메뉴 건너뛰기




Volumn 122, Issue 10, 2012, Pages 3439-3447

Hodgkin lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

4 SC 202; AFM 13; BLEOMYCIN; BRENTUXIMAB VEDOTIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; ETOPOSIDE; EVEROLIMUS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; LENALIDOMIDE; OFATUMUMAB; PREDNISONE; PROCARBAZINE; RESMINOSTAT; STAT PROTEIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

EID: 84867166303     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61245     Document Type: Review
Times cited : (229)

References (122)
  • 2
    • 57749171165 scopus 로고    scopus 로고
    • The biology of Hodgkin's lymphoma
    • Küppers R. The biology of Hodgkin's lymphoma. Nat Rev Cancer. 2009;9(1):15-27.
    • (2009) Nat Rev Cancer , vol.9 , Issue.1 , pp. 15-27
    • Küppers, R.1
  • 3
    • 66149109978 scopus 로고    scopus 로고
    • Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphoma
    • Schmitz R, Stanelle J, Hansmann ML, Küppers R. Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphoma. Annu Rev Pathol. 2009;4:151-174.
    • (2009) Annu Rev Pathol , vol.4 , pp. 151-174
    • Schmitz, R.1    Stanelle, J.2    Hansmann, M.L.3    Küppers, R.4
  • 4
    • 17144391393 scopus 로고    scopus 로고
    • Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma
    • DOI 10.1002/path.1746
    • Greiner A, et al. Differential expression of activa-tion- induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma. J Pathol. 2005;205(5):541-547. (Pubitemid 40514826)
    • (2005) Journal of Pathology , vol.205 , Issue.5 , pp. 541-547
    • Greiner, A.1    Tobollik, S.2    Buettner, M.3    Jungnickel, B.4    Herrmann, K.5    Kremmer, E.6    Niedobitek, G.7
  • 8
    • 0037381009 scopus 로고    scopus 로고
    • Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma
    • Bräuninger A, Wacker HH, Rajewsky K, Küppers R, Hansmann ML. Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma. Cancer Res. 2003;63(7):1644-1651. (Pubitemid 36373657)
    • (2003) Cancer Research , vol.63 , Issue.7 , pp. 1644-1651
    • Brauninger, A.1    Wacker, H.-H.2    Rajewsky, K.3    Kuppers, R.4    Hansmann, M.-L.5
  • 9
    • 0029952779 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
    • DOI 10.1084/jem.184.4.1495
    • Kanzler H, Küppers R, Hansmann ML, Rajewsky K. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med. 1996;184(4):1495-1505. (Pubitemid 26354704)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.4 , pp. 1495-1505
    • Kanzler, H.1    Kuppers, R.2    Hansmann, M.-L.3    Rajewsky, K.4
  • 10
    • 0028007479 scopus 로고
    • Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development
    • Küppers R, et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci U S A. 1994;91(23):10962-10966.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.23 , pp. 10962-10966
    • Küppers, R.1
  • 11
    • 17044443197 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription
    • Marafioti T, et al. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood. 2000;95(4):1443-1450. (Pubitemid 30099859)
    • (2000) Blood , vol.95 , Issue.4 , pp. 1443-1450
    • Marafioti, T.1    Hummel, M.2    Foss, H.-D.3    Laumen, H.4    Korbjuhn, P.5    Anagnostopoulos, I.6    Lammert, H.7    Demel, G.8    Theil, J.9    Wirth, T.10    Stein, H.11
  • 13
    • 0034658050 scopus 로고    scopus 로고
    • Detection of clonal T-cell receptor gamma-chain gene rearrangements Reed-Sternberg cells of classic Hodgkin disease
    • Seitz V, Hummel M, Marafioti T, Anagnostopoulos I, Assaf C, Stein H. Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed- Sternberg cells of classic Hodgkin disease. Blood. 2000;95(10):3020-3024. (Pubitemid 30321149)
    • (2000) Blood , vol.95 , Issue.10 , pp. 3020-3024
    • Seitz, V.1    Hummel, M.2    Marafioti, T.3    Anagnostopoulos, I.4    Assaf, C.5    Stein, H.6
  • 14
    • 78650223333 scopus 로고    scopus 로고
    • Tumorigenic potential of mononucleated small cells of Hodgkin lymphoma cell lines
    • Ikeda J, et al. Tumorigenic potential of mononucleated small cells of Hodgkin lymphoma cell lines. Am J Pathol. 2010;177(6):3081-3088.
