Role of leptin in pregnancy - A review

Placenta

Volumn 23, Issue SUPPL. 1, 2002, Pages

  Sagawa, N ^a   Yura, S ^a   Itoh, H ^a   Mise, H ^a   Kakui, K ^a   Korita, D ^a   Takemura, M ^a   Nuamah, M A ^a   Ogawa, Y ^a   Masuzaki, H ^a   Nakao, K ^a   Fujii, S ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN DERIVATIVE; HORMONE; NERVE GROWTH FACTOR; PROTEIN; RESISTIN; RESISTIN LIKE ALPHA, MOUSE; RESISTIN-LIKE ALPHA, MOUSE; RETN PROTEIN, HUMAN; RETN PROTEIN, MOUSE; RETNLB PROTEIN, HUMAN; SIGNAL PEPTIDE;

5' UNTRANSLATED REGION; BODY MASS; CORRELATION ANALYSIS; DERIVATIZATION; DNA FLANKING REGION; ENERGY METABOLISM; FETUS GROWTH; GENE EXPRESSION; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HUMAN; INSULIN SENSITIVITY; MEAN ARTERIAL PRESSURE; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PLACENTA DEVELOPMENT; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN SECRETION; REVIEW; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE; TROPHOBLAST; ADULT; ANIMAL; BLOOD; BREEDING; EATING; FEMALE; FETOMATERNAL TRANSFUSION; FETUS WEIGHT; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; PLACENTA; PLACENTA INSUFFICIENCY;

ADULT; ANIMALS; EATING; FEMALE; FETAL WEIGHT; HORMONES, ECTOPIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MATERNAL-FETAL EXCHANGE; MICE; MICE, TRANSGENIC; NERVE GROWTH FACTOR; PLACENTA; PLACENTAL INSUFFICIENCY; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY, ANIMAL; PROTEINS; RESISTIN;

EID: 0001820949     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1053/plac.2002.0814     Document Type: Article

References (52)

