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Volumn 7, Issue 10, 2012, Pages

The Alternative Epac/cAMP Pathway and the MAPK Pathway Mediate hCG Induction of Leptin in Placental Cells

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP DERIVATIVE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPAC PROTEIN; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP; LEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN; RAP1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84867012124     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046216     Document Type: Article
Times cited : (26)

References (94)
  • 2
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5
  • 3
    • 0032215839 scopus 로고    scopus 로고
    • Leptin and its receptors: regulators of whole-body energy homeostasis
    • Houseknecht KL, Portocarrero CP, (1998) Leptin and its receptors: regulators of whole-body energy homeostasis. Domest Anim Endocrinol 15: 457-475.
    • (1998) Domest Anim Endocrinol , vol.15 , pp. 457-475
    • Houseknecht, K.L.1    Portocarrero, C.P.2
  • 6
  • 7
    • 0030866843 scopus 로고    scopus 로고
    • Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans
    • Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, et al. (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029-1033.
    • (1997) Nat Med , vol.3 , pp. 1029-1033
    • Masuzaki, H.1    Ogawa, Y.2    Sagawa, N.3    Hosoda, K.4    Matsumoto, T.5
  • 9
    • 33845478388 scopus 로고    scopus 로고
    • Effect of leptin on the regulation of placental hormone secretion in cultured human placental cells
    • Coya R, Martul P, Algorta J, Aniel-Quiroga MA, Busturia MA, et al. (2006) Effect of leptin on the regulation of placental hormone secretion in cultured human placental cells. Gynecol Endocrinol 22: 620-626.
    • (2006) Gynecol Endocrinol , vol.22 , pp. 620-626
    • Coya, R.1    Martul, P.2    Algorta, J.3    Aniel-Quiroga, M.A.4    Busturia, M.A.5
  • 10
    • 77953289537 scopus 로고    scopus 로고
    • MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells
    • Perez-Perez A, Gambino Y, Maymo J, Goberna R, Fabiani F, et al. (2010) MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells. Biochem Biophys Res Commun 396: 956-960.
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 956-960
    • Perez-Perez, A.1    Gambino, Y.2    Maymo, J.3    Goberna, R.4    Fabiani, F.5
  • 12
  • 13
    • 70350632468 scopus 로고    scopus 로고
    • Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells
    • Perez-Perez A, Maymo J, Gambino Y, Duenas JL, Goberna R, et al. (2009) Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells. Biol Reprod 81: 826-832.
    • (2009) Biol Reprod , vol.81 , pp. 826-832
    • Perez-Perez, A.1    Maymo, J.2    Gambino, Y.3    Duenas, J.L.4    Goberna, R.5
  • 14
    • 0001820949 scopus 로고    scopus 로고
    • Role of leptin in pregnancy-a review
    • Sagawa N, Yura S, Itoh H, Mise H, Kakui K, et al. (2002) Role of leptin in pregnancy-a review. Placenta 23 Suppl: S80-86.
    • (2002) Placenta , vol.23 , Issue.SUPPL. , pp. 80-86
    • Sagawa, N.1    Yura, S.2    Itoh, H.3    Mise, H.4    Kakui, K.5
  • 15
    • 0036484871 scopus 로고    scopus 로고
    • Prospective function of placental leptin at maternal-fetal interface
    • Bajoria R, Sooranna SR, Ward BS, Chatterjee R, (2002) Prospective function of placental leptin at maternal-fetal interface. Placenta 23: 103-115.
    • (2002) Placenta , vol.23 , pp. 103-115
    • Bajoria, R.1    Sooranna, S.R.2    Ward, B.S.3    Chatterjee, R.4
  • 16
    • 0034892629 scopus 로고    scopus 로고
    • Effect of cyclic 3′,5′-adenosine monophosphate, glucocorticoids, and insulin on leptin messenger RNA levels and leptin secretion in cultured human trophoblast
    • Coya R, Gualillo O, Pineda J, Garcia MC, Busturia MA, et al. (2001) Effect of cyclic 3′,5′-adenosine monophosphate, glucocorticoids, and insulin on leptin messenger RNA levels and leptin secretion in cultured human trophoblast. Biol Reprod 65: 814-819.
