proc Natl Acad Sci U S A 1997, 94:4598-4603.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4598-4603
    • Thomas-Vaslin, V.1    Damotte, D.2    Coltey, M.3    Le Douarin, N.M.4    Coutinho, A.5    Salaün, J.6
  • 42
    • 0035175577 scopus 로고    scopus 로고
    • A defect in central tolerance in NOD mice
    • Kishimoto H., Sprent J. A defect in central tolerance in NOD mice. Nat Immunol 2001, 2:1025-1031.
    • (2001) Nat Immunol , vol.2 , pp. 1025-1031
    • Kishimoto, H.1    Sprent, J.2
  • 43
    • 15244338878 scopus 로고    scopus 로고
    • Defective central tolerance induction in NOD mice: genomics and genetics
    • Zucchelli S., Holler P., Yamagata T., Roy M., Benoist C., Mathis D. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 2005, 22:385-396.
    • (2005) Immunity , vol.22 , pp. 385-396
    • Zucchelli, S.1    Holler, P.2    Yamagata, T.3    Roy, M.4    Benoist, C.5    Mathis, D.6
  • 45
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P., Bennett S.T., Todd J.A., Nadeau J., Grabs R., Goodyer C.G., et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 1997, 15:289-292.
    • (1997) Nat Genet , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3    Nadeau, J.4    Grabs, R.5    Goodyer, C.G.6
  • 46
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A., Zeller M., Fernandez A., Zalcberg L.J., Barnett R.J., Ricordi C., et al. The insulin gene is transcribed in human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997, 15:293-297.
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez, A.3    Zalcberg, L.J.4    Barnett, R.J.5    Ricordi, C.6
  • 47
    • 78149475225 scopus 로고    scopus 로고
    • Dietary intervention in infancy and later signs of beta-cell autoimmunity
    • Knip M., Virtanen S.M., Seppä K., Ilonen J., Savilahti E., Vaarala O., et al. Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med 2010, 363:1900-1908.
    • (2010) N Engl J Med , vol.363 , pp. 1900-1908
    • Knip, M.1    Virtanen, S.M.2    Seppä, K.3    Ilonen, J.4    Savilahti, E.5    Vaarala, O.6
  • 49
    • 0025754853 scopus 로고
    • Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
    • Oldstone M.B., Nerenberg M., Southern P., Price J., Lewicki H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response. Cell 1991, 65:319-331.
    • (1991) Cell , vol.65 , pp. 319-331
    • Oldstone, M.B.1    Nerenberg, M.2    Southern, P.3    Price, J.4    Lewicki, H.5
  • 50
    • 63249084374 scopus 로고    scopus 로고
    • Can we learn from viruses how to prevent type 1 diabetes? The role of viral infections in the pathogenesis of type 1 diabetes and the development of novel combination therapies
    • von Herrath M. Can we learn from viruses how to prevent type 1 diabetes? The role of viral infections in the pathogenesis of type 1 diabetes and the development of novel combination therapies. Diabetes 2009, 58:2-11.
    • (2009) Diabetes , vol.58 , pp. 2-11
    • von Herrath, M.1
  • 51
    • 20244384697 scopus 로고
    • A prospective role of coxsackie B and enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group
    • Hyöti H., Hiltunen M., Knip M., Laakonen M., Vähäsalo P., Karjalainen J., et al. A prospective role of coxsackie B and enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes 1995, 44:652-667.
    • (1995) Diabetes , vol.44 , pp. 652-667
    • Hyöti, H.1    Hiltunen, M.2    Knip, M.3    Laakonen, M.4    Vähäsalo, P.5    Karjalainen, J.6
  • 52
    • 0018799757 scopus 로고
    • Isolation of a virus from the pancreas of a child with diabetic ketoacidosis
    • Yoon J.W., Austin M., Onodear T., Notkins A.L. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 1979, 300:1173-1179.
    • (1979) N Engl J Med , vol.300 , pp. 1173-1179
    • Yoon, J.W.1    Austin, M.2    Onodear, T.3    Notkins, A.L.4
  • 53
    • 0029034877 scopus 로고
    • Coxsackie B virus infection and onset of childhood diabetes
    • Clements C.B., Galbraith D.N., Taylor K.W. Coxsackie B virus infection and onset of childhood diabetes. Lancet 1995, 346:221-223.
    • (1995) Lancet , vol.346 , pp. 221-223
    • Clements, C.B.1    Galbraith, D.N.2    Taylor, K.W.3
  • 54
    • 1842405396 scopus 로고    scopus 로고
    • Detection of coxsackie B virus mRNA sequences in whole blood samples from adult patients at the onset of type 1 diabetes
    • Andreoletti L., Hober D., Hober-Vandenberghe C., Belaich S., Vantyghem M.C., Lefebvre J., et al. Detection of coxsackie B virus mRNA sequences in whole blood samples from adult patients at the onset of type 1 diabetes. J Med Virol 1997, 52:121-127.
