Phospho-LAT-independent activation of the Ras-mitogen-activated protein kinase pathway: A differential recruitment model of TCR partial agonist signaling

Journal of Immunology

Volumn 163, Issue 4, 1999, Pages 1853-1858

  Chau, Luan A ^a   Madrenas, Joaquín ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN KINASE; PROTEIN P21; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; TYROSINE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARRIER PROTEINS; CLONE CELLS; ENZYME ACTIVATION; GRB2 ADAPTOR PROTEIN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; RAS PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0033566749     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Alberola-Ila, J., S. Takaki, J. D. Kerner, and R. M. Perlmutter. 1997. Differential signaling by lymphocyte antigen receptors. Annu. Rev. Immunol. 15:125.
2. Qian, D., and A. Weiss. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205.
3. Wange, R. L., and L. E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity 5:197.
4. Rudd, C. E. 1999. Adaptors and molecular scaffolds in immune cell signaling. Immunity 96:5.
5. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83.
6. Weber, J. R., S. Orstavik, K. M. Torgersen, N. C. Danbolt, S. F. Berg, J. C. Ryan, K. Tasken, J. B. Imboden, and J. T. Vaage. 1998. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J. Exp. Med. 187:1157.
7. Bruyns, E., A. M. Cardine, H. Kirchgessner, K. Sagolla, A. Shevchenko, M. Mann, F. Autschbach, A. Bensussan, S. Meuer, and B. Schraven. 1998. T cell receptor (TCR) interacting molecule (TRIM), a novel disulphide-linked dimer associated with the TCR-CD3-ζ complex, recruits intracellular signaling proteins to the plasma membrane. J. Exp. Med. 188:561.
8. ras during T-cell activation and growth. Immunol. Today 16:159.
9. Robinson, M. J., and M. H. Cobb. 1997. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9:180.
10. Seger, R., and E. G. Krebs. 1995. The MAPK signaling cascade. FASEB J. 9:726.
11. Koretzky, G. A. 1997. The role of Grb2-associated proteins in T-cell activation. Immunol. Today 18:401.
12. Finco, T. S., T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCγ1 and the ras pathway. Immunity 9:617.
13. Yablonski, D., M. R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from the PLC-γ1 in an SLP-76-deficient T cell. Science 281:413.
14. Chau, L. A., J. A. Bluestone, and J. Madrenas. 1998. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J. Exp. Med. 187:1699.
15. 2 and CD3 cross-linking. J. Biol. Chem. 273:10771.
16. Penninger, J. M., and G. R. Crabtree. 1999. The actin cytoskeleton and lymphocyte activation. Cell 96:9.
17. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
18. Madrenas, J., L. A. Chau, J. Smith, J. A. Bluestone, and R. N. Germain. 1997. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/ partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185: 219.
19. Akerstrom, B., T. Brodin, K. Reis, and L. Bjorck. 1985. Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodies. J. Immunol. 135:2589.
20. Eliasson, M., R. Andersson, A. Olsson, H. Wigzell, and M. Uhlen. 1989. Differential IgG-binding characteristics of staphylococcal protein A, streptococcal protein G, and a chimeric protein AG. J. Immunol. 142:575.
21. Bouvet, J. P. 1994 Immunoglobulin Fab fragment-binding proteins. Int. J. Immunopharmacol. 16:419.
22. ras activation in T cell CD69 expression. Eur. J. Immunol. 24:616.
23. Purbhoo, M. A., A. K. Sewell, P. Klenerman, P. J. Goulder, K. L. Hilyard, J. I. Bell, B. K. Jakobsen, and R. E. Phillips. 1998. Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade. Proc. Natl. Acad. Sci. USA 95:4527.
24. Osman, N., S. C. Lucas, H. Turner, and D. Cantrell. 1995. A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor ζ chain tyrosine-based activation motif. J. Biol. Chem. 270:13981.