    • (2010) Am J Pathol , vol.177 , Issue.6 , pp. 3081-3088
    • Ikeda, J.1
  • 15
    • 0023692636 scopus 로고
    • L-428 Reed-Sternberg cells and mononuclear Hodgkin's cells arise from a single cloned mononuclear cell
    • Newcom SR, Kadin ME, Phillips C. L-428 Reed-Sternberg cells and mononuclear Hodgkin's cells arise from a single cloned mononuclear cell. Int J Cell Cloning. 1988;6(6):417-431.
    • (1988) Int J Cell Cloning , vol.6 , Issue.6 , pp. 417-431
    • Newcom, S.R.1    Kadin, M.E.2    Phillips, C.3
  • 17
    • 0035254647 scopus 로고    scopus 로고
    • Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions
    • DOI 10.1182/blood.V97.3.818
    • Küppers R, Bräuninger A, Müschen M, Distler V, Hansmann ML, Rajewsky K. Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood. 2001;97(3):818-821. (Pubitemid 32113421)
    • (2001) Blood , vol.97 , Issue.3 , pp. 818-821
    • Kuppers, R.1    Brauninger, A.2    Muschen, M.3    Distler, V.4    Hansmann, M.-L.5    Rajewsky, K.6
  • 18
    • 67651092337 scopus 로고    scopus 로고
    • Circulating clonotypic B cells in classic Hodgkin lymphoma
    • Jones RJ, et al. Circulating clonotypic B cells in classic Hodgkin lymphoma. Blood. 2009;113(23):5920-5926.
    • (2009) Blood , vol.113 , Issue.23 , pp. 5920-5926
    • Jones, R.J.1
  • 19
    • 70449715493 scopus 로고    scopus 로고
    • Clonogenic B cells in classic Hodgkin lymphoma
    • Küppers R. Clonogenic B cells in classic Hodgkin lymphoma. Blood. 2009;114(18):3970-3971.
    • (2009) Blood , vol.114 , Issue.18 , pp. 3970-3971
    • Küppers, R.1
  • 20
    • 77958571409 scopus 로고    scopus 로고
    • The side population, as a precursor of Hodgkin and Reed-Sternberg cells and a target for nuclear factor-kappaB inhibitors in Hodgkin's lymphoma
    • Nakashima M, et al. The side population, as a precursor of Hodgkin and Reed-Sternberg cells and a target for nuclear factor-kappaB inhibitors in Hodgkin's lymphoma. Cancer Sci. 2010;101(11):2490-2496.
    • (2010) Cancer Sci , vol.101 , Issue.11 , pp. 2490-2496
    • Nakashima, M.1
  • 21
    • 77951869394 scopus 로고    scopus 로고
    • Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma
    • Shafer JA, et al. Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma. Leuk Lymphoma. 2010;51(5):870-880.
    • (2010) Leuk Lymphoma , vol.51 , Issue.5 , pp. 870-880
    • Shafer, J.A.1
  • 22
    • 48349133869 scopus 로고    scopus 로고
    • Side population cells in human cancers
    • Wu C, Alman BA. Side population cells in human cancers. Cancer Lett. 2008;268(1):1-9.
    • (2008) Cancer Lett , vol.268 , Issue.1 , pp. 1-9
    • Wu, C.1    Alman, B.A.2
  • 24
    • 0035863760 scopus 로고    scopus 로고
    • Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription
    • DOI 10.1182/blood.V97.2.496
    • Stein H, et al. Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Blood. 2001;97(2):496-501. (Pubitemid 32060336)
    • (2001) Blood , vol.97 , Issue.2 , pp. 496-501
    • Stein, H.1    Marafioti, T.2    Foss, H.-D.3    Laumen, H.4    Hummel, M.5    Anagnostopoulos, I.6    Wirth, T.7    Demel, G.8    Falini, B.9
  • 26
    • 0035155253 scopus 로고    scopus 로고
    • The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease
    • Torlakovic E, Tierens A, Dang HD, Delabie J. The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease. Am J Pathol. 2001;159(5):1807-1814. (Pubitemid 33062523)
    • (2001) American Journal of Pathology , vol.159 , Issue.5 , pp. 1807-1814
    • Torlakovic, E.1    Tierens, A.2    Dang, H.D.3    Delabie, J.4
  • 27
    • 84856732148 scopus 로고    scopus 로고
    • Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes
    • Ammerpohl O, et al. Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes. Leukemia. 2012;26(1):185-188.