    • (1997) J Med Virol , vol.52 , pp. 121-127
    • Andreoletti, L.1    Hober, D.2    Hober-Vandenberghe, C.3    Belaich, S.4    Vantyghem, M.C.5    Lefebvre, J.6
  • 55
    • 0033779186 scopus 로고    scopus 로고
    • Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha-interferon synthesis in beta cells
    • Chehadeh W., Kerr-Conte J., Patou F., Alm G., Lefebvre J., Wattre P., et al. Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha-interferon synthesis in beta cells. J Virol 2000, 74:10153-10164.
    • (2000) J Virol , vol.74 , pp. 10153-10164
    • Chehadeh, W.1    Kerr-Conte, J.2    Patou, F.3    Alm, G.4    Lefebvre, J.5    Wattre, P.6
  • 56
    • 0036883660 scopus 로고    scopus 로고
    • Complete nucleotide sequence of a coxsackievirus B4 strain capable of establishing persistent infection in human pancreatic islet cells: effects on insulin release, proinsulin synthesis, and cell morphology
    • Yin H., Berg A.K., Westman J., Hellerström C., Frisk G. Complete nucleotide sequence of a coxsackievirus B4 strain capable of establishing persistent infection in human pancreatic islet cells: effects on insulin release, proinsulin synthesis, and cell morphology. J Med Virol 2002, 68:544-547.
    • (2002) J Med Virol , vol.68 , pp. 544-547
    • Yin, H.1    Berg, A.K.2    Westman, J.3    Hellerström, C.4    Frisk, G.5
  • 57
    • 17844387429 scopus 로고    scopus 로고
    • OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes
    • Field L.L., Bonnevie-Nielsen V., Pociot F., Lu S., Nielsen T.B., Beck-Nielsen H. OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes. Diabetes 2005, 54:1588-1591.
    • (2005) Diabetes , vol.54 , pp. 1588-1591
    • Field, L.L.1    Bonnevie-Nielsen, V.2    Pociot, F.3    Lu, S.4    Nielsen, T.B.5    Beck-Nielsen, H.6
  • 58
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of non-synonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • Smyth D.J., Cooper J.D., Bailey R., Field S., Burren O., Smink L.J., et al. A genome-wide association study of non-synonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 2006, 38:617-619.
    • (2006) Nat Genet , vol.38 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3    Field, S.4    Burren, O.5    Smink, L.J.6
  • 59
    • 0031874342 scopus 로고    scopus 로고
    • Diabetes induced by coxsackievirus: initiation by bystander damage and not molecular mimicry
    • Horwitz M.S., Bradley L.M., Harbetson J., Krahl T., Lee J., Sarvetnick N. Diabetes induced by coxsackievirus: initiation by bystander damage and not molecular mimicry. Nat Med 1998, 4:781-785.
    • (1998) Nat Med , vol.4 , pp. 781-785
    • Horwitz, M.S.1    Bradley, L.M.2    Harbetson, J.3    Krahl, T.4    Lee, J.5    Sarvetnick, N.6
  • 61
    • 4444348507 scopus 로고    scopus 로고
    • Coxsackievirus B4 infection of human fetal thymus cells
    • Brilot F., Geenen V., Hober D., Stoddart C. Coxsackievirus B4 infection of human fetal thymus cells. J Virol 2004, 78:9854-9861.
    • (2004) J Virol , vol.78 , pp. 9854-9861
    • Brilot, F.1    Geenen, V.2    Hober, D.3    Stoddart, C.4
  • 62
    • 33845790704 scopus 로고    scopus 로고
    • Prolonged viral detection in blood and lymphoid tissues from coxsackievirus B4 E2 orally-inoculated mice
    • Jaïdane H., Gharbi J., Lobert P.E., Lucas B., Hiar R., M'Hadheb M.B., et al. Prolonged viral detection in blood and lymphoid tissues from coxsackievirus B4 E2 orally-inoculated mice. Microbiol Immunol 2006, 50:971-974.
    • (2006) Microbiol Immunol , vol.50 , pp. 971-974
    • Jaïdane, H.1    Gharbi, J.2    Lobert, P.E.3    Lucas, B.4    Hiar, R.5    M'Hadheb, M.B.6
  • 63
    • 79953220761 scopus 로고    scopus 로고
    • Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
    • Fourlanos S., Perry C., Gellert S.A., Martinuzzi E., Mallone R., Butler J., et al. Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes 2011, 60:1237-1245.
    • (2011) Diabetes , vol.60 , pp. 1237-1245
    • Fourlanos, S.1    Perry, C.2    Gellert, S.A.3    Martinuzzi, E.4    Mallone, R.5    Butler, J.6
  • 64
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • Diabetes Prevention Trial-Type 1 Diabetes Study Group
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 2002, 346:1685-1691. Diabetes Prevention Trial-Type 1 Diabetes Study Group.
