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Volumn 60, Issue 7, 2006, Pages 760-766

The Benzodiazepine Alprazolam Dissociates Contextual Fear from Cued Fear in Humans as Assessed by Fear-potentiated Startle

Author keywords

Alprazolam; anxiety; benzodiazepine; context; fear; startle reflex

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE; DIPHENHYDRAMINE;

EID: 33748905504     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.11.027     Document Type: Article
Times cited : (136)

References (42)
  • 2
    • 0034328861 scopus 로고    scopus 로고
    • Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory
    • Barlow D.H. Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. Am Psychol 55 (2000) 1247-1263
    • (2000) Am Psychol , vol.55 , pp. 1247-1263
    • Barlow, D.H.1
  • 3
    • 0032868704 scopus 로고    scopus 로고
    • Comparison of the effects of diazepam on the fear-potentiated startle reflex and the fear-inhibited light reflex in man
    • Bitsios P., Philpott A., Langley R.W., Bradshaw C.M., and Szabadi E. Comparison of the effects of diazepam on the fear-potentiated startle reflex and the fear-inhibited light reflex in man. J Psychopharmacol 13 (1999) 226-234
    • (1999) J Psychopharmacol , vol.13 , pp. 226-234
    • Bitsios, P.1    Philpott, A.2    Langley, R.W.3    Bradshaw, C.M.4    Szabadi, E.5
  • 4
    • 0035196041 scopus 로고    scopus 로고
    • Stimulus-preceding negativity induced by fear: A manifestation of affective anticipation
    • Bocker K.B., Baas J.M., Kenemans J.L., and Verbaten M.N. Stimulus-preceding negativity induced by fear: A manifestation of affective anticipation. Int J Psychophysiol 43 (2001) 77-90
    • (2001) Int J Psychophysiol , vol.43 , pp. 77-90
    • Bocker, K.B.1    Baas, J.M.2    Kenemans, J.L.3    Verbaten, M.N.4
  • 6
    • 0032535291 scopus 로고    scopus 로고
    • Are different parts of the extended amygdala involved in fear versus anxiety?
    • Davis M. Are different parts of the extended amygdala involved in fear versus anxiety?. Biol Psychiatry 44 (1998) 1239-1247
    • (1998) Biol Psychiatry , vol.44 , pp. 1239-1247
    • Davis, M.1
  • 7
    • 0027763474 scopus 로고
    • Fear-potentiated startle: A neural and pharmacological analysis
    • Davis M., Falls W.A., Campeau S., and Kim M. Fear-potentiated startle: A neural and pharmacological analysis. Behav Brain Res 58 (1993) 175-198
    • (1993) Behav Brain Res , vol.58 , pp. 175-198
    • Davis, M.1    Falls, W.A.2    Campeau, S.3    Kim, M.4
  • 8
    • 0029955144 scopus 로고    scopus 로고
    • Startle and spider phobia: Unilateral probes and the prediction of treatment effects
    • de Jong P.J., Visser S., and Merckelbach H. Startle and spider phobia: Unilateral probes and the prediction of treatment effects. J Psychophysiol 10 (1996) 150-160
    • (1996) J Psychophysiol , vol.10 , pp. 150-160
    • de Jong, P.J.1    Visser, S.2    Merckelbach, H.3
  • 9
    • 0036171363 scopus 로고    scopus 로고
    • The light-enhanced startle paradigm as a putative animal model of anxiety: Effects of chlordiazepoxide, flesonoxan and fluvoxamine
    • de Jong R., Groenink L., van der Gugten J., and Olivier B. The light-enhanced startle paradigm as a putative animal model of anxiety: Effects of chlordiazepoxide, flesonoxan and fluvoxamine. Psychopharmacology (Berl) 159 (2002) 176-180
    • (2002) Psychopharmacology (Berl) , vol.159 , pp. 176-180
    • de Jong, R.1    Groenink, L.2    van der Gugten, J.3    Olivier, B.4
  • 11
    • 1642457250 scopus 로고    scopus 로고
    • Anxiolytic-like effects of escitalopram, citalopram, and R-citalopram in maternally separated mouse pups
    • Fish E.W., Faccidomo S.S., Gupta S.S., and Miczek K.A.K.A. Anxiolytic-like effects of escitalopram, citalopram, and R-citalopram in maternally separated mouse pups. J Pharmacol Exp Ther 308 (2004) 474-480
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 474-480
    • Fish, E.W.1    Faccidomo, S.S.2    Gupta, S.S.3    Miczek, K.A.K.A.4
  • 12
    • 0032077699 scopus 로고    scopus 로고