    • (2012) Leukemia , vol.26 , Issue.1 , pp. 185-188
    • Ammerpohl, O.1
  • 28
    • 33644765802 scopus 로고    scopus 로고
    • Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma
    • DOI 10.1182/blood-2005-09-3765
    • Ushmorov A, et al. Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma. Blood. 2006;107(6):2493-2500. (Pubitemid 43345573)
    • (2006) Blood , vol.107 , Issue.6 , pp. 2493-2500
    • Ushmorov, A.1    Leithauser, F.2    Sakk, O.3    Weinhausel, A.4    Popov, S.W.5    Moller, P.6    Wirth, T.7
  • 29
    • 49449100160 scopus 로고    scopus 로고
    • Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma
    • Jundt F, et al. Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma. Leukemia. 2008;22(8):1587-1594.
    • (2008) Leukemia , vol.22 , Issue.8 , pp. 1587-1594
    • Jundt, F.1
  • 33
    • 47149098995 scopus 로고    scopus 로고
    • IL-21 is expressed in Hodgkin lymphoma and activates STAT5; evidence that activated STAT5 is required for Hodgkin lymphomagenesis
    • Scheeren FA, et al. IL-21 is expressed in Hodgkin lymphoma and activates STAT5; evidence that activated STAT5 is required for Hodgkin lymphomagenesis. Blood. 2008;111(9):4706-4715.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4706-4715
    • Scheeren, F.A.1
  • 40
    • 37149031657 scopus 로고    scopus 로고
    • Contribution of the Epstein-Barr virus to the molecular pathogenesis of Hodgkin lymphoma
    • DOI 10.1136/jcp.2007.050146
    • Kapatai G, Murray P. Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma. J Clin Pathol. 2007;60(12):1342- 1349. (Pubitemid 350252944)
    • (2007) Journal of Clinical Pathology , vol.60 , Issue.12 , pp. 1342-1349
    • Kapatai, G.1    Murray, P.2
  • 41
    • 0024328065 scopus 로고
    • Demonstration of monoclonal EBV genomes in Hodgkin's disease and KI-1-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization
    • Anagnostopoulos I, Herbst H, Niedobitek G, Stein H. Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1- positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization. Blood. 1989;74(2):810-816. (Pubitemid 19208827)
    • (1989) Blood , vol.74 , Issue.2 , pp. 810-816
    • Anagnostopoulos, I.1    Herbst, H.2    Niedobitek, G.3    Stein, H.4
  • 42
    • 0032536860 scopus 로고    scopus 로고
    • Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor
    • DOI 10.1093/emboj/17.6.1700
    • Kilger E, Kieser A, Baumann M, Hammerschmidt W. Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J. 1998;17(6):1700-1709. (Pubitemid 28119123)
    • (1998) EMBO Journal , vol.17 , Issue.6 , pp. 1700-1709
    • Kilger, E.1    Kieser, A.2    Baumann, M.3    Hammerschmidt, W.4
  • 43
    • 0031919997 scopus 로고    scopus 로고
    • The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease
    • DOI 10.1146/annurev.immunol.16.1.471
    • Küppers R, Rajewsky K. The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease. Annu Rev Immunol. 1998;16:471-493. (Pubitemid 28183373)
    • (1998) Annual Review of Immunology , vol.16 , pp. 471-493
    • Kuppers, R.1    Rajewsky, K.2
  • 44
    • 28844444995 scopus 로고    scopus 로고
    • Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas
    • DOI 10.1182/blood-2005-06-2342
    • Bechtel D, Kurth J, Unkel C, Küppers R. Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas. Blood. 2005;106(13):4345-4350. (Pubitemid 41775946)
    • (2005) Blood , vol.106 , Issue.13 , pp. 4345-4350
    • Bechtel, D.1    Kurth, J.2    Unkel, C.3    Kuppers, R.4
  • 45
    • 28844502383 scopus 로고    scopus 로고
    • Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus
    • DOI 10.1182/blood-2005-06-2341
    • Mancao C, Altmann M, Jungnickel B, Hammerschmidt W. Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus. Blood. 2005;106(13):4339-4344. (Pubitemid 41775945)
    • (2005) Blood , vol.106 , Issue.13 , pp. 4339-4344
    • Mancao, C.1    Altmann, M.2    Jungnickel, B.3    Hammerschmidt, W.4
  • 47
    • 0029086127 scopus 로고
    • Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin's disease
    • Weber-Matthiesen K, Deerberg J, Poetsch M, Grote W, Schlegelberger B. Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin's disease. Blood. 1995;86(4):1464-1468.