    • (2001) Biol Reprod , vol.65 , pp. 814-819
    • Coya, R.1    Gualillo, O.2    Pineda, J.3    Garcia, M.C.4    Busturia, M.A.5
  • 17
    • 0030813619 scopus 로고    scopus 로고
    • Identification of a placental enhancer for the human leptin gene
    • Bi S, Gavrilova O, Gong DW, Mason MM, Reitman M, (1997) Identification of a placental enhancer for the human leptin gene. J Biol Chem 272: 30583-30588.
    • (1997) J Biol Chem , vol.272 , pp. 30583-30588
    • Bi, S.1    Gavrilova, O.2    Gong, D.W.3    Mason, M.M.4    Reitman, M.5
  • 19
    • 77954891467 scopus 로고    scopus 로고
    • Regulation of placental leptin expression by cyclic adenosine 5′-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways
    • Maymo JL, Perez Perez A, Duenas JL, Calvo JC, Sanchez-Margalet V, et al. (2010) Regulation of placental leptin expression by cyclic adenosine 5′-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways. Endocrinology 151: 3738-3751.
    • (2010) Endocrinology , vol.151 , pp. 3738-3751
    • Maymo, J.L.1    Perez Perez, A.2    Duenas, J.L.3    Calvo, J.C.4    Sanchez-Margalet, V.5
  • 20
    • 0024210533 scopus 로고
    • Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA
    • Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF, (1988) Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242: 1430-1433.
    • (1988) Science , vol.242 , pp. 1430-1433
    • Hoeffler, J.P.1    Meyer, T.E.2    Yun, Y.3    Jameson, J.L.4    Habener, J.F.5
  • 21
    • 0025330489 scopus 로고
    • cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes
    • Taylor SS, Buechler JA, Yonemoto W, (1990) cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu Rev Biochem 59: 971-1005.
    • (1990) Annu Rev Biochem , vol.59 , pp. 971-1005
    • Taylor, S.S.1    Buechler, J.A.2    Yonemoto, W.3
  • 22
    • 0030792753 scopus 로고    scopus 로고
    • Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells
    • Renstrom E, Eliasson L, Rorsman P, (1997) Protein kinase A-dependent and-independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol 502 (Pt 1): 105-118.
    • (1997) J Physiol , vol.502 , Issue.1 , pp. 105-118
    • Renstrom, E.1    Eliasson, L.2    Rorsman, P.3
  • 23
    • 0032807749 scopus 로고    scopus 로고
    • Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation
    • Cass LA, Summers SA, Prendergast GV, Backer JM, Birnbaum MJ, et al. (1999) Protein kinase A-dependent and-independent signaling pathways contribute to cyclic AMP-stimulated proliferation. Mol Cell Biol 19: 5882-5891.
    • (1999) Mol Cell Biol , vol.19 , pp. 5882-5891
    • Cass, L.A.1    Summers, S.A.2    Prendergast, G.V.3    Backer, J.M.4    Birnbaum, M.J.5
  • 24
    • 0035880274 scopus 로고    scopus 로고
    • Adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A. J Immunol
    • Staples KJ, Bergmann M, Tomita K, Houslay MD, McPhee I, et al. (2001) Adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A. J Immunol. 167: 2074-2080.
    • (2001) , vol.167 , pp. 2074-2080
    • Staples, K.J.1    Bergmann, M.2    Tomita, K.3    Houslay, M.D.4    McPhee, I.5
  • 25
    • 79960631270 scopus 로고    scopus 로고
    • Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts
    • Ge YC, Li JN, Ni XT, Guo CM, Wang WS, et al. (2011) Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts. Reproduction 142: 369-375.
