The PREMM1,2,6 model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history

Gastroenterology

Volumn 140, Issue 1, 2011, Pages 73-81.e5

  Kastrinos, Fay ^a,b   Steyerberg, Ewout W ^c   Mercado, Rowena ^d   Balmaña, Judith ^e   Holter, Spring ^f   Gallinger, Steven ^f,g   Siegmund, Kimberly D ^h   Church, James M ⁱ   Jenkins, Mark A ^j   Lindor, Noralane M ^k   Thibodeau, Stephen N ^k   Burbidge, Lynn Anne ^l   Wenstrup, Richard J ^l   Syngal, Sapna ^d,m,n  

^a Division of Digestive and Liver Diseases   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f MOUNT SINAI HOSPITAL   (Canada)

^g UNIVERSITY HEALTH NETWORK   (Canada)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

ⁱ LERNER RESEARCH INSTITUTE   (United States)

^j CANCER EPIDEMIOLOGY CENTRE   (Australia)

^k MAYO CLINIC   (United States)

^l Myriad Genetic Laboratories   (United States)

^m BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁿ HARVARD MEDICAL SCHOOL   (United States)

more..

Author keywords

Colon Cancer Family Registry; Gene Specific Risk Estimates; Lynch Syndrome; Prediction Model

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADULT; ARTICLE; COHORT ANALYSIS; COLORECTAL CANCER; ENDOMETRIUM CANCER; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC MODEL; GENETIC RISK; GERMLINE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MISMATCH REPAIR; MULTIPLE CANCER; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; RELATIVE;

EID: 78650513224     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.08.021     Document Type: Article

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