    • (1995) Blood , vol.86 , Issue.4 , pp. 1464-1468
    • Weber-Matthiesen, K.1    Deerberg, J.2    Poetsch, M.3    Grote, W.4    Schlegelberger, B.5
  • 50
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive nuclear factor-kap-paB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
    • Bargou RC, et al. Constitutive nuclear factor-kap-paB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest. 1997;100(12):2961-2969.
    • (1997) J Clin Invest , vol.100 , Issue.12 , pp. 2961-2969
    • Bargou, R.C.1
  • 53
    • 84861529287 scopus 로고    scopus 로고
    • Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma
    • Otto C, et al. Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma. Br J Haematol. 2012;157(6):702-708.
    • (2012) Br J Haematol , vol.157 , Issue.6 , pp. 702-708
    • Otto, C.1
  • 54
    • 77955866440 scopus 로고    scopus 로고
    • Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome
    • Steidl C, et al. Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome. Blood. 2010;116(3):418-427.
    • (2010) Blood , vol.116 , Issue.3 , pp. 418-427
    • Steidl, C.1
  • 58
    • 68249135153 scopus 로고    scopus 로고
    • Mutations of NFKBIA, encoding IkappaBalpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases
    • Lake A, et al. Mutations of NFKBIA, encoding IkappaBalpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases. Int J Cancer. 2009;125(6):1334-1342.
    • (2009) Int J Cancer , vol.125 , Issue.6 , pp. 1334-1342
    • Lake, A.1
  • 59
    • 66649112854 scopus 로고    scopus 로고
    • Frequent inactivation of A20 in B-cell lymphomas
    • Kato M, et al. Frequent inactivation of A20 in B-cell lymphomas. Nature. 2009;459(7247):712-716.
    • (2009) Nature , vol.459 , Issue.7247 , pp. 712-716
    • Kato, M.1
  • 60
    • 66049124247 scopus 로고    scopus 로고
    • TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
    • Schmitz R, et al. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med. 2009;206(5):981-989.
    • (2009) J Exp Med , vol.206 , Issue.5 , pp. 981-989
    • Schmitz, R.1
  • 61
    • 77955497092 scopus 로고    scopus 로고
    • Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma
    • Schmidt A, et al. Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma. Genes Chromosomes Cancer. 2010;49(9):803-809.
    • (2010) Genes Chromosomes Cancer , vol.49 , Issue.9 , pp. 803-809
    • Schmidt, A.1
  • 64
    • 79954606783 scopus 로고    scopus 로고
    • JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma
    • Van Roosbroeck K, et al. JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma. Blood. 2011;117(15):4056-4064.
    • (2011) Blood , vol.117 , Issue.15 , pp. 4056-4064
    • Van Roosbroeck, K.1
  • 65
    • 78650012116 scopus 로고    scopus 로고
    • Cooperative epigenetic modulation by cancer amplicon genes
    • Rui L, et al. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell. 2010;18(6):590-605.
    • (2010) Cancer Cell , vol.18 , Issue.6 , pp. 590-605
    • Rui, L.1
  • 66
    • 33646382121 scopus 로고    scopus 로고
    • Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation
    • Weniger MA, et al. Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. Oncogene. 2006;25(18):2679-2684.
