Contextual control over expression of fear is affected by cortisol

Frontiers in Behavioral Neuroscience

Volumn , Issue SEPTEMBER, 2012, Pages

  van Ast, Vanessa A ^a   Vervliet, Bram ^b   Kindt, Merel ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Anxiety Disorders; Context; Cortisol; Fear conditioning; Fear potentiated startle; Sex differences

Indexed keywords

HYDROCORTISONE;

ADULT; ANXIETY DISORDER; ARTICLE; BEHAVIOR CONTROL; CONTROLLED STUDY; ELECTROSTIMULATION; FEAR; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL STRESS; NEUROMODULATION; RATING SCALE; SEX DIFFERENCE; SKIN CONDUCTANCE; STARTLE REFLEX; STATE TRAIT ANXIETY INVENTORY; STIMULUS GENERALIZATION;

EID: 84867036795     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2012.00067     Document Type: Article

References (111)

1. Abercrombie, H.C., Kalin, N.H., Thurow, M.E., Rosenkranz, M.A., and Davidson, R.J. (2003). Cortisol variation in humans affects memory for emotionally laden and neutral information. BehavioralNeuroscience 117, 505-516.
2. Acheson, D.T., Gresack, J.E., and Risbrough, V.B. (2011). Hippocampal dysfunction effects on context memory: Possible etiology for post-traumatic stress disorder. Neuropharmacology, 674-685.
3. Baas, J.M., Nugent, M., Lissek, S., Pine, D.S., and Grillon, C. (2004). Fear conditioning in virtual reality contexts: a new tool for the study of anxiety. Biological Psychiatry 55, 1056-1060.
4. Baeyens, F., Vansteenwegen, D., Hermans, D., Vervliet, B., and Eelen, P. (2001). Sequential and simultaneous feature positive discriminations: occasion setting and configural learning in human Pavlovian conditioning. Journal of Experimental Psychology: Animal Behavior Processes 27, 279-295.
5. Baeyens, F., Vervliet, B., Vansteenwegen, D., Beckers, T., Hermans, D., and Eelen, P. (2004). Simultaneous and sequential Feature Negative discriminations: Elemental learning and occasion setting in human Pavlovian conditioning. Learning and Motivation 35, 136-166.
6. Bangasser, D.A., and Shors, T.J. (2004). Acute stress impairs trace eye blink conditioning in females without altering the unconditioned response. Neurobiology of learning and memory 82, 57-60.
7. Barbas, H., Saha, S., Rempel-Clower, N., and Ghashghaei, T. (2003). Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression. BMC Neuroscience 4, 25.
8. Blumenthal, T.D., Cuthbert, B.N., Filion, D.L., Hackley, S., Lipp, O.V., and Van Boxtel, A. (2005). Committee report: Guidelines for human startle eyeblink electromyographic studies. Psychophysiology 42, 1-15.
9. Bouton, M.E. (2002). Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biological Psychiatry 52, 976-986.
10. Bouton, M.E., and Swartzentruber, D. (1986). Analysis of the associative and occasion-setting properties of contexts participating in a Pavlovian discrimination. Journal of Experimental Psychology: Animal Behavior Processes 12, 333-350.
11. Bradley, M.M., and Lang, P.J. (1994). Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. Journal of Behavior Therapy & Experimental Psychiatry 25, 49-59.
12. Buchanan, T.W., Brechtel, A., Sollers, J.J., and Lovallo, W.R. (2001). Exogenous cortisol exerts effects on the startle reflex independent of emotional modulation. Pharmacology, Biochemistry and Behavior 68, 203-210.
13. Cahill, L. (2006). Why sex matters for neuroscience. Nature Reviews Neuroscience 7, 477-484.
14. Cahill, L., Haier, R.J., White, N.S., Fallon, J., Kilpatrick, L., Lawrence, C., Potkin, S.G., and Alkire, M.T. (2001). Sex-related difference in amygdala activity during emotionally influenced memory storage. Neurobiology of learning and memory 75, 1-9.
