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Volumn 60, Issue 4, 2001, Pages 873-879

Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCINEURIN; CALCINEURIN INHIBITOR; CALCIUM CHANNEL L TYPE; CALCIUM ION; CYCLOSPORIN A; DELTAMETHRIN; GLUCOSE; IMMUNOSUPPRESSIVE AGENT; INSULIN; POTASSIUM CHANNEL BLOCKING AGENT; TACROLIMUS; TOLBUTAMIDE;

EID: 0034807816     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (46)

References (42)
  • 3
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    • Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion
    • (1988) Diabetes , vol.37 , pp. 1574-1582
  • 8
    • 0033118649 scopus 로고    scopus 로고
    • Contributions of mitochondria to animal physiology: From homeostatic sensor to calcium signalling and cell death
    • (1999) J Physiol (Lond) , vol.516 , pp. 1-17
    • Duchen, M.R.1
  • 18
    • 0025193488 scopus 로고
    • 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase
    • (1990) Biochem J , vol.268 , pp. 153-160
    • Halestrap, A.P.1    Davidson, A.M.2
  • 22
    • 0032504717 scopus 로고    scopus 로고
    • From calcium signaling to cell death: Two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state
    • (1998) Biochim Biophys Acta , vol.1366 , pp. 33-50
    • Ichas, F.1    Mazat, J.-P.2
  • 26
    • 0031892854 scopus 로고    scopus 로고
    • α-ketoisocaproate is not a true substrate for ATP production by pancreatic β-cell mitochondria
    • (1998) Diabetes , vol.47 , pp. 339-344
    • Lembert, N.1    Idahl, L.Å.2
  • 29
    • 0025946452 scopus 로고
    • Mechanisms of action of cyclosporin A on islet α-and β-cells. Effects on cAMP-and calcium-dependent pathways
    • (1991) Life Sci , vol.49 , pp. 1915-1921
    • Martin, F.1    Bedoya, F.J.2
  • 36
    • 0022544940 scopus 로고
    • Cyclosporin-induced inhibition of insulin secretion in isolated rat islets and HIT cells
    • (1986) Diabetes , vol.35 , pp. 1016-1019
    • Robertson, R.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.