How does the W434F mutation block current in Shaker potassium channels?

Journal of General Physiology

Volumn 109, Issue 6, 1997, Pages 779-789

  Yang, Youshan ^a   Yan, Yangyang ^a   Sigworth, Fred J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inactivation; Ion channel gating; Mutation; Patch clamp; Potassium channels physiology

Indexed keywords

POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; GENE MUTATION; NONHUMAN; PATCH CLAMP; XENOPUS;

ANIMALS; KINETICS; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; XENOPUS;

EID: 0030906796     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.109.6.779     Document Type: Article

References (39)

1. Aggarwal, S.K. 1996. Analysis of the voltage sensor in a voltage-activated potassium channel. Ph.D. Thesis, Harvard University. 80 pp.
2. Bezanilla, F., and C.M. Armstrong. 1977. Inactivation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol. 70:549-566.
3. Bezanilla, F., E. Perozo, D.M. Papazian, and E. Stefani. 1991. Molecular basis of gating charge immobilization in Shaker potassium channels. Science (Wash. DC). 254:679-683.
4. 1 channels. Proc. Natl Acad. Sci. USA. 88:5092-5095.
5. Colquhoun, D., and F.J. Sigworth. 1995. Fitting and statistical analysis of single-channel records. In Single Channel Recording. 2nd ed. Plenum Press, New York. 483-587.
6. + pores. Pflüg. Arch. 422:354-363.
7. Fedida, D., R. Bouchard, and F.S.P. Chen. 1996. Slow gating charge immobilization in the human potassium channel Kv1.5 and its prevention by 4-aminopyridine. J. Physiol. (Lond.). 494:377-387.
8. + channels in human T lymphocytes. Biophys. J. 55:203-206.
9. + channel signature sequence. Biophys. J. 66: 1061-1067.
10. Heginbotham, L., and R. MacKinnon. 1992. The aromatic binding site for tetraethylammonium ion in potassium channels. Neuron. 8:483-491.
11. Horn, R., C.A. Vandenberg, and K. Lange. 1984. Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophys. J. 45:323-335.
12. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science (Wash. DC). 250:533-538.
13. + channels: effects of alterations in the carboxy-terminal region. Neuron. 7:547-556.
14. Hurst, R.S., M.P. Kavanaugh, J. Yakel, J.P. Adelman, and R.A. North. 1992. Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs. J. Biol. Chem. 267:23742-23745.
15. Hurst, R.S., R.A. North, and J.P. Adelman. 1995. Potassium channel assembly from concatenated subunits: effects of proline substitutions in S4 segments. Receptors and Channels. 3:263-272.
16. Kamb, A., J. Tseng-Crank, and M.A. Tanouye. 1988. Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity. Neuron. 1:421-430.
17. + conductance switch. Biophys. J. 62:136-143.
18. + channels must deactivate to recover from inactivation. Neuron. 12:819-829.
19. + channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis. Biophys. J. 68:900-905.
20. Levy, D.I., and C. Deutsch. 1996. Recovery from C-type inactivation is modulated by extracellular potassium. Biophys. J. 70:798-805.
21. + channel determined by construction of multimeric cDNAs. Neuron. 9:861-871.
22. + channel gating. Biophys. J. 66:106a.
23. Lopez-Barneo, J., T. Hoshi, S.H. Heinemann, and R.W. Aldrich. 1993. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors and Channels. 1:61-71.
24. Lü, Q., and C. Miller. 1995. Silver as a probe of pore-forming residues in a potassium channel. Science (Wash. DC). 268:304-307.
25. + channel subunits does not ensure the stoichiometry of expressed channels. Biophys. J. 63:1406-1411.
26. Ogielska, E.M., W.N. Zagotta, T. Hoshi, S.H. Heinemann, J. Haab, and R.W. Aldrich. 1995. Cooperative subunit interactions in C-type inactivation of K channels. Biophys. J. 69:2449-2457.
27. + channel occurs by a cooperative mechanism. Biophys. J. 69:896-903.
28. + channel. Proc. Natl. Acad. Sci. USA. 89:2466-2470.
29. + channels. Neuron. 11:353-358.
30. + channels. Implications for activation and inactivation models. Biophys. J. 62:160-168.
31. Roux, M.J., R. Olcese, L. Toro, and E. Stefani. 1995. Stabilization of the C-inactivated state by the fast inactivation particle in non-conducting Shaker H4 W434F potassium channels. Biophys. J. 68:A33.
32. Schwarz, T.L., B.L. Tempel, D.L. Papazian, Y.N. Jan, and L.Y. Jan. 1988. Multiple potassium-channel components are produced by alternative splicing at the Shaker locus of Drosophila. Nature (Lond.). 331:137-142.
33. Sigg, D., E. Stefani, and F. Bezanilla. 1994. Gating current noise produced by elementary transitions in Shaker potassium channels. Science (Wash. DC). 264:578-582.
34. Sigworth, F.J., and S.M. Sine. 1987. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys. J. 52:1047-1054.
35. + channel mutant W434F. Biophys. J. 72:232a.
36. Swanson, R., J. Marshall, J.S. Smith, J.B. Williams, M.B. Boyle, K. Folander, C.J. Luneau, J. Antanavage, C. Oliva, S.A. Buhrow, et al. 1990. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron. 4:929-939.
37. Tytgat, J., and P. Hess. 1992. Evidence for cooperative interactions in potassium channel gating. Nature (Lond.). 359:420-423.
38. + channel allows inactivation to be modulated by metal binding. Biophys. J. 66: 1068-1075.
39. + channel by mutation of the H5 region. Nature (Lond.). 349: 700-704.