Importance of β-catenin in glucose and energy homeostasis

Scientific Reports

Volumn 2, Issue , 2012, Pages

  Elghazi, Lynda ^a   Gould, Aaron P ^a   Weiss, Aaron J ^a   Barker, Daniel J ^a   Callaghan, John ^a   Opland, Darren ^a   Myers, Martin ^a   Cras Méneur, Corentin ^a   Bernal Mizrachi, Ernesto ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLUCOSE; HOMEODOMAIN PROTEIN; INSULIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN; WNT PROTEIN;

ANIMAL; ARTICLE; CYTOLOGY; ENERGY METABOLISM; GENE DELETION; GENETICS; HOMEOSTASIS; HYPOTHALAMUS; INSULIN RESISTANCE; METABOLISM; MOUSE; PANCREAS ISLET BETA CELL; PHYSIOLOGY; STEM CELL; TRANSGENIC MOUSE; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; ENERGY METABOLISM; GENE DELETION; GLUCOSE; HOMEODOMAIN PROTEINS; HOMEOSTASIS; HYPOTHALAMUS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; STEM CELLS; TRANS-ACTIVATORS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84867031940     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00693     Document Type: Article

References (46)

1. Talchai, C., Lin, H. V., Kitamura, T. & Accili, D. Genetic and biochemical pathways of beta-cell failure in type 2 diabetes. Diabetes, obesity & metabolism 11 Suppl 4, 38-45 (2009).
2. Chang-Chen, K., Mullur, R. & Bernal-Mizrachi, E. beta-cell failure as a complication of diabetes. Reviews in Endocrine and Metabolic Disorders 9, 329-343 (2008).
3. Prokopenko, I., McCarthy, M. I. & Lindgren, C. M. Type 2 diabetes: new genes, new understanding. Trends in genetics : TIG 24, 613-621 (2008).
4. Florez, J. C. Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. The Journal of clinical endocrinology and metabolism 93, 4633-4642 (2008).
5. Florez, J. C. Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 51, 1100-1110 (2008).
6. Sladek, R. et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885 (2007).
7. van Hoek, M. et al. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 57, 3122-3128 (2008).
8. Zeggini, E. et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature genetics 40, 638-645 (2008). (Pubitemid 351601209)
9. Lyssenko, V. et al.Clinical risk factors, DNAvariants, and the development of type 2 diabetes. The New England journal of medicine 359, 2220-2232 (2008).
10. Liu, Z. & Habener, J. F. Wnt signaling in pancreatic islets. Adv Exp Med Biol 654, 391-419 (2010).
11. Grant, S. F. A. et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature genetics 38, 320-323 (2006).
12. Jin, T. The WNT signalling pathway and diabetes mellitus. Diabetologia 51, 1771-1780 (2008).
13. Gloyn, A. L., Braun,M. &Rorsman, P. Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes 58, 800-802 (2009).
14. Bonetti, S. et al. Variants and haplotypes of TCF7L2 are associated with b-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2Diabetes Study (VNDS) 1. The Journal of clinical endocrinology and metabolism 96, E389-393 (2011).
15. Liu, Z. & Habener, J. F. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. The Journal of biological chemistry 283, 8723-8735 (2008).
16. Shu, L. et al. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57, 645-653 (2008).
17. Dessimoz, J., Bonnard, C., Huelsken, J. & Grapin-Botton, A. Pancreas-Specific Deletion of beta-Catenin Reveals Wnt-Dependent and Wnt-Independent Functions during Development. Current biology : CB 15, 1677-1683 (2005). (Pubitemid 41323747)
18. Rulifson, I. C. et al. Wnt signaling regulates pancreatic beta cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 104, 6247-6252 (2007). (Pubitemid 47186080)
19. MacDonald, B. T., Tamai, K. & He, X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17, 9-26 (2009).
20. Cadigan, K. M. Wnt-beta-catenin signaling. Curr Biol 18, R943-947 (2008).
21. Nelson, W. J. & Nusse, R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science (New York, NY) 303, 1483-1487 (2004). (Pubitemid 38314410)
