Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: A study in streptozotocin diabetic animals

Xenotransplantation

Volumn 7, Issue 3, 2000, Pages 214-220

  Wu, Guosheng ^a   Korsgren, Olle ^b   Zhang, Jianguo ^a   Song, Zhenshun ^a   Van Rooijen, Nico ^c   Tibell, Annika ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Islets; Macrophages; NK cells; Rejection; Xenotransplantation

Indexed keywords

CD3 ANTIGEN; CLODRONIC ACID; GLUCOSE; LIPOSOME; MONOCLONAL ANTIBODY; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; DIABETES MELLITUS; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOMODULATION; KIDNEY CAPSULE; MACROPHAGE; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; XENOTRANSPLANTATION;

ANIMALS; BLOOD GLUCOSE; CLODRONIC ACID; DIABETES MELLITUS, EXPERIMENTAL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSION; ISLETS OF LANGERHANS TRANSPLANTATION; KILLER CELLS, NATURAL; LIPOSOMES; LYMPHOCYTE DEPLETION; LYMPHOCYTES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033806804     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2000.00071.x     Document Type: Article

References (24)

1. Xenogeneic islet transplantation
2. The immunopathology of discordant xenograft rejection
3. Role of anti-donor antibody in the rejection of pig proislet xenografts in mice
4. Unique problems with nonvascularized xenografts, especially pancreatic islets
5. Efficacy of immunosuppressive drugs in islet xenotransplantation: Ieflunomide in combination with cyclosporine and mycophenolate mofetil prevents islet xenograft rejection in the pig-to-rat model
6. Xenograft rejection of porcine islet-like cell clusters in normal and natural killer cell-depleted mice
7. Role of CD4+ T-lymphocytes in rejection by mice of fetal pig proislet xenografts
8. Prolonged survival of discordant porcine islet xenografts
9. Isolation of the elusive pig islet
10. Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications
11. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection
12. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice
13. Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate
14. Transient suppression of macrophage functions by liposome-encapsulated drugs
15. Cytokine mRNA expression in peripheral blood cells of immunosuppressed human islet transplant recipients
16. Transplantation of allogeneic islets of Langerhans in the rat liver
17. Nitric oxide: A cytotoxic activated macrophage effector molecule
18. The effect of macrophage depletion on delayed xenograft rejection: Studies in the guinea pig-to-C6-deficient rat heart transplantation model
19. Effect of Gk1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD4+ T cell-depleted mice
20. Expression of cytokines during rejection of fetal pig islet xenografts in non-obese diabetic mice
21. Importance of natural killer cells in the rejection of hamster skin xenografts
22. Possible role of preformed natural antibodies in preventing bone marrow engraftment in a discordant xenogeneic species combination (human-to-mouse)
23. Role of antibody-independent complement activation in rejection of porcine bone marrow cells in mice
24. Xenograft rejection of porcine islet-like cell clusters in immunoglobulin- or Fc-receptor γ-deficient mice