Connectomic intermediate phenotypes for psychiatric disorders

Frontiers in Psychiatry

Volumn 3, Issue APR, 2012, Pages

  Fornito, Alex ^a   Bullmore, Edward T ^b,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Alzheimer's disease; Anxiety; Complex; Default mode; Depression; Graph analysis; Schizophrenia; Sendophenotype

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; APOLIPOPROTEIN A; SEROTONIN TRANSPORTER;

ALZHEIMER DISEASE; AMYLOID PLAQUE; APOLIPOPROTEIN A GENE; ATTENTION DEFICIT DISORDER; BIPOLAR DISORDER; BOLD SIGNAL; BRAIN FUNCTION; BRAIN REGION; CONNECTOME; DIFFUSION WEIGHTED IMAGING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE; GENE LOCATION; GENE LOCUS; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MENTAL DISEASE; MENTAL TASK; MONOAMINE OXIDASE A GENE; NERVE CELL NETWORK; NONHUMAN; PATHOGENESIS; PHENOTYPE; REVIEW; SCHIZOPHRENIA; SEROTONIN TRANSPORTER GENE; TASK PERFORMANCE; WORKING MEMORY; ZNF804A GENE;

EID: 84866845650     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2012.00032     Document Type: Review

References (204)

1. Achard, S., and Bullmore, E. (2007). Efficiency and cost of economical brain functional networks. PLoS Comput Biol. 3, e17. doi:10.1371/journal.pcbi.0030017
2. Achard, S., Salvador, R., Whitcher, B., Suckling, J., and Bullmore, E. (2006). A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J. Neurosci. 26, 63-72.
3. Agrawal, A., and Lynskey, M. T. (2008). Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction 103, 1069-1081.
4. Alexander-Bloch, A. F., Gogtay, N., Meunier, D., Birn, R., Clasen, L., Lalonde, F., Lenroot, R., Giedd, J., and Bullmore, E. T. (2010). Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. Front. Syst. Neurosci. 4:147. doi:10.3389/fnsys.2010.00147
5. Ansorge, M. S., Zhou, M., Lira, A., Hen, R., and Gingrich, J. A. (2004). Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306, 879-881.
6. Barrat, A., Barthelemy, M., Pastor-Satorras, R., and Vespignani, A. (2004). The architecture of complex weighted networks. Proc. Natl. Acad. Sci. U.S.A. 101,3747-3752.
7. Bassett, D. S., Bullmore, E., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., and Meyer-Lindenberg, A. (2008). Hierarchical organization ofhuman cortical networks in health and schizophrenia. J. Neurosci. 28, 9239-9248.
8. Bassett, D. S., Bullmore, E. T., Meyer-Lindenberg, A., Apud, J. A., Weinberger, D. R., and Coppola, R. (2009). Cognitive fitness of cost-efficient brain functional networks. Proc. Natl. Acad. Sci. U.S.A. 106, 11747-11752.
9. Bassett, D. S., Greenfield, D. L., Meyer-Lindenberg, A., Weinberger, D R., Moore, S. W., and Bullmore, E. T. (2010). Efficient physical embedding of topologically complex information processing networks in brains and computer circuits. PLoS Comput. Biol. 6, e1000748. doi:10.1371/journal.pcbi.1000748
10. Bassett, D. S., Nelson, B. G., Mueller, B. A., Camchong, J., and Lim, K. O. (2012). Altered resting state complexity in schizophrenia. Neuroim-age 59,2196-2207.
11. Beckmann, C. F., and Smith, S. M. (2004). Probabilistic independent component analysis for functional magnetic resonance imaging. IEEE Trans. Med. Imaging 23, 137-152.
12. Belmonte, M. K., Allen, G., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., and Webb, S. J. (2004). Autism and abnormal development of brain connectivity. J. Neurosci. 24, 9228-9231.
13. Bennett, M. R. (2011). Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss. Prog. Neurobiol. 95, 275-300.
14. Bertolino, A., Rubino, V., Sambataro,E, Blasi, G., Latorre, V., Fazio,L., Caforio, G., Petruzzella, V., Kolachana, B., Hariri, A., Meyer-Lindenberg, A., Nardini, M., Weinberger, D. R., and Scarabino, T. (2006). Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biol. Psychiatry 60,1250-1258.
15. Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., and Tanzi, R. E. (2007). Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39,17-23.
16. Bertram, L., and Tanzi, R. E. (2008). Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat. Rev. Neurosci. 9, 768-778.
17. Biswal,B.,Yetkin,F.Z.,Haughton,V.M., and Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn. Reson. Med. 34, 537-541.
18. Blasi, G., Lo Bianco, L., Taurisano, P., Gelao, B., Romano, R., Fazio, L., Papazacharias, A., Di Giorgio, A., Caforio, G., Rampino, A., Masellis, R., Papp, A., Ursini, G., Sinibaldi, L., Popolizio, T., Sadee, W., and Bertolino, A. (2009). Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. J. Neurosci. 29, 14812-14819.
19. Blokland, G. A., McMahon, K. L., Thompson, P. M., Martin, N. G.,de Zubicaray, G. I., and Wright, M. J. (2011). Heritability of working memory brain activation. J. Neurosci. 31, 10882-10890.
20. Bluhm, R. L., Miller, J., Lanius, R. A., Osuch, E. A., Boksman, K., Neufeld, R. W., Theberge, J., Schaefer, B., and Williamson, P. (2007). Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr. Bull. 33, 1004-1012.
21. Boomsma, D., Busjahn, A., and Peltonen, L. (2002). Classical twin studies and beyond. Nat. Rev. Genet. 3, 872-882.
22. Bouchard, T. J. Jr. (1998). Genetic and environmental influences on adult intelligence and special mental abilities. Hum. Biol. 70, 257-279.
23. Braitenberg, V., and Schüz, A. (1991). Anatomy of the Cortex Statistics and Geometry. Berlin: Springer.Bressler, S. L., and Seth, A. K. (2011). Wiener-Granger causality: a well established methodology. Neuroim-age 58, 323-329.
