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Volumn 18, Issue 2, 2007, Pages 152-156

The role of perilipin in human obesity and insulin resistance

Author keywords

Metabolic syndrome; Nutrigenomics; Obesity; Perilipin; Women

Indexed keywords

GLUCOSE; PERILIPIN; PHOSPHOLIPID;

EID: 33947109987     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e328086aeab     Document Type: Review
Times cited : (38)

References (37)
  • 1
    • 0032742418 scopus 로고    scopus 로고
    • The disease burden associated with overweight and obesity
    • Must A, Spadano J, Coakley EH, et al. The disease burden associated with overweight and obesity. JAMA 1999; 282:1523-1529.
    • (1999) JAMA , vol.282 , pp. 1523-1529
    • Must, A.1    Spadano, J.2    Coakley, E.H.3
  • 2
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348:1625-1638.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 5
    • 33748797136 scopus 로고    scopus 로고
    • Genes, environment and the value of prospective cohort studies
    • • This review underscores the strengths of prospective cohort studies and the establishment of large collaborative efforts for understanding gene-environment interactions in complex human disease
    • Manolio TA, Bailey-Wilson JE, Collins FS. Genes, environment and the value of prospective cohort studies. Nat Rev Genet 2006; 7:812-820. • This review underscores the strengths of prospective cohort studies and the establishment of large collaborative efforts for understanding gene-environment interactions in complex human disease.
    • (2006) Nat Rev Genet , vol.7 , pp. 812-820
    • Manolio, T.A.1    Bailey-Wilson, J.E.2    Collins, F.S.3
  • 6
    • 33749058310 scopus 로고    scopus 로고
    • A proposed model of fat packaging by exchangeable lipid droplet proteins
    • Wolins NE, Brasaemle DL, Bickel PE. A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett 2006; 580:5484-5491.
    • (2006) FEBS Lett , vol.580 , pp. 5484-5491
    • Wolins, N.E.1    Brasaemle, D.L.2    Bickel, P.E.3
  • 7
    • 29044440372 scopus 로고    scopus 로고
    • Signalling mechanisms regulating lipolysis
    • Carmen GY, Victor SM. Signalling mechanisms regulating lipolysis. Cell Signal 2006; 18:401-408.
    • (2006) Cell Signal , vol.18 , pp. 401-408
    • Carmen, G.Y.1    Victor, S.M.2
  • 9
    • 29244465509 scopus 로고    scopus 로고
    • Human fat cell lipolysis: Biochemistry, regulation and clinical role
    • Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab 2005; 19:471-482.
    • (2005) Best Pract Res Clin Endocrinol Metab , vol.19 , pp. 471-482
    • Arner, P.1
  • 11
    • 0034623950 scopus 로고    scopus 로고
    • Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
    • Brasaemle DL, Rubin B, Harten IA, et al. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem 2000; 275:38486-38493.
    • (2000) J Biol Chem , vol.275 , pp. 38486-38493
    • Brasaemle, D.L.1    Rubin, B.2    Harten, I.A.3
  • 12
    • 33744962185 scopus 로고    scopus 로고
    • Hormonal control of reversible translocation of perilipin B to the plasma membrane in primary human adipocytes
    • Aboulaich N, Vener AV, Stralfors P. Hormonal control of reversible translocation of perilipin B to the plasma membrane in primary human adipocytes. J Biol Chem 2006; 281:11446-11449.
    • (2006) J Biol Chem , vol.281 , pp. 11446-11449
    • Aboulaich, N.1    Vener, A.V.2    Stralfors, P.3
  • 13
    • 0027145164 scopus 로고
    • Isolation of cDNAs for perilipins A and B: Sequence and expression of lipid droplet-associated proteins of adipocytes
    • Greenberg AS, Egan JJ, Wek SA, et al. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc Natl Acad Sci U S A 1993; 90:12035-12039.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 12035-12039
    • Greenberg, A.S.1    Egan, J.J.2    Wek, S.A.3
  • 14
    • 33745607386 scopus 로고    scopus 로고
    • Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes: Segregation of specific proteins and functions
    • Ortegren U, Yin L, Ost A, et al. Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes: segregation of specific proteins and functions. FEBS J 2006; 273:3381-3392.
