The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage

Journal of Immunology

Volumn 182, Issue 9, 2009, Pages 5596-5604

  Shen, Shudan ^a   Zhu, Minghua ^a   Lau, Jasmine ^a   Chuck, Mariana ^a   Zhang, Weiguo ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD4 ANTIGEN; CD5 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CRE RECOMBINASE; GREEN FLUORESCENT PROTEIN; LAT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOLIPASE C GAMMA1; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; LAT PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; GENE; GENE DELETION; GENE EXPRESSION; HOMEOSTASIS; IMMUNOSTIMULATION; LAT GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; GENE TARGETING; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; THYMUS; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CELL DIFFERENTIATION; GENE DELETION; GENE KNOCK-IN TECHNIQUES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THYMUS GLAND;

EID: 66949162691     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803170     Document Type: Article

References (41)

1. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92: 83-92. (Pubitemid 28053300)
2. Finco, T. S., T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity 9: 617-626.
3. Zhang, W., B. J. Irvin, R. P. Trible, R. T. Abraham, and L. E. Samelson. 1999. Functional analysis of LAT in TCR-mediated signaling pathways using a LATdeficient Jurkat cell line. Int. Immunol. 11: 943-950. (Pubitemid 29276606)
4. Liu, S. K., N. Fang, G. A. Koretzky, and C. J. McGlade. 1999. The hematopoietic- specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9: 67-75.
5. Asada, H., N. Ishii, Y. Sasaki, K. Endo, H. Kasai, N. Tanaka, T. Takeshita, S. Tsuchiya, T. Konno, and K. Sugamura. 1999. Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. J. Exp. Med. 189: 1383-1390. (Pubitemid 29227524)
6. Yablonski, D., T. Kadlecek, and A. Weiss. 2001. Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT. Mol. Cell. Biol. 21: 4208-4218. (Pubitemid 32565303)
7. Wu, J., D. G. Motto, G. A. Koretzky, and A. Weiss. 1996. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4: 593-602. (Pubitemid 26233313)
8. Ebinu, J. O., S. L. Stang, C. Teixeira, D. A. Bottorff, J. Hooton, P. M. Blumberg, M. Barry, R. C. Bleakley, H. L. Ostergaard, and J. C. Stone. 2000. RasGRP links T-cell receptor signaling to Ras. Blood 95: 3199-3203.
9. Dower, N. A., S. L. Stang, D. A. Bottorff, J. O. Ebinu, P. Dickie, H. L. Ostergaard, and J. C. Stone. 2000. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat. Immunol. 1: 317-321.
10. Buday, L., S. E. Egan, P. Rodriguez Viciana, D. A. Cantrell, and J. Downward. 1994. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J. Biol. Chem. 269: 9019-9023. (Pubitemid 24209221)
11. Zhang, W., C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. DeJarnette, R. P. Trible, A. Grinberg, H. C. Tsay, H. M. Jacobs, C. M. Kessler, et al. 1999. Essential role of LAT in T cell development. Immunity 10: 323-332. (Pubitemid 29165287)
12. Sommers, C. L., R. K. Menon, A. Grinberg, W. Zhang, L. E. Samelson, and P. E. Love. 2001. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. J. Exp. Med. 194: 135-142.
13. Aguado, E., S. Richelme, S. Nunez-Cruz, A. Miazek, A. M. Mura, M. Richelme, X. J. Guo, D. Sainty, H. T. He, B. Malissen, and M. Malissen. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296: 2036-2040. (Pubitemid 34627528)
14. Sommers, C. L., C. S. Park, J. Lee, C. Feng, C. L. Fuller, A. Grinberg, J. A. Hildebrand, E. Lacana, R. K. Menon, E. W. Shores, et al. 2002. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296: 2040-2043.
15. Sommers, C. L., J. Lee, K. L. Steiner, J. M. Gurson, C. L. Depersis, D. El-Khoury, C. L. Fuller, E. W. Shores, P. E. Love, and L. E. Samelson. 2005. Mutation of the phospholipase C-γ1-binding site of LAT affects both positive and negative thymocyte selection. J. Exp. Med. 201: 1125-1134.
16. + regulatory T cell development. J. Exp. Med. 203: 119-129.