24. Buckholtz, J. W., Callicott, J. H., Kolachana, B., Hariri, A. R., Goldberg, T. E., Genderson, M., Egan, M. F., Mattay, V. S., Weinberger, D. R., and Meyer-Lindenberg, A. (2008). Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Mol. Psychiatry 13, 313-324.
25. Buckholtz, J. W., Meyer-Lindenberg, A., Honea, R. A., Straub, R. E., Peza-was, L., Egan, M. F., Vakkalanka, R., Kolachana, B., Verchinski, B. A., Sust, S., Mattay, V. S., Weinberger, D. R., and Callicott, J. H. (2007). Allelic variation in RGS4 impacts functional and structural connectivity in the human brain. J. Neurosci. 27,1584-1593.
26. Buckner, R. L., Andrews-Hanna, J. R., and Schacter, D. L. (2008). The brain's default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 1124, 1-38.
27. Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, E M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., and Johnson, K. A. (2009). Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J. Neurosci. 29, 1860-1873.
28. Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., and Mintun, M. A. (2005). Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci. 25, 7709-7717.
29. Bullmore, E., Barnes, A., Bassett, D. S., Fornito, A., Kitzbichler, M., Meunier, D., and Suckling, J. (2009). Generic aspects of complexity in brain imaging data and other biological systems. Neuroimage 47, 1125-1134.
30. Bullmore, E., and Sporns, O. (2009). Complex brain networks: graph theoretical analysis of structural and functional systems. Nat. Rev. Neurosci. 10, 186-198.
31. Bullmore, E. T., and Bassett, D. S. (2011). Brain graphs: graphical models of the human brain connectome. Annu. Rev. Clin. Psychol. 7, 113-140.
32. Buzsaki, G., Geisler, C., Henze, D. A., and Wang, X. J. (2004). Interneuron diversity series: circuit complexity and axon wiring economy of cortical interneurons. Trends Neurosci. 27,186-193.
33. Calhoun, V. D., Adali, T., and Pekar, J. J. (2004). A method for comparing group fMRI data using independent component analysis: application to visual, motor and visuomo-tor tasks. Magn. Reson. Imaging 22, 1181-1191.
34. Calhoun, V. D., Maciejewski, P. K., Pearlson, G. D., and Kiehl, K. A. (2008). Temporal lobe and "default" hemo-dynamic brain modes discriminate between schizophrenia and bipolardisorder. Hum. Brain Mapp. 29, 1265-1275.
35. Canli, T., Qiu, M., Omura, K., Congdon, E., Haas, B. W., Amin, Z., Herrmann, M. J., Constable, R. T., and Lesch, K. P. (2006). Neural correlates of epi-genesis. Proc. Natl. Acad. Sci. U.S.A. 103,16033-16038.
36. Cannon, T. D., Kaprio, J., Lönnqvist, J., Huttunen, M., and Koskenvuo, M. (1998). The genetic epidemiology of schizophrenia in a Finnish twin cohort: a population-based modeling study. Arch. Gen. Psychiatry 55, 67-74.
37. Cannon, T. D., and Keller, M. C. (2006). Endophenotypes in the genetic analyses of mental disorders. Annu. Rev. Clin. Psychol. 2, 267-290.
38. Cardno, A. G., Marshall, E. J., Cold, B., MacDonald, A. M., Ribchester, T. R., Davies, N. J., Venturi, P., Jones, L. A., Lewis, S. W., Sham, P. C., Gottesman, I. I., Farmer, A. E., McGuffin, P., Reveley, A. M., and Murray, R. M. (1999). Heritability estimates for psychotic disorders: the Mauds-ley twin psychosis series. Arch. Gen. Psychiatry 56,162-168.
39. Caspi, A., Hariri, A. R., Holmes, A., Uher, R., and Moffitt, T. E. (2010). Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am. J. Psychiatry 167, 509-527.
40. Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., and Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science 297, 851-854.
41. Castellanos, F. X., Margulies, D. S., Kelly, C., Uddin, L. Q., Ghaffari, M., Kirsch, A., Shaw, D., Shehzad, Z., Di Martino, A., Biswal, B., Sonuga-Barke, E. J., Rotrosen, J., Adler, L. A., and Milham, M. P. (2008). Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol. Psychiatry 63, 332-337.
42. Chen, B. L., Hall, D. H., and Chklovskii, D. B. (2006). Wiring optimization can relate neuronal structure and function. Proc. Natl. Acad. Sci. U.S.A. 103,4723-4728.
43. Cherniak, C., Changizi, M., and Won Kang, D. (1999). Large-scale optimization of neuron arbors. Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 59, 6001-6009.
44. Cherniak, C., Mokhtarzada, Z., Rodriguez-Esteban, R., and Changizi, K. (2004). Global optimization of cerebral cortexlayout. Proc. Natl. Acad. Sci. U.S.A. 101, 1081-1086.
45. Chiang, M. C., Barysheva, M., Shattuck, D. W., Lee, A. D., Madsen, S. K., Avedissian, C., Klunder, A. D., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Wright, M. J.,Srivastava, A., Balov, N., and Thompson, P. M. (2009). Genetics of brain fiber architecture and intellectual performance. J. Neurosci. 29, 2212-2224.
46. Chklovskii, D. B. (2004). Synaptic connectivity and neuronal morphology: two sides of the same coin. Neuron 43, 609-617.
47. Chklovskii, D. B., Schikorski, T., and Stevens, C. F. (2002). Wiring optimization in cortical circuits. Neuron 34, 341-347.
48. Chung, H. J., Lee, J. Y., Deocaris, C. C., Min, H., Kim, S. H., and Kim, M. H. (2010). Mouse homologue of the schizophrenia susceptibility gene ZNF804A as a target of Hoxc8. J. Biomed. Biotechnol. 2010, 231708.
49. Clare Kelly, A. M., Uddin, L. Q., Biswal, B. B., Castellanos, F. X., and Milham, M. P. (2008). Competition between functional brain networks mediates behavioral variability. Neuroimage 39, 527-537.
50. Clarke, H., Flint, J., Attwood, A. S., and Munafo, M. R. (2010). Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis. Psychol. Med. 40, 1767-1778.
