Extracellular factors and immunosuppressive drugs influencing insulin secretion of murine islets

Clinical and Experimental Immunology

Volumn 170, Issue 2, 2012, Pages 238-247

  Auer, V J ^a   Janas, E ^a   Ninichuk, V ^a   Eppler, E ^e   Weiss, T S ^b   Kirchner, S ^c   Otto, A M ^a   Stangl, M J ^d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c Hepacult GmbH   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cytokines; Extracellular matrix; IL 1 ; Immunosuppressive drugs; Insulin secretion; Islet transplantation; Laminin

Indexed keywords

CYCLOSPORIN A; FIBRONECTIN; GLUCOSE; INTERLEUKIN 1BETA; LAMININ; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; INSULIN RELEASE; KUPFFER CELL; LIVER SINUSOID; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CYCLOSPORINE; EXTRACELLULAR MATRIX; FIBRONECTINS; GLUCOSE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; INSULIN; INTERLEUKIN-1BETA; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; KUPFFER CELLS; LAMININ; MICE; MICE, INBRED C57BL; TACROLIMUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84867212762     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04645.x     Document Type: Article

References (73)

1. Stock PG, Bluestone JA. Beta-cell replacement for type I diabetes. Annu Rev Med 2004; 55:133-56.
2. Nanji SA, Shapiro AM. Advances in pancreatic islet transplantation in humans. Diabetes Obes Metab 2006; 8:15-25.
3. Gadi VK, Nelson JL, Guthrie KA etal. Soluble donor DNA and islet injury after transplantation. Transplantation 2011; 92:607-11.
4. Shapiro AM, Lakey JR, Ryan EA etal. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343:230-8.
5. Ryan EA, Paty BW, Senior PA etal. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54:2060-9.
6. Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE. Pancreas and islet transplantation for patients with diabetes. Diabetes Care 2000; 23:112-6.
7. Wang RN, Rosenberg L. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol 1999; 163:181-90.
8. Kragl M, Lammert E. Basement membrane in pancreatic islet function. Adv Exp Med Biol 2010; 654:217-34.
9. Souza YE, Chaib E, Lacerda PG, Crescenzi A, Bernal-Filho A, D'Albuquerque LA. Islet transplantation in rodents. Do encapsulated islets really work? Arq Gastroenterol 2011; 48:146-52.
10. Weber LM, Anseth KS. Hydrogel encapsulation environments functionalized with extracellular matrix interactions increase islet insulin secretion. Matrix Biol 2008; 27:667-73.
11. Stendahl JC, Kaufman DB, Stupp SI. Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation. Cell Transplant 2009; 18:1-12.
12. Daoud J, Petropavlovskaia M, Rosenberg L, Tabrizian M. The effect of extracellular matrix components on the preservation of human islet function in vitro. Biomaterials 2010; 31:1676-82.
13. Desai NM, Goss JA, Deng S etal. Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity? Transplantation 2003; 76:1623-5.
14. Shapiro AM, Gallant HL, Hao EG etal. The portal immunosuppressive storm: relevance to islet transplantation? Ther Drug Monit 2005; 27:35-7.
15. Heisel O, Heisel R, Balshaw R, Keown P. New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta-analysis. Am J Transplant 2004; 4:583-95.
16. Barshes NR, Wyllie S, Goss JA. Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts. J Leukoc Biol 2005; 77:587-97.
17. Dinarello CA, Donath MY, Mandrup-Poulsen T. Role of IL-1beta in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 2010; 17:314-21.
18. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11:98-107.
19. Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996; 39:1005-29.
20. Nathan CF. Secretory products of macrophages. J Clin Invest 1987; 79:319-26.
21. Bendtzen K, Mandrup-Poulsen T, Nerup J, Nielsen JH, Dinarello CA, Svenson M. Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science 1986; 232:1545-7.