    • (2006) Oncogene , vol.25 , Issue.18 , pp. 2679-2684
    • Weniger, M.A.1
  • 67
    • 78049370405 scopus 로고    scopus 로고
    • Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
    • Green MR, et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010;116(17):3268-3277.
    • (2010) Blood , vol.116 , Issue.17 , pp. 3268-3277
    • Green, M.R.1
  • 68
    • 79952816655 scopus 로고    scopus 로고
    • MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
    • Steidl C, et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature. 2011;471(7338):377-381.
    • (2011) Nature , vol.471 , Issue.7338 , pp. 377-381
    • Steidl, C.1
  • 71
    • 36148989576 scopus 로고    scopus 로고
    • Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6
    • DOI 10.1182/blood-2007-03-082511
    • Mottok A, Renné C, Willenbrock K, Hansmann ML, Bräuninger A. Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6. Blood. 2007;110(9):3387-3390. (Pubitemid 350106334)
    • (2007) Blood , vol.110 , Issue.9 , pp. 3387-3390
    • Mottok, A.1    Renne, C.2    Willenbrock, K.3    Hansmann, M.-L.4    Brauninger, A.5
  • 72
    • 53349174860 scopus 로고    scopus 로고
    • Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
    • Brune V, et al. Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J Exp Med. 2008;205(10):2251-2268.
    • (2008) J Exp Med , vol.205 , Issue.10 , pp. 2251-2268
    • Brune, V.1
  • 73
    • 73949120423 scopus 로고    scopus 로고
    • Mutations in the genes coding for the NF-kappaB regulating factors IkappaBalpha and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma
    • Schumacher MA, et al. Mutations in the genes coding for the NF-kappaB regulating factors IkappaBalpha and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma. Haematologica. 2010;95(1):153-157.
    • (2010) Haematologica , vol.95 , Issue.1 , pp. 153-157
    • Schumacher, M.A.1
  • 75
    • 70349279998 scopus 로고    scopus 로고
    • Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells
    • Salipante SJ, et al. Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells. Proc Natl Acad Sci U S A. 2009;106(35):14920-14925.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.35 , pp. 14920-14925
    • Salipante, S.J.1
  • 76
    • 79960685230 scopus 로고    scopus 로고
    • Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma
    • Saarinen S, et al. Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma. Blood. 2011;118(3):493-498.
    • (2011) Blood , vol.118 , Issue.3 , pp. 493-498
    • Saarinen, S.1
  • 77
    • 78649471895 scopus 로고    scopus 로고
    • A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
    • Enciso-Mora V, et al. A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nat Genet. 2010;42(12):1126-1130.
    • (2010) Nat Genet , vol.42 , Issue.12 , pp. 1126-1130
    • Enciso-Mora, V.1
  • 78
    • 78349241478 scopus 로고    scopus 로고
    • Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells
    • Stanelle J, Döring C, Hansmann ML, Küppers R. Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells. Blood. 2010;116(20):4202-4211.
