The portal immunosuppressive storm: Relevance to islet transplantation?

Therapeutic Drug Monitoring

Volumn 27, Issue 1, 2005, Pages 35-37

  Shapiro, A M James ^a,c   Gallant, Heather L ^a   Er, Geng Hao ^a   Lakey, Jonathan R T ^a   McCready, Tara ^a   Rajotte, Ray V ^a   Yatscoff, Randall W ^b   Kneteman, Norman M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Isotechnika Inc   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Immunosuppression; Islet; Sirolimus; Tacrolimus; Transplantation

Indexed keywords

CYCLOSPORIN; RAPAMYCIN; TACROLIMUS;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CAROTID ARTERY; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PORTAL VEIN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; SYSTEMIC CIRCULATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CAROTID ARTERIES; CYCLOSPORINE; DOGS; IMMUNOSUPPRESSION; ISLETS OF LANGERHANS TRANSPLANTATION; LIVER CIRCULATION; PORTAL SYSTEM; PORTAL VEIN; SIROLIMUS; TABLETS; TACROLIMUS; TIME FACTORS;

EID: 13244298984     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200502000-00008     Document Type: Article

References (11)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230.
2. Ricordi C, Fraker C, Szust J, et al. Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution. Transplantation. 2003;75:1524.
3. Hering BJ, Matsumoto I, Sawada T, et al. Impact of two-layer pancreas preservation on islet isolation and transplantation. Transplantation. 2002; 74:1813.
4. Markmann JF, Deng S, Huang X, et al. Insulin independence following isolated islet transplantation and single islet infusions. Ann Surg. 2003; 237:741.
5. Oellerich M, Armstrong VW, Schutz E, et al. Therapeutic drug monitoring of cyclosporine and tacrolimus. Update on Lake Louise Consensus Conference on cyclosporine and tacrolimus. Clin Biochem. 1998;31:309.
6. Yatscoff R, Faraci C, Bolingbroke P. Measurement of rapamycin in whole blood using reverse-phase high-performance liquid chromatography. Ther Drug Monit. 1992;14:138.
7. Desai N, Goss J, Deng S, et al. Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: Local immunosuppression or islet toxicity? Transplantation. 2003;76:1623.
8. Oetjen E, Baun D, Beimesche S, et al. Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice. Mol Pharmacol. 2003; 63:1289.
9. Bell E, Cao X, Gao Z, et al. The deleterious effect of rapamycin on beta cells and islets. Diabetes. 2002;51(Suppl 2):A459.
10. Helmchen U, Schmidt W, Siegel E, et al. Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats. Diabetologia. 1984;27:416.
11. Drachenberg CB, Klassen DK, Weir MR, et al. Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation. 1999;68:396.