Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis

Biophysical Journal

Volumn 100, Issue 4, 2011, Pages 885-894

  Ma, Li Juan ^a   Ohmert, Iris ^a   Vardanyan, Vitya ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79951841829     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.12.3726     Document Type: Article

References (59)

1. Sanguinetti, M. C., M. E. Curran, ..., M. T. Keating. 1996. Coassembly of K (V) LQT1 and minK (IsK) proteins to form cardiac I (Ks) potassium channel. Nature. 384:80-83. (Pubitemid 26374592)
2. Roepke, T. K., A. Anantharam, ..., G. W. Abbott. 2006. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J. Biol. Chem. 281:23740-23747. (Pubitemid 44274149)
3. Heitzmann, D., F. Grahammer, ..., R. Warth. 2004. Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J. Physiol. 561:547-557. (Pubitemid 39646542)
4. + channels. Physiol. Rev. 90:755-796.
5. Marx, S. O., J. Kurokawa, ..., R. S. Kass. 2002. Requirementofa macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science. 295:496-499. (Pubitemid 34101639)
6. Shamgar, L., L. Ma, ..., B. Attali. 2006. Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations. Circ. Res. 98:1055-1063.
7. Wiener, R., Y. Haitin, ..., J. A. Hirsch. 2008. The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J. Biol. Chem. 283:5815-5830.
8. Jespersen, T., M. Grunnet, and S. P. Olesen. 2005. The KCNQ1 potassium channel: from gene to physiological function. Physiology (Bethesda). 20:408-416. (Pubitemid 41812424)
9. Pusch, M., R. Magrassi, ..., F. Conti. 1998. Activation and inactivation of homomeric KvLQT1 potassium channels. Biophys. J. 75:785-792. (Pubitemid 28357520)
10. Pusch, M., L. Bertorello, and F. Conti. 2000. Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels. Biophys. J. 78:211-226. (Pubitemid 30207132)
11. + channels. J. Physiol. 533:135-143.
12. Peroz, D., N. Rodriguez, ..., G. Loussouarn. 2008. Kv7.1 (KCNQ1) properties and channelopathies. J. Physiol. 586:1785-1789. (Pubitemid 351997507)
13. Restier, L., L. Cheng, and M. C. Sanguinetti. 2008. Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels. J. Physiol. 586:4179-4191.
14. Wang, Q., M. E. Curran, ..., M. T. Keating. 1996. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 12:17-23. (Pubitemid 26011314)
15. + channel (minK) subunits. J. Physiol. 510:37-45. (Pubitemid 28351923)
16. Seebohm, G., M. C. Sanguinetti, and M. Pusch. 2003. Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels. J. Physiol. 552:369-378. (Pubitemid 37321836)
17. + selectivity filter. Nature. 414:37-42.
18. + channel-Fab complex at 2.0 Å resolution. Nature. 414:43-48. (Pubitemid 33041616)
19. Barhanin, J., F. Lesage, ..., G. Romey. 1996. K (V) LQT1 and lsK (minK) proteins associate to form the I (Ks) cardiac potassium current. Nature. 384:78-80. (Pubitemid 26374591)
20. Schroeder, B. C., S. Waldegger, ..., T. J. Jentsch. 2000. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature. 403:196-199. (Pubitemid 30050962)
21. Angelo, K., T. Jespersen, ..., S. P. Olesen. 2002. KCNE5 induces timeand voltage-dependent modulation of the KCNQ1 current. Biophys. J. 83:1997-2006.
22. Takumi, T., H. Ohkubo, and S. Nakanishi. 1988. Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science. 242:1042-1045.
23. Tinel, N., S. Diochot, ..., J. Barhanin. 2000. KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J. 19:6326-6330.
24. Melman, Y. F., S. Y. Um, ..., T. V. McDonald. 2004. KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron. 42:927-937. (Pubitemid 38798231)
25. Melman, Y. F., A. Domènech, ..., T. V. McDonald. 2001. Structural determinants of KvLQT1 control by the KCNE family of proteins. J. Biol. Chem. 276:6439-6444.
26. + channel pore. J. Physiol. 570:455-467.
27. Haitin, Y., R. Wiener, ..., B. Attali. 2009. Intracellular domains interactions and gated motions of I (KS) potassium channel subunits. EMBO J. 28:1994-2005.
