KCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 protein

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34212-34224

  Meisel, Eshcar ^a   Dvir, Meidan ^a   Haitin, Yoni ^a   Giladi, Moshe ^a   Peretz, Asher ^a   Attali, Bernard ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC ACTION POTENTIAL; CARDIAC ARRHYTHMIA; CHANNEL ACTIVATION; CHANNEL GATING; CHANNEL OPENING; COOPERATIVE TRANSITIONS; GATING MECHANISMS; MUTANT CYCLE; OPEN CHANNELS; REPOLARIZATION; VOLTAGE DEPENDENCE; VOLTAGE SENSOR;

BIOCHEMISTRY;

BIOLOGY;

POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; SHAKER POTASSIUM CHANNEL;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRIC POTENTIAL; GAIN OF FUNCTION MUTATION; LOSS OF FUNCTION MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; THERMODYNAMIC MUTANT CYCLE ANALYSIS; VOLTAGE SENSOR DOMAIN;

AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; MUTATION, MISSENSE; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS;

EID: 84867238397     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.364901     Document Type: Article

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