    • Lesions of the bed nucleus of the stria terminalis block sensitization of acoustic startle reflex produced by repeated stress, but not fear-potentiated startle
    • Gewirtz J.C., McNish K.A., and Davis M. Lesions of the bed nucleus of the stria terminalis block sensitization of acoustic startle reflex produced by repeated stress, but not fear-potentiated startle. Prog Neuropsychopharmacol Biol Psychiatry 22 (1998) 625-648
    • (1998) Prog Neuropsychopharmacol Biol Psychiatry , vol.22 , pp. 625-648
    • Gewirtz, J.C.1    McNish, K.A.2    Davis, M.3
  • 13
    • 0032899151 scopus 로고    scopus 로고
    • Fear appears fast: Temporal course of startle reflex potentiation in animal fearful subjects
    • Globisch J., Hamm A.O., Esteves F., and Ohman A. Fear appears fast: Temporal course of startle reflex potentiation in animal fearful subjects. Psychophysiology 36 (1999) 66-75
    • (1999) Psychophysiology , vol.36 , pp. 66-75
    • Globisch, J.1    Hamm, A.O.2    Esteves, F.3    Ohman, A.4
  • 15
    • 0032079590 scopus 로고    scopus 로고
    • Effects of threat of shock, shock electrode placement, and darkness on startle
    • Grillon C., and Ameli R. Effects of threat of shock, shock electrode placement, and darkness on startle. Int J Psychophysiol 28 (1998) 223-231
    • (1998) Int J Psychophysiol , vol.28 , pp. 223-231
    • Grillon, C.1    Ameli, R.2
  • 16
    • 0028196695 scopus 로고
    • Baseline and fear-potentiated startle in panic disorder patients
    • Grillon C., Ameli R., Goddard A., Woods S., and Davis M. Baseline and fear-potentiated startle in panic disorder patients. Biol Psychiatry 35 (1994) 431-439
    • (1994) Biol Psychiatry , vol.35 , pp. 431-439
    • Grillon, C.1    Ameli, R.2    Goddard, A.3    Woods, S.4    Davis, M.5
  • 17
    • 0026353242 scopus 로고
    • Fear-potentiated startle in humans: Effects of anticipatory anxiety on the acoustic blink reflex
    • Grillon C., Ameli R., Woods S.W., Merikangas K., and Davis M. Fear-potentiated startle in humans: Effects of anticipatory anxiety on the acoustic blink reflex. Psychophysiology 28 (1991) 588-595
    • (1991) Psychophysiology , vol.28 , pp. 588-595
    • Grillon, C.1    Ameli, R.2    Woods, S.W.3    Merikangas, K.4    Davis, M.5
  • 18
    • 0027251607 scopus 로고
    • Measuring the time-course of anxiety using the fear-potentiated startle reflex
    • Grillon C., Ameli R., Woods S.W., Merikangas K., and Davis M. Measuring the time-course of anxiety using the fear-potentiated startle reflex. Psychophysiology 30 (1993) 340-346
    • (1993) Psychophysiology , vol.30 , pp. 340-346
    • Grillon, C.1    Ameli, R.2    Woods, S.W.3    Merikangas, K.4    Davis, M.5
  • 19
    • 0036912504 scopus 로고    scopus 로고
    • Comments on the use of the startle reflex in psychopharmacological challenges: Impact of baseline startle on measurement of fear-potentiated startle
    • Grillon C., and Baas J.M.P. Comments on the use of the startle reflex in psychopharmacological challenges: Impact of baseline startle on measurement of fear-potentiated startle. Psychopharmacology (Berl) 164 (2002) 236-238
    • (2002) Psychopharmacology (Berl) , vol.164 , pp. 236-238
    • Grillon, C.1    Baas, J.M.P.2
  • 20
    • 5144234428 scopus 로고    scopus 로고
    • Anxious responses to predictable and unpredictable aversive events
    • Grillon C., Baas J.P., Lissek S., Smith K., and Milstein J. Anxious responses to predictable and unpredictable aversive events. Behav Neurosci 118 (2004) 916-924
    • (2004) Behav Neurosci , vol.118 , pp. 916-924
    • Grillon, C.1    Baas, J.P.2    Lissek, S.3    Smith, K.4    Milstein, J.5
  • 21
    • 0030853977 scopus 로고    scopus 로고
    • Fear-potentiated startle conditioning in humans: Explicit and contextual cue conditioning following paired vs. unpaired training
    • Grillon C., and Davis M. Fear-potentiated startle conditioning in humans: Explicit and contextual cue conditioning following paired vs. unpaired training. Psychophysiology 34 (1997) 451-458
    • (1997) Psychophysiology , vol.34 , pp. 451-458
    • Grillon, C.1    Davis, M.2
  • 22
    • 0033013682 scopus 로고    scopus 로고