28. + channels. PLoS One. 3: e1943.
29. Nakajo, K., and Y. Kubo. 2007. KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel. J. Gen. Physiol. 130:269-281. (Pubitemid 47443289)
30. + channels. J. Gen. Physiol. 131:59-68.
31. Tapper, A. R., and A. L. George, Jr. 2000. MinK subdomains that mediate modulation of and association with KvLQT1. J. Gen. Physiol. 116:379-390.
32. Vanoye, C. G., R. C. Welch, ..., A. L. George, Jr. 2009. Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits. J. Gen. Physiol. 134:207-217.
33. Lewis, A., Z. A. McCrossan, and G. W. Abbott. 2004. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J. Biol. Chem. 279:7884-7892. (Pubitemid 38294675)
34. McCrossan, Z. A., and G. W. Abbott. 2004. The MinK-related peptides. Neuropharmacology. 47:787-821. (Pubitemid 39440975)
35. Um, S. Y., and T. V. McDonald. 2007. Differential association between HERG and KCNE1 or KCNE2. PLoS One. 2: e933.
36. McCrossan, Z. A., T. K. Roepke, ..., G. W. Abbott. 2009. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J. Membr. Biol. 228:1-14.
37. + channel. Cell. 111:231-239. (Pubitemid 35292443)
38. Soler-Llavina, G. J., T. H. Chang, and K. J. Swartz. 2006. Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K (v) channel. Neuron. 52:623-634. (Pubitemid 44750565)
39. + channel. J. Gen. Physiol. 119:521-532.
40. Wang, H. S., B. S. Brown, ..., I. S. Cohen. 2000. Molecular basis for differential sensitivity of KCNQ and I (Ks) channels to the cognitive enhancer XE991. Mol. Pharmacol. 57:1218-1223. (Pubitemid 30354394)
41. + channel. Neuron. 25:411-423.
42. Ledwell, J. L., and R. W. Aldrich. 1999. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J. Gen. Physiol. 113:389-414. (Pubitemid 29219810)
43. Zagotta, W. N., T. Hoshi, and R. W. Aldrich. 1994. Shaker potassium channel gating. III: Evaluation of kinetic models for activation. J. Gen. Physiol. 103:321-362. (Pubitemid 24068562)
44. Schoppa, N. E., and F. J. Sigworth. 1998. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2+++ mutant channels. J. Gen. Physiol. 111:313-342. (Pubitemid 28113080)
45. + channel. Biophys. J. 95:2759-2778.
46. Monod, J., J. Wyman, and J. P. Changeux. 1965. On the Nature of Allosteric Transitions: A Plausible Model. J. Mol. Biol. 12:88-118.
47. Hoshi, T., W. N. Zagotta, and R. W. Aldrich. 1994. Shaker potassium channel gating. I: Transitions near the open state. J. Gen. Physiol. 103:249-278. (Pubitemid 24068560)
48. 2+. J. Gen. Physiol. 114:277-304. (Pubitemid 29380155)
49. Altomare, C., A. Bucchi, ..., D. DiFrancesco. 2001. Integrated allosteric model of voltage gating of HCN channels. J. Gen. Physiol. 117:519-532. (Pubitemid 32552261)
50. Sukhareva, M., D. H. Hackos, and K. J. Swartz. 2003. Constitutive activation of the Shaker Kv channel. J. Gen. Physiol. 122:541-556. (Pubitemid 37420849)
51. + channels. J. Gen. Physiol. 120:663-676. (Pubitemid 35332586)
52. Islas, L. D., and F. J. Sigworth. 1999. Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. J. Gen. Physiol. 114:723-742.
53. Panaghie, G., and G. W. Abbott. 2007. The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J. Gen. Physiol. 129:121-133. (Pubitemid 46184870)
54. Romey, G., B. Attali, ..., M. Lazdunski. 1997. Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity. J. Biol. Chem. 272:16713-16716. (Pubitemid 27289761)
55. Smith, J. A., C. G. Vanoye, ..., C. R. Sanders. 2007. Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry. 46:14141-14152. (Pubitemid 350250308)
56. + channel. Science. 309:897-903. (Pubitemid 41099919)
57. + conduction and selectivity. Science. 280:69-77. (Pubitemid 28169082)
58. + channel in a lipid membrane-like environment. Nature. 450:376-382. (Pubitemid 350126743)
59. Long, S. B., E. B. Campbell, and R. Mackinnon. 2005. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science. 309:903-908. (Pubitemid 41099920)