    • (2011) Reproduction , vol.142 , pp. 369-375
    • Ge, Y.C.1    Li, J.N.2    Ni, X.T.3    Guo, C.M.4    Wang, W.S.5
  • 26
    • 77949538387 scopus 로고    scopus 로고
    • Epac: defining a new mechanism for cAMP action
    • Gloerich M, Bos JL, (2010) Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol 50: 355-375.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 355-375
    • Gloerich, M.1    Bos, J.L.2
  • 27
    • 0032545328 scopus 로고    scopus 로고
    • A family of cAMP-binding proteins that directly activate Rap1
    • Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, et al. (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282: 2275-2279.
    • (1998) Science , vol.282 , pp. 2275-2279
    • Kawasaki, H.1    Springett, G.M.2    Mochizuki, N.3    Toki, S.4    Nakaya, M.5
  • 28
    • 0032480888 scopus 로고    scopus 로고
    • Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    • de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, et al. (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396: 474-477.
    • (1998) Nature , vol.396 , pp. 474-477
    • de Rooij, J.1    Zwartkruis, F.J.2    Verheijen, M.H.3    Cool, R.H.4    Nijman, S.M.5
  • 29
    • 0036607064 scopus 로고    scopus 로고
    • Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
    • Stork PJ, Schmitt JM, (2002) Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12: 258-266.
    • (2002) Trends Cell Biol , vol.12 , pp. 258-266
    • Stork, P.J.1    Schmitt, J.M.2
  • 30
    • 0041315574 scopus 로고    scopus 로고
    • cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension
    • Christensen AE, Selheim F, de Rooij J, Dremier S, Schwede F, et al. (2003) cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J Biol Chem 278: 35394-35402.
    • (2003) J Biol Chem , vol.278 , pp. 35394-35402
    • Christensen, A.E.1    Selheim, F.2    de Rooij, J.3    Dremier, S.4    Schwede, F.5
  • 32
    • 77955953775 scopus 로고    scopus 로고
    • Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells
    • Yoshie M, Kaneyama K, Kusama K, Higuma C, Nishi H, et al. (2010) Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells. Hum Reprod 25: 2229-2238.
    • (2010) Hum Reprod , vol.25 , pp. 2229-2238
    • Yoshie, M.1    Kaneyama, K.2    Kusama, K.3    Higuma, C.4    Nishi, H.5
  • 33
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 35
    • 0026654216 scopus 로고
    • Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells
    • Clegg CH, Abrahamsen MS, Degen JL, Morris DR, McKnight GS, (1992) Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells. Biochemistry 31: 3720-3726.
    • (1992) Biochemistry , vol.31 , pp. 3720-3726
    • Clegg, C.H.1    Abrahamsen, M.S.2    Degen, J.L.3    Morris, D.R.4    McKnight, G.S.5
  • 36
    • 0032531756 scopus 로고    scopus 로고
    • Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling
    • Zwartkruis FJ, Wolthuis RM, Nabben NM, Franke B, Bos JL, (1998) Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling. EMBO J 17: 5905-5912.
    • (1998) EMBO J , vol.17 , pp. 5905-5912
    • Zwartkruis, F.J.1    Wolthuis, R.M.2    Nabben, N.M.3    Franke, B.4    Bos, J.L.5
  • 37
    • 0024445798 scopus 로고
    • Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
    • Gonzalez GA, Montminy MR, (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59: 675-680.
    • (1989) Cell , vol.59 , pp. 675-680
    • Gonzalez, G.A.1    Montminy, M.R.2
  • 38
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 39
    • 0141838111 scopus 로고    scopus 로고
    • Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation
    • Cauzac M, Czuba D, Girard J, Hauguel-de Mouzon S, (2003) Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation. Placenta 24: 378-384.
