Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma

Blood

Volumn 99, Issue 4, 2002, Pages 1474-1477

  Martín Subero, José I ^a,b,c,d,e,f   Gesk, Stefan ^a,b,c,d,e,f   Harder, Lana ^a,b,c,d,e,f   Sonoki, Takashi ^a,b,c,d,e,f   Tucker, Philip W ^a,b,c,d,e,f   Schlegelberger, Brigitte ^a,b,c,d,e,f   Grote, Werner ^a,b,c,d,e,f   Novo, Francisco J ^a,b,c,d,e,f   Calasanz, María J ^a,b,c,d,e,f   Hansmann, Martin L ^a,b,c,d,e,f   Dyer, Martin J S ^a,b,c,d,e,f   Siebert, Reiner ^a,b,c,d,e,f  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF NAVARRA   (Spain)

^c KUMAMOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^e GOETHE UNIVERSITY   (Germany)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CENTROMERE; CHILD; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE LOCUS; GENE TARGETING; HODGKIN DISEASE; HUMAN; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; ONCOGENE; PRIORITY JOURNAL;

EID: 0037082493     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.4.1474     Document Type: Article

References (26)

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10. + Hodgkin cells
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15. The use of real-time quantitative polymerase chain reaction and comparative genomic hybridization to identify amplification of the REL gene in follicular lymphoma
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21. c-Rel is essential for B lymphocyte survival and cell cycle progression
22. Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
23. Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB
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26. Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2