Trans-10, cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: Role of mTOR and ERK signaling

Journal of Lipid Research

Volumn 46, Issue 5, 2005, Pages 885-895

  Chung, Soonkyu ^a   Brown, Jonathan Mark ^b   Sandberg, Maria Boysen ^c   McIntosh, Michael ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Adipose differentiation related protein; Conjugated linoleic acid; Mammalian target of rapamycin; Mitogen activated protein kinase kinase extracellular signal related kinase signaling; Perilipin; Triglycerides

Indexed keywords

ADIPOPHILIN; CONJUGATED LINOLEIC ACID; FAT DROPLET; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PERILIPIN; PERILIPIN A; PROTEIN DERIVATIVE; S6 KINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ADFP PROTEIN, HUMAN; MEMBRANE PROTEIN; PHOSPHOPROTEIN; PRIMER DNA; PROTEIN KINASE; RAPAMYCIN;

ADIPOCYTE; ADULT; ARTICLE; CONTROLLED STUDY; CYTOSOL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPOLYSIS; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; ADOLESCENT; DRUG EFFECT; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADIPOCYTES; ADOLESCENT; ADULT; BASE SEQUENCE; DNA PRIMERS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; LINOLEIC ACIDS, CONJUGATED; LIPOLYSIS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; PROTEIN KINASES; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 27244434149     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M400476-JLR200     Document Type: Article

References (47)