    • (2003) Placenta , vol.24 , pp. 378-384
    • Cauzac, M.1    Czuba, D.2    Girard, J.3    Hauguel-de Mouzon, S.4
  • 40
    • 0026025792 scopus 로고
    • Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA
    • Wang H, Segaloff DL, Ascoli M, (1991) Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA. J Biol Chem 266: 780-785.
    • (1991) J Biol Chem , vol.266 , pp. 780-785
    • Wang, H.1    Segaloff, D.L.2    Ascoli, M.3
  • 43
    • 0029809348 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases by gonadotropins and cyclic adenosine 5′-monophosphates in porcine granulosa cells
    • Cameron MR, Foster JS, Bukovsky A, Wimalasena J, (1996) Activation of mitogen-activated protein kinases by gonadotropins and cyclic adenosine 5′-monophosphates in porcine granulosa cells. Biol Reprod 55: 111-119.
    • (1996) Biol Reprod , vol.55 , pp. 111-119
    • Cameron, M.R.1    Foster, J.S.2    Bukovsky, A.3    Wimalasena, J.4
  • 44
    • 0028176297 scopus 로고
    • cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
    • Faure M, Voyno-Yasenetskaya TA, Bourne HR, (1994) cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem 269: 7851-7854.
    • (1994) J Biol Chem , vol.269 , pp. 7851-7854
    • Faure, M.1    Voyno-Yasenetskaya, T.A.2    Bourne, H.R.3
  • 46
    • 0142024483 scopus 로고    scopus 로고
    • Rap1 GTPase: functions, regulation, and malignancy
    • Hattori M, Minato N, (2003) Rap1 GTPase: functions, regulation, and malignancy. J Biochem 134: 479-484.
    • (2003) J Biochem , vol.134 , pp. 479-484
    • Hattori, M.1    Minato, N.2
  • 47
    • 85006314494 scopus 로고    scopus 로고
    • A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    • Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, et al. (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol 4: 901-906.
    • (2002) Nat Cell Biol , vol.4 , pp. 901-906
    • Enserink, J.M.1    Christensen, A.E.2    de Rooij, J.3    van Triest, M.4    Schwede, F.5
  • 48
    • 0032439745 scopus 로고    scopus 로고
    • Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels
    • Schubring C, Englaro P, Siebler T, Blum WF, Demirakca T, et al. (1998) Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. Horm Res 50: 276-283.
    • (1998) Horm Res , vol.50 , pp. 276-283
    • Schubring, C.1    Englaro, P.2    Siebler, T.3    Blum, W.F.4    Demirakca, T.5
  • 49
    • 0030739466 scopus 로고    scopus 로고
    • Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy
    • Hardie L, Trayhurn P, Abramovich D, Fowler P, (1997) Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol (Oxf) 47: 101-106.
    • (1997) Clin Endocrinol (Oxf) , vol.47 , pp. 101-106
    • Hardie, L.1    Trayhurn, P.2    Abramovich, D.3    Fowler, P.4
  • 52
    • 0036020029 scopus 로고    scopus 로고
    • Leptin: roles and regulation in primate pregnancy
    • Henson MC, Castracane VD, (2002) Leptin: roles and regulation in primate pregnancy. Semin Reprod Med 20: 113-122.
    • (2002) Semin Reprod Med , vol.20 , pp. 113-122
    • Henson, M.C.1    Castracane, V.D.2
  • 53
    • 31044439034 scopus 로고    scopus 로고
    • Leptin in pregnancy: an update
    • Henson MC, Castracane VD, (2006) Leptin in pregnancy: an update. Biol Reprod 74: 218-229.
    • (2006) Biol Reprod , vol.74 , pp. 218-229
    • Henson, M.C.1    Castracane, V.D.2
  • 54
    • 84856016663 scopus 로고    scopus 로고
    • Elsevier Trophoblast Research Award Lecture: Molecular mechanisms underlying estrogen functions in trophoblastic cells- Focus on leptin expression
    • Gambino YP, Maymo JL, Perez Perez A, Calvo JC, Sanchez-Margalet V, et al. (2012) Elsevier Trophoblast Research Award Lecture: Molecular mechanisms underlying estrogen functions in trophoblastic cells- Focus on leptin expression. Placenta.