15. Cohen, H., Liberzon, I., and Richter-Levin, G. (2009). Exposure to extreme stress impairs contextual odour discrimination in an animal model of PTSD. International Journal of Neuropsychopharmacology 12, 291-303.
16. Cohen, S., Kamarck, T., and Mermelstein, R. (1983). A global measure of perceived stress. Journal of health and social behavior 24, 385-396.
17. Cordero, M., Venero, C., Kruyt, N., and Sandi, C. (2003). Prior exposure to a single stress session facilitates subsequent contextual fear conditioning in rats: Evidence for a role of corticosterone. Hormones and Behavior 44, 338-345.
18. Czock, D., Keller, F., Rasche, F.M., and Häussler, U. (2005). Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet 44, 61-98.
19. Dalla, C., and Shors, T.J. (2009). Sex differences in learning processes of classical and operant conditioning. Physiology & Behavior 97, 229-238.
20. De Houwer, J., Crombez, G., and Baeyens, F. (2005). Avoidance behavior can function as a negative occasion setter. Journal of Experimental Psychology: Animal Behavior Processes 31, 101-106.
21. De Jongh, R., Geyer, M.A., Olivier, B., and Groenink, L. (2005). The effects of sex and neonatal maternal separation on fear-potentiated and light-enhanced startle. Behavioural Brain Research 161, 190-196.
22. De Vries, J. (1998). "The Perceived Stress Scale, Dutch Translation". (Tilburg, the Netherlands: Tilburg University).
23. Duncko, R., Cornwell, B., Cui, L., Merikangas, K.R., and Grillon, C. (2007). Acute exposure to stress improves performance in trace eyeblink conditioning and spatial learning tasks in healthy men. Learning & Memory 14, 329-335.
24. Effting, M., and Kindt, M. (2007). Contextual control of human fear associations in a renewal paradigm. Behaviour Research and Therapy 45, 2002-2018.
25. Ehlers, A., and Clark, D.M. (2000). A cognitive model of posttraumatic stress disorder. Behaviour Research and Therapy 38, 319-345.
26. Elzinga, B.M., and Bremner, J.D. (2002). Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)? Journal of Affective Disorders 70, 1-17.
27. Enkel, T., Gholizadeh, D., Von Bohlen Und Halbach, O., Sanchis-Segura, C., Hurlemann, R., Spanagel, R., Gass, P., and Vollmayr, B. (2010). Ambiguous-cue interpretation is biased under stress-and depression-like states in rats. Neuropsychopharmacology 35, 1008-1015.
28. Filion, D.L., Dawson, M.E., Schell, A.M., and Hazlett, E.A. (1991). The relationship between skin conductance orienting and the allocation of processing resources. Psychphysiology 28, 410-424.
29. Fridlund, A.J., and Cacioppo, J.T. (1986). Guidelines for human electromyographic research. Psychophysiology 23, 567-589.
30. Grillon, C. (2002). Associative learning deficits increase symptoms of anxiety in humans. Biological psychiatry 51, 851-858.
31. Grillon, C. (2008). Models and mechanisms of anxiety: evidence from startle studies. Psychopharmacology 199, 421-437.
32. Grillon, C., Baas, J.M.P., Pine, D.S., Lissek, S., Lawley, M., Ellis, V., and Levine, J. (2006). The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle. Biological Psychiatry 60, 760-766.
33. Grillon, C., Baas, J.P., Lissek, S., Smith, K., and Milstein, J. (2004). Anxious responses to predictable and unpredictable aversive events. Behavioral Neuroscience 118, 916-924.
34. Grillon, C., Cordova, J., Levine, L.R., and Morgan, C.A. (2003). Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans. Psychopharmacology 168, 446-454.
35. Grillon, C., Heller, R., Hirschhorn, E., Kling, M.A., Pine, D.S., Schulkin, J., and Vythilingam, M. (2011). Acute Hydrocortisone Treatment Increases Anxiety but Not Fear in Healthy Volunteers: A Fear-Potentiated Startle Study. Biological Psychiatry, 1-7.