    • (2010) Blood , vol.116 , Issue.20 , pp. 4202-4211
    • Stanelle, J.1    Döring, C.2    Hansmann, M.L.3    Küppers, R.4
  • 79
    • 0036566557 scopus 로고    scopus 로고
    • Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
    • DOI 10.1182/blood.V99.9.3398
    • Jundt F, Anagnostopoulos I, Förster R, Mathas S, Stein H, Dörken B. Activated Notch 1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood. 2002;99(9):3398-3403. (Pubitemid 34525322)
    • (2002) Blood , vol.99 , Issue.9 , pp. 3398-3403
    • Jundt, F.1    Anagnostopoulos, I.2    Forster, R.3    Mathas, S.4    Stein, H.5    Dorken, B.6
  • 80
    • 14944339657 scopus 로고    scopus 로고
    • Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR
    • DOI 10.1002/path.1725
    • Dutton A, Reynolds GM, Dawson CW, Young LS, Murray PG. Constitutive activation of phosphati-dyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. J Pathol. 2005;205(4):498-506. (Pubitemid 40361339)
    • (2005) Journal of Pathology , vol.205 , Issue.4 , pp. 498-506
    • Dutton, A.1    Reynolds, G.M.2    Dawson, C.W.3    Young, L.S.4    Murray, P.G.5
  • 81
    • 0042744812 scopus 로고    scopus 로고
    • MEK/ERK pathway is aberrantly active in Hodgkin disease: A signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival
    • DOI 10.1182/blood-2002-11-3507
    • Zheng B, et al. MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival. Blood. 2003;102(3):1019-1027. (Pubitemid 36917799)
    • (2003) Blood , vol.102 , Issue.3 , pp. 1019-1027
    • Zheng, B.1    Flumara, P.2    Li, Y.V.3    Georgakis, G.4    Snell, V.5    Younes, M.6    Vauthey, J.N.7    Carbone, A.8    Younes, A.9
  • 82
    • 18544380247 scopus 로고    scopus 로고
    • Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma
    • DOI 10.1182/blood-2004-10-4008
    • Renné C, Willenbrock K, Küppers R, Hansmann ML, Bräuninger A. Autocrine and paracrine activated receptor tyrosine kinases in classical Hodgkin lymphoma. Blood. 2005;105(10):4051-4059. (Pubitemid 40656155)
    • (2005) Blood , vol.105 , Issue.10 , pp. 4051-4059
    • Renne, C.1    Willenbrock, K.2    Kuppers, R.3    Hansmann, M.-L.4    Brauninger, A.5
  • 83
    • 77952190003 scopus 로고    scopus 로고
    • Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
    • Lamprecht B, et al. Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat Med. 2010;16(5):571-579.
    • (2010) Nat Med , vol.16 , Issue.5 , pp. 571-579
    • Lamprecht, B.1
  • 84
    • 61349196873 scopus 로고    scopus 로고
    • Hodgkin lymphoma cell lines are characterized by a specific miRNA expression profile
    • Gibcus JH, et al. Hodgkin lymphoma cell lines are characterized by a specific miRNA expression profile. Neoplasia. 2009;11(2):167-176.
    • (2009) Neoplasia , vol.11 , Issue.2 , pp. 167-176
    • Gibcus, J.H.1
  • 85
    • 70449341842 scopus 로고    scopus 로고
    • Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs
    • Van Vlierberghe P, et al. Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs. Br J Haematol. 2009;147(5):686-690.
    • (2009) Br J Haematol , vol.147 , Issue.5 , pp. 686-690
    • Van Vlierberghe, P.1
  • 86
    • 70449500709 scopus 로고    scopus 로고
    • Regulation of JAK2 by miR-135a: Prognostic impact in classic Hodgkin lymphoma
    • Navarro A, et al. Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma. Blood. 2009;114(14):2945-2951.
    • (2009) Blood , vol.114 , Issue.14 , pp. 2945-2951
    • Navarro, A.1
  • 87
    • 81355160436 scopus 로고    scopus 로고
    • MiR-17/106b seed family regulates p21 in Hodgkin's lymphoma
    • Gibcus JH, et al. MiR-17/106b seed family regulates p21 in Hodgkin's lymphoma. J Pathol. 2011;225(4):609-617.
    • (2011) J Pathol , vol.225 , Issue.4 , pp. 609-617
    • Gibcus, J.H.1
  • 88
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice
    • Costinean S, et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A. 2006;103(18):7024-7029.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.18 , pp. 7024-7029
    • Costinean, S.1
  • 90
    • 0032532634 scopus 로고    scopus 로고
    • Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged V(H) genes in different biopsies in relapsed Hodgkin's disease
    • Vockerodt M, et al. Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged VH genes in different biopsies in relapsed Hodgkin's disease. Blood. 1998;92(8):2899-2907. (Pubitemid 28469105)
    • (1998) Blood , vol.92 , Issue.8 , pp. 2899-2907
    • Vockerodt, M.1    Soares, M.2    Kanzler, H.3    Kuppers, R.4    Kube, D.5    Hansmann, M.-L.6    Diehl, V.7    Tesch, H.8
  • 91
    • 0028857781 scopus 로고
    • CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease
    • Carbone A, Gloghini A, Gruss HJ, Pinto A. CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease. Am J Pathol. 1995;147(4):912-922.
