Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells

Diabetologia

Volumn 52, Issue 10, 2009, Pages 2151-2158

  Levi, D ^a   Polychronakos, C ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Cell lines; Cytokines; Diabetes; Experimental immunology; Insulin; Thymus; Tolerance

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CYTOKINE; GAMMA INTERFERON; GLUCOSE; INSULIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CONTACT; CELL CULTURE; CELL INTERACTION; CONTROLLED STUDY; EPITHELIUM; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; IMMUNE SYSTEM; INS1 GENE; MOUSE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS; UPREGULATION;

ANIMALS; CELL COMMUNICATION; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; INSULIN; INTERFERON-GAMMA; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMUS GLAND;

EID: 69949172829     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1448-y     Document Type: Article

References (43)

1. L Zhang M Nakayama GS Eisenbarth 2008 Insulin as an autoantigen in NOD/human diabetes Curr Opin Immunol 20 111 118
2. L Klein T Klein U Ruther B Kyewski 1998 CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium J Exp Med 188 5 16
3. J Derbinski A Schulte B Kyewski L Klein 2001 Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self Nat Immunol 2 1032 1039
4. MW Hoffmann J Allison JF Miller 1992 Tolerance induction by thymic medullary epithelium Proc Natl Acad Sci U S A 89 2526 2530
5. M Ciofani JC Zuniga-Pflucker 2007 The thymus as an inductive site for T lymphopoiesis Annu Rev Cell Dev Biol 23 463 493
6. A Martini GR Burgio 1999 Tolerance and auto-immunity: 50 years after Burnet Eur J Pediatr 158 769 775
7. M Oukka M Cohen-Tannoudji Y Tanaka C Babinet K Kosmatopoulos 1996 Medullary thymic epithelial cells induce tolerance to intracellular proteins J Immunol 156 968 975 (Pubitemid 26048089)
8. M Oukka E Colucci-Guyon PL Tran, et al. 1996 CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium Immunity 4 545 553
9. MS Jordan A Boesteanu AJ Reed, et al. 2001 Thymic selection of CD4+ CD25+ regulatory T cells induced by an agonist self-peptide Nat Immunol 2 301 306
10. AA Chentoufi C Polychronakos 2002 Insulin expression levels in the thymus modulate insulin-specific autoreactive T cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes Diabetes 51 1383 1390
11. P Vafiadis ST Bennett JA Todd, et al. 1997 Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus Nat Genet 15 289 292
12. A Pugliese M Zeller A Fernandez Jr, et al. 1997 The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes Nat Genet 15 293 297
13. SJ Antonia T Geiger J Miller RA Flavell 1995 Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein Int Immunol 7 715 725
14. VL Heath NC Moore SM Parnell DW Mason 1998 Intrathymic expression of genes involved in organ specific autoimmune disease J Autoimmun 11 309 318
15. C Jolicoeur D Hanahan KM Smith 1994 T cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus Proc Natl Acad Sci U S A 91 6707 6711
16. AM Salmon C Bruand A Cardona JP Changeux S Berrih-Aknin 1998 An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis J Clin Invest 101 2340 2350
17. KM Smith DC Olson R Hirose D Hanahan 1997 Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance Int Immunol 9 1355 1365
18. H Wekerle M Bradl C Linington G Kaab K Kojima 1996 The shaping of the brain-specific T lymphocyte repertoire in the thymus Immunol Rev 149 231 243
19. K Nagamine P Peterson HS Scott, et al. 1997 Positional cloning of the APECED gene Nat Genet 17 393 398
20. P Ahonen 1985 Autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED): autosomal recessive inheritance Clin Genet 27 535 542
21. MS Anderson ES Venanzi L Klein, et al. 2002 Projection of an immunological self shadow within the thymus by the aire protein Science 298 1395 1401
22. C Ramsey O Winqvist L Puhakka, et al. 2002 Aire deficient mice develop multiple features of APECED phenotype and show altered immune response Hum Mol Genet 11 397 409
23. S Zuklys G Balciunaite A Agarwal E Fasler-Kan E Palmer GA Hollander 2000 Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis- ectodermal dystrophy (APECED) J Immunol 165 1976 1983
24. J Gotter B Brors M Hergenhahn B Kyewski 2004 Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters J Exp Med 199 155 166
25. J Derbinski S Pinto S Rosch K Hexel B Kyewski 2008 Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism Proc Natl Acad Sci U S A 105 657 662
26. GO Gillard AG Farr 2006 Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression J Immunol 176 5815 5824
27. MO Palumbo D Levi AA Chentoufi C Polychronakos 2006 Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones Diabetes 55 2595 2601
28. GK Lam HX Liao Y Xue, et al. 2005 Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma J Clin Immunol 25 41 49
29. C Evans-Molina S Regan LE Henault EM Hylek GR Schwartz 2007 The new Medicare Part D prescription drug benefit: an estimation of its effect on prescription drug costs in a Medicare population with atrial fibrillation J Am Geriatr Soc 55 1038 1043
30. V Poitout D Hagman R Stein I Artner RP Robertson JS Harmon 2006 Regulation of the insulin gene by glucose and fatty acids J Nutr 136 873 876
31. AA Yarilin IM Belyakov 2004 Cytokines in the thymus: production and biological effects Curr Med Chem 11 447 464
32. JM Lagrota-Candido DM Villa-Verde FH Vanderlei Jr W Savino 1996 Extracellular matrix components of the mouse thymus microenvironment V. Interferon-gamma modulates thymic epithelial cell/thymocyte interactions via extracellular matrix ligands and receptors. Cell Immunol 170 235 244
33. J Derbinski J Gabler B Brors, et al. 2005 Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels J Exp Med 202 33 45
34. W Jiang MS Anderson R Bronson D Mathis C Benoist 2005 Modifier loci condition autoimmunity provoked by Aire deficiency J Exp Med 202 805 815
35. M Giraud R Taubert C Vandiedonck, et al. 2007 An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus Nature 448 934 937
36. B Faideau JP Briand C Lotton, et al. 2004 Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice J Immunol 172 25 33
37. B Faideau C Lotton B Lucas, et al. 2006 Tolerance to proinsulin-2 is due to radioresistant thymic cells J Immunol 177 53 60
38. K Thebault-Baumont D Dubois-Laforgue P Krief, et al. 2003 Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice J Clin Invest 111 851 857
39. JC Henquin 2000 Triggering and amplifying pathways of regulation of insulin secretion by glucose Diabetes 49 1751 1760
40. P Vafiadis ST Bennett E Colle R Grabs CG Goodyer C Polychronakos 1996 Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes J Autoimmun 9 397 403
41. CS Heinly GD Sempowski DM Lee, et al. 2001 Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice Int Immunol 13 157 166
42. M Pezzano M Samms JC Guyden 2001 TNF and Fas-induced apoptosis during negative selection in thymic nurse cells Ethn Dis 11 154 156
43. RK Chin JC Lo O Kim, et al. 2003 Lymphotoxin pathway directs thymic Aire expression Nat Immunol 4 1121 1127