51. Curcic-Blake, B., Swart, M., Ter Horst, G. J., Langers, D. R., Kema, I. P., and Aleman, A. (2012). Variation of the gene coding for DARPP-32 (PPP1R1B) and brain connectivity during associative emotional learning. Neuroimage 59, 1540-1550.
52. Damoiseaux, J. S., Rombouts, S. A., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., and Beckmann, C. E (2006). Consistent resting-state networks across healthy subjects. Proc. Natl. Acad. Sci. U.S.A. 103, 13848-13853.
53. Dennis, N. A., Browndyke, J. N., Stokes, J., Need, A., Burke, J. R., Welsh-Bohmer, K. A., and Cabeza, R. (2010a). Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers. Alzheimers Dement. 6, 303-311.
54. Dennis, N. A., Need, A. C., LaBar, K. S., Waters-Metenier, S., Cirulli, E. T., Kragel, J., Goldstein, D. B., and Cabeza, R. (2010b). COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. Cereb. Cortex 20, 672-683
55. Ellison-Wright, I., and Bullmore, E. (2009). Meta-analysis of diffusiontensor imaging studies in schizophrenia. Schizophr. Res. 108, 3-10.
56. Erhardt, E. B., Allen, E. A., Damaraju, E., and Calhoun, V. D. (2011). On network derivation, classification and visualization: a response to habeck and moeller. Brain Connect. 1, 105-110.
57. Erk, S., Meyer-Lindenberg, A., Schnell, K., Opitz von Boberfeld, C., Essli-nger, C., Kirsch, P., Grimm, O., Arnold, C., Haddad, L., Witt, S. H., Cic-hon, S., Nothen, M. M., Rietschel, M., and Walter, H. (2010). Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch. Gen. Psychiatry 67, 803-811.
58. Esslinger, C., Kirsch, P., Haddad, L., Mier, D., Sauer, C., Erk, S., Schnell, K., Arnold, C., Witt, S. H., Rietschel, M., Cichon, S., Walter, H., and Meyer-Lindenberg, A. (2011). Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A. Neuroimage 54,2514-2523.
59. Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., Witt, S. H., Rietschel, M., Cichon, S., and Meyer-Lindenberg, A. (2009). Neural mechanisms of a genome-wide supported psychosis variant. Science 324, 605.
60. Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W A., Mayeux, R., Myers, R. H., Pericak-Vance, M. A., Risch, N., and van Duijn, C. M. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278, 1349-1356.
61. Filippini, N., MacIntosh, B. J., Hough, M. G., Goodwin, G. M., Frisoni, G. B., Smith, S. M., Matthews, P. M., Beckmann, C. F., and Mackay, C. E. (2009). Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc. Natl. Acad. Sci. U.S.A. 106, 7209-7214.
62. Fleisher, A. S., Sherzai, A., Taylor, C., Langbaum, J. B., Chen, K., and Buxton, R. B. (2009). Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups. Neuroimage 47,1678-1690.
63. Flint, J., and Munafo, M. R. (2007). The endophenotype concept in psychiatric genetics. Psychol. Med. 37, 163-180.
64. Fornito, A., and Bullmore, E. T. (2010). What can spontaneous fluctuations of the blood oxygenation-level-dependent signal tell us aboutpsychiatric disorders? Curr. Opin. Psychiatry 23, 239-249.
65. Fornito, A., Yoon, J., Zalesky, A., Bullmore, E. T., and Carter, C. S. (2011a). General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance. Biol. Psychiatry 70, 64-72.
66. Fornito, A., Zalesky, A., Bassett, D. S., Meunier, D., Ellison-Wright, I., Yucel, M., Wood, S. J., Shaw, K., O'Connor, J., Nertney, D., Mowry, B. J., Pantelis, C., and Bullmore, E. T. (2011b). Genetic influences on cost-efficient organization of human cortical functional networks. J. Neu-rosci. 31,3261-3270.
67. Fornito, A., Yucel, M., Patti, J., Wood, S. J., and Pantelis, C. (2009). Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studies. Schiz-ophr. Res. 108, 104-113.
68. Fornito, A., Zalesky, A., Pantelis, C., and Bullmore, E. T. (2012). Schizophrenia, neuroimaging and connectomics. Neuroimage. doi: 10.1016/j.neuroimage.2011.12.090
69. Fox, M. D., and Raichle, M. E. (2007). Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat. Rev. Neurosci. 8,700-711.
70. Fox, M. D., Snyder, A. Z., Vincent, J. L., and Raichle, M. E. (2007). Intrinsic fluctuations within cortical systems account for intertrial variability in human behavior. Neuron 56, 171-184.
71. Fox, M. D., Snyder, A. Z., Zacks, J. M., and Raichle, M. E. (2006). Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses. Nat. Neurosci. 9, 23-25.
72. Friston, K. J. (1994). Functional and effective connectivity in neuroimaging: a synthesis. Hum. Brain Mapp. 2, 56-78.
73. Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., and Dolan, R. J. (1997). Psychophysiological and modulatory interactions in neuroimaging. Neuroimage 6, 218-229.
74. Friston, K. J., Harrison, L., and Penny, W. (2003). Dynamic causal modelling. Neuroimage 19,1273-1302.
75. Gai, X., Xie, H. M., Perin, J. C., Takahashi, N., Murphy, K., Wenocur, A. S., D'Arcy, M., O'Hara, R. J., Goldmuntz, E., Grice, D. E., Shaikh, T. H., Hakonarson, H., Buxbaum, J. D., Elia, J., and White, P. S. (2012). Rare structural variation of synapse and neurotransmission genes in autism. Mol. Psychiatry 17, 402-411.
76. Gibbons, A. S., Udawela, M., Jeon, W. J., Seo, M. S., Brooks, L., and Dean, B. (2011). The neurobiology of APOE in schizophrenia and mood disorders. Front. Biosci. 16, 962-979.
77. Glahn, D. C., Winkler, A. M., Kochunov, P., Almasy, L., Duggirala, R., Carless, M. A., Curran, J. C., Olvera, R. L., Laird, A. R., Smith, S. M., Beckmann, C. F., Fox, P. T., and Blangero, J. (2010). Genetic control over the resting brain. Proc. Natl. Acad. Sci. U.S.A. 107, 1223-1228.