36. Guimarães, F.S., Hellewell, J., Hensman, R., Wang, M., and Deakin, J.F. (1991). Characterization of a psychophysiological model of classical fear conditioning in healthy volunteers: influence of gender, instruction, personality and placebo. Psychopharmacology 104, 231-236.
37. Hamm, A.O., and Weike, A.I. (2005). The neuropsychology of fear learning and fear regulation. International Journal of Psychophysiology 57, 5-14.
38. Hartley, C.A., and Phelps, E.A. (2009). Changing Fear: The Neurocircuitry of Emotion Regulation. Neuropsychopharmacology 35, 136-146.
39. Herman, J.P., Ostrander, M.M., Mueller, N.K., and Figueiredo, H. (2005). Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Progress in Neuro-Psychopharmacology & Biological Psychiatry 29, 1201-1213.
40. Het, S., Ramlow, G., and Wolf, O.T. (2005). A meta-analytic review of the effects of acute cortisol administration on human memory. Psychoneuroendocrinology 30, 771-784.
41. Jackson, E.D., Payne, J.D., Nadel, L., and Jacobs, W.J. (2006). Stress differentially modulates fear conditioning in healthy men and women. Biological Psychiatry 59, 516-522.
42. Joëls, M., and Baram, T. (2009). The neuro-symphony of stress. Nature Reviews Neuroscience.
43. Joëls, M., Karst, H., Derijk, R., and De Kloet, E.R. (2008). The coming out of the brain mineralocorticoid receptor. Trends in Neurosciences 31, 1-7.
44. Jovanovic, T., Norrholm, S.D., Keyes, M., Fiallos, A., Jovanovic, S., Myers, K.M., Davis, M., and Duncan, E.J. (2006). Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm. Behavioral Neuroscience 120, 995-1004.
45. Kalisch, R., Korenfeld, E., Stephan, K., Weiskopf, N., Seymour, B., and Dolan, R. (2006). Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. Journal of Neuroscience 26, 9503.
46. Kaouane, N., Porte, Y., Vallée, M., Brayda-Bruno, L., Mons, N., Calandreau, L., Marighetto, A., Piazza, P.V., and Desmedt, A. (2012). Glucocorticoids can induce PTSD-like memory impairments in mice. Science 335, 1510-1513.
47. Kessler, R.C., Mcgonagle, K.A., Swartz, M., Blazer, D.G., and Nelson, C.B. (1993). Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence. Journal of affective disorders 29, 85-96.
48. Kindt, M., Soeter, M., and Vervliet, B. (2009). Beyond extinction: erasing human fear responses and preventing the return of fear. Nature neuroscience 12, 256-258.
49. Kohn, P.M., and Macdonald, J.E. (1992). The Survey of Recent Life Experiences: a decontaminated Hassles Scale for adults. Journal of behavioral medicine 15, 221-236.
50. Korte, S. (2001). Corticosteroids in relation to fear, anxiety and psychopathology. Neuroscience and Biobehavioral reviews.
51. Kuehl, L.K., Lass-Hennemann, J., Richter, S., Blumenthal, T.D., Oitzl, M., and Schachinger, H. (2010). Accelerated trace eyeblink conditioning after cortisol IV-infusion. Neurobiology of learning and memory 94, 547-553.
52. Kukolja, J., Schläpfer, T.E., Keysers, C., Klingmüller, D., Maier, W., Fink, G.R., and Hurlemann, R. (2008). Modeling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactions. Journal of Neuroscience 28, 12868-12876.
53. Labar, K.S., Cook, C.A., Torpey, D.C., and Welsh-Bohmer, K.A. (2004). Impact of Healthy Aging on Awareness and Fear Conditioning. Behavioral Neuroscience 118, 905-915.