    • (2012) Placenta
    • Gambino, Y.P.1    Maymo, J.L.2    Perez Perez, A.3    Calvo, J.C.4    Sanchez-Margalet, V.5
  • 55
    • 79952004504 scopus 로고    scopus 로고
    • Review: Leptin gene expression in the placenta-regulation of a key hormone in trophoblast proliferation and survival
    • Maymo JL, Perez AP, Gambino Y, Calvo JC, Sanchez-Margalet V, et al. (2011) Review: Leptin gene expression in the placenta-regulation of a key hormone in trophoblast proliferation and survival. Placenta 32 (Suppl 2):: S146-153.
    • (2011) Placenta , vol.32 , Issue.SUPPL. 2
    • Maymo, J.L.1    Perez, A.P.2    Gambino, Y.3    Calvo, J.C.4    Sanchez-Margalet, V.5
  • 56
    • 21044434934 scopus 로고    scopus 로고
    • alpha2- to beta3-Adrenoceptor switch in 3T3-L1 preadipocytes and adipocytes: modulation by testosterone, 17beta-estradiol, and progesterone
    • Monjo M, Pujol E, Roca P, (2005) alpha2- to beta3-Adrenoceptor switch in 3T3-L1 preadipocytes and adipocytes: modulation by testosterone, 17beta-estradiol, and progesterone. Am J Physiol Endocrinol Metab 289: E145-150.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Monjo, M.1    Pujol, E.2    Roca, P.3
  • 57
    • 31044441953 scopus 로고    scopus 로고
    • Leptin, nutrition and reproduction: new insights
    • Popovic V, Casanueva FF, (2002) Leptin, nutrition and reproduction: new insights. Hormones (Athens) 1: 204-217.
    • (2002) Hormones (Athens) , vol.1 , pp. 204-217
    • Popovic, V.1    Casanueva, F.F.2
  • 58
    • 0037072868 scopus 로고    scopus 로고
    • Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1
    • Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J, (2002) Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem 277: 34601-34609.
    • (2002) J Biol Chem , vol.277 , pp. 34601-34609
    • Ambrosini, G.1    Nath, A.K.2    Sierra-Honigmann, M.R.3    Flores-Riveros, J.4
  • 59
    • 77954186819 scopus 로고    scopus 로고
    • 17Beta-Estradiol Enhances Leptin Expression in Human Placental Cells Through Genomic and Nongenomic Actions
    • Gambino YP, Maymo JL, Perez-Perez A, Duenas JL, Sanchez-Margalet V, et al. (2010) 17Beta-Estradiol Enhances Leptin Expression in Human Placental Cells Through Genomic and Nongenomic Actions. Biol Reprod.
    • (2010) Biol Reprod
    • Gambino, Y.P.1    Maymo, J.L.2    Perez-Perez A.Duenas, J.L.3    Sanchez-Margalet, V.4
  • 61
    • 0036015048 scopus 로고    scopus 로고
    • Identification of a functional Na+/Mg2+ exchanger in human trophoblast cells
    • Standley PR, Standley CA, (2002) Identification of a functional Na+/Mg2+ exchanger in human trophoblast cells. Am J Hypertens 15: 565-570.
    • (2002) Am J Hypertens , vol.15 , pp. 565-570
    • Standley, P.R.1    Standley, C.A.2
  • 62
    • 0031792141 scopus 로고    scopus 로고
    • Invasion of cytotrophoblastic JEG-3 cells is stimulated by hCG in vitro
    • Zygmunt M, Hahn D, Munstedt K, Bischof P, Lang U, (1998) Invasion of cytotrophoblastic JEG-3 cells is stimulated by hCG in vitro. Placenta 19: 587-593.