    • (2002) N Engl J Med , vol.346 , pp. 1685-1691
  • 65
    • 17444437590 scopus 로고    scopus 로고
    • Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicenter randomized controlled trial
    • Chaillous L., Lefèvre H., Thivolet C., Boitard C., Lahlou N., Atlan-Gepner C., et al. Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicenter randomized controlled trial. Lancet 2000, 356:545-549.
    • (2000) Lancet , vol.356 , pp. 545-549
    • Chaillous, L.1    Lefèvre, H.2    Thivolet, C.3    Boitard, C.4    Lahlou, N.5    Atlan-Gepner, C.6
  • 66
    • 0036790542 scopus 로고    scopus 로고
    • Anti-peptide antibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
    • Liu E., Moriyama H., Abiru N., Miao D., Yu L., Taylor R.M., et al. Anti-peptide antibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest 2002, 110:1021-1027.
    • (2002) J Clin Invest , vol.110 , pp. 1021-1027
    • Liu, E.1    Moriyama, H.2    Abiru, N.3    Miao, D.4    Yu, L.5    Taylor, R.M.6
  • 67
    • 0029807595 scopus 로고    scopus 로고
    • Induction of autoimmune diabetes by oral administration of autoantigen
    • Blanas E., Carbone F.R., Allison J., Miller J.F.A.P. Induction of autoimmune diabetes by oral administration of autoantigen. Science 1996, 274:1707-1709.
    • (1996) Science , vol.274 , pp. 1707-1709
    • Blanas, E.1    Carbone, F.R.2    Allison, J.3    Miller, J.F.A.P.4
  • 68
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larche M., Wraith D.C. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 2006, 11:569-576.
    • (2006) Nat Med , vol.11 , pp. 569-576
    • Larche, M.1    Wraith, D.C.2
  • 69
    • 70349098142 scopus 로고    scopus 로고
    • Antigen-based therapy for the treatment of type 1 diabetes
    • Tian J., Kaufman D.L. Antigen-based therapy for the treatment of type 1 diabetes. Diabetes 2009, 58:1939-1946.
    • (2009) Diabetes , vol.58 , pp. 1939-1946
    • Tian, J.1    Kaufman, D.L.2
  • 70
    • 77956360380 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential
    • Peakman M., von Herrath M. Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential. Diabetes 2011, 2087-2093.
    • (2011) Diabetes , pp. 2087-2093
    • Peakman, M.1    von Herrath, M.2
  • 71
    • 79960369940 scopus 로고    scopus 로고
    • Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
    • Daniel C., Weigmann B., Bronson R., von Boehmer H. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med 2011, 208:1501-1510.
    • (2011) J Exp Med , vol.208 , pp. 1501-1510
    • Daniel, C.1    Weigmann, B.2    Bronson, R.3    von Boehmer, H.4
  • 72
    • 33645779272 scopus 로고    scopus 로고
    • Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice
    • Hansenne I., Renard-Charlet C., Greimers R., Geenen V. Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice. J Immunol 2006, 176:4651-4657.
    • (2006) J Immunol , vol.176 , pp. 4651-4657
    • Hansenne, I.1    Renard-Charlet, C.2    Greimers, R.3    Geenen, V.4
  • 73
    • 34447646127 scopus 로고    scopus 로고
    • Thymus-dependent T-cell tolerance of neuroendocrine functions. Principles, reflections, and implications for tolerogenic/negative self-vaccination
    • Geenen V. Thymus-dependent T-cell tolerance of neuroendocrine functions. Principles, reflections, and implications for tolerogenic/negative self-vaccination. Ann NY Acad Sci U S A 2006, 1088:284-296.
    • (2006) Ann NY Acad Sci U S A , vol.1088 , pp. 284-296
    • Geenen, V.1
  • 74
    • 14544305615 scopus 로고    scopus 로고
    • The Belgian Diabetes Registry. An insulin-like growth factor 2-derived self antigen inducing a regulatory cytokine profile after presentation to peripheral blood mononuclear cells from DQ8+ type 1 diabetic adolescents: preliminary design of a thymus-based tolerogenic self-vaccination
    • Geenen V., Louis C., Martens H. The Belgian Diabetes Registry. An insulin-like growth factor 2-derived self antigen inducing a regulatory cytokine profile after presentation to peripheral blood mononuclear cells from DQ8+ type 1 diabetic adolescents: preliminary design of a thymus-based tolerogenic self-vaccination. Ann NY Acad Sci 2004, 1037:59-64.
    • (2004) Ann NY Acad Sci , vol.1037 , pp. 59-64
    • Geenen, V.1    Louis, C.2    Martens, H.3
  • 75
    • 77955282695 scopus 로고    scopus 로고
    • Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes
    • Geenen V., Mottet M., Dardenne O., Kermani H., Martens H., François J.M., et al. Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes. Curr Opin Pharmacol 2010, 10:461-472.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 461-472
    • Geenen, V.1    Mottet, M.2    Dardenne, O.3    Kermani, H.4    Martens, H.5    François, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.