    • Fear-potentiated startle conditioning to explicit and contextual cues in Gulf War veterans with posttraumatic stress disorder
    • Grillon C., and Morgan C.A. Fear-potentiated startle conditioning to explicit and contextual cues in Gulf War veterans with posttraumatic stress disorder. J Abnorm Psychol 108 (1999) 134-142
    • (1999) J Abnorm Psychol , vol.108 , pp. 134-142
    • Grillon, C.1    Morgan, C.A.2
  • 23
    • 0031744980 scopus 로고    scopus 로고
    • Effect of darkness on acoustic startle in Vietnam veterans with PTSD
    • Grillon C., Morgan C.A., Davis M., and Southwick S.M. Effect of darkness on acoustic startle in Vietnam veterans with PTSD. Am J Psychiatry 155 (1998) 812-817
    • (1998) Am J Psychiatry , vol.155 , pp. 812-817
    • Grillon, C.1    Morgan, C.A.2    Davis, M.3    Southwick, S.M.4
  • 24
    • 0032533222 scopus 로고    scopus 로고
    • Effects of experimental context and explicit threat cues on acoustic startle in Vietnam veterans with posttraumatic stress disorder
    • Grillon C., Morgan C.A., Davis M., and Southwick S.M. Effects of experimental context and explicit threat cues on acoustic startle in Vietnam veterans with posttraumatic stress disorder. Biol Psychiatry 44 (1998) 1027-1036
    • (1998) Biol Psychiatry , vol.44 , pp. 1027-1036
    • Grillon, C.1    Morgan, C.A.2    Davis, M.3    Southwick, S.M.4
  • 26
    • 0033813788 scopus 로고    scopus 로고
    • Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: A comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists
    • Guscott M.R., Cook G.P., and Bristow L.J. Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: A comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists. Behav Pharmacol 11 (2000) 495-504
    • (2000) Behav Pharmacol , vol.11 , pp. 495-504
    • Guscott, M.R.1    Cook, G.P.2    Bristow, L.J.3
  • 27
    • 0029966805 scopus 로고    scopus 로고
    • Affective learning: Awareness and aversion
    • Hamm A.O., and Vaitl D. Affective learning: Awareness and aversion. Psychophysiology 33 (1996) 698-710
    • (1996) Psychophysiology , vol.33 , pp. 698-710
    • Hamm, A.O.1    Vaitl, D.2
  • 28
    • 1842531466 scopus 로고    scopus 로고
    • Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress
    • Hammack S.E., Richey K.J., Watkins L.R., and Maier S.F. Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. Behav Neurosci 118 (2004) 443-448
    • (2004) Behav Neurosci , vol.118 , pp. 443-448
    • Hammack, S.E.1    Richey, K.J.2    Watkins, L.R.3    Maier, S.F.4
  • 29
    • 0028939779 scopus 로고
    • Predictive validity of the potentiated startle response as a behavioral model for anxiolytic drugs
    • Hijzen T.H., Houtzager S.W., Joordens R.J., Olivier B., and Slangen J.L. Predictive validity of the potentiated startle response as a behavioral model for anxiolytic drugs. Psychopharmacology (Berl) 118 (1995) 150-154
    • (1995) Psychopharmacology (Berl) , vol.118 , pp. 150-154
    • Hijzen, T.H.1    Houtzager, S.W.2    Joordens, R.J.3    Olivier, B.4    Slangen, J.L.5
  • 30
    • 0034597928 scopus 로고    scopus 로고
    • Fear and anxiety: Animal models and human cognitive psychophysiology
    • Lang P.J., Davis M., and Ohman A. Fear and anxiety: Animal models and human cognitive psychophysiology. J Affect Disord 61 (2000) 137-159
    • (2000) J Affect Disord , vol.61 , pp. 137-159
    • Lang, P.J.1    Davis, M.2    Ohman, A.3
  • 31
    • 0025979147 scopus 로고
    • Effects of septal lesions on fear-potentiated startle, and on the anxiolytic effects of buspirone and diazepan
    • Melia K.R., and Davis M. Effects of septal lesions on fear-potentiated startle, and on the anxiolytic effects of buspirone and diazepan. Physiol Behav 49 (1991) 603-611
    • (1991) Physiol Behav , vol.49 , pp. 603-611
    • Melia, K.R.1    Davis, M.2
  • 32
    • 0016499354 scopus 로고
    • The role of background stimuli during Pavlovian conditioning
    • Odling-Smee F.J. The role of background stimuli during Pavlovian conditioning. Q J Exp Psychol 27 (1975) 201-209
    • (1975) Q J Exp Psychol , vol.27 , pp. 201-209