    • (1998) Placenta , vol.19 , pp. 587-593
    • Zygmunt, M.1    Hahn, D.2    Munstedt, K.3    Bischof, P.4    Lang, U.5
  • 63
    • 3042725709 scopus 로고    scopus 로고
    • Drug transfer and metabolism by the human placenta
    • Syme MR, Paxton JW, Keelan JA, (2004) Drug transfer and metabolism by the human placenta. Clin Pharmacokinet 43: 487-514.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 487-514
    • Syme, M.R.1    Paxton, J.W.2    Keelan, J.A.3
  • 64
    • 0035109551 scopus 로고    scopus 로고
    • Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions
    • Terasaki T, Hosoya K, (2001) Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions. Biol Pharm Bull 24: 111-118.
    • (2001) Biol Pharm Bull , vol.24 , pp. 111-118
    • Terasaki, T.1    Hosoya, K.2
  • 65
    • 33845472453 scopus 로고    scopus 로고
    • Expression in human trophoblast and choriocarcinoma cell lines, BeWo, Jeg-3 and JAr of genes involved in the hepatobiliary-like excretory function of the placenta
    • Serrano MA, Macias RI, Briz O, Monte MJ, Blazquez AG, et al. (2007) Expression in human trophoblast and choriocarcinoma cell lines, BeWo, Jeg-3 and JAr of genes involved in the hepatobiliary-like excretory function of the placenta. Placenta 28: 107-117.
    • (2007) Placenta , vol.28 , pp. 107-117
    • Serrano, M.A.1    Macias, R.I.2    Briz, O.3    Monte, M.J.4    Blazquez, A.G.5
  • 66
    • 34249885877 scopus 로고    scopus 로고
    • Biochemical characterization and modulation of LH/CG-receptor during human trophoblast differentiation
    • Pidoux G, Gerbaud P, Tsatsaris V, Marpeau O, Ferreira F, et al. (2007) Biochemical characterization and modulation of LH/CG-receptor during human trophoblast differentiation. J Cell Physiol 212: 26-35.
    • (2007) J Cell Physiol , vol.212 , pp. 26-35
    • Pidoux, G.1    Gerbaud, P.2    Tsatsaris, V.3    Marpeau, O.4    Ferreira, F.5
  • 67
    • 0027522771 scopus 로고
    • Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts
    • Shi QJ, Lei ZM, Rao CV, Lin J, (1993) Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts. Endocrinology 132: 1387-1395.
    • (1993) Endocrinology , vol.132 , pp. 1387-1395
    • Shi, Q.J.1    Lei, Z.M.2    Rao, C.V.3    Lin, J.4
  • 69
    • 0035013450 scopus 로고    scopus 로고
    • An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine
    • Rao CV, (2001) An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine. Semin Reprod Med 19: 7-17.
    • (2001) Semin Reprod Med , vol.19 , pp. 7-17
    • Rao, C.V.1
  • 70
    • 0027158153 scopus 로고
    • The lutropin/choriogonadotropin receptor 4 years later
    • Segaloff DL, Ascoli M, (1993) The lutropin/choriogonadotropin receptor 4 years later. Endocr Rev 14: 324-347.
    • (1993) Endocr Rev , vol.14 , pp. 324-347
    • Segaloff, D.L.1    Ascoli, M.2
  • 71
    • 1642268837 scopus 로고    scopus 로고
    • Regulation of luteinizing hormone/human chorionic gonadotropin receptor expression: a perspective
    • Menon KM, Munshi UM, Clouser CL, Nair AK, (2004) Regulation of luteinizing hormone/human chorionic gonadotropin receptor expression: a perspective. Biol Reprod 70: 861-866.