78. Gogtay, N., Vyas, N. S., Testa, R., Wood, S. J., and Pantelis, C. (2011). Age of onset of schizophrenia: perspectives from structural neuroimaging studies. Schizophr. Bull. 37, 504-513.
79. Gottesman, I. I. (1991). Schizophrenia Genesis: The Origins ofMadness. New York: W.H. Freeman and Company.
80. Gottesman, I. I., and Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 1-10.
81. Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., and Schatzberg, A. F. (2007). Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol. Psychiatry 62, 429-437.
82. Greicius, M. D., Srivastava, G., Reiss, A. L., and Menon, V. (2004). Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc. Natl Acad. Sci. U.S.A. 101,4637-4642.
83. Habeck, C., and Moeller, J. R. (2011). Intinsic functional-connectivity networks for diagnosis: just beautiful pictures? Brain Connect. 1, 99-103.
84. Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., and Sporns, O. (2008). Mapping the structural core of human cerebral cortex. PLoS Biol. 6, e159. doi:10.1371/journal.pbio.0060159
85. Hagmann, P., Kurant, M., Gigandet, X., Thiran, P., Wedeen, V. J., Meuli, R., and Thiran, J. P. (2007). Mapping human whole-brain structural networks with diffusion MRI. PLoS ONE 2, e597. doi:10.1371/jour-nal.pone.0000597
86. Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., Miller, J., Fedele, A., Collins, J., Smith, K., Lotspeich, L., Croen, L. A., Ozonoff, S., Lajonchere, C., Grether, J. K., and Risch, N. (2011). Genetic heritability and shared environmental factors among twins pairs withautism. Arch. Gen. Psychiatry 68, 1095-1102.
87. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., and Weinberger, D. R. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400-403.
88. Harrison, B. J., Pujol, J., Contreras-Rodriguez, O., Soriano-Mas, C., Lopez-Sola, M., Deus, J., Ortiz, H., Blanco-Hinojo, L., Alonso, P., Hernandez-Ribas, R., Cardoner, N., and Menchon, J. M. (2011). Task-induced deactivation from rest extends beyond the default mode brain network. PLoS ONE 6, e22964. doi:10.1371/journal.pone.0022964
89. Harrison, B. J., Pujol, J., Lopez-Sola, M., Hernandez-Ribas, R., Deus, J., Ortiz, H., Soriano-Mas, C., Yucel, M., Pantelis, C., and Cardoner, N. (2008). Consistency and functional specialization in the default mode brain network. Proc. Natl. Acad. Sci. U.S.A. 105,9781-9786.
90. Harrison, P. J., and Weinberger, D. R. (2005). Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 10, 40-68.
91. He, B. J., Snyder, A. Z., Zempel, J. M., Smyth, M. D., and Raichle, M. E. (2008). Electrophysiological correlates of the brain's intrinsic large-scale functional architecture. Proc. Natl. Acad. Sci. U.S.A. 105, 16039-16044.
92. He, Y., Chen, Z. J., and Evans, A. C. (2007). Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Cereb. Cortex 17,2407-2419.
93. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., and Lesch, K. P. (1996). Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66, 2621-2624.
94. Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Klein, S., Grusser, S. M., Flor, H., Schumann, G., Mann, K., and Buchel, C. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat. Neurosci. 8,20-21.
95. Heinz, A., Jones, D. W., Mazzanti, C., Goldman, D., Ragan, P., Hommer, D., Linnoila, M., and Weinberger, D. R. (2000). A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol. Psychiatry 47, 643-649.
96. Hesselmann, G., Kell, C. A., Eger, E., and Kleinschmidt, A. (2008). Spontaneous local variations in ongoingneural activity bias perceptual decisions. Proc. Natl. Acad. Sci. U.S.A. 105,10984-10989.
97. Hettema, J. M., Neale, M. C., and Kendler, K. S. (2001). A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am. J. Psychiatry 158, 1568-1578.
98. Hill, M. J., and Bray, N. J. (2011). Allelic differences in nuclear protein binding at a genome-wide significant risk variant for schizophrenia in ZNF804A. Mol. Psychiatry 16, 787-789.
99. Hong, L. E., Hodgkinson, C. A., Yang, Y., Sampath, H., Ross, T. J., Buchholz, B., Salmeron, B. J., Srivastava, V., Thaker, G. K., Goldman, D., and Stein, E. A. (2010). A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proc. Natl. Acad. Sci. U.S.A. 107, 13509-13514.
100. Insel, T. R. (2011). Rethinking schizophrenia. Nature 468,187-193.
101. Jbabdi, S., and Johansen-Berg, H. (2011). Tractography: where do we go from here? Brain Connect. 1, 169-183.
102. Jedema, H. P., Gianaros, P. J., Greer, P. J., Kerr, D. D., Liu, S., Higley, J. D., Suomi, S. J., Olsen, A. S., Porter, J. N., Lopresti, B. J., Hariri, A. R., and Bradberry, C. W (2010). Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. Mol. Psychiatry 15,512-522,446.
103. Kaiser, M., Gorner, M., and Hilgetag, C. C. (2007). Criticality of spreading dynamics in hierarchical cluster networks without inhibition. New J. Phys. 9,2-13.
104. Kaiser, M., and Hilgetag, C. C. (2006). Nonoptimal component placement, but short processing paths, due to long-distance projections in neural systems. PLoS Comput. Biol. 2, e95. doi:10.1371/journal.pcbi.0020095
105. Kempf, L., Nicodemus, K. K., Kolachana, B., Vakkalanka, R., Verchinski, B. A., Egan, M. F., Straub, R. E., Mattay, V. A., Callicott, J. H., Weinberger, D. R., and Meyer-Lindenberg, A. (2008). Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. PLoS Genet. 4, e1000252. doi:10.1371/journal.pgen.1000252
106. Kendler, K. S. (2006). Reflections on the relationship between psychiatric genetics and psychiatric nosology. Am. J. Psychiatry 163, 1138-1146.
