Design of human granzyme B variants resistant to serpin B9

Proteins: Structure, Function and Bioinformatics

Volumn 80, Issue 11, 2012, Pages 2514-2522

  Losasso, Valeria ^a   Schiffer, Sonja ^b   Barth, Stefan ^b,c   Carloni, Paolo ^a,d  

^a German Research School for Simulation Sciences ^*  (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^d FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Cancer therapy; Enzyme inhibition; In vitro essays; Molecular dynamics; Serine protease

Indexed keywords

ENZYME VARIANT; GRANZYME B; PROTEIN INHIBITOR; PROTEIN INHIBITOR HSB9; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BIOCATALYSIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STABILITY; ENZYME STRUCTURE; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; GRANZYMES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PROTEIN BINDING; PROTEIN ENGINEERING; RATS; SEQUENCE ALIGNMENT; SERPINS;

EID: 84867214367     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24133     Document Type: Article

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