17. Nunez-Cruz, S., E. Aguado, S. Richelme, B. Chetaille, A. M. Mura, M. Richelme, L. Pouyet, E. Jouvin-Marche, L. Xerri, B. Malissen, and M. Malissen. 2003. LAT regulates γδ T cell homeostasis and differentiation. Nat. Immunol. 4: 999-1008. (Pubitemid 37265921)
18. Zhang, W., R. P. Trible, M. Zhu, S. K. Liu, C. J. McGlade, and L. E. Samelson. 2000. Association of Grb2, Gads, and phospholipase C-γ1 with phosphorylated LAT tyrosine residues: effect of LAT tyrosine mutations on T cell angigen receptor- mediated signaling. J. Biol. Chem. 275: 23355-23361. (Pubitemid 30646238)
19. Lee, P. P., D. R. Fitzpatrick, C. Beard, H. K. Jessup, S. Lehar, K. W. Makar, M. Perez-Melgosa, M. T. Sweetser, M. S. Schlissel, S. Nguyen, et al. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15: 763-774.
20. Wolfer, A., A. Wilson, M. Nemir, H. R. MacDonald, and F. Radtke. 2002. Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes. Immunity 16: 869-879. (Pubitemid 34786485)
21. Paterson, D. J., and A. F. Williams. 1987. An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen. J. Exp. Med. 166: 1603-1608.
22. + cells. Eur. J. Immunol. 18: 519-523.
23. Ciofani, M., G. C. Knowles, D. L. Wiest, H. von Boehmer, and J. C. Zuniga-Pflucker. 2006. Stage-specific and differential notch dependency at the αβ and γδ T lineage bifurcation. Immunity 25: 105-116. (Pubitemid 44066824)
24. Prinz, I., A. Sansoni, A. Kissenpfennig, L. Ardouin, M. Malissen, and B. Malissen. 2006. Visualization of the earliest steps of γδ T cell development in the adult thymus. Nat. Immunol. 7: 995-1003. (Pubitemid 44263914)
25. Taghon, T., M. A. Yui, R. Pant, R. A. Diamond, and E. V. Rothenberg. 2006. Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus. Immunity 24: 53-64. (Pubitemid 43077200)
26. Starr, T. K., S. C. Jameson, and K. A. Hogquist. 2003. Positive and negative selection of T cells. Annu. Rev. Immunol. 21: 139-176.
27. Mariathasan, S., R. G. Jones, and P. S. Ohashi. 1999. Signals involved in thymocyte positive and negative selection. Semin. Immunol. 11: 263-272. (Pubitemid 29401500)
28. Lanier, L. L., J. P. Allison, and J. H. Phillips. 1986. Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation. J. Immunol. 137: 2501-2507.
29. Fowlkes, B. J., L. Edison, B. J. Mathieson, and T. M. Chused. 1985. Early T lymphocytes: differentiation in vivo of adult intrathymic precursor cells. J. Exp. Med. 162: 802-822.
30. + thymocytes. Eur. J. Immunol. 23: 739-746.
31. Bendelac, A., P. Matzinger, R. A. Seder, W. E. Paul, and R. H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175: 731-742.
32. + subsets of thymocytes expressing intermediate or high levels of T cell receptor. Int. Immunol. 3: 265-272.
33. Chau, L. A., and J. Madrenas. 1999. Phospho-LAT-independent activation of the Ras-mitogen-activated protein kinase pathway: a differential recruitment model of TCR partial agonist signaling. J. Immunol. 163: 1853-1858.
34. Maltzman, J. S., L. Kovoor, J. L. Clements, and G. A. Koretzky. 2005. Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection. J. Exp. Med. 202: 893-900.
35. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2: 301-306.
36. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
37. + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168: 4399-4405.
38. Yu, P., C. L. Haymaker, R. D. Divekar, J. S. Ellis, J. Hardaway, R. Jain, D. M. Tartar, C. M. Hoeman, J. A. Cascio, A. Ostermeier, and H. Zaghouani. 2008. Fetal exposure to high-avidity TCR ligand enhances expansion of peripheral T regulatory cells. J. Immunol. 181: 73-80.
39. Yablonski, D., M. R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell. Science 281: 413-416. (Pubitemid 28340785)
40. Clements, J. L., B. Yang, S. E. Ross-Barta, S. L. Eliason, R. F. Hrstka, R. A. Williamson, and G. A. Koretzky. 1998. Requirement for the leukocytespecific adapter protein SLP-76 for normal T cell development. Science 281: 416-419.
41. Pivniouk, V., E. Tsitsikov, P. Swinton, G. Rathbun, F. W. Alt, and R. S. Geha. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94: 229-238. (Pubitemid 28348010)