    • (2004) Biol Reprod , vol.70 , pp. 861-866
    • Menon, K.M.1    Munshi, U.M.2    Clouser, C.L.3    Nair, A.K.4
  • 72
    • 0015888898 scopus 로고
    • Human chorionic gonadotropin-mediated glycogenolysis in human placental villi: a role of prostaglandins
    • Demers LM, Gabbe SG, Villee CA, Greep RO, (1973) Human chorionic gonadotropin-mediated glycogenolysis in human placental villi: a role of prostaglandins. Biochim Biophys Acta 313: 202-210.
    • (1973) Biochim Biophys Acta , vol.313 , pp. 202-210
    • Demers, L.M.1    Gabbe, S.G.2    Villee, C.A.3    Greep, R.O.4
  • 73
    • 0015859452 scopus 로고
    • Chorionic gonadotropin sensitive adenylate cyclase in human term placenta
    • Menon KM, Jaffe RB, (1973) Chorionic gonadotropin sensitive adenylate cyclase in human term placenta. J Clin Endocrinol Metab 36: 1104-1109.
    • (1973) J Clin Endocrinol Metab , vol.36 , pp. 1104-1109
    • Menon, K.M.1    Jaffe, R.B.2
  • 74
    • 0032852479 scopus 로고    scopus 로고
    • CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals
    • Shaywitz AJ, Greenberg ME, (1999) CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68: 821-861.
    • (1999) Annu Rev Biochem , vol.68 , pp. 821-861
    • Shaywitz, A.J.1    Greenberg, M.E.2
  • 75
    • 33744810660 scopus 로고    scopus 로고
    • FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A. Cell Signal
    • Hunzicker-Dunn M, Maizels ET, (2006) FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A. Cell Signal. 18: 1351-1359.
    • (2006) , vol.18 , pp. 1351-1359
    • Hunzicker-Dunn, M.1    Maizels, E.T.2
  • 76
    • 33645884139 scopus 로고    scopus 로고
    • Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications
    • Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, Plant TM, (2006) Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology 147: 2122-2126.
    • (2006) Endocrinology , vol.147 , pp. 2122-2126
    • Seminara, S.B.1    Dipietro, M.J.2    Ramaswamy, S.3    Crowley Jr., W.F.4    Plant, T.M.5
  • 78
    • 0037305575 scopus 로고    scopus 로고
    • Signal transduction pathways activated by chorionic gonadotropin in the primate endometrial epithelial cells
    • Srisuparp S, Strakova Z, Brudney A, Mukherjee S, Reierstad S, et al. (2003) Signal transduction pathways activated by chorionic gonadotropin in the primate endometrial epithelial cells. Biol Reprod 68: 457-464.
    • (2003) Biol Reprod , vol.68 , pp. 457-464
    • Srisuparp, S.1    Strakova, Z.2    Brudney, A.3    Mukherjee, S.4    Reierstad, S.5
  • 79
    • 0036320795 scopus 로고    scopus 로고
    • Acute signaling by the LH receptor is independent of protein kinase C activation
    • Salvador LM, Maizels E, Hales DB, Miyamoto E, Yamamoto H, et al. (2002) Acute signaling by the LH receptor is independent of protein kinase C activation. Endocrinology 143: 2986-2994.
    • (2002) Endocrinology , vol.143 , pp. 2986-2994
    • Salvador, L.M.1    Maizels, E.2    Hales, D.B.3    Miyamoto, E.4    Yamamoto, H.5
  • 81
    • 0032904758 scopus 로고    scopus 로고
    • Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle
    • Bornfeldt KE, Krebs EG, (1999) Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle. Cell Signal 11: 465-477.
    • (1999) Cell Signal , vol.11 , pp. 465-477
    • Bornfeldt, K.E.1    Krebs, E.G.2
  • 82
    • 0027485031 scopus 로고
    • Increasing cAMP attenuates activation of mitogen-activated protein kinase
    • Sevetson BR, Kong X, Lawrence JC Jr, (1993) Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A 90: 10305-10309.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10305-10309
    • Sevetson, B.R.1    Kong, X.2    Lawrence Jr., J.C.3
  • 83
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • Cook SJ, McCormick F, (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262: 1069-1072.
