Plakilactones from the marine sponge Plakinastrella mamillaris. discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ

Journal of Medicinal Chemistry

Volumn 55, Issue 19, 2012, Pages 8303-8317

  Festa, Carmen ^a   Lauro, Gianluigi ^b   De Marino, Simona ^a   D'Auria, Maria Valeria ^a   Monti, Maria Chiara ^b   Casapullo, Agostino ^b   D'Amore, Claudio ^c   Renga, Barbara ^c   Mencarelli, Andrea ^c   Petek, Sylvain ^d   Bifulco, Giuseppe ^b   Fiorucci, Stefano ^c   Zampella, Angela ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

^d INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GEMFIBROZIL; GRACILIOETHER A; GRACILIOETHER B; GRACILIOETHER C; GRACILIOETHER D; KETONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PLAKILACTONE A; PLAKILACTONE B; PLAKILACTONE C; PLAKILACTONE D; PLAKILACTONE DERIVATIVE; PLAKILACTONE E; PLAKILACTONE F; POLYKETIDE; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HEPG2; CONTROLLED STUDY; COVALENT BOND; DRUG ISOLATION; DRUG STRUCTURE; ENANTIOSELECTIVITY; GENE EXPRESSION; HYDROGENATION; LIGAND BINDING; MARINE ENVIRONMENT; MICHAEL ADDITION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; OXYGENATION; PLAKINASTRELLA MAMILLARIS; PROTON NUCLEAR MAGNETIC RESONANCE; SPONGE (PORIFERA); STEREOCHEMISTRY;

4-BUTYROLACTONE; ANIMALS; AQUATIC ORGANISMS; BINDING SITES; FURANS; HEP G2 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; POLYKETIDES; PORIFERA; PPAR GAMMA; PROTEIN STRUCTURE, TERTIARY; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTIONAL ACTIVATION;

EID: 84867352661     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300911g     Document Type: Article

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