1. Abrams B & Pickett KE (1999) Maternal nutrition. In Maternal-fetal medicine, 4th edn (Ed.) Creasy RK & Resnik R, pp. 122-131. Philadelphia, Pennsylvania, W.B. Saunders company.
2. Ahima RS & Flier JS (2000) Leptin. Annu Rev Physiol, 62, 413-437.
3. Aizawa-Abe M, Ogawa Y, Masuzaki H, Ebihara K, Satoh N, Iwai H, Matsuoka N, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y & Nakao K (2000) Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest, 105, 1243-1252.
4. Ashworth CJ, Hoggard N, Thomas L, Mercer JG, Wallace JM & Lea RG (2000) Placental leptin. Rev Reprod, 5, 18-24.
5. Bodner J, Ebenbichler C, Wolf H, Muller-Holzner E, Stanzl U, Gander R, Huter O & Patsch J (1999) Leptin receptor in human term placenta: in situ hybridization and immunohistochemical localization. Placenta, 20, 677-682.
6. Campfield LA, Smith FJ, Guisez Y, Devos R & Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science, 269, 546-549.
7. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK & Considine RV (1997) Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet, 348, 159-161.
8. Chehab FF, Lim ME & Lu R (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet, 12, 318-320.
9. Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gbur J, Mikhail A, Platika D & Snodgrass HR (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med, 2, 585-589.
10. De la Brousse FC, Shan B & Chen JL (1996) Identification of the promoter of the mouse obese gene. Proc Natl Acad Sci USA, 93, 4096-4101.
11. Ebihara K, Ogawa Y, Isse N, Mori K, Tamura N, Masuzaki H, Kohno K, Yura S, Hosoda K, Sagawa N & Nakao K (1997) Identification of the human leptin 5′-flanking sequences involved in the trophoblast-specific translation. Biochem Biophys Res Commun, 241, 658-663.
12. Ebihara K, Ogawa Y, Masuzaki H, Shintani M, Miyanaga F, Aizawa-Abe M, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Gavrilova O, Reitman ML & Nakao K (2001) Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes, 50, 1440-1448.
13. Festa A, Shnawa N, Krugluger W, Hopmeier P, Schernthaner G & Haffner SM (1999) Relative hypoleptinaemia in women with mild gestational diabetes mellitus. Diabet Med, 16, 656-662.
14. Flier JS (2001) The missing link with obesity? Nature, 409, 292-293.
15. Gavrilova O, Barr V, Marcus-Samuels B & Reitman M (1997) Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J Biol Chem, 272, 30546-30551.
16. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK & Friedman JM (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 269, 543-546.
17. He Y, Chen H, Quon MJ & Reitman M (1995) The mouse obese gene: Genomic organization, promoter activity, and activation by CCAAT/enhancer- binding protein α. J Biol Chem, 270, 28887-28891.
18. Henson M, Swan K & O'Neil JS (1998) Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term. Obstet Gynecol, 92, 1020-1028.
19. Henson MC & Castracane VD (2000) Leptin in pregnancy. Biol Reprod, 63, 1219-1228.
20. Hoggard N, Hunter L, Duncan JS, Williams LM, Trayhurn P & Mercer JG (1997) Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci USA, 94, 11073-11078.
21. Hoggard N, Crabtree J, Allstaff S, Abramovich DR & Haggarty P (2001) Leptin secretion to both the maternal and fetal circulation in the ex vivo perfused human term placenta. Placenta, 22, 347-352.
22. Holness MJ, Munns MJ & Sugden MC (1999) Current concepts concerning the role of leptin in reproductive function. Mol Cell Endocrinol, 157, 11-20.
23. Hwang CH, Mandrup S, MacDougald OA, Geiman DE & Lane MD (1996) Transcriptional activation of the mouse obese (ob) gene by GCAAT/enhancer binding protein α. Proc Natl Acad Sci USA, 93, 873-877.
24. Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H, Carlsson LM & Carlsson B (1997) Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab, 82, 4144-4148.
25. Kastin AJ & Pan W (2000) Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul Pept, 92, 37-43.
26. Kim YB, Uotani S, Pierroz DD, Flier JS & Kahn BB (2000) In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin. Endocrinology, 141, 2328-2339.
27. Lea RG, Howe D, Hannah LT, Bonneau O, Hunter L & Hoggard N (2000) Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod, 6, 763-769.
28. Lepercq J, Cauzac M, Lahlou N, Timsit J, Girard J, Auwerx J & Hauguel-de Mouzon S (1998) Overexpression of placental leptin in diabetic pregnancy-A critical role for insulin. Diabetes, 47, 847-850.
29. Lepercq J, Challier JC, Guerre-Millo M, Cauzac M, Vidal H & Hauguel-de Mouzon S (2001) Prenatal leptin production: evidence that fetal adipose tissue produces leptin. J Clin Endocrinol Metab, 86, 2409-2413.
30. Linnemann K, Malek A, Sager R, Blum WF, Schneider H & Fusch C (2000) Leptin production and release in the dually in vitro perfused human placenta. J Clin Endocrinol Metab, 85, 4298-4301.
31. MacDougald OA, Hwang CH, Fan H & Lane MD (1995) Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA, 92, 9034-9037.
32. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T & Nakao K (1997) Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nat Med, 3, 1029-1033.
33. Masuzaki H, Ogawa Y, Aizawa-Abe M, Hosoda K, Suga J, Ebihara K, Satoh N, Iwai H, Inoue G, Nishimura H, Yoshimasa Y & Nakao K (1999) Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation. Diabetes, 48, 1615-1622.
34. Mikhail AA, Beck EX, Shafer A, Barut B, Gbur JS, Zupancic TJ, Schweitzer AC, Cioffi JA, Lacaud G, Ouyang B, Keller G & Snodgrass HR (1997) Leptin stimulate fetal and adult erythroid and myeloid development. Blood, 89, 1507-1512.
35. Miller SG, deVos P, Guerre-Millo M, Wong K, Hermann T, Staels B, Briggs MR & Auwerx J (1996) The adipocyte specific transcription factor G/EBPα modulates human ob gene expression. Proc Natl Acad Sci USA, 93, 5507-5511.
36. Mise H, Sagawa N, Matsumoto T, Yura S, Nanno H, Itoh H, Mori T, Masuzaki H, Hosoda K, Ogawa Y & Nakao K (1998) Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab, 83, 3225-3229.
37. Ogawa Y, Masuzaki H, Hosoda K, Aizawa Abe M, Suga J, Suda M, Ebihara K, Iwai H, Matsuoka N, Satoh N, Odaka H, Kasuga H, Fujisawa Y, Inoue G, Nishimura H, Yoshimasa Y & Nakao K (1999) Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes, 48, 1822-1829.
38. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T & Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269, 540-543.
39. Pineiro V, Casabiell X, Peino R, Garcia-Vallejo L, Dieguez C & Casanueva FF (1998) PMA inhibits both spontaneous and glucocorticold-mediated leptin secretion by human omental adipose tissue explants in vitro. Biochem Biophys Res Commun, 252, 345-347.
40. Reitman ML, Marcus-Samuels B & Gavrilova O (2001) Leptin and its role in pregnancy and fetal development-an overview. Biochem Soc Trans, 29 part 2, 68-72.
41. Rentsch J & Chiesi M (1996) Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett, 379, 55-59.
42. Sagawa N, Mori T, Masuzaki H, Ogawa Y & Nakao K (1997) Leptin production by hydatidiform mole. Lancet, 350, 1518-1519.
43. Sagawa N, Yura S, Itoh H, Ogawa Y, Masuzaki H, Nakao K & Fujii S (2001) Placental protein and fetal growth. Proceedings of 12th Fukuoka International Symposium on Perinatal Medicine, Fukuoka, Japan, 2001 (in press).
44. Shek EW, Brands MW & Hall JE (1998) Chronic leptin infusion increases arterial pressure. Hypertension, 31{1}part 2{2}409-414.
45. Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ & Flores-Riveros JR (1998) Biological action of leptin as an angiogenic factor. Science, 281, 1683-1686.
46. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS & Lazar MA (2001) The hormone resistin links obesity to diabetes. Nature, 409, 307-712.
47. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarity A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA & Tepper RI (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell, 83, 1263-1271.
48. db/+ mice: Effects on placental leptin and fetal growth. Endocrinology, 142, 2888-2897.
49. Yura S, Sagawa N, Mise H, Mori T, Masuzaki H, Ogawa Y & Nakao K (1998a) A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth. Am J Obstet Gynecol, 178, 926-930.
50. Yura S, Sagawa N, Ogawa Y, Masuzaki H, Mise H, Matsumoto T, Ebihara K, Fujii S & Nakao K (1998b) Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells. J Clin Endocrinol Metab, 83, 3609-3614.
51. Yura S, Ogawa Y, Sagawa N, Masuzaki H, Itoh H, Ebihara K, Aizawa-Abe M, Fujii S & Nakao K (2000) Accelarated puberty and late onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin. J Clin Invest, 105, 749-755.
52. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.