22. Nusse, R. Wnt signaling in disease and in development. Cell Res 15, 28-32 (2005). (Pubitemid 41653961)
23. Gooding, J. M., Yap, K. L. & Ikura, M. The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures. Bioessays 26, 497-511 (2004). (Pubitemid 38684965)
24. Welters, H. J. & Kulkarni, R. N. Wnt signaling: relevance to beta-cell biology and diabetes. Trends in endocrinology and metabolism: TEM 19, 349-355 (2008).
25. Dabernat, S. et al. Lack of beta-catenin in early life induces abnormal glucose homeostasis in mice. Diabetologia 52, 1608-1617 (2009).
26. Murtaugh, L., Law, A., Dor, Y. & Melton, D. {beta}-Catenin is essential for pancreatic acinar but not islet development. Development (Cambridge, England) 132, 4663-4674 (2005). (Pubitemid 41685277)
27. Papadopoulou, S. & Edlund, H. Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54, 2844-2851 (2005). (Pubitemid 41401078)
28. Heiser, P. W., Lau, J., Taketo, M. M., Herrera, P. L. & Hebrok, M. Stabilization of beta-catenin impacts pancreas growth. Development (Cambridge, England) 133, 2023-2032 (2006). (Pubitemid 43881267)
29. Wells, J. M. et al. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol 7, 4 (2007).
30. Heller, R. et al. Expression patterns ofWnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Developmental dynamics : an official publication of the American Association of Anatomists 225, 260-270 (2002). (Pubitemid 35265801)
31. Fujino, T. et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA 100, 229-234 (2003). (Pubitemid 36078057)
32. Ahlgren, U., Jonsson, J. & Edlund, H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development (Cambridge, England) 122, 1409-1416 (1996). (Pubitemid 26159631)
33. Gu, G., Dubauskaite, J. & Melton, D. Direct evidence for the pancreatic lineage: NGN31 cells are islet progenitors and are distinct from duct progenitors. Development (Cambridge, England) 129, 2447-2457 (2002). (Pubitemid 34863851)
34. Wicksteed, B. et al. Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59, 3090-3098 (2010).
35. Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature genetics 21, 70-71 (1999). (Pubitemid 29036285)
36. Herrera, P. Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages. Development (Cambridge, England) 127, 2317-2322 (2000). (Pubitemid 30386571)
37. Alagramam, K.N. et al. The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene. Nature genetics 27, 99-102 (2001). (Pubitemid 32044527)
38. Matsuki, T. et al. Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proceedings of the National Academy of Sciences of the United States of America 106, 4459-4464 (2009).
39. Brault, V. et al. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (Cambridge, England) 128, 1253-1264 (2001). (Pubitemid 32409648)
40. Bernal-Mizrachi, C. et al. Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arteriosclerosis, thrombosis, and vascular biology 22, 961-968 (2002). (Pubitemid 34655224)
41. Bernal-Mizrachi, E., Wen, W., Stahlhut, S., Welling, C. & Permutt, M. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. The Journal of clinical investigation 108, 1631-1638 (2001). (Pubitemid 33144873)
42. Fatrai, S. et al. Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 55, 318-325 (2006). (Pubitemid 43343259)
43. Towler, D. A., Bidder, M., Latifi, T., Coleman, T. & Semenkovich, C. F. Dietinduced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. The Journal of biological chemistry 273, 30427-30434 (1998). (Pubitemid 28545516)
44. Jeejeebhoy, K. N., Ahmad, S. & Kozak, G. Determination of fecal fats containing both medium and long chain triglycerides and fatty acids. Clin Biochem 3, 157-163 (1970).
45. Ma, T. et al.Defective dietary fat processing in transgenicmice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol 280, C126-134 (2001).
46. Girish, V. & Vijayalakshmi, A. Affordable image analysis using NIH Image/ImageJ. Indian J Cancer 41, 47 (2004). (Pubitemid 38623932)