Genetic control over the resting brain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 3, 2010, Pages 1223-1228

  Glahn, D C ^a,b   Winkler, A M ^a,b   Kochunov, P ^c   Almasy, L ^d   Duggirala, R ^d   Carless, M A ^d   Curran, J C ^d   Olvera, R L ^e   Laird, A R ^c   Smith, S M ^f   Beckmann, C F ^f,g   Fox, P T ^c   Blangero, J ^d  

^a INSTITUTE OF LIVING   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^e University of Texas Health Science Center   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Default mode; Functional MRI; Heritability; Resting state networks

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CEREBELLUM; CINGULATE GYRUS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENETIC REGULATION; GRAY MATTER; HEREDITY; HERITABILITY; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; MALE; NEUROANATOMY; PEDIGREE; PREFRONTAL CORTEX; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REST;

BRAIN; GENOME, HUMAN; HUMANS; MAGNETIC RESONANCE IMAGING;

EID: 75749118564     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909969107     Document Type: Article

References (52)

1. Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537-541.
2. Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700-711.
3. Beckmann CF, DeLuca M, Devlin JT, Smith SM (2005) Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci 360:1001-1013.
4. Smith S, et al. (2009) Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci USA 106:13040-13045.
5. Raichle ME, et al. (2001) A default mode of brain function. Proc Natl Acad Sci USA 98: 676-682.
6. Gusnard DA, Akbudak E, Shulman GL, Raichle ME (2001) Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function. Proc Natl Acad Sci USA 98:4259-4264.
7. Greicius MD, Krasnow B, Reiss AL, Menon V (2003) Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100:253-258.
8. Greicius MD, Menon V (2004) Default-mode activity during a passive sensory task: Uncoupled from deactivation but impacting activation. J Cogn Neurosci 16:1484-1492.
9. Mason MF, et al. (2007) Wandering minds: The default network and stimulus-independent thought. Science 315:393-395.
10. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD (2009) Neurodegenerative diseases target large-scale human brain networks. Neuron 62:42-52.
11. Fransson P, et al. (2007) Resting-state networks in the infant brain. Proc Natl Acad Sci USA 104:15531-15536.
12. Vincent JL, et al. (2007) Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447:83-86.
13. Broyd SJ, et al. (2009) Default-mode brain dysfunction in mental disorders: A systematic review. Neurosci Biobehav Rev 33:279-296.
14. Persson J, et al. (2008) Altered deactivation in individuals with genetic risk for Alzheimer's disease. Neuropsychologia 46:1679-1687.
15. Whitfield-Gabrieli S, et al. (2009) Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc Natl Acad Sci USA 106:1279-1284.
16. Filippini N, et al. (2009) Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci USA 106:7209-7214.
17. Meyer-Lindenberg A (2009) Neural connectivity as an intermediate phenotype: Brain networks under genetic control. Hum Brain Mapp 30:1938-1946.
18. Greicius MD, Srivastava G, Reiss AL, Menon V (2004) Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI. Proc Natl Acad Sci USA 101:4637-4642.
19. Kennedy DP, Redcay E, Courchesne E (2006) Failing to deactivate: Resting functional abnormalities in autism. Proc Natl Acad Sci USA 103:8275-8280.
20. Castellanos FX, et al. (2005) Varieties of attention-deficit/ hyperactivity disorder-related intra-individual variability. Biol Psychiatry 57:1416-1423.
21. Garrity AG, et al. (2007) Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry 164:450-457.
22. Damoiseaux JS, et al. (2006) Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci USA 103:13848-13853.
23. Buckner RL, Andrews-Hanna JR, Schacter DL (2008) The brain's default network: Anatomy, function, and relevance to disease. Ann N Y Acad Sci 1124:1-38.
24. Fox MD, Snyder AZ, Zacks JM, Raichle ME (2006) Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses. Nat Neurosci 9: 23-25.
25. Greicius MD, Supekar K, Menon V, Dougherty RF (2009) Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex 19:72-78.
26. Skudlarski P, et al. (2008) Measuring brain connectivity: diffusion tensor imaging validates resting state temporal correlations. Neuroimage 43:554-561.
27. Glahn DC, Thompson PM, Blangero J (2007) Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function. Hum Brain Mapp 28:488-501.
28. Kochunov P, et al. (2009) Genetics of DTI-derived parameters of cerebral white matter. A track-based heritability and linkage study in extended pedigree. Neuroimage 47 (Suppl 1):S139.
29. Chiang MC, et al. (2009) Genetics of brain fiber architecture and intellectual performance. J Neurosci 29:2212-2224.
30. Uddin LQ, Kelly AM, Biswal BB, Xavier Castellanos F, Milham MP (2009) Functional connectivity of default mode network components: Correlation, anticorrelation, and causality. Hum Brain Mapp 30:625-637.
31. Laird A, et al. (2009) Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling. J Neurosci 29:14496-14505.
32. Svoboda E, McKinnon MC, Levine B (2006) The functional neuroanatomy of autobiographical memory: A meta-analysis. Neuropsychologia 44:2189-2208.
33. Vincent JL, et al. (2006) Coherent spontaneous activity identifies a hippocampal-parietal memory network. J Neurophysiol 96:3517-3531.
34. Buxton RB, Frank LR (1997) A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 17: 64-72.
35. Buxton RB, Wong EC, Frank LR (1998) Dynamics of blood flow and oxygenation changes during brain activation: The balloon model. Magn Reson Med 39:855-864.
36. Raichle ME, Mintun MA (2006) Brain work and brain imaging. Annu Rev Neurosci 29: 449-476.
37. Caspi A, Moffitt TE (2006) Gene-environment interactions in psychiatry: Joining forces with neuroscience. Nat Rev Neurosci 7:583-590.
38. Koten JW, Jr, et al. (2009) Genetic contribution to variation in cognitive function: An FMRI study in twins. Science 323:1737-1740.
39. Matthews SC, et al. (2007) Heritability of anterior cingulate response to conflict: An fMRI study in female twins. Neuroimage 38:223-227.
40. Blokland GA, et al. (2008) Quantifying the heritability of task-related brain activation and performance during the N-back working memory task: A twin fMRI study. Biol Psychol 79:70-79.
41. Smit DJ, Stam CJ, Posthuma D, Boomsma DI, de Geus EJ (2008) Heritability of "small-world" networks in the brain: A graph theoretical analysis of resting-state EEG functional connectivity. Hum Brain Mapp 29:1368-1378.
42. Thompson PM, et al. (2001) Genetic influences on brain structure. Nat Neurosci 4: 1253-1258.
43. Peper JS, Brouwer RM, Boomsma DI, Kahn RS, Hulshoff Pol HE (2007) Genetic influences on human brain structure: A review of brain imaging studies in twins. Hum Brain Mapp 28:464-473.
44. Blangero J, Williams JT, Almasy L (2003) Novel family-based approaches to genetic risk in thrombosis. J Thromb Haemost 1:1391-1397.
45. Kochunov P, et al. (2006) Retrospective motion correction protocol for high-resolution anatomical MRI. Hum Brain Mapp 27:957-962.
46. Smith SM, et al. (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23 (Suppl 1):S208-S219.
47. Beckmann CF, Smith SM (2004) Probabilistic independent component analysis for functional magnetic resonance imaging. IEEE Trans Med Imaging 23:137-152.
48. Beckmann C, Mackay C, Filippini N, Smith S (2009) Group comparison of resting-state FMRI data using multi-subject ICA and dual regression. Neuroimage 47 (Suppl 1):S148.
49. Ashburner J, Friston K (2000) Voxel-based morphometry-the methods. Neuroimage 11:805-821.
50. Good CD, et al. (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:21-36.
51. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
52. Almasy L, Dyer TD, Blangero J (1997) Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages. Genet Epidemiol 14:953-958.