    • (2006) FEBS J , vol.273 , pp. 3381-3392
    • Ortegren, U.1    Yin, L.2    Ost, A.3
  • 15
    • 14344268795 scopus 로고    scopus 로고
    • Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
    • Tansey JT, Sztalryd C, Gruia-Gray J, et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A 2001; 98:6494-6499.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6494-6499
    • Tansey, J.T.1    Sztalryd, C.2    Gruia-Gray, J.3
  • 16
    • 0033671833 scopus 로고    scopus 로고
    • Absence of perilipin results in leanness and reverses obesity in Lepr (db/db) mice
    • Martinez-Botas J, Anderson JB, Tessier D, et al. Absence of perilipin results in leanness and reverses obesity in Lepr (db/db) mice. Nat Genet 2000; 26:474-479.
    • (2000) Nat Genet , vol.26 , pp. 474-479
    • Martinez-Botas, J.1    Anderson, J.B.2    Tessier, D.3
  • 17
    • 0037040911 scopus 로고    scopus 로고
    • Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system
    • Souza SC, Muliro KV, Liscum L, et al. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem 2002; 277:8267-8272.
    • (2002) J Biol Chem , vol.277 , pp. 8267-8272
    • Souza, S.C.1    Muliro, K.V.2    Liscum, L.3
  • 18
    • 0347065339 scopus 로고    scopus 로고
    • Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis
    • Zhang HH, Souza SC, Muliro KV, et al. Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. J Biol Chem 2003; 278:51535-51542.
    • (2003) J Biol Chem , vol.278 , pp. 51535-51542
    • Zhang, H.H.1    Souza, S.C.2    Muliro, K.V.3
  • 19
    • 33744944318 scopus 로고    scopus 로고
    • Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation- dependent and -independent mechanisms
    • Miyoshi H, Souza SC, Zhang HH, et al. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation- dependent and -independent mechanisms. J Biol Chem 2006; 281:15837-15844.
    • (2006) J Biol Chem , vol.281 , pp. 15837-15844
    • Miyoshi, H.1    Souza, S.C.2    Zhang, H.H.3
  • 20
    • 33747874325 scopus 로고    scopus 로고
    • Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol
    • Ren T, He J, Jiang H, et al. Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol. J Mol Endocrinol 2006; 37:175-183.
    • (2006) J Mol Endocrinol , vol.37 , pp. 175-183
    • Ren, T.1    He, J.2    Jiang, H.3
  • 21
    • 30044438117 scopus 로고    scopus 로고
    • Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase
    • Moore HP, Silver RB, Mottillo EP, et al. Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J Biol Chem 2005; 280:43109-43120.
    • (2005) J Biol Chem , vol.280 , pp. 43109-43120
    • Moore, H.P.1    Silver, R.B.2    Mottillo, E.P.3
  • 22
    • 0036230486 scopus 로고    scopus 로고
    • Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p
    • Mori Y, Otabe S, Dina C, et al. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 2002; 51:1247-1255.
    • (2002) Diabetes , vol.51 , pp. 1247-1255
    • Mori, Y.1    Otabe, S.2    Dina, C.3
  • 23
    • 0033942570 scopus 로고    scopus 로고
    • A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans
    • Duggirala R, Blangero J, Almasy L, et al. A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am J Hum Genet 2000; 66:1237-1245.
    • (2000) Am J Hum Genet , vol.66 , pp. 1237-1245
    • Duggirala, R.1    Blangero, J.2    Almasy, L.3
  • 24
    • 0033976374 scopus 로고    scopus 로고
    • Genome-wide search for genes related to the fat-free body mass in the Quebec family study
    • Chagnon YC, Borecki IB, Perusse L, et al. Genome-wide search for genes related to the fat-free body mass in the Quebec family study. Metabolism 2000; 49:203-207.
    • (2000) Metabolism , vol.49 , pp. 203-207
    • Chagnon, Y.C.1    Borecki, I.B.2    Perusse, L.3
  • 25
    • 0038235846 scopus 로고    scopus 로고
    • Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis
    • Mottagui-Tabar S, Ryden M, Lofgren P, et al. Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Diabetologia 2003; 46:789-797.
    • (2003) Diabetologia , vol.46 , pp. 789-797
    • Mottagui-Tabar, S.1    Ryden, M.2    Lofgren, P.3
  • 26