107. Kendler, K. S., Gatz, M., Gardner, C. O., and Pedersen, N. L. (2006). A Swedish national twin study of lifetime major depression. Am. J. Psychiatry 163, 109-114.
108. Kendler, K. S., and Neale, M. C. (2010). Endophenotype: a conceptual analysis. Mol. Psychiatry 15, 789-797.
109. Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., and Eaves, L. J. (1993). The lifetime history of major depression in women. Reliability of diagnosis and heritability. Arch. Gen. Psychiatry 50, 863-870.
110. Kennedy, D. P., and Courchesne, E. (2008). The intrinsic functional organization of the brain is altered in autism. Neuroimage 39, 1877-1885.
111. Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., and Moffitt, T. E. (2006). MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis. Mol. Psychiatry 11,903-913.
112. Klyachko, V. A., and Stevens, C. F. (2003). Connectivity optimization and the positioning of cortical areas. Proc. Natl Acad. Sci. U.S.A. 100, 7937-7941.
113. Konrad, A., Vucurevic, G., Musso, F., Stoeter, P., Dahmen, N., and Winterer, G. (2009). ErbB4 genotype predicts left frontotemporal structural connectivity in human brain. Neuropsychopharmacology 34, 641-650.
114. Koten, J. W Jr., Wood, G., Hagoort, P., Goebel, R., Propping, P., Willmes, K., and Boomsma, D. I. (2009). Genetic contribution to variation in cognitive function: an FMRI study in twins. Science 323,1737-1740.
115. Krugel, L. K., Biele, G., Mohr, P. N., Li, S. C., and Heekeren, H. R. (2009). Genetic variation in dopaminer-gic neuromodulation influences the ability to rapidly and flexibly adapt decisions. Proc. Natl Acad. Sci. U.S.A. 106, 17951-17956.
116. Latora, V., and Marchiori, M. (2001). Efficient behavior of small-world networks. Phys. Rev. Lett. 87,198701.
117. Latora, V., and Marchiori, M. (2003). Economic small-world behavior in weighted networks. Eur. Phys. J. B 32, 249-263.
118. Laughlin, S. B., and Sejnowski, T. J. (2003). Communication in neuronal networks. Science 301,1870-1874.
119. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., and Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonintransporter gene regulatory region. Science 274, 1527-1531.
120. Li, D., and He, L. (2007). Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry 12, 47-54.
121. Li, Y., Liu, Y., Li, J., Qin, W., Li, K., Yu, C., and Jiang, T. (2009). Brain anatomical network and intelligence. PLoS Comput. Biol. 5, e1000395. doi:10.1371/jour-nal.pcbi. 1000395
122. Lips, E. S., Cornelisse, L. N., Toonen, R. F., Min, J. L., Hultman, C. M., Holmans, P. A., O'Donovan, M. C., Purcell, S. M., Smit, A. B., Verhage, M., Sullivan, P. F., Visscher, P. M., and Posthuma, D. (2011). Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Mol Psychiatry. doi: 10.1038/mp.2011.117
123. Lo, C. Y., Wang, P. N., Chou, K. H., Wang, J., He, Y., and Lin, C. P. (2010). Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer's disease. J. Neurosci. 30, 16876-16885.
124. Lynall, M. E., Bassett, D. S., Kerwin, R., McKenna, P. J., Kitzbichler, M., Muller, U., and Bullmore, E. (2010). Functional connectivity and brain networks in schizophrenia. J. Neurosci. 30,9477-9487.
125. Machulda, M. M., Jones, D. T., Vemuri, P., McDade, E., Avula, R., Przybelski, S., Boeve, B. F., Knopman, D. S., Petersen, R. C., and Jack, C. R. Jr. (2011). Effect of APOEepsilon4 status on intrinsic network connectivity in cognitively normal elderly subjects. Arch. Neurol. 68, 1131-1136.
126. Mahley, R. W., and Rall, S. C. Jr. (2000). Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1,507-537.
127. Margulies, D. S., Bottger, J., Long, X., Lv, Y., Kelly, C., Schafer, A., Goldhahn, D., Abbushi, A., Milham, M. P., Lohmann, G., and Villringer, A. (2010). Resting developments: a review of fMRI postprocessing methodologies for spontaneous brain activity. MAGMA 23, 289-307.
128. McClearn, G. E., Johansson, B., Berg, S., Pedersen, N. L., Ahern, F., Petrill, S. A., and Plomin, R. (1997). Substantial genetic influence on cognitive abilities in twins 80 or more years old. Science 276, 1560-1563.
129. McGuffin, P., Rijsdijk, F., Andrew, M., Sham, P., Katz, R., and Cardno, A. (2003). The heritability of bipolar affective disorder and the genetic relationship to unipolardepression. Arch. Gen. Psychiatry 60, 497-502.
130. McHugh, R. K., Hofmann, S. G., Asnaani, A., Sawyer, A. T., and Otto, M. W (2010). The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review. Drug Alcohol Depend. 108,1-6.
131. Mennes, M., Zuo, X. N., Kelly, C., Di Martino, A., Zang, Y F., Biswal, B., Castellanos, F. X., and Milham, M. P. (2011). Linking inter-individual differences in neural activation and behavior to intrinsic brain dynamics. Neuroimage 54,2950-2959.
132. Menzies, L., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., and Bullmore, E. T. (2008). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orb-itofronto-striatal model revisited. Neurosci. Biobehav. Rev. 32,525-549.
133. Meunier, D., Lambiotte, R., Fornito, A., Ersche, K. D., and Bullmore, E. T. (2009). Hierarchical modularity in human brain functional networks. Front. Neuroinformatics 3, 37.
134. Meyer-Lindenberg, A. (2009). Neural connectivity as an intermediate phenotype: brain networks under genetic control. Hum. Brain Mapp. 30,1938-1946.
135. Meyer-Lindenberg, A. (2010). From maps to mechanisms through neuroimaging of schizophrenia. Nature 468,194-202.
136. Meyer-Lindenberg, A., Straub, R. E., Lipska, B. K., Verchinski, B. A., Goldberg, T., Callicott, J. H., Egan, M. E, Huffaker, S. S., Mattay, V. S., Kolachana, B., Kleinman, J. E., and Weinberger, D. R. (2007). Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J. Clin. Invest. 117,672-682.