22. Donath MY, Ehses JA, Maedler K etal. Mechanisms of beta-cell death in type 2 diabetes. Diabetes 2005; 54 (Suppl. 2):S108-113.
23. Vignali S, Leiss V, Karl R, Hofmann F, Welling A. Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J Physiol (Lond) 2006; 572:691-706.
24. Walbrun P, Hellerbrand C, Weiss TS etal. Characterization of rat and human Kupffer cells after cryopreservation. Cryobiology 2007; 54:164-72.
25. Gehring S, Dickson EM, San Martin ME etal. Kupffer cells abrogate cholestatic liver injury in mice. Gastroenterology 2006; 130:810-22.
26. Bank HL. Assessment of islet cell viability using fluorescent dyes. Diabetologia 1987; 30:812-6.
27. Giroix MH, Agascioglu E, Oguzhan B etal. Opposite effects of d-fructose on total versus cytosolic ATP/ADP ratio in pancreatic islet cells. Biochim Biophys Acta 2006; 1757:773-80.
28. Göpel S, Kanno T, Barg S, Galvanovskis J, Rorsman P. Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets. J Physiol (Lond) 1999; 521:717-28.
29. Nikolova G, Jabs N, Konstantinova I etal. The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell 2006; 10:397-405.
30. Santos RM, Rosario LM, Nadal A, Garcia-Sancho J, Soria B, Valdeolmillos M. Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets. Pflugers Arch 1991; 418:417-22.
31. Bergsten P, Grapengiesser E, Gylfe E, Tengholm A, Hellman B. Synchronous oscillations of cytoplasmic Ca2+ and insulin release in glucose-stimulated pancreatic islets. J Biol Chem 1994; 269:8749-53.
32. Draznin B, Metz SA, Sussman KE, Leitner JW. Cyclosporin-induced inhibition of insulin release. Possible role of voltage-dependent calcium transport channels. Biochem Pharmacol 1988; 37:3941-5.
33. Tarasov A, Dusonchet J, Ashcroft F. Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux. Diabetes 2004; 53 (Suppl. 3):S113-122.
34. Palmer JP, Helqvist S, Spinas GA etal. Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans. Diabetes 1989; 38:1211-6.
35. Mandrup-Poulsen T, Pickersgill L, Donath MY. Blockade of interleukin 1 in type 1 diabetes mellitus. Nat Rev Endocrinol 2010; 6:158-66.
36. Shirahama M, Ishibashi H, Tsuchiya Y, Kurokawa S, Okumura Y, Niho Y. Kinetics and parameters of the induction of interleukin 1 secretion by rat Kupffer cells. J Clin Lab Immunol 1988; 27:127-32.
37. Krüger B, Yin N, Zhang N etal. Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation. Eur J Immunol 2010; 40:2914-24.
38. Nikolova G, Strilic B, Lammert E. The vascular niche and its basement membrane. Trends Cell Biol 2007; 17:19-25.
39. Lin HY, Tsai CC, Chen LL, Chiou SH, Wang YJ, Hung SC. Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK. J Biomed Sci 2010; 17:56.
40. Aumailley M, Smyth N. The role of laminins in basement membrane function. J Anat 1998; 193:1-21.
41. Jiang F-X, Naselli G, Harrison LC. Distinct distribution of laminin and its integrin receptors in the pancreas. J Histochem Cytochem 2002; 50:1625-32.
42. Bosco D, Meda P, Halban PA, Rouiller DG. Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin. Diabetes 2000; 49:233-43.
43. Hammar EB, Irminger JC, Rickenbach K etal. Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. J Biol Chem 2005; 280:30630-7.
44. van Deijnen JH, Hulstaert CE, Wolters GH, van Schilfgaarde R. Significance of the peri-insular extracellular matrix for islet isolation from the pancreas of rat, dog, pig, and man. Cell Tissue Res 1992; 267:139-46.
45. Wang RN, Paraskevas S, Rosenberg L. Characterization of integrin expression in islets isolated from hamster, canine, porcine, and human pancreas. J Histochem Cytochem 1999; 47:499-506.
46. Kantengwa S, Baetens D, Sadoul K, Buck CA, Halban PA, Rouiller DG. Identification and characterization of alpha 3 beta 1 integrin on primary and transformed rat islet cells. Exp Cell Res 1997; 237:394-402.
47. Zhao Y, Xu J, Wei J, Li J, Cai J, Miao G. Preservation of islet survival by upregulating α3 integrin signaling: the importance of 3-dimensional islet culture in basement membrane extract. Transplant Proc 2010; 42:4638-42.
