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Volumn 26, Issue 7, 2012, Pages 3021-3031

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition

Author keywords

G6Pase; Nuclear receptors; PEPCK; SHP

Indexed keywords

FARNESOID X RECEPTOR; GLUCOCORTICOID RECEPTOR; GLUCOSE; GLUCOSE 6 PHOSPHATASE; MIFEPRISTONE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SMALL INTERFERING RNA;

EID: 84863228232     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-195701     Document Type: Article
Times cited : (46)

References (36)
  • 1
    • 78651272137 scopus 로고    scopus 로고
    • Hormonal regulation of gluconeogenic gene transcription in the liver
    • Yabaluri, N., and Bashyam, M. D. (2010) Hormonal regulation of gluconeogenic gene transcription in the liver. J. Biosci. 35, 473-484
    • (2010) J. Biosci. , vol.35 , pp. 473-484
    • Yabaluri, N.1    Bashyam, M.D.2
  • 3
    • 76549086983 scopus 로고    scopus 로고
    • Bile acid-activated receptors in the treatment of dyslipidemia and related disorders
    • Fiorucci, S., Cipriani, S., Baldelli, F., and Mencarelli, A. (2010) Bile acid-activated receptors in the treatment of dyslipidemia and related disorders. Prog. Lipid Res. 49, 171-185
    • (2010) Prog. Lipid Res. , vol.49 , pp. 171-185
    • Fiorucci, S.1    Cipriani, S.2    Baldelli, F.3    Mencarelli, A.4
  • 4
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., and Staels, B. (2009) Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89, 147-191
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 9
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma, K., Saha, P. K., Chan, L., and Moore, D. D. (2006) Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Invest. 116, 1102-1109
    • (2006) J. Clin. Invest. , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 11
    • 77950613528 scopus 로고    scopus 로고
    • FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
    • Cipriani, S., Mencarelli, A., Palladino, G., and Fiorucci, S. (2010) FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats. J. Lipid Res. 51, 771-784
    • (2010) J. Lipid Res. , vol.51 , pp. 771-784
    • Cipriani, S.1    Mencarelli, A.2    Palladino, G.3    Fiorucci, S.4
  • 12
    • 0037147304 scopus 로고    scopus 로고
    • Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
    • DOI 10.1074/jbc.M205641200
    • Borgius, L. J., Steffensen, K. R., Gustafsson, J. A., and Treuter, E. (2002) Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP. J. Biol. Chem. 277, 49761-49766 (Pubitemid 36014422)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.51 , pp. 49761-49766
    • Borgius, L.J.1    Steffensen, K.R.2    Gustafsson, J.-A.3    Treuter, E.4
  • 13
    • 2542435874 scopus 로고    scopus 로고
    • Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
    • DOI 10.1074/jbc.M314322200
    • Yamagata, K., Daitoku, H., Shimamoto, Y., Matsuzaki, H., Hirota, K., Ishida, J., and Fukamizu, A. (2004) Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J. Biol. Chem. 279, 23158-23165 (Pubitemid 38685621)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.22 , pp. 23158-23165
    • Yamagata, K.1    Daitoku, H.2    Shimamoto, Y.3    Matsuzaki, H.4    Hirota, K.5    Ishida, J.6    Fukamizu, A.7
  • 16
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., and Gonzalez, F. J. (2000) Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102, 731-744
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 17
    • 84855837566 scopus 로고    scopus 로고
    • Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei
    • Sepe, V., Ummarino, R., D'Auria, M. V., Chini, M. G., Bifulco, G., Renga, B., D'Amore, C., Debitus, C., Fiorucci, S., and Zampella, A. (2012) Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei. J. Med. Chem. 55, 84-93
    • (2012) J. Med. Chem. , vol.55 , pp. 84-93
    • Sepe, V.1    Ummarino, R.2    D'Auria, M.V.3    Chini, M.G.4    Bifulco, G.5    Renga, B.6    D'Amore, C.7    Debitus, C.8    Fiorucci, S.9    Zampella, A.10
  • 18
    • 67651174552 scopus 로고    scopus 로고
    • Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation
    • Renga, B., Mencarelli, A., Migliorati, M., Distrutti, E., and Fiorucci, S. (2009) Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. World J. Gastroenterol. 15, 2097-2108
    • (2009) World J. Gastroenterol. , vol.15 , pp. 2097-2108
    • Renga, B.1    Mencarelli, A.2    Migliorati, M.3    Distrutti, E.4    Fiorucci, S.5
  • 21
    • 70349829691 scopus 로고    scopus 로고
    • Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells
    • Nehmé, A., Lobenhofer, E. K., Stamer, W. D., and Edelman, J. L. (2009) Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med. Genomics 2, 58
    • (2009) BMC Med. Genomics , vol.2 , pp. 58
    • Nehmé, A.1    Lobenhofer, E.K.2    Stamer, W.D.3    Edelman, J.L.4
  • 23
    • 33847620168 scopus 로고    scopus 로고
    • Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor
    • DOI 10.1677/jme.1.02183
    • Presul, E., Schmidt, S., Kofler, R., and Helmberg, A. (2007) Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor. J. Mol. Endocrinol. 38, 79-90 (Pubitemid 46351594)
    • (2007) Journal of Molecular Endocrinology , vol.38 , Issue.1-2 , pp. 79-90