137. Meyer-Lindenberg, A., and Weinberger, D R. (2006). Intermediate pheno-types and genetic mechanisms of psychiatric disorders. Nat. Rev. Neu rosci. 7,818-827.
138. Meyer-Lindenberg, A. S., Olsen, R. K., Kohn, P. D., Brown, T., Egan, M. E, Weinberger, D. R., and Berman, K. F. (2005). Regionally specific dis turbance of dorsolateral prefrontal-hippocampal functional connectiv ity in schizophrenia. Arch. Gen. Psy chiatry 62, 379-386.
139. Minzenberg, M. J., Laird, A. R., Thelen, S., Carter, C. S., and Glahn, D. C. (2009). Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch. Gen. Psychiatry 66, 811-822.
140. Morcom, A. M., and Fletcher, P. C. (2007). Does the brain have abaseline? Why we should be resisting a rest. Neuroimage 37, 1073-1082.
141. Mori, S., and Zhang, J. (2006). Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 51, 527-539.
142. Mukherjee, P., Whalley, H. C., McKirdy, J. W., McIntosh, A. M., Johnstone, E. C., Lawrie, S. M., and Hall, J. (2011). Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion. Psychiatry Res. 191, 182-188.
143. Munafo, M. R., Freimer, N. B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., Jarvelin, M. R., Taanila, A., and Flint, J. (2009). 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B,271-281.
144. Murthy, N. V., Selvaraj, S., Cowen, P. J., Bhagwagar, Z., Riedel, W. J., Peers, P., Kennedy, J. L., Sahakian, B. J., Laruelle, M. A., Rabiner, E. A., and Grasby, P. M. (2010). Serotonin transporter polymorphisms (SLC6A4insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain. Neuroimage 52, 50-54.
145. Nikulina, V., Widom, C. S., and Brzustowicz, L. M. (2012). Child abuse and neglect, MAOA, and mental health outcomes: a prospective examination. Biol. Psychiatry 71, 350-357.
146. O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C., Howie, B., Leung, H. T., Hartmann, A. M., Moller, H. J., Morris, D. W., Shi, Y., Feng, G., Hoffmann, P., Propping, P., Vasilescu, C., Maier, W., Rietschel, M., Zammit, S., Schumacher, J., Quinn, E. M., Schulze, T. G., Williams, N. M., Giegling, I., Iwata, N., Ikeda, M., Darvasi, A., Shifman, S., He, L., Duan, J., Sanders, A. R., Levinson, D. F., Gejman, P. V., Cichon, S., Nothen, M. M., Gill, M., Corvin, A., Rujescu, D., Kirov, G., Owen, M. J., Buccola, N. G., Mowry, B. J., Freedman, R., Amin, F., Black, D. W., Silverman, J. M., Byerley, W F., and Cloninger, C. R. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat. Genet. 40, 1053-1055.
147. Pacheco, J.,Beevers, C. G.,Benavides, C., McGeary, J., Stice, E., and Schnyer, D. M. (2009). Frontal-limbic white matter pathway associations withthe serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J. Neurosci. 29, 6229-6233.
148. Pantelis, C., Yucel, M., Bora, E., Fornito, A., Testa, R., Brewer, W. J., Velakoulis, D., and Wood, S. J. (2009). Neurobiological markers of illness onset in psychosis and schizophrenia: the search for a moving target. Neuropsychol. Rev. 19, 385-398.
149. Papagni, S. A., Mechelli, A., Prata, D. P., Kambeitz, J., Fu, C. H., Picchioni, M., Walshe, M., Toulopoulou, T., Bramon, E., Murray, R. M., Collier, D. A., Bellomo, A., and McGuire, P. (2011). Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controls. Neuroimage 56,2283-2291.
150. Peper, J. S., Brouwer, R. M., Boomsma, D. I., Kahn, R. S., and Hulshoff Pol, H. E. (2007). Genetic influences on human brain structure: a review of brain imaging studies in twins. Hum. Brain Mapp. 28, 464-473.
151. Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., and Mechelli, A. (2011). Dysconnectivity in schizophrenia: where are we now? Neurosci. Biobehav. Rev. 35, 1110-1124.
152. Pezawas,L., Meyer-Lindenberg,A.,Dra-bant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., and Weinberger, D. R. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat. Neurosci. 8, 828-834.
153. Phillips, M. L., Drevets, W C, Rauch, S. L., and Lane, R. (2003a). Neu-robiology of emotion perception I: the neural basis of normal emotion perception. Biol. Psychiatry 54, 504-514.
154. Phillips, M. L., Drevets, W. C., Rauch, S. L., and Lane, R. (2003b). Neurobiol-ogy of emotion perception II: implications for major psychiatric disorders. Biol. Psychiatry 54, 515-528.
155. Potkin, S. G., Turner, J. A., Fallon, J. A., Lakatos, A., Keator, D. B., Guffanti, G., and Macciardi, F. (2009). Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol. Psychiatry 14,416-428.
156. Prata, D. P., Papagni, S. A., Mechelli, A., Fu, C. H., Kambeitz, J., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Kravariti, E., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R., Collier, D. A., and McGuire, P. K. (2012). Effect of D-amino acidoxidase activator (DAOA; G72) on brain function during verbal fluency. Hum. Brain Mapp. 33, 143-153.
157. Purcell, S. M., Wray, N. R., Stone, J. L., Visscher, P. M., O'Donovan, M. C., Sullivan, P. F., and Sklar, P. (2009). Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748-752.
158. Ramón y Cajal, S. (1995). Histology of the Nervous System. New York: Oxford University Press.
159. Rasch, B., Spalek, K., Buholzer, S., Luechinger, R., Boesiger, P., de Quervain, D. J., and Papassotiropoulos, A. (2010). Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype. Neuroimage 52, 1712-1719.
160. Rasch, B., Spalek, K., Buholzer, S., Luechinger, R., Boesiger, P., Papassotiropoulos, A., and de Quervain, D. J. (2009). A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. Proc. Natl. Acad. Sci. U.S.A. 106, 19191-19196.