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 84
    • 0027772672 scopus 로고
    • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate
    • Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, et al. (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science 262: 1065-1069.
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Jelinek, T.3    Wolfman, A.4    Weber, M.J.5
  • 85
    • 0027374550 scopus 로고
    • Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells
    • Graves LM, Bornfeldt KE, Raines EW, Potts BC, Macdonald SG, et al. (1993) Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci U S A 90: 10300-10304.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10300-10304
    • Graves, L.M.1    Bornfeldt, K.E.2    Raines, E.W.3    Potts, B.C.4    Macdonald, S.G.5
  • 86
    • 0027501802 scopus 로고
    • cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor
    • Burgering BM, Pronk GJ, van Weeren PC, Chardin P, Bos JL, (1993) cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J 12: 4211-4220.
    • (1993) EMBO J , vol.12 , pp. 4211-4220
    • Burgering, B.M.1    Pronk, G.J.2    van Weeren, P.C.3    Chardin, P.4    Bos, J.L.5
  • 87
    • 0030963439 scopus 로고    scopus 로고
    • cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
    • Vossler MR, Yao H, York RD, Pan MG, Rim CS, et al. (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89: 73-82.
    • (1997) Cell , vol.89 , pp. 73-82
    • Vossler, M.R.1    Yao, H.2    York, R.D.3    Pan, M.G.4    Rim, C.S.5
  • 88
    • 0032499282 scopus 로고    scopus 로고
    • Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
    • York RD, Yao H, Dillon T, Ellig CL, Eckert SP, et al. (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392: 622-626.
    • (1998) Nature , vol.392 , pp. 622-626
    • York, R.D.1    Yao, H.2    Dillon, T.3    Ellig, C.L.4    Eckert, S.P.5
  • 89
    • 0033807228 scopus 로고    scopus 로고
    • Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling
    • Houslay MD, Kolch W, (2000) Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling. Mol Pharmacol 58: 659-668.
    • (2000) Mol Pharmacol , vol.58 , pp. 659-668
    • Houslay, M.D.1    Kolch, W.2
  • 90
    • 0033520311 scopus 로고    scopus 로고
    • Differential effects of cAMP in neurons and astrocytes. Role of B-raf
    • Dugan LL, Kim JS, Zhang Y, Bart RD, Sun Y, et al. (1999) Differential effects of cAMP in neurons and astrocytes. Role of B-raf. J Biol Chem 274: 25842-25848.
    • (1999) J Biol Chem , vol.274 , pp. 25842-25848
    • Dugan, L.L.1    Kim, J.S.2    Zhang, Y.3    Bart, R.D.4    Sun, Y.5
  • 91
    • 0033531946 scopus 로고    scopus 로고
    • Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase
    • MacNicol MC, MacNicol AM, (1999) Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase. J Biol Chem 274: 13193-13197.
    • (1999) J Biol Chem , vol.274 , pp. 13193-13197
    • MacNicol, M.C.1    MacNicol, A.M.2
  • 92
    • 0030048696 scopus 로고    scopus 로고
    • Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein
    • Ohtsuka T, Shimizu K, Yamamori B, Kuroda S, Takai Y, (1996) Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein. J Biol Chem 271: 1258-1261.
    • (1996) J Biol Chem , vol.271 , pp. 1258-1261
    • Ohtsuka, T.1    Shimizu, K.2    Yamamori, B.3    Kuroda, S.4    Takai, Y.5
  • 93
    • 0028111836 scopus 로고
    • B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP
    • Vaillancourt RR, Gardner AM, Johnson GL, (1994) B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP. Mol Cell Biol 14: 6522-6530.
    • (1994) Mol Cell Biol , vol.14 , pp. 6522-6530
    • Vaillancourt, R.R.1    Gardner, A.M.2    Johnson, G.L.3


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