1. Ha, Y., N. Grimm, and M. Pariza. 1987. Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis. 8: 1881-1887.
2. Belury, M. 2002. Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J. Nutr. 132: 2995-2998.
3. Evans, M., J. M. Brown, and M. McIntosh. 2002. Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J. Nutr. Biochem. 13: 508-516.
4. Brown, J. M., and M. McIntosh. 2003. Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. J. Nutr. 133: 3041-3046.
5. Park, Y., K. Albright, W. Liu, J. Storkson, M. Cook, and M. Pariza. 1997. Effect of conjugated linoleic acid on body composition in mice. Lipids. 32: 853-858.
6. Park, Y., J. Storkson, K. Albright, W. Liu, M. Cook, and M. Pariza. 1999. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. 34: 235-241.
7. Park, Y., K. Albright, J. Storkson, W. Liu, and M. Pariza. 1999. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids. 33: 243-248.
8. Delany, J., F. Blohm, A. Truett, J. Scimeca, and D. West. 1999. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am. J. Physiol. 276: R1172-R1179.
9. Ostrowska, E., M. Muralitharian, R. Cross, D. Bauman, and F. Dunshea. 1999. Dietary conjugated linoleic acid increases lean tissue and decreases body fat deposition in growing pigs. J. Nutr. 129: 2037-2042.
10. Brown, J. M., Y-D. Halvorsen, R. Lea-Currie, C. Geigerman, and M. McIntosh. 2001. Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells isolated from human adipose tissue. J. Nutr. 131: 2316-2321.
11. Brown, J. M., M. Sandberg-Boysen, S. Jensen, R. Morrison, J. Storkson, R. Lea-Currie, M. Pariza, S. Mandrup, and M. McIntosh. 2003. Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes. J. Lipid Res. 44: 1287-1300.
12. Brown, J. M., M. S. Boysen, S. Chung, O. Fabiyi, R. Morrison, S. Mandrup, and M. McIntosh. 2004. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J. Biol. Chem. 279: 26735-26747.
13. Landos, C., D. Brasaemle, C. Schultz, J. Segrest, and A. Kimmel. 1999. Perilipins, ADRP, and other proteins that associate with intracellular lipid droplets in animal cells. Cell Dev. Biol. 10: 51-58.
14. Brasaemle, D., D. Levin, D. Adler-Wailes, and C. Londos. 2000. The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone sensitive lipase to the surface of lipid storage droplets. Biochim. Biophys. Acta. 1483: 251-262.
15. Souza, S., L. de Vargas, M. Yamamoto, P. Lien, M. Franciosa, L. Moss, and A. Greenberg. 1998. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J. Biol. Chem. 273: 24665-24669.
16. Tansey, J., C. Sztalryd, J. Gruia-Grav, D. Roush, J. Gavrilova, M. Reitman, C-X. Deng, C. Li, A. Kimmel, and C. Londos. 2001. Perilipin ablation results in a lean mouse with aberrant lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA 98: 6494-6499.
17. Martinez-Botas, J., J. Anderson, D. Tessier, A. Lapillonne, B. Chang, M. Quast, D. Gorenstein, K. Chen, and L. Chan. 2000. Absence of perilipin results in leanness and reverses obesity in Lepr (db/db) mice. Nat. Genet. 26: 474-479.
18. Clifford, G., C. Londos, F. Kraemer, and R. Vernon. 2000. Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes. J. Biol. Chem. 275: 5011-5015.
19. Sztalryd, C., G. Xu, H. Dorward, J. Tansey, J. Contreras, A. Kimmel, and C. Landos. 2003. Perilipin A is essential for the translocation of hormone sensitive lipase during lipolytic activation. J. Cell Biol. 161: 1093-1103.
20. Brasaemle, D., T. Barber, N. Wolins, G. Serrero, E. Blanchette-Mackie, and C. Londos. 1997. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 38: 2249-2262.
21. Heid, H., R. Moll, I. Schwetlick, H. Rackwitz, and T. Keenan. 1998. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res. 294: 309-321.
22. Gao, J., and G. Serrero. 1999. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. J. Biol. Chem. 274: 16825-16830.
23. Serrero, G., F. Frolov, K. Schroeder, L. Tanaka, and L. Gelhaar. 2000. Adipose differentiation related protein: expression, purification of recombinant protein in Escherichia coli and characterization of its fatty acid binding properties. Biochim. Biophys. Acta. 1488: 245-254.
24. Guan, H., Y. Li, M. Jensen, C. Newfard, C. Steppan, and M. Lazar. 2002. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat. Med. 8: 1122-1128.
25. Brasaemle, D., B. Rubin, I. Harten, and J. Gruia-Guy. 2000. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J. Biol. Chem. 275: 38486-38493.
26. Dalen, K., K. Schoonjans, S. Ulven, M. Weedon-Fekjaer, T. Bentzen, A. Koutnikova, J. Auwerx, and H. Nebb. 2004. Adipose tissue expression of lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-γ. Diabetes. 53: 1243-1252.
27. Tokunaga, C., K. Yoshino, and K. Yonezawa. 2004. mTOR integrates amino acid- and energy-sensing pathways. Biochem. Biophys. Res. Commun. 313: 443-446.
28. Hay, N., and N. Sonnenberg. 2004. Upstream and downstream of mTOR. Genes Dev. 18: 1926-1945.
29. Terada, N., H. Patel, K. Takase, K. Kohno, A. Nairn, R. Pearson, and G. Thomas. 1994. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. USA. 91: 11477-11481.
30. Thom, E., J. Wadstein, and O. Gudmundsen. 2001. Conjugated linoleic acid reduces body fat in healthy exercising humans. J. Int. Med. Res. 29: 392-396.
31. Blankson, H., J. Stakkestad, H. Fagertun, E. Thom, J. Wadstein, and O. Gudmundsen. 2000. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J. Nutr. 130: 2943-2948.
32. Riserus, U., P. Arner, K. Brismar, and B. Vessby. 2002. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 25: 1516-1521.
33. Okazaki, H., J. Osuga, Y. Tamura, N. Yahagi, S. Tomita, F. Shionoiri, Y. Iizuka, K. Ohashi, K. Harada, S. Kimura, T. Gotoda, H. Shimano, Y. Nobuhiro, and S. Ishibashi. 2002. Lipolysis in the absence of hormone-sensitive lipase. Diabetes. 51: 3368-3375.
34. Soni, K., R. Lehner, R. Metalnikov, P. O'Donnell, M. Semache, W. Gao, K. Ashman, A. Pshezhetsky, and G. Mitchell. 2004. Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. J. Biol. Chem. 279: 40683-40689.
35. Holm, C. 2003. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem. Soc. Trans. 31: 1120-1124.
36. Greenberg, A., W. Shen, K. Muliro, S. Patel, S. Souza, R. Roth, and F. Kraemer. 2001. Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. J. Biol. Chem. 276: 45456-45461.
37. Zimmerman, R., J. Strauss, G. Haemmerle, G. Schoiswohl, R. Birner-Gruenberger, M. Riederer, A. Lass, G. Neuberger, F. Esienhaber, A. Hermetter, R. Zechner. 2004. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 306: 1383-1386.
38. Villena, J., S. Roy, E. Sarkadi-Nagy, K. Kim, and H. S. Sul. 2004. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids. J. Biol. Chem. 279: 47066-47075.
39. Zhang, H., M. Halbleib, F. Ahmad, V. Manganiello, and A. Greensberg. 2002. Tumor necrosis factor alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes. 51: 2929-2935.
40. Cohen, A., B. Razani, W. Schubert, T. Williams, X. Wang, P. Iyengar, D. Brasaemle, P. Scherer, and M. Lisanti. 2004. Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes. 53: 1261-1270.
41. Imamura, M., T. Inoguchi, S. Ikuyama, S. Taniguchi, K. Kobayashi, N. Nakashima, and H. Nawata. 2002. ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Am. J. Physiol. Endocrinol. Metab. 283: E775-E783.
42. Gao, J., H. Ye, and G. Serrero. 2000. Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids. J. Cell. Physiol. 182: 297-302.
43. Jiang, H., and G. Serrero. 1992. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc. Natl. Acad. Sci. USA. 89: 7856-7860.
44. Gatlin, L., M. See, D. Larick, X. Lin, and J. Odle. 2002. Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality. J. Nutr. 132: 3105-3112.
45. Gingras, A., B. Raught, and N. Soneburg. 2001. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15: 807-826.
46. Tuxworth, W., A. Saghir, L. Spruill, D. Menick, and P. McDermott. 2004. Regulation of protein synthesis by eIF4E of secondary structure in the 5′-untranslated region of mRNA. Biochem. J. 378: 73-82.
47. Roh, C., J. Han, A. Tzatsos, and K. Kandror. 2003. Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes. Am. J. Physiol. Endocrinol. Metab. 284: E322-E330.