54. Lebron-Milad, K., and Milad, M.R. (2012). Sex differences, gonadal hormones and the fear extinction network: implications for anxiety disorders. Biology of Mood & Anxiety Disorders 2, 3.
55. Liberzon, I., and Sripada, C. (2008). The functional neuroanatomy of PTSD: a critical review. Progress in brain research.
56. Lissek, S., Biggs, A., Rabin, S., Cornwell, B., Alvarez, R., Pine, D., and Grillon, C. (2008). Generalization of conditioned fear-potentiated startle in humans: Experimental validation and clinical relevance. Behaviour Research and Therapy 46, 678-687.
57. Lissek, S., Rabin, S., Heller, R.E., Lukenbaugh, D., Geraci, M., Pine, D.S., and Grillon, C. (2010). Overgeneralization of conditioned fear as a pathogenic marker of panic disorder. The American Journal of Psychiatry 167, 47-55.
58. Lovibond, P.F., and Shanks, D.R. (2002). The role of awareness in Pavlovian conditioning: Empirical evidence and theoretical implications. Journal of Experimental Psychology: Animal Behavior Processes 28, 3-26.
59. Lupien, S.J., Gillin, C.J., and Hauger, R.L. (1999). Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behavioral Neuroscience 113, 420-430.
60. Lupien, S.J., Wilkinson, C.W., Brière, S., Ménard, C., Ng Ying Kin, N.M.K., and Nair, N.P.V. (2002). The modulatory effects of corticosteroids on cognition: studies in young human populations. Psychoneuroendocrinology 27, 401-416.
61. Lykken, D.T. (1972). Range correction applied to heart rate and to GSR data. Psychophysiology 9, 373-379.
62. Majella De Jong, G., Timmerman, I.G.H., and Emmelkamp, P.M.G. (1996). The survey of recent life experiences: a psychometric evaluation. Journal of Behavioral Medicine 19, 529-542.
63. Merz, C.J., Stark, R., Vaitl, D., Tabbert, K., and Wolf, O.T. (2012). Stress hormones are associated with the neuronal correlates of instructed fear conditioning. Biological psychology.
64. Merz, C.J., Tabbert, K., Schweckendiek, J., Klucken, T., Vaitl, D., Stark, R., and Wolf, O.T. (2010). Investigating the impact of sex and cortisol on implicit fear conditioning with fMRI. Psychoneuroendocrinology 35, 33-46.
65. Merz, C.J., Tabbert, K., Schweckendiek, J., Klucken, T., Vaitl, D., Stark, R., and Wolf, O.T. (2011). Neuronal correlates of extinction learning are modulated by sex hormones. Social Cognitive and Affective Neuroscience.
66. Milad, M., Orr, S., Pitman, R., and Rauch, S. (2005). Context modulation of memory for fear extinction in humans. Psychophysiology 42, 456-464.
67. Milad, M.R., Goldstein, J.M., Orr, S.P., Wedig, M.M., Klibanski, A., Pitman, R.K., and Rauch, S.L. (2006a). Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans. Behavioral Neuroscience 120, 1196-1203.
68. Milad, M.R., Rauch, S.L., Pitman, R.K., and Quirk, G.J. (2006b). Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biological Psychology 73, 61-71.
69. Milad, M.R., Wright, C.I., Orr, S.P., Pitman, R.K., Quirk, G.J., and Rauch, S.L. (2007). Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biological Psychiatry 62, 446-454.
70. Milad, M.R., Zeidan, M.A., Contero, A., Pitman, R.K., Klibanski, A., Rauch, S.L., and Goldstein, J.M. (2010). The influence of gonadal hormones on conditioned fear extinction in healthy humans. Neuroscience 168, 652-658.
71. Mineka, S., and Oehlberg, K. (2008). The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders. Acta Psychologica 127, 567-580.
72. Mineka, S., and Ohman, A. (2002). Phobias and preparedness: the selective, automatic, and encapsulated nature of fear. Biological Psychiatry 52, 927-937.