161. Rasetti, R., Sambataro, F., Chen, Q., Callicott, J. H., Mattay, V. S., and Weinberger, D. R. (2011). Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. Arch. Gen. Psychiatry 68,1207-1217.
162. Riley, B., Thiselton, D., Maher, B. S., Bigdeli, T., Wormley, B., McMichael, G. O., Fanous, A. H., Vladimirov, V., O'Neill, E A., Walsh, D., and Kendler, K. S. (2010). Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of schizophrenia sample. Mol. Psychiatry 15,29-37.
163. Robinson, E. B., Koenen, K. C., McCormick, M. C., Munir, K., Hallett, V., Happe, E, Plomin, R., and Ronald, A. (2012). A mutlivari-ate twin study of autistic traits in 12-year olds: testing the fraction-able autism triad hypothesis. Behav. Genet. 42,245-255.
164. Rubinov, M., and Sporns, O. (2010). Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52, 1059-1069.
165. Rubinov, M., Sporns, O., Thivierge, J. P., and Breakspear, M. (2011). Neuro-biologically realistic determinants of self-organized criticality in networks of spiking neurons. PLoS Comput. Biol. 7, e1002038. doi:10.1371/jour-nal.pcbi. 1002038
166. Sabol, S. Z., Hu, S., and Hamer, D. (1998). A functional polymorphismin the monoamine oxidase A gene promoter. Hum. Genet. 103, 273-279.
167. Schardt, D. M., Erk, S., Nusser, C., Nothen, M. M., Cichon, S., Rietschel, M., Treutlein, J., Goschke, T., and Walter, H. (2010). Volition diminishes genetically mediated amygdala hyperreactivity. Neuroimage 53, 943-951.
168. Seeley, W. W (2011). Divergent network connectivity changes in healthy APOE epsilon4 carriers: disinhibi-tion or compensation? Arch. Neurol. 68, 1107-1108.
169. Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., and Greicius, M. D. (2009). Neurodegenerative diseases target large-scale human brain networks. Neuron 62, 42-52.
170. Shehzad, Z., Kelly, A. M., Reiss, P. T., Gee, D. G., Gotimer, K., Uddin, L. Q., Lee, S. H., Margulies, D. S., Roy, A. K., Biswal, B. B., Petkova, E., Castellanos, E X., and Milham, M. P. (2009). The resting brain: unconstrained yet reliable. Cereb. Cortex 19,2209-2229.
171. Sheline, Y. I., Morris, J. C., Snyder, A. Z., Price, J. L., Yan, Z., D'Angelo, G., Liu, C., Dixit, S., Benzinger, T., Fagan, A., Goate, A., and Mintun, M. A. (2010a). APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Abeta42. J. Neurosci. 30,17035-17040.
172. Sheline, Y. I., Raichle, M. E., Snyder, A. Z., Morris, J. C., Head, D., Wang, S., and Mintun, M. A. (2010b). Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biol. Psychiatry 67, 584-587.
173. Shmuel, A., and Leopold, D. A. (2008). Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest. Hum. Brain Mapp. 29,751-761.
174. Shulman, G. L., Fiez, J. A., Corbetta, M., Buckner, R. L., Miezin, E M., Raichle, M. E., and Petersen, S. E. (1997). Common blood flow changes across visual tasks: II. Decreases in cerebral cortex.J. Cogn. Neurosci. 9,648-663.
175. Smit, D. J., Stam, C. J., Posthuma, D., Boomsma, D. I., and de Geus, E. J. (2008). Heritability of "small-world" networks in the brain: a graph theoretical analysis of resting-state EEG functional connectivity. Hum. Brain Mapp. 29, 1368-1378.
176. Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., and Beckmann, C. E (2009). Correspondence of thebrain's functional architecture during activation and rest. Proc. Natl. Acad. Sci. U.S.A. 106, 13040-13045.
177. Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Cic-carelli, O., Cader, M. Z., Matthews, P. M., and Behrens, T. E. (2006). Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31, 1487-1505.
178. Sonuga-Barke, E. J., and Castellanos, E X. (2007). Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci. Biobehav. Rev. 31,977-986.
179. Sporns, O. (2011). The human connec-tome: a complex network. Ann. N. Y. Acad. Sci. 1224, 109-125.
180. Sporns, O., Tononi, G., and Edelman, G. M. (2000). Theoretical neu-roanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices. Cereb. Cortex 10, 127-141.
181. Sporns, O., Tononi, G., and Kotter, R. (2005). The human connectome: a structural description of the human brain. PLoS Comput. Biol. 1, e42. doi:10.1371/journal.pcbi.0010042
182. Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietilainen, O. P., Mors, O., Mortensen, P. B., Sigurdsson, E., Gustafsson, O., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Suvisaari, J., Lonnqvist, J., Paunio, T., Borglum, A. D., Hartmann, A., Fink-Jensen, A., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Bottcher, Y., Olesen, J., Breuer, R., Moller, H. J., Giegling, I., Rasmussen, H. B., Timm, S., Mattheisen, M., Bitter, I., Rethelyi, J. M., Magnusdottir, B. B., Sigmundsson, T., Olason, P., Mas-son, G., Gulcher, J. R., Haraldsson, M., Fossdal, R., Thorgeirsson, T. E., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Franke, B., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S.,Abramova, L.,Kaleda,V., Sanjuan, J., de Frutos, R., Bramon, E., Vas-sos, E., Fraser, G., Ettinger, U., Picchioni, M., Walker, N., Toulopoulou, T.,Need,A.C.,Ge,D.,Yoon,J.L.,Shi-anna, K. V., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golim-bet, V., Carracedo, A., Arango, C., Costas, J., Jonsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nothen, M. M., Rietschel, M., Matthews, P. M., Muglia, P., Peltonen, L., St Clair, D., Goldstein, D. B., Stefansson, K., and Collier, D. A. (2009). Common variants conferring risk of schizophrenia. Nature 460, 744-747.