    • Presul, E.1    Schmidt, S.2    Kofler, R.3    Helmberg, A.4
  • 24
    • 0034909433 scopus 로고    scopus 로고
    • Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids
    • DOI 10.1210/me.15.8.1381
    • Breslin, M. B., Geng, C. D., and Vedeckis, W. V. (2001) Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol. Endocrinol. 15, 1381-1395 (Pubitemid 32703485)
    • (2001) Molecular Endocrinology , vol.15 , Issue.8 , pp. 1381-1395
    • Breslin, M.B.1    Geng, C.-D.2    Vedeckis, W.V.3
  • 25
    • 27644447622 scopus 로고    scopus 로고
    • Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: Identification, and tissue distribution of multiple new human exon 1
    • DOI 10.1677/jme.1.01822
    • Turner, J. D., and Muller, C. P. (2005) Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: identification, and tissue distribution of multiple new human exon 1. J. Mol. Endocrinol. 35, 283-292 (Pubitemid 41556176)
    • (2005) Journal of Molecular Endocrinology , vol.35 , Issue.2 , pp. 283-292
    • Turner, J.D.1    Muller, C.P.2
  • 26
    • 26644472453 scopus 로고    scopus 로고
    • Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit
    • DOI 10.1074/jbc.M504119200
    • Cassuto, H., Kochan, K., Chakravarty, K., Cohen, H., Blum, B., Olswang, Y., Hakimi, P., Xu, C., Massillon, D., Hanson, R. W., and Reshef, L. (2005) Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. J. Biol. Chem. 280, 33873-33884 (Pubitemid 41443107)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.40 , pp. 33873-33884
    • Cassuto, H.1    Kochan, K.2    Chakravarty, K.3    Cohen, H.4    Blum, B.5    Olswang, Y.6    Hakimi, P.7    Xu, C.8    Massillon, D.9    Hanson, R.W.10    Reshef, L.11
  • 27
    • 2542495763 scopus 로고    scopus 로고
    • Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus
    • DOI 10.1210/me.2003-0283
    • Opherk, C., Tronche, F., Kellendonk, C., Kohlmuller, D., Schulze, A., Schmid, W., and Schutz, G. (2004) Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol. Endocrinol. 18, 1346-1353 (Pubitemid 38692174)
    • (2004) Molecular Endocrinology , vol.18 , Issue.6 , pp. 1346-1353
    • Opherk, C.1    Tronche, F.2    Kellendonk, C.3    Kohlmuller, D.4    Schulze, A.5    Schmid, W.6    Schutz, G.7
  • 28
    • 0030099538 scopus 로고    scopus 로고
    • Abnormal regulation of hepatic glucocorticoid receptor mRNA and receptor protein distribution in the obese zucker rat
    • Jenson, M., Kilroy, G., York, D. A., and Braymer, D. (1996) Abnormal regulation of hepatic glucocorticoid receptor mRNA and receptor protein distribution in the obese Zucker rat. Obes. Res. 4, 133-143 (Pubitemid 126690240)
    • (1996) Obesity Research , vol.4 , Issue.2 , pp. 133-143
    • York, D.A.1
  • 29
    • 0026075960 scopus 로고
    • Glucocorticoid and mineralocorticoid receptor-binding characteristics in obese (ob/ob) mice
    • Tsai, H. J., and Romsos, D. R. (1991) Glucocorticoid and mineralocorticoid receptor-binding characteristics in obese (ob/ob) mice. Am. J. Physiol. Endocrinol. Metab. Physiol. 261, E495-E499
    • (1991) Am. J. Physiol. Endocrinol. Metab. Physiol. , vol.261
    • Tsai, H.J.1    Romsos, D.R.2
  • 30
    • 12144250997 scopus 로고    scopus 로고
    • Increased glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 1 expression in hepatocytes
    • may contribute to the phenotype of type 2 diabetes in db/db mice.
    • Liu, Y., Nakagawa, Y., Wang, Y., Sakurai, R., Tripathi, P. V., Lutfy, K., and Friedman, T. C. (2005) Increased glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes 54, 32-40
    • (2005) Diabetes , vol.54 , pp. 32-40
    • Liu, Y.1    Nakagawa, Y.2    Wang, Y.3    Sakurai, R.4    Tripathi, P.V.5    Lutfy, K.6    Friedman, T.C.7
  • 31
    • 51349085477 scopus 로고    scopus 로고
    • Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice
    • Liu, Y., Nakagawa, Y., Wang, Y., Liu, L., Du, H., Wang, W., Ren, X., Lutfy, K., and Friedman, T. C. (2008) Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J. Mol. Endocrinol. 41, 53-64
    • (2008) J. Mol. Endocrinol. , vol.41 , pp. 53-64
    • Liu, Y.1    Nakagawa, Y.2    Wang, Y.3    Liu, L.4    Du, H.5    Wang, W.6    Ren, X.7    Lutfy, K.8    Friedman, T.C.9
  • 32
    • 33751210100 scopus 로고    scopus 로고
    • Liver, X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice
    • Liu, Y., Yan, C., Wang, Y., Nakagawa, Y., Nerio, N., Anghel, A., Lutfy, K., and Friedman, T. C. (2006) Liver, X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology 147, 5061-5068
    • (2006) Endocrinology , vol.147 , pp. 5061-5068
    • Liu, Y.1    Yan, C.2    Wang, Y.3    Nakagawa, Y.4    Nerio, N.5    Anghel, A.6    Lutfy, K.7    Friedman, T.C.8
  • 36
    • 0034616147 scopus 로고    scopus 로고
    • Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
    • DOI 10.1074/jbc.275.14.10638
    • Laffitte, B. A., Kast, H. R., Nguyen, C. M., Zavacki, A. M., Moore, D. D., and Edwards, P. A. (2000) Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J. Biol. Chem. 275, 10638-10647 (Pubitemid 30202131)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.14 , pp. 10638-10647
    • Laffitte, B.A.1    Kast, H.R.2    Nguyen, C.M.3    Zavacki, A.M.4    Moore, D.D.5    Edwards, P.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.