73. Nees, F., Richter, S., Lass-Hennemann, J., Blumenthal, T.D., and Schächinger, H. (2008). Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning. Psychopharmacology 199, 183-190.
74. Nelson, J.B. (2002). Context specificity of excitation and inhibition in ambiguous stimuli. Learning and Motivation 33, 284-310.
75. Neumann, D.L., and Kitlertsirivatana, E. (2010). Exposure to a novel context after extinction causes a renewal of extinguished conditioned responses: implications for the treatment of fear. Behaviour Research and Therapy 48, 565-570.
76. Orr, S.P., Metzger, L.J., Lasko, N.B., Macklin, M.L., Hu, F.B., Shalev, A.Y., and Pitman, R.K. (2003). Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: association with posttraumatic stress disorder. Archives of General Psychiatry 60, 283-288.
77. Pole, N., Neylan, T.C., Otte, C., Henn-Hasse, C., Metzler, T.J., and Marmar, C.R. (2009). Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses. Biological Psychiatry 65, 235-240.
78. Pruessner, J.C., Wolf, O.T., Hellhammer, D.H., Buske-Kirschbaum, A., Von Auer, K., Jobst, S., Kaspers, F., and Kirschbaum, C. (1997). Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sciences 61, 2539-2549.
79. Pugh, C.R., Tremblay, D., Fleshner, M., and Rudy, J.W. (1997). A selective role for corticosterone in contextual-fear conditioning. Behavioral Neuroscience 111, 503-511.
80. Rauch, S.L., Shin, L.M., and Phelps, E.A. (2006). Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biological Psychiatry 60, 376-382.
81. Rescorla, R.A., and Wagner, A.R. (1972). "A theory of pavlovian conditioning, variations in the effectiveness of reinforcement and nonreinforcement., " in Classical Conditioning II: Current Theory and Research., eds. A.H. Black & W.F. Prokasy. (New York: Appleton-Century-Crofts), 64-99.
82. Rodrigues, S.M., Ledoux, J.E., and Sapolsky, R.M. (2009). The influence of stress hormones on fear circuitry. Annual Review of Neuroscience 32, 289-313.
83. Schiller, D., Levy, I., Niv, Y., Ledoux, J.E., and Phelps, E.A. (2008). From fear to safety and back: reversal of fear in the human brain. Journal of Neuroscience 28, 11517-11525.
84. Schmajuk, N.A., and Buhusi, C.V. (1997). Stimulus configuration, occasion setting, and the hippocampus. Behavioral Neuroscience 111, 235-257; appendix 258.
85. Schwabe, L., Böhringer, A., and Wolf, O.T. (2009a). Stress disrupts context-dependent memory. Learn Mem 16, 110-113.
86. Schwabe, L., Dalm, S., Schächinger, H., and Oitzl, M.S. (2008). Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man. Neurobiology of Learning and Memory 90, 495-503.
87. Schwabe, L., Oitzl, M., Philippsen, C., Richter, S., Bohringer, A., Wippich, W., and Schachinger, H. (2007). Stress modulates the use of spatial versus stimulus-response learning strategies in humans. Learning & Memory 14, 109.
88. Schwabe, L., Oitzl, M., Richter, S., and Schächinger, H. (2009b). Modulation of spatial and stimulus-response learning strategies by exogenous cortisol in healthy young women. Psychoneuroendocrinology 34, 358-366.
89. Sevenster, D., Beckers, T., and Kindt, M. (2012). Retrieval per se is not sufficient to trigger reconsolidation of human fear memory. Neurobiology of Learning and Memory.
90. Shin, L., and Liberzon, I. (2009). The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology.
91. Soeter, M., and Kindt, M. (2010). Dissociating Response Systems: Erasing Fear from Memory. Neurobiology of Learning and Memory.
92. Soeter, M., and Kindt, M. (2011). Stimulation of the Noradrenergic System during Memory Formation Impairs Extinction Learning but not the Disruption of Reconsolidation. Neuropsychopharmacology.