48. Robertson RP. Cyclosporin-induced inhibition of insulin secretion in isolated rat islets and HIT cells. Diabetes 1986; 35:1016-9.
49. Ishizuka J, Gugliuzza KK, Wassmuth Z etal. Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets. Transplantation 1993; 56:1486-90.
50. Ricordi C, Zeng YJ, Alejandro R etal. In vivo effect of FK506 on human pancreatic islets. Transplantation 1991; 52:519-22.
51. Düfer M, Krippeit-Drews P, Lembert N, Idahl LA, Drews G. Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Mol Pharmacol 2001; 60:873-9.
52. Fuhrer DK, Kobayashi M, Jiang H. Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channel. Diabetes Obes Metab 2001; 3:393-402.
53. Martin F, Bedoya FJ. Short-term effects of cyclosporine on secretagogue-induced insulin release by isolated islets. Transplantation 1990; 50:551-3.
54. Herold KC, Nagamatsu S, Buse JB, Kulsakdinun P, Steiner DF. Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506. Transplantation 1993; 55:186-92.
55. Redmon JB, Olson LK, Armstrong MB, Greene MJ, Robertson RP. Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. J Clin Invest 1996; 98:2786-93.
56. Paty BW, Harmon JS, Marsh CL, Robertson RP. Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets. Transplantation 2002; 73:353-7.
57. Rostambeigi N, Lanza IR, Dzeja PP etal. Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction. Transplantation 2011; 91:615-23.
58. Uchizono Y, Iwase M, Nakamura U, Sasaki N, Goto D, Iida M. Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling. Endocrinology 2004; 145:2264-72.
59. Øzbay LA, Smidt K, Mortensen DM, Carstens J, Jørgensen KA, Rungby J. Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells. Br J Pharmacol 2011; 162:136-46.
60. Heit JJ, Apelqvist AA, Gu X etal. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature 2006; 443:345-9.
61. Bottino R, Fernandez LA, Ricordi C etal. Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 1998; 47:316-23.
62. Spinas GA, Palmer JP, Mandrup-Poulsen T, Andersen H, Nielsen JH, Nerup J. The bimodal effect of interleukin 1 on rat pancreatic beta-cells-stimulation followed by inhibition-depends upon dose, duration of exposure, and ambient glucose concentration. Acta Endocrinol 1988; 119:307-11.
63. Maedler K, Schumann DM, Sauter N etal. Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes 2006; 55:2713-22.
64. Ribaux P, Ehses JA, Lin-Marq N etal. Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. Endocrinology 2007; 148:5582-90.
65. Mandrup-Poulsen T, Bendtzen K, Dinarello CA, Nerup J. Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J Immunol 1987; 139:4077-82.
66. Parnaud G, Hammar E, Ribaux P, Donath MY, Berney T, Halban PA. Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix. Mol Endocrinol 2009; 23:1264-71.
67. Chang I, Kim S, Kim JY etal. Nuclear factor B protects pancreatic-cells from tumor necrosis factor-mediated apoptosis. Diabetes 2003; 52:1169-75.
68. Krishnamurthy M, Wang R. Integrins and extracellular matrices in pancreatic tissue engineering. Front Biosci (Schol Ed) 2009; 1:477-91.
69. Westwell-Roper C, Dai DL, Soukhatcheva G etal. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol 2011; 187:2755-65.
70. Cailleau C, Diu-Hercend A, Ruuth E, Westwood R, Carnaud C. Treatment with neutralizing antibodies specific for IL-1beta prevents cyclophosphamide-induced diabetes in nonobese diabetic mice. Diabetes 1997; 46:937-40.
71. Wu G, Korsgren O, Zhang J, Song Z, van Rooijen N, Tibell A. Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation 2000; 7:214-20.
72. Daoud JT, Petropavlovskaia MS, Patapas JM etal. Long-term in vitro human pancreatic islet culture using three-dimensional microfabricated scaffolds. Biomaterials 2011; 32:1536-42.
73. Astrof S, Hynes RO. Fibronectins in vascular morphogenesis. Angiogenesis 2009; 12:165-75.