    • Odling-Smee, F.J.1
  • 33
    • 0142073258 scopus 로고    scopus 로고
    • Fear-potentiated startle and posttraumatic stress symptoms in urban police officers
    • Pole N., Neylan T.C., Best S.R., Orr S.P., and Marmar C.R. Fear-potentiated startle and posttraumatic stress symptoms in urban police officers. J Trauma Stress 16 (2003) 471-479
    • (2003) J Trauma Stress , vol.16 , pp. 471-479
    • Pole, N.1    Neylan, T.C.2    Best, S.R.3    Orr, S.P.4    Marmar, C.R.5
  • 34
    • 0031593410 scopus 로고    scopus 로고
    • The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes
    • Privou C.C., Knoche A.A., Hasenöhrl R.R.U., and Huston J.J.P. The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes. Neuropharmacology 37 (1998) 1019-1032
    • (1998) Neuropharmacology , vol.37 , pp. 1019-1032
    • Privou, C.C.1    Knoche, A.A.2    Hasenöhrl, R.R.U.3    Huston, J.J.P.4
  • 35
    • 0034779840 scopus 로고    scopus 로고
    • Differential effects of alprazolam on the baseline and fear-potentiated startle reflex in humans: A dose-response study
    • Riba J., Rodriguez-Fornells A., Urbano G., Morte A., Antonijoan R., and Barbanoj M.J. Differential effects of alprazolam on the baseline and fear-potentiated startle reflex in humans: A dose-response study. Psychopharmacology (Berl) 157 (2001) 358-367
    • (2001) Psychopharmacology (Berl) , vol.157 , pp. 358-367
    • Riba, J.1    Rodriguez-Fornells, A.2    Urbano, G.3    Morte, A.4    Antonijoan, R.5    Barbanoj, M.J.6
  • 36
    • 22344443644 scopus 로고    scopus 로고
    • Diazepam suppresses the acquisition but not the expression of "fear-potentiation" of the acoustic startle response in man
    • Scaife J.J.C., Langley R.R.W., Bradshaw C.C.M., and Szabadi E.E. Diazepam suppresses the acquisition but not the expression of "fear-potentiation" of the acoustic startle response in man. J Psychopharmacol 19 (2005) 347-356
    • (2005) J Psychopharmacol , vol.19 , pp. 347-356
    • Scaife, J.J.C.1    Langley, R.R.W.2    Bradshaw, C.C.M.3    Szabadi, E.E.4
  • 38
    • 0030698102 scopus 로고    scopus 로고
    • Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear
    • Walker D.L., and Davis M. Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear. J Neurosci 17 (1997) 9375-9383
    • (1997) J Neurosci , vol.17 , pp. 9375-9383
    • Walker, D.L.1    Davis, M.2
  • 39
    • 0030771893 scopus 로고    scopus 로고
    • Anxiogenic effects of high illumination levels assessed with the acoustic startle response in rats
    • Walker D.L., and Davis M. Anxiogenic effects of high illumination levels assessed with the acoustic startle response in rats. Biol Psychiatry 42 (1997) 461-471
    • (1997) Biol Psychiatry , vol.42 , pp. 461-471
    • Walker, D.L.1    Davis, M.2
  • 40
    • 0036169780 scopus 로고    scopus 로고
    • Light-enhanced startle: Further pharmacological and behavioral characterization
    • Walker D.L., and Davis M. Light-enhanced startle: Further pharmacological and behavioral characterization. Psychopharmacology (Berl) 159 (2002) 304-310
    • (2002) Psychopharmacology (Berl) , vol.159 , pp. 304-310
    • Walker, D.L.1    Davis, M.2
  • 41
    • 0036428733 scopus 로고    scopus 로고
    • Quantifying fear potentiated startle using absolute versus proportional increase scoring methods: Implications for the neurocircuitry of fear and anxiety
    • Walker D.L., and Davis M. Quantifying fear potentiated startle using absolute versus proportional increase scoring methods: Implications for the neurocircuitry of fear and anxiety. Psychopharmacology (Berl) 164 (2002) 318-328
    • (2002) Psychopharmacology (Berl) , vol.164 , pp. 318-328
    • Walker, D.L.1    Davis, M.2
  • 42
    • 0037470082 scopus 로고    scopus 로고
    • Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
    • Walker D.L., Toufexis D.J., and Davis M. Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 463 (2003) 199-216
    • (2003) Eur J Pharmacol , vol.463 , pp. 199-216
    • Walker, D.L.1    Toufexis, D.J.2    Davis, M.3


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