25. Meisner, H., B. R. Conway, D. Hartley, and M. P. Czech. 1995. Interactions of Cbl with Grb2 and phosphatidylinositol 3′-kinase in activated Jurkat cells. Mol. Cell. Biol. 15:3571.
26. Fournel, M., D. Davidson, R. Weil, and A. Veillette. 1996. Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes. J. Exp. Med. 183:301.
27. Lupher, M. L., Jr., Z. Songyang, S. E. Shoelson, L. C. Cantley, and H. Band. 1997. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J. Biol. Chem. 272:33140.
28. Ota, Y., and L. E. Samelson. 1997. The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. Science 276:418.
29. Boussiotis, V. A., G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler. 1997. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science 278:124.
30. La Face, D. M., C. Couture, K. Anderson, G. Shih, J. Alexander, A. Sette, T. Mustelin, A. Altman, and H. M. Grey. 1997. Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses. J. Immunol. 158:2057.
31. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signalling: altered phospho-ζ and lack of Zap70 recruitment in APL-indnced T cell anergy. Cell 79:913.
32. Ravichandran, K. S., U. Lorenz, S. E. Shoelson, and S. J. Burakoff. 1995. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol. Cell. Biol. 15:593.
33. Neumeister Kersh, E., A. S. Shaw, and P. M. Allen 1998. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281:572.
34. Ravichandran, K. S., K. K. Lee, Z. Songyang, L. C. Cantley, P. Burn, and S. J. Burakoff. 1993. Interaction of Shc with the ζ chain of the T cell receptor upon T cell activation. Science 262:902.
35. Marengere, L. E., P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
36. Walk, S. F., M. E. March, and K. S. Ravichandran. 1998. Roles of lck, syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc. Eur. J. Immunol. 28:2265.
37. Li, B., M. Subleski, N. Fusaki, T. Yamamoto, T. Copeland, G. L. Princler, H. Kung, and T. Kamata. 1996. Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells. Proc. Natl. Acad. Sci. USA 93:1001.
38. Milia, E., M. M. Di Somma, F. Baldoni, R. Chiari, L. Lanfrancone, P. G. Pelicci, J. L. Telford, and C. T. Baldari. 1996. The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation. Oncogene 13:767.
39. Labadia, M. E., R. H. Ingraham, J. Schembri-King, M. M. Morelock, and S. Jakes. 1996. Binding affinities of the SH2 domains of ZAP-70, p56lck and Shc to the ζ chain ITAMs of the T-cell receptor determined by surface plasmon resonance. J. Leukocyte Biol. 59:740.
40. McCormick, F. 1993. How receptors turn Ras on. Nature 363:15.
41. Boriack-Sjodin, P. A., S. M. Margarit, D. Bar-Sagi, and J. Kuriyan. 1998. The structural basis of the activation of Ras by Sos. Nature 394:337.
42. Sternberg, P. W., and J. Alberola-Ila. 1998. Conspiracy theory: ras and raf do not act alone. Cell 95:457.
43. Motto, D. G., S. E. Ross, J. Wu, L. R. Hendricks-Taylor, and G. A. Koretzky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J. Exp. Med. 183:1937.
44. Liu, S. K., N. Fang, G. A. Koretzky, and C. J. McGlade. 1999. The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9:67.
45. Motto, D. G., M. A. Musci, S. E. Ross, and G. A. Koretzky. 1996. Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase Cγ1 activation in T cells. Mol. Cell. Biol. 16:2823.
46. Bubeck Wardenburg, J., R. Pappu, J.-Y. Bu, B. Mayer, J. Chernoff, D. Straus, and A. C. Chan. 1998. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 9:607.
47. Clements, J. L., B. Yang, S. E. Ross-Barta, S. L. Eliason, R. F. Hrstka, R. A. Williamson, and G. A. Koretzky. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281:416.
48. Pivniouk, V., E. Tsitsikov, P. Swinton, G. Rathbun, F. W. Alt, and R. S. Geha. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94:229.