    • 4844229398 scopus 로고    scopus 로고
    • Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women
    • Qi L, Corella D, Sorli JV, et al. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clin Genet 2004; 66:299-310.
    • (2004) Clin Genet , vol.66 , pp. 299-310
    • Qi, L.1    Corella, D.2    Sorli, J.V.3
  • 27
    • 16644390197 scopus 로고    scopus 로고
    • Gender-specific association of a perilipin gene haplotype with obesity risk in a white population
    • Qi L, Shen H, Larson I, et al. Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes Res 2004; 12:1758-1765.
    • (2004) Obes Res , vol.12 , pp. 1758-1765
    • Qi, L.1    Shen, H.2    Larson, I.3
  • 28
    • 21544449457 scopus 로고    scopus 로고
    • Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population
    • Qi L, Tai ES, Tan CE, et al. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J Mol Med 2005; 83:448-456.
    • (2005) J Mol Med , vol.83 , pp. 448-456
    • Qi, L.1    Tai, E.S.2    Tan, C.E.3
  • 29
    • 33747142750 scopus 로고    scopus 로고
    • Study of the impact of perilipin polymorphisms in a French population
    • Meirhaeghe A, Thomas S, Ancot F, et al. Study of the impact of perilipin polymorphisms in a French population. J Negat Results Biomed 2006; 5:10.
    • (2006) J Negat Results Biomed , vol.5 , pp. 10
    • Meirhaeghe, A.1    Thomas, S.2    Ancot, F.3
  • 30
    • 24344504484 scopus 로고    scopus 로고
    • Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
    • Corella D, Qi L, Sorli JV, et al. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J Clin Endocrinol Metab 2005; 90:5121-5126.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5121-5126
    • Corella, D.1    Qi, L.2    Sorli, J.V.3
  • 31
    • 33746456909 scopus 로고    scopus 로고
    • The 11482G>A polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes
    • Kang ES, Cha BS, Kim HJ, et al. The 11482G>A polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes. Diabetes Care 2006; 29:1320-1324.
    • (2006) Diabetes Care , vol.29 , pp. 1320-1324
    • Kang, E.S.1    Cha, B.S.2    Kim, H.J.3
  • 32
    • 33745208246 scopus 로고    scopus 로고
    • Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity
    • Abidov MT, del Rio MJ, Ramazanov TZ, et al. Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity. Bull Exp Biol Med 2006; 141:343-346.
    • (2006) Bull Exp Biol Med , vol.141 , pp. 343-346
    • Abidov, M.T.1    del Rio, M.J.2    Ramazanov, T.Z.3
  • 33
    • 33750449358 scopus 로고    scopus 로고
    • Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss
    • Jang Y, Kim OY, Lee JH, et al. Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss. Int J Obes (Lond) 2006; 30:1601-1608.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1601-1608
    • Jang, Y.1    Kim, O.Y.2    Lee, J.H.3
  • 34
    • 22544467290 scopus 로고    scopus 로고
    • Adipose tissue fatty acid metabolism and cardiovascular disease
    • Frayn KN, Fielding BA, Karpe F. Adipose tissue fatty acid metabolism and cardiovascular disease. Curr Opin Lipidol 2005; 16:409-415.
    • (2005) Curr Opin Lipidol , vol.16 , pp. 409-415
    • Frayn, K.N.1    Fielding, B.A.2    Karpe, F.3
  • 35
    • 33746386861 scopus 로고    scopus 로고
    • Corella D, Qi L, Tai ES, et al. Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care 2006; 29:1313-1319. • First report to demonstrate a significant interaction between insulin resistance and diet modulated by perilipin genetic variation.
    • Corella D, Qi L, Tai ES, et al. Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care 2006; 29:1313-1319. • First report to demonstrate a significant interaction between insulin resistance and diet modulated by perilipin genetic variation.
  • 37
    • 33748168883 scopus 로고    scopus 로고
    • Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals
    • Yamada Y, Ando F, Shimokata H. Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals. Int J Mol Med 2006; 18:119-127.
    • (2006) Int J Mol Med , vol.18 , pp. 119-127
    • Yamada, Y.1    Ando, F.2    Shimokata, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.