183. Steinberg, S., Mors, O., Borglum, A. D., Gustafsson, O., Werge, T., Mortensen, P. B., Andreassen, O. A., Sigurdsson, E., Thorgeirsson, T. E., Bottcher, Y., Olason, P., Ophoff, R. A., Cichon, S., Gudjonsdot-tir, I. H., Pietilainen, O. P., Nye-gaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Athanasiu, L., Suvisaari, J., Lonnqvist, J., Paunio, T., Hartmann, A., Jurgens, G., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Breuer, R., Moller, H. J., Giegling, I., Glenthoj, B., Rasmussen, H. B., Mattheisen, M., Bitter, I., Rethelyi, J. M., Sigmundsson, T., Fossdal, R., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Walshe, M., Bramon, E., Vassos, E., Li, T., Fraser, G., Walker, N., Toulopoulou, T., Yoon, J., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golim-bet, V., Jonsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nothen, M. M., Rietschel, M., Peltonen, L., Rujescu, D., Collier, D. A., Stefansson, H., St Clair, D., and Stefansson, K. (2011). Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry 16,59-66.
184. Sullivan, P. F., Neale, M. C., and Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. Am. J. Psychiatry 157, 1552-1562.
185. Tan, H. Y., Chen, Q., Sust, S., Buck-holtz, J. W., Meyers, J. D., Egan, M. F., Mattay, V. S., Meyer-Lindenberg, A., Weinberger, D. R., and Callicott, J. H. (2007). Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proc. Natl.Acad. Sci. U.S.A. 104, 12536-12541.
186. Thompson, P. M., Cannon, T. D., Narr, K. L., Van Erp, T. G. M., Poutanen, V.-P., Huttunen, M., Lönnqvist,J., Standertskjöld-Nordenstam, C. G., Kaprio, J., Khaledy, M., Dail, R., Zoumalan, C. I., and Toga, A. W. (2001). Genetic influences on brain structure. Nat. Neurosci. 4, 1253-1258.
187. van den Heuvel, M. P., Mandl, R. C., Stam, C. J., Kahn, R. S., and Hulshoff Pol, H. E. (2010). Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis. J. Neurosci. 30,15915-15926.
188. van den Heuvel, M. P., Stam, C. J., Kahn, R. S., and Hulshoff Pol, H. E. (2009). Efficiency of functional brain networks and intellectual performance. J. Neurosci. 29, 7619-7624.
189. Van Essen, D. C. (1997). A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature 385, 313-318.
190. van Grootheest, D. S., Cath, D. C., Beekman, A. T., and Boomsma, D. I. (2005). Twin studies on obsessive-compulsive disorder: a review. Twin Res. Hum. Genet. 8, 450-458.
191. Walters, J. T., and Owen, M. J. (2007). Endophenotypes in psychiatric genetics. Mol. Psychiatry 12, 886-890.
192. Wang, L., Zhu, C., He, Y., Zang, Y., Cao, Q., Zhang, H., Zhong, Q., and Wang, Y. (2009). Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder. Hum. Brain Mapp. 30, 638-649.
193. Wei, L., Li, Y., Tang, Y., and Wang, J. (2010). Brain functional connectivity in depression during emotion processing. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 27, 961-967.
194. Weinberger, D. R., Berman, K. F., Suddath, R., and Torrey, E. F. (1992). Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotictwins. Arch. Gen. Psychiatry 149, 890-897.
195. Westlye, E. T., Lundervold, A., Rootwelt, H., Lundervold, A. J., and Westlye, L. T. (2011). Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE epsilon4 carriers: relationships with memory performance. J. Neurosci. 31,7775-7783.
196. Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., Shenton, M. E., Green, A. I., Nieto-Castanon, A., LaViolette, P., Wojcik, J., Gabrieli, J. D., and Seidman, L. J. (2009). Hyperactivity and hyper-connectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc. Natl Acad. Sci. U.S.A. 106, 1279-1284.
197. Williams, H. J., Norton, N., Dwyer, S., Moskvina, V., Nikolov, I., Carroll, L., Georgieva, L., Williams, N. M., Morris, D. W., Quinn, E. M., Giegling, I., Ikeda, M., Wood, J., Lencz, T., Hultman, C., Lichtenstein, P., This-elton, D., Maher, B. S., Malhotra, A. K., Riley, B., Kendler, K. S., Gill, M., Sullivan, P., Sklar, P., Purcell, S., Nim-gaonkar,V L., Kirov, G.,Holmans,P., Corvin, A., Rujescu, D., Craddock, N., Owen, M. J., and O'Donovan, M. C. (2011). Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry 16, 429-441.
198. Winterer, G., Konrad, A., Vucurevic, G., Musso, F., Stoeter, P., and Dahmen, N. (2008). Association of 5' endneuregulin-1 (NRG 1) gene variation with subcortical medial frontal microstructure in humans. Neu-roimage 40, 712-718.
199. Xu, L., Groth, K. M., Pearlson, G., Schretlen, D. J., and Calhoun, V D. (2009a). Source-based morphome-try: the use of independent component analysis to identify gray matter differences with application to schizophrenia. Hum. Brain Mapp. 30, 711-724.
200. Xu, L., Pearlson, G., and Calhoun, V. D. (2009b). Joint source based mor-phometry identifies linked gray and white matter group differences. Neu-roimage 44, 777-789.
201. Zalesky, A., and Fornito, A. (2009). A DTI-derived measure of cortico-cortical connectivity. IEEE Trans. Med. Imaging 28, 1023-1036.
202. Zalesky, A., Fornito, A., Harding, I. H., Cocchi, L., Yucel, M., Pantelis, C., and Bullmore, E. T. (2010). Whole-brain anatomical networks: does the choice of nodes matter? Neuroimage 50, 970-983.
203. Zalesky, A., Fornito, A., Seal, M. L., Cocchi, L., Westin, C. F., Bullmore, E. T., Egan, G. F., and Pantelis, C. (2011). Disrupted axonal fiber connectivity in schizophrenia. Biol. Psychiatry 69, 80-89.
204. Zhang, D., and Raichle, M. E. (2010). Disease and the brain's dark energy. Nat. Rev. Neurol. 6, 15-28.