Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells

British Journal of Pharmacology

Volumn 162, Issue 1, 2011, Pages 136-146

  Ozbay L A ^a   Smidt, K ^b   Mortensen, D M ^a   Carstens, J ^a   Jorgensen K A ^a   Rungby, J ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

beta cells; calcineurin; cyclosporin A; insulin; NFAT; SREBP diabetes transplantation; tacrolimus

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; GLUCOSE; INSULIN; MESSENGER RNA; PHOSPHATASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN NFAT C1; PROTEIN NFAT C2; PROTEIN NFAT C3; PROTEIN NFAT C4; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; DRUG EXPOSURE; ENZYME INHIBITION; GENE EXPRESSION REGULATION; INCUBATION TIME; INSULIN RELEASE; INSULIN RESISTANCE; METABOLIC INHIBITION; NEW ONSET DIABETES MELLITUS AFTER TRANSPLANTATION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CALCINEURIN; CELL LINE; CYCLOSPORINE; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOSUPPRESSIVE AGENTS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; NFATC TRANSCRIPTION FACTORS; POLYMERASE CHAIN REACTION; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TACROLIMUS;

EID: 78650116753     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01018.x     Document Type: Article

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