93. Soeter, M., and Kindt, M. (2012). Erasing fear for an imagined threat event. Psychoneuroendocrinology.
94. Spielberger, C.D., Gorsuch, R.L., and Lusthene, R.E. (1970). Manual for the State-Trait Anxiety Inventory. Consulting Psychologist Press, Palo Alto (CA).
95. Stark, R., Wolf, O.T., Tabbert, K., Kagerer, S., Zimmermann, M., Kirsch, P., Schienle, A., and Vaitl, D. (2006). Influence of the stress hormone cortisol on fear conditioning in humans: evidence for sex differences in the response of the prefrontal cortex. Neuroimage 32, 1290-1298.
96. Stroud, L.R., Salovey, P., and Epel, E.S. (2002). Sex differences in stress responses: social rejection versus achievement stress. Biological Psychiatry 52, 318-327.
97. Swartzentruber, D. (1995). Modulatory mechanisms in pavlovian conditioning. Animal Learning and Behavior.
98. Tabbert, K., Merz, C.J., Klucken, T., Schweckendiek, J., Vaitl, D., Wolf, O.T., and Stark, R. (2010). Cortisol enhances neural differentiation during fear acquisition and extinction in contingency aware young women. Neurobiology of learning and memory 94, 392-401.
99. Tottenham, N., Tanaka, J.W., Leon, A.C., Mccarry, T., Nurse, M., Hare, T.A., Marcus, D.J., Westerlund, A., Casey, B.J., and Nelson, C. (2009). The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Research 168, 242-249.
100. Trentani, A., Kuipers, S.D., Te Meerman, G.J., Beekman, J., Ter Horst, G.J., and Den Boer, J.A. (2003). Immunohistochemical changes induced by repeated footshock stress: revelations of gender-based differences. Neurobiology of Disease 14, 602-618.
101. Van Der Ploeg, H., Defares, P., and Spielberger, C.D. (1979). Handleiding bij de Zelf-Beoordelings Vragenlijst ZBV: een nederlandstalige bewerking van de Spielberger State-Trait Anxiety Inventory STAI-DY. Swets&Zeitlinger, Lisse.
102. Vansteenwegen, D., Hermans, D., Vervliet, B., Francken, G., Beckers, T., Baeyens, F., and Eelen, P. (2005). Return of fear in a human differential conditioning paradigm caused by a return to the original acquistion context. Behaviour Research Therapy 43, 323-336.
103. Vythilingam, M., Lawley, M., Collin, C., Bonne, O., Agarwal, R., Hadd, K., Charney, D. S., and Grillon, C. (2006). Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder. Neuropsychopharmacology 31, 182-188.
104. Walker, D.L., Toufexis, D.J., and Davis, M. (2003). Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. European Journal of Pharmacology 463, 199-216.
105. Watson, D., Clark, L.A., and Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of Personality and Social Psychology 54, 1063-1070.
106. Weike, A., Schupp, H., and Hamm, A. (2007). Fear acquisition requires awareness in trace but not delay conditioning. Psychophysiology 44, 170-180.
107. Weiss, C., Sametsky, E., Sasse, A., Spiess, J., and Disterhoft, J.F. (2005). Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons. Learning & Memory 12, 138-143.
108. Wolf, O. (2008). The influence of stress hormones on emotional memory: Relevance for psychopathology. Acta Psychologica 127, 513-531.
109. Wolf, O.T., Bauser, D.S., and Daum, I. (2012). Eyeblink conditional discrimination learning in healthy young men is impaired after stress exposure. Psychophysiology 49, 164-171.
110. Zorawski, M., Blanding, N.Q., Kuhn, C.M., and Labar, K.S. (2006). Effects of stress and sex on acquisition and consolidation of human fear conditioning. Learning & Memory 13, 441-450.
111. Zorawski, M., Cook, C.A., Kuhn, C.M., and Labar, K.S. (2005). Sex, stress, and fear: individual differences in conditioned learning. Cognitive, Affective, & Behavioral Neuroscience 5, 191-201.