메뉴 건너뛰기




Volumn 17, Issue 10, 2012, Pages 996-1006

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia

Author keywords

GAIN; gene group analysis; genome wide association; GWAS; ISC; synapse

Indexed keywords

ARTICLE; CELL ADHESION; CONTROLLED STUDY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK FACTOR; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPSE;

EID: 84866736529     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2011.117     Document Type: Article
Times cited : (129)

References (35)
  • 1
    • 0029082109 scopus 로고
    • Symptoms, signs, and diagnosis of schizophrenia
    • Andreasen NC. Symptoms, signs, and diagnosis of schizophrenia. Lancet 1995; 346: 477-481.
    • (1995) Lancet , vol.346 , pp. 477-481
    • Andreasen, N.C.1
  • 3
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
    • Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60: 1187-1192.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 5
    • 68449096727 scopus 로고    scopus 로고
    • Common variants on chromosome 6p22.1 are associated with schizophrenia
    • Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009; 460: 753-757.
    • (2009) Nature , vol.460 , pp. 753-757
    • Shi, J.1    Levinson, D.F.2    Duan, J.3    Sanders, A.R.4    Zheng, Y.5    Pe'Er, I.6
  • 8
    • 53649098737 scopus 로고    scopus 로고
    • Pathway analysis of seven common diseases assessed by genome-wide association
    • Torkamani A, Topol EJ, Schork NJ. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 2008; 92: 265-272.
    • (2008) Genomics , vol.92 , pp. 265-272
    • Torkamani, A.1    Topol, E.J.2    Schork, N.J.3
  • 9
    • 67649584052 scopus 로고    scopus 로고
    • Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    • Holmans P, Green EK, Pahwa JS, Ferreira MA, Purcell SM, Sklar P et al. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am J Hum Genet 2009; 85: 13-24.
    • (2009) Am J Hum Genet , vol.85 , pp. 13-24
    • Holmans, P.1    Green, E.K.2    Pahwa, J.S.3    Ferreira, M.A.4    Purcell, S.M.5    Sklar, P.6
  • 10
    • 77956192274 scopus 로고    scopus 로고
    • Common variants conferring risk of schizophrenia: A pathway analysis of GWAS data
    • Jia P, Wang L, Meltzer HY, Zhao Z. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophr Res 2010; 122: 38-42.
    • (2010) Schizophr Res , vol.122 , pp. 38-42
    • Jia, P.1    Wang, L.2    Meltzer, H.Y.3    Zhao, Z.4
  • 11
    • 76049098158 scopus 로고    scopus 로고
    • Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability
    • Ruano D, Abecasis GR, Glaser B, Lips ES, Cornelisse LN, de Jong AP et al. Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability. Am J Hum Genet 2010; 86: 113-125.
    • (2010) Am J Hum Genet , vol.86 , pp. 113-125
    • Ruano, D.1    Abecasis, G.R.2    Glaser, B.3    Lips, E.S.4    Cornelisse, L.N.5    De Jong, A.P.6
  • 12
    • 78549252909 scopus 로고    scopus 로고
    • Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility
    • O'Dushlaine C, Kenny E, Heron E, Donohoe G, Gill M, Morris D et al. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol Psychiatry 2011; 16: 286-292.
    • (2011) Mol Psychiatry , vol.16 , pp. 286-292
    • O'Dushlaine, C.1    Kenny, E.2    Heron, E.3    Donohoe, G.4    Gill, M.5    Morris, D.6
  • 14
    • 36249029788 scopus 로고    scopus 로고
    • Pathway-based approaches for analysis of genomewide association studies
    • Wang K, Li M, Bucan M. Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet 2007; 81: 1278-1283.
    • (2007) Am J Hum Genet , vol.81 , pp. 1278-1283
    • Wang, K.1    Li, M.2    Bucan, M.3
  • 15
    • 12444258700 scopus 로고    scopus 로고
    • Schizophrenia: A genetic disorder of the synapse?
    • Owen MJ, O'Donovan MC, Harrison PJ. Schizophrenia: a genetic disorder of the synapse? BMJ 2005; 330: 158-159.
    • (2005) BMJ , vol.330 , pp. 158-159
    • Owen, M.J.1    O'Donovan, M.C.2    Harrison, P.J.3
  • 16
    • 12344327212 scopus 로고    scopus 로고
    • Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence
    • image 45
    • Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10: 40-68; image 45.
    • (2005) Mol Psychiatry , vol.10 , pp. 40-68
    • Harrison, P.J.1    Weinberger, D.R.2
  • 17
    • 77956647414 scopus 로고    scopus 로고
    • Disturbed synaptic connectivity in schizophrenia: Convergence of genetic risk factors during neurodevelopment
    • Hayashi-Takagi A, Sawa A. Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment. Brain Res Bull 2010; 83: 140-146.
    • (2010) Brain Res Bull , vol.83 , pp. 140-146
    • Hayashi-Takagi, A.1    Sawa, A.2
  • 18
    • 58249129772 scopus 로고    scopus 로고
