Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site

Chemistry and Biology

Volumn 19, Issue 9, 2012, Pages 1152-1163

  Busschots, Katrien ^a   Lopez Garcia, Laura A ^a   Lammi, Carmen ^a   Stroba, Adriana ^b   Zeuzem, Stefan ^a   Piiper, Albrecht ^a   Alzari, Pedro M ^c   Neimanis, Sonja ^a   Arencibia, Jose M ^a   Engel, Matthias ^b   Schulze, Jörg O ^a   Biondi, Ricardo M ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PIF PROTEIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PS 182; PS 210; PS 423; S6 KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; IN VITRO STUDY; MOLECULAR DOCKING; PROTEIN BINDING; PROTEIN PHOSPHORYLATION;

ALLOSTERIC SITE; ANIMALS; CELL LINE; CHALCONES; DICARBOXYLIC ACIDS; HEK293 CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PRODRUGS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84866652604     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.07.017     Document Type: Article

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