    • (1995) Am J Pathol , vol.147 , Issue.4 , pp. 912-922
    • Carbone, A.1    Gloghini, A.2    Gruss, H.J.3    Pinto, A.4
  • 92
    • 0031901617 scopus 로고    scopus 로고
    • Costimulatory molecules (CD80 and CD86) on Reed-Sternberg cells are associated with the proliferation of background T cells in Hodgkin's disease
    • Nozawa Y, Wakasa H, Abe M. Costimulatory molecules (CD80 and CD86) on Reed-Sternberg cells are associated with the proliferation of background T cells in Hodgkin's disease. Pathol Int. 1998;48(1):10-14.
    • (1998) Pathol Int , vol.48 , Issue.1 , pp. 10-14
    • Nozawa, Y.1    Wakasa, H.2    Abe, M.3
  • 94
    • 42449147063 scopus 로고    scopus 로고
    • PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
    • Yamamoto R, et al. PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood. 2008;111(6):3220-3224.
    • (2008) Blood , vol.111 , Issue.6 , pp. 3220-3224
    • Yamamoto, R.1
  • 97
    • 0028910228 scopus 로고
    • Transforming growth factor beta 1 messenger RNA in Reed-Sternberg cells in nodular sclerosing Hodgkin's disease
    • Newcom SR, Gu L. Transforming growth factor beta 1 messenger RNA in Reed-Sternberg cells in nodular sclerosing Hodgkin's disease. J Clin Pathol. 1995;48(2):160-163.
    • (1995) J Clin Pathol , vol.48 , Issue.2 , pp. 160-163
    • Newcom, S.R.1    Gu, L.2
  • 99
    • 77956646155 scopus 로고    scopus 로고
    • Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma
    • Engert A, et al. Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma. N Engl J Med. 2010;363(7):640-652.
    • (2010) N Engl J Med , vol.363 , Issue.7 , pp. 640-652
    • Engert, A.1
  • 100
    • 56149083907 scopus 로고    scopus 로고
    • Involved-node radiotherapy in early-stage Hodgkin's lymphoma
    • Definition and guidelines of the German Hodgkin Study Group (GHSG)
    • Eich HT, et al. Involved-node radiotherapy in early-stage Hodgkin's lymphoma. Definition and guidelines of the German Hodgkin Study Group (GHSG). Strahlenther Onkol. 2008;184(8):406-410.
    • (2008) Strahlenther Onkol , vol.184 , Issue.8 , pp. 406-410
    • Eich, H.T.1
  • 103
    • 0036175693 scopus 로고    scopus 로고
    • The achievements of the EORTC Lymphoma Group
    • European Organisation for Research and Treatment of Cancer
    • Raemaekers J, et al. The achievements of the EORTC Lymphoma Group. European Organisation for Research and Treatment of Cancer. Eur J Cancer. 2002;38:S107-S113.
    • (2002) Eur J Cancer , vol.38
    • Raemaekers, J.1
  • 104
    • 59949089090 scopus 로고    scopus 로고
    • ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin's lymphoma: Results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial
    • Federico M, et al. ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin's lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial. J Clin Oncol. 2009;27(5):805-811.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 805-811
    • Federico, M.1
  • 105
    • 79960583495 scopus 로고    scopus 로고
    • ABVD versus BEACOPP for Hodgkin's lymphoma when high-dose salvage is planned
    • Viviani S, et al. ABVD versus BEACOPP for Hodgkin's lymphoma when high-dose salvage is planned. N Engl J Med. 2011;365(3):203-212.
    • (2011) N Engl J Med , vol.365 , Issue.3 , pp. 203-212
    • Viviani, S.1
  • 106
    • 84860833364 scopus 로고    scopus 로고
    • Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): A randomised, open-label, phase 3 non-inferiority trial
    • Engert A, et al. Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial. Lancet. 2012;379(9828):1791-1799.
    • (2012) Lancet , vol.379 , Issue.9828 , pp. 1791-1799
    • Engert, A.1
  • 109
    • 38049162295 scopus 로고    scopus 로고
    • Rituximab in relapsed lymphocyte-predominant Hodgkin lymphoma: Long-term results of a phase 2 trial by the German Hodgkin Lymphoma Study Group (GHSG)
    • Schulz H, et al. Rituximab in relapsed lymphocyte-predominant Hodgkin lymphoma: long-term results of a phase 2 trial by the German Hodgkin Lymphoma Study Group (GHSG). Blood. 2008;111(1):109-111.
