Functional dissociation of Δψm and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

Cell Death and Differentiation

Volumn 13, Issue 4, 2006, Pages 607-618

  Waterhouse, Nigel J ^a   Sedelies, K A ^a   Sutton, V R ^a   Pinkoski, M J ^b   Thia, K Y ^a   Johnstone, R ^a   Bird, P I ^c   Green, D R ^b   Trapani, J A ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Apoptosis; Cytochrome c; Granzyme B; Mitochondrial outer membrane permeabilization; Mitochondrial transmembrane potential

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; CYTOCHROME C; DACTINOMYCIN; ENDONUCLEASE; ENDONUCLEASE G; GRANZYME B; PERFORIN; PROTEIN BID; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; BID PROTEIN, HUMAN; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CASP3 PROTEIN, HUMAN; CASPASE 3; CYSTEINE PROTEINASE INHIBITOR; GRANZYME; GZMB PROTEIN, HUMAN; MEMBRANE PROTEIN; PEPTIDE CHLOROMETHYL KETONE; PEPTIDE FRAGMENT; PORE FORMING CYTOTOXIC PROTEIN; PROTEIN BCL 2; SERINE PROTEINASE; UNCOUPLING PROTEIN;

APOPTOSIS; ARTICLE; CELL CLONING; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN DEGRADATION; CELL MEMBRANE POTENTIAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HELA CELL; LEUKEMIA CELL LINE; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CASPASE 3; CASPASES; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; GRANZYMES; HELA CELLS; HUMANS; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MITOCHONDRIA; PEPTIDE FRAGMENTS; PORE FORMING CYTOTOXIC PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SERINE ENDOPEPTIDASES; TRANSFECTION; TUMOR STEM CELL ASSAY; UNCOUPLING AGENTS;

EID: 33644945863     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401772     Document Type: Article

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