    • SNARE proteins and schizophrenia: Linking synaptic and neurodevelopmental hypotheses
    • Johnson RD, Oliver PL, Davies KE. SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses. Acta Biochim Pol 2008; 55: 619-628.
    • (2008) Acta Biochim Pol , vol.55 , pp. 619-628
    • Johnson, R.D.1    Oliver, P.L.2    Davies, K.E.3
  • 19
    • 78549251736 scopus 로고    scopus 로고
    • Analysing biological pathways in genome-wide association studies
    • Wang K, Li M, Hakonarson H. Analysing biological pathways in genome-wide association studies. Nat Rev Genet 2010; 11: 843-854.
    • (2010) Nat Rev Genet , vol.11 , pp. 843-854
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 20
    • 31544444484 scopus 로고    scopus 로고
    • Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    • Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C et al. Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am J Hum Genet 2006; 78: 315-333.
    • (2006) Am J Hum Genet , vol.78 , pp. 315-333
    • Suarez, B.K.1    Duan, J.2    Sanders, A.R.3    Hinrichs, A.L.4    Jin, C.H.5    Hou, C.6
  • 21
    • 20844455428 scopus 로고    scopus 로고
    • Organelle proteomics of rat synaptic proteins: Correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins
    • Li K, Hornshaw MP, van Minnen J, Smalla KH, Gundelfinger ED, Smit AB. Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins. J Proteome Res 2005; 4: 725-733.
    • (2005) J Proteome Res , vol.4 , pp. 725-733
    • Li, K.1    Hornshaw, M.P.2    Van Minnen, J.3    Smalla, K.H.4    Gundelfinger, E.D.5    Smit, A.B.6
  • 23
    • 28444493739 scopus 로고    scopus 로고
    • Combining probability from independent tests: The weighted Z-method is superior to Fisher's approach
    • Whitlock MC. Combining probability from independent tests: the weighted Z-method is superior to Fisher's approach. J Evol Biol 2005; 18: 1368-1373.
    • (2005) J Evol Biol , vol.18 , pp. 1368-1373
    • Whitlock, M.C.1
  • 26
    • 1842539516 scopus 로고    scopus 로고
    • A simple correction for multiple testing for singlenucleotide polymorphisms in linkage disequilibrium with each other
    • Nyholt DR. A simple correction for multiple testing for singlenucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004; 74: 765-769.
    • (2004) Am J Hum Genet , vol.74 , pp. 765-769
    • Nyholt, D.R.1
  • 27
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA 2009; 106: 9362-9367.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5    Collins, F.S.6
  • 28
    • 50449089356 scopus 로고    scopus 로고
    • Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    • Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008; 40: 1056-1058.
    • (2008) Nat Genet , vol.40 , pp. 1056-1058
    • Ferreira, M.A.1    O'Donovan, M.C.2    Meng, Y.A.3    Jones, I.R.4    Ruderfer, D.M.5    Jones, L.6
  • 29
    • 77954510735 scopus 로고    scopus 로고
    • The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
    • Green EK, Grozeva D, Jones I, Jones L, Kirov G, Caesar S et al. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry 2010; 15: 1016-1022.
    • (2010) Mol Psychiatry , vol.15 , pp. 1016-1022
    • Green, E.K.1    Grozeva, D.2    Jones, I.3    Jones, L.4    Kirov, G.5    Caesar, S.6
  • 30
    • 68649090485 scopus 로고    scopus 로고
    • Presynaptic signal transduction pathways that modulate synaptic transmission
    • de Jong AP, Verhage M. Presynaptic signal transduction pathways that modulate synaptic transmission. Curr Opin Neurobiol 2009; 19: 245-253.
    • (2009) Curr Opin Neurobiol , vol.19 , pp. 245-253
    • De Jong, A.P.1    Verhage, M.2
  • 31
    • 84875003821 scopus 로고    scopus 로고
    • The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium Genome-Wide Association Study Identifies Five Novel Schizophrenia Loci
    • in press
    • The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-Wide Association Study Identifies Five Novel Schizophrenia Loci. Nat Genet, in press.
    • Nat Genet
  • 33
    • 73449129712 scopus 로고    scopus 로고
    • From disease association to risk assessment: An optimistic view from genome-wide association studies on type 1 diabetes
    • Wei Z, Wang K, Qu HQ, Zhang H, Bradfield J, Kim C et al. From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet 2009; 5: e1000678.
    • (2009) PLoS Genet , vol.5
    • Wei, Z.1    Wang, K.2    Qu, H.Q.3    Zhang, H.4    Bradfield, J.5    Kim, C.6
  • 34
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • Kitano H. Biological robustness. Nat Rev Genet 2004; 5: 826-837.
    • (2004) Nat Rev Genet , vol.5 , pp. 826-837
    • Kitano, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.