    • (2008) Blood , vol.111 , Issue.1 , pp. 109-111
    • Schulz, H.1
  • 112
    • 0035725231 scopus 로고    scopus 로고
    • 18F]-fluorodeoxyglucose after first-line treatment distinguish Hodgkin's disease patients who need additional therapy from others in whom additional therapy would mean avoidable toxicity?
    • DOI 10.1046/j.1365-2141.2001.03169.x
    • Spaepen K, et al. Can positron emission tomography with [(18)F]-fluorodeoxyglucose after first-line treatment distinguish Hodgkin's disease patients who need additional therapy from others in whom additional therapy would mean avoidable toxicity? Br J Haematol. 2001;115(2):272-278. (Pubitemid 34203488)
    • (2001) British Journal of Haematology , vol.115 , Issue.2 , pp. 272-278
    • Spaepen, K.1    Stroobants, S.2    Dupont, P.3    Thomas, J.4    Vandenberghe, P.5    Balzarini, J.6    De Wolf-Peeters, C.7    Mortelmans, L.8    Verhoef, G.9
  • 114
    • 80054101992 scopus 로고    scopus 로고
    • Results of a pivotal phase II study of Brentuximab Vedotin (SGN-35) for patients with relapsed or refractory Hodgkin lymphoma
    • abstr 8031
    • Younes A, et al. Results of a pivotal phase II study of Brentuximab Vedotin (SGN-35) for patients with relapsed or refractory Hodgkin lymphoma. J Clin Oncol. 2011;29(suppl; abstr 8031).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Younes, A.1
  • 115
    • 78049515807 scopus 로고    scopus 로고
    • Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
    • Younes A, et al. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med. 2010;363(19):1812-1821.
    • (2010) N Engl J Med , vol.363 , Issue.19 , pp. 1812-1821
    • Younes, A.1
  • 116
    • 84873983455 scopus 로고    scopus 로고
    • Affimed Therapeutics AG. NIH Web site. Updated June 26, 2011. Accessed April 10, 2012
    • Affimed Therapeutics AG. A Study to Assess AFM13 in Patients With Hodgkin Lymphoma. NIH Web site. http://clinicaltrials.gov/ct2/show/ NCT01221571. Updated June 26, 2011. Accessed April 10, 2012.
    • A Study to Assess AFM13 in Patients with Hodgkin Lymphoma
  • 117
    • 84873982294 scopus 로고    scopus 로고
    • Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea. NIH Web site. Updated September 3, 2010. Accessed April 10, 2012
    • Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea. Study of Ofatumumab and ESHAP for the Treatment of Hodgkin's Lymphoma. NIH Web site. http://clinicaltrials.gov/ct2/show/ NCT01195766. Updated September 3, 2010. Accessed April 10, 2012.
    • Study of Ofatumumab and ESHAP for the Treatment of Hodgkin's Lymphoma
  • 118
    • 74049104854 scopus 로고    scopus 로고
    • Lenalidomide in patients with refractory or multiple relapsed Hodgkin lymphoma
    • Böll B, et al. Lenalidomide in patients with refractory or multiple relapsed Hodgkin lymphoma. Br J Haematol. 2009;148(3):480-482.
    • (2009) Br J Haematol , vol.148 , Issue.3 , pp. 480-482
    • Böll, B.1
  • 121
    • 77951559617 scopus 로고    scopus 로고
    • A phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma
    • Johnston PB, et al. A phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma. Am J Hematol. 2010;85(5):320-324.
    • (2010) Am J Hematol , vol.85 , Issue.5 , pp. 320-324
    • Johnston, P.B.1
  • 122
    • 84867150047 scopus 로고    scopus 로고
    • Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma
    • published online ahead of print doi:10.1182/blood-2012-05-428896
    • Tiacci E, et al. Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma [published online ahead of print]. Blood. doi:10.1182/blood-2012-05